The electroencephalogram (EEG) reflects the activity of thousands or even millions of cortical neurons with important input from subcortical structures. As changes in milliseconds may be visible in EEG, temporal resolution ...

Platelet function plays a critical role in hemostasis, and dysfunction in this mechanism is implicated in a range of bleeding disorders. The most rare inherited platelet function disorders (IPFDs) are relatively easy to ...

Heart failure is an incurable condition with a low 5-year survival rate (~60%) and a significant impact on quality of life. Biological clocks, which regulate 24-hour rhythms, play a crucial role in cardiac function. In ...

Proteins are essential drivers of virtually all cellular processes, and their timely and accurate production is critical for proper cell functioning. Protein synthesis is carried out by a molecular machine known as the ...

Cardiovascular disease (CVD) remains a major health burden, requiring lifelong cardiovascular risk management (CVRM) for millions of patients. This is complex because patients often have multiple health conditions requiring ...

This thesis explores a range of strategies aimed at enhancing RNA delivery beyond the liver through the use of lipid nanoparticles (LNPs). A major focus of the work is on mitigating the rapid clearance of LNPs by the ...

Chronic kidney disease and pregnancy are not a rare combination. In the Netherlands, approximately 4.5% of women aged 20 to 44 have a form of chronic kidney disease. Among a subset of these patients who develop kidney ...

In the Netherlands, approximately 600 children are diagnosed with cancer each year. Advances in treatment and supportive care have increased the five-year survival rate to 75%, but this also means more children experience ...

In 2007, sentinel lymph node biopsy (SLNB) was applied for the first time in the Netherlands in a patient with early-stage oral cavity carcinoma without any signs of lymph node metastasis on clinical and radiological ...