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Now showing items 3781-3800 of 40729

Dupilumab improves patient-reported symptoms of atopic dermatitis, symptoms of anxiety and depression, and health-related quality of life in moderate-to-severe atopic dermatitis: analysis of pooled data from the randomized trials SOLO 1 and SOLO 2

Cork, Michael J; Eckert, Laurent; Simpson, Eric L; Armstrong, April; Barbarot, Sébastien; Puig, Luis; Girolomoni, Giampiero; de Bruin-Weller, Marjolein; Wollenberg, Andreas; Kataoka, Yoko; Remitz, Anita; Beissert, Stefan; Mastey, Vera; Ardeleanu, Marius; Chen, Zhen; Gadkari, Abhijit; Chao, Jingdong (Informa Healthcare, 2020-09)

Background: Atopic dermatitis (AD) profoundly affects quality of life (QoL). Dupilumab significantly improves clinical outcomes, is well tolerated, and approved to treat inadequately controlled moderate-to-severe AD in ...
Dupilumab Versus Cyclosporine for the Treatment of Moderate-to-Severe Atopic Dermatitis in Adults: Indirect Comparison Using the Eczema Area and Severity Index

Ariëns, Lieneke F M; Gadkari, Abhijit; van Os-Medendorp, Harmieke; Ayyagari, Rajeev; Terasawa, Emi; Kuznik, Andreas; Chen, Zhen; Bégo-Le Bagousse, Gaëlle; Lu, Yufang; Rizova, Elena; Graham, Neil M H; Pirozzi, Gianluca; De Bruin-Weller, Marjolein; Eckert, Laurent (Medical Journals Sweden AB, 2019-09-01)

Dupilumab is approved for uncontrolled moderate-to-severe atopic dermatitis (AD); cyclosporine is approved for severe AD for ≤ 1 year. The efficacy/effectiveness of these treat-ments was compared indirectly. Regression ...
Economic Burden of Adult Patients with Moderate to Severe Atopic Dermatitis Indicated for Systemic Treatment

Ariëns, Lieneke F M; van Nimwegen, Kirsten J M; Shams, Marjan; de Bruin, Digna T; van der Schaft, Jorien; van Os-Medendorp, Harmieke; De Bruin-Weller, Marjolein (Medical Journals Sweden AB, 2019-07-01)

Given the introduction of new therapies targeting specific immune pathways for atopic dermatitis (AD), information on the economic burden of AD patients is needed. Direct costs (medication use and healthcare resource ...
Time to get rid of the Investigator's Global Assessment as the primary outcome for clinical trials in atopic dermatitis?

de Bruin-Weller, M (Wiley-Blackwell, 2019-07)
Effect of dupilumab on hand eczema in patients with atopic dermatitis: An observational study

Oosterhaven, Jart A F; Voorberg, Angelique N; Romeijn, Geertruida L E; de Bruin-Weller, Marjolein S; Schuttelaar, Marie L A (John Wiley & Sons Inc., 2019-08)

Systemic treatment options for chronic hand eczema are limited. Dupilumab is used in atopic dermatitis (AD) but is not licensed for (isolated) hand eczema. In this observational prospective study we aimed to determine the ...
Management of dupilumab-associated conjunctivitis in atopic dermatitis

Aszodi, Nora; Thurau, Stephan; Seegräber, Marlene; de Bruin-Weller, Marjolein; Wollenberg, Andreas (Wiley-Blackwell Publishing Ltd, 2019-05)

Since September 2017, the monoclonal antibody dupilumab (Dupixent® ) has been approved in the EU for the treatment of moderate-to-severe atopic dermatitis. By blocking IL-4 and IL-13 signaling pathways, dupilumab improves ...
Infections in Dupilumab Clinical Trials in Atopic Dermatitis: A Comprehensive Pooled Analysis

Eichenfield, Lawrence F; Bieber, Thomas; Beck, Lisa A; Simpson, Eric L; Thaçi, Diamant; de Bruin-Weller, Marjolein; Deleuran, Mette; Silverberg, Jonathan I; Ferrandiz, Carlos; Fölster-Holst, Regina; Chen, Zhen; Graham, Neil M H; Pirozzi, Gianluca; Akinlade, Bolanle; Yancopoulos, George D; Ardeleanu, Marius (Adis, 2019-06)

Background: Patients with moderate-to-severe atopic dermatitis (AD) have increased infection risk, including skin infections and systemic infections. Immunomodulators (e.g., anti-tumor necrosis factors, anti-interleukin ...
Dupilumab shows long-term safety and efficacy in patients with moderate to severe atopic dermatitis enrolled in a phase 3 open-label extension study

Deleuran, Mette; Thaçi, Diamant; Beck, Lisa A; de Bruin-Weller, Marjolein; Blauvelt, Andrew; Forman, Seth; Bissonnette, Robert; Reich, Kristian; Soong, Weily; Hussain, Iftikhar; Foley, Peter; Hide, Michihiro; Bouaziz, Jean-David; Gelfand, Joel M; Sher, Lawrence; Schuttelaar, Marie L A; Wang, Chen; Chen, Zhen; Akinlade, Bolanle; Gadkari, Abhijit; Eckert, Laurent; Davis, John D; Rajadhyaksha, Manoj; Staudinger, Heribert; Graham, Neil M H; Pirozzi, Gianluca; Ardeleanu, Marius (Mosby Inc., 2020-02)

BACKGROUND: Significant unmet need exists for long-term treatment of moderate to severe atopic dermatitis (AD). OBJECTIVE: To assess the long-term safety and efficacy of dupilumab in patients with AD. METHODS: This ongoing, ...
The patient-reported disease burden in adults with atopic dermatitis: a cross-sectional study in Europe and Canada

de Bruin-Weller, M; Gadkari, A; Auziere, S; Simpson, E L; Puig, L; Barbarot, S; Girolomoni, G; Papp, K; Pink, A E; Saba, G; Werfel, T; Eckert, L (Wiley-Blackwell, 2020-05)

Background: Cross-sectional data on patient burden in adults with atopic dermatitis (AD) from real-world clinical practice are limited. Objective: This study compared patient-reported burden associated with adult AD across ...
Protocol for a prospective, observational, longitudinal study in paediatric patients with moderate-to-severe atopic dermatitis (PEDISTAD): study objectives, design and methodology

Paller, Amy S; Guttman-Yassky, Emma; Irvine, Alan D; Baselga, Eulalia; de Bruin-Weller, Marjolein; Jayawardena, Shyamalie; Zhang, Annie; Mina-Osorio, Paola; Rizova, Elena; Ozturk, Zafer E (BMJ Publishing Group, 2020-03-24)

INTRODUCTION: Atopic dermatitis (AD) is a chronic inflammatory skin disease often associated with atopic comorbidities and has significant impact on children and their families. There is a lack of robust and longitudinal ...
European Task Force on Atopic Dermatitis statement on severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection and atopic dermatitis

Wollenberg, A; Flohr, C; Simon, D; Cork, M J; Thyssen, J P; Bieber, T; de Bruin-Weller, M S; Weidinger, S; Deleuran, M; Taieb, A; Paul, C; Trzeciak, M; Werfel, T; Seneschal, J; Barbarot, S; Darsow, U; Torrelo, A; Stalder, J-F; Svensson, Å; Hijnen, D; Gelmetti, C; Szalai, Z; Gieler, U; De Raeve, L; Kunz, B; Spuls, P; von Kobyletzki, L B; Fölster-Holst, R; Chernyshov, P V; Christen-Zaech, S; Heratizadeh, A; Ring, J; Vestergaard, C (Wiley-Blackwell, 2020-06-01)
European Task Force on Atopic Dermatitis (ETFAD): treatment targets and treatable traits in atopic dermatitis

Thyssen, J P; Vestergaard, C; Deleuran, M; de Bruin-Weller, M S; Bieber, T; Taieb, A; Seneschal, J; Cork, M J; Paul, C; Flohr, C; Weidinger, S; Trzeciak, M; Werfel, T; Heratizadeh, A; Barbarot, S; Darsow, U; Simon, D; Torrelo, A; Chernyshov, P V; Stalder, J-F; Gelmetti, C; Szalai, Z; Svensson, Å; von Kobyletzki, L B; De Raeve, L; Fölster-Holst, R; Cristen-Zaech, S; Hijnen, D; Gieler, U; Ring, J; Wollenberg, A (Wiley-Blackwell, 2020-12)
Dupilumab reduces absenteeism in patients with moderate to severe atopic dermatitis: Pooled results from the LIBERTY AD SOLO clinical trials

de Bruin-Weller, Marjolein; Simpson, Eric L; Cork, Michael; Chen, Zhen; Msihid, Jerome; Taniou, Christine; Eckert, Laurent; Gadkari, Abhijit; Bégo-Le Bagousse, Gaëlle (Mosby Inc., 2020-11)
Management of Ocular Manifestations of Atopic Dermatitis: A Consensus Meeting Using a Modified Delphi Process

Thyssen, Jacob P; Heegaard, Steffen; Ivert, Lena; Remitz, Anita; Agner, Tove; De Bruin-Weller, Marjolein; Huldt-Nystrøm, Theis; Korhonen, Laura; Ivert, Lina U; Leinonen, Pekka; Mandelin, Johanna; Särnhult, Tore; Schopf, Thomas; Sundlisæter, Eirik; Thomsen, Simon F; Tzellos, Thrasyvoulos; Vestergaard, Christian; von Kobyletzki, Laura; Bradley, Maria (Medical Journals Sweden AB, 2020-09-16)

There is a need for unified guidance on the management of ocular manifestations of atopic dermatitis and ocular manifestations associated with dupilumab in the Nordic region (Denmark, Finland, Norway and Sweden). This ...
ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children

Wollenberg, A; Christen-Zäch, S; Taieb, A; Paul, C; Thyssen, J P; de Bruin-Weller, M; Vestergaard, C; Seneschal, J; Werfel, T; Cork, M J; Kunz, B; Fölster-Holst, R; Trzeciak, M; Darsow, U; Szalai, Z; Deleuran, M; von Kobyletzki, L; Barbarot, S; Heratizadeh, A; Gieler, U; Hijnen, D J; Weidinger, S; De Raeve, L; Svensson, Å; Simon, D; Stalder, J F; Ring, J; European Task Force on Atopic Dermatitis/EADV Eczema Task Force (Wiley-Blackwell, 2020-12)

Atopic dermatitis (AD) is a highly pruritic, chronic inflammatory skin disease. The diagnosis is made using evaluated clinical criteria. Disease activity and burden are best measured with a composite score, assessing both ...
Functional assays to assess the therapeutic potential of extracellular vesicles

Nguyen, Vivian V.T.; Witwer, Kenneth W.; Verhaar, Marianne C.; Strunk, Dirk; van Balkom, Bas W.M. (John Wiley & Sons Inc., 2020-11)

An important aspect in the development of extracellular vesicle (EV) therapeutics is identifying and quantifying the key features defining their identity, purity, sterility, potency and stability to ensure batch-to-batch ...
Een infantiel hemangioom herken je zo

de Graaf, M (DCHG Partners in Mediscne Communicatie, 2019-04-01)

Infantile hemangioma’s (IH) have a characteristic growth pattern and in most cases the diagnosis of IH can be made by the clinical picture. Nevertheless, making an accurate first diagnosis can be challenging. A careful ...
Leprosy and the Colonial Gaze: Comparing the Dutch West and East Indies, 1750-1950

Snelders, Stephen; van Bergen, L.; Huisman, Frank G. (Oxford University Press, 2019)

This article is looking at colonial governance with regard to leprosy, comparing two settings of the Dutch colonial empire: Suriname and the Dutch East Indies. Whereas segregation became formal policy in Suriname, leprosy ...
Why Do We Do What We Do? The Values of the Social History of Medicine: 'Roundtable comment'

McKay, R.A.; Huisman, Frank G. (Oxford University Press, 2019)
Effects of shared medical appointments compared to individual appointments in children with atopic dermatitis: A pragmatic randomized controlled trial

Zijlstra, Wieneke T; van Os-Medendorp, Harmieke; Fieten, Karin B; Sinnema, Gerben; Bruijnzeel-Koomen, Carla A F M; Zuithoff, Nicolaas P A; L'Hoir, Monique P; Pasmans, Suzanne G M A (Wiley-Blackwell, 2019-08)

BACKGROUND: Atopic dermatitis (AD) needs intensive treatment and has a negative impact on quality of life. Shared medical appointments (SMAs) showed to be effective in clinical outcomes of chronic diseases, but little is ...

Now showing items 3781-3800 of 40729