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Now showing items 3581-3600 of 40729

Sex-specific associations between cardiovascular risk factors and myocardial infarction in patients with type 2 diabetes: The ADVANCE-ON study

Ohkuma, Toshiaki; Peters, Sanne A E; Jun, Min; Harrap, Stephen; Cooper, Mark; Hamet, Pavel; Poulter, Neil; Chalmers, John; Woodward, Mark; ADVANCE Collaborative Group (Wiley-Blackwell, 2020-10)

AIM: To examine possible sex differences in the excess risk of myocardial infarction (MI) consequent to a range of conventional risk factors in a large-scale international cohort of patients with diabetes, and to quantify ...
Gender differences in the accuracy of dietary assessment methods to measure energy intake in adults: protocol for a systematic review and meta-analysis

McKenzie, Briar L; Coyle, Daisy H; Burrows, Tracy; Rosewarne, Emalie; Peters, Sanne A E; Carcel, Cheryl; Collins, Clare E; Norton, Robyn; Woodward, Mark; Jaacks, Lindsay M; Webster, Jacqui (BMJ Publishing Group, 2020-06-01)

INTRODUCTION: Diet is an important modifiable risk factor for many chronic diseases. Measurement of dietary intake usually relies on self-report, subject to multiple biases. There is a need to understand gender differences ...
Sex, Gender, and Precision Medicine

Peters, Sanne A E; Woodward, Mark (American Medical Association, 2020-08-01)
What Sex-Disaggregated Metrics Are Needed to Explain Sex Differences in COVID-19?

Hockham, Carinna; Thompson, Kelly; Carcel, Cheryl; Pinho-Gomes, Ana-Catarina; Woodward, Mark; Peters, Sanne A E (Frontiers Media S. A., 2020-07-03)
Diabetes, Glycated Hemoglobin, and the Risk of Myocardial Infarction in Women and Men: A Prospective Cohort Study of the UK Biobank

de Jong, Marit; Woodward, Mark; Peters, Sanne A E (American Diabetes Association Inc., 2020-09)

OBJECTIVE: Diabetes has shown to be a stronger risk factor for myocardial infarction (MI) in women than men. Whether sex differences exist across the glycemic spectrum is unknown. We investigated sex differences in the ...
Diabetes as a risk factor for incident peripheral arterial disease in women compared to men: a systematic review and meta-analysis

Chase-Vilchez, Alyssa Z; Chan, Isaac H Y; Peters, Sanne A E; Woodward, Mark (BioMed Central, 2020-09-26)

AIMS/HYPOTHESIS: Previous meta-analyses have suggested that diabetes confers a greater excess risk of coronary heart disease, stroke, vascular dementia, and heart failure in women compared to men. While the underlying ...
Sex Differences in Incident and Recurrent Coronary Events and All-Cause Mortality

Peters, Sanne A E; Colantonio, Lisandro D; Chen, Ligong; Bittner, Vera; Farkouh, Michael E; Rosenson, Robert S; Jackson, Elizabeth A; Dluzniewski, Paul; Poudel, Bharat; Muntner, Paul; Woodward, Mark (Elsevier, 2020-10-13)

BACKGROUND: Women have lower age-specific rates of incident coronary heart disease (CHD) than men. It is unclear whether women remain at lower risk for CHD events versus men following a myocardial infarction (MI). OBJECTIVES: ...
Sex differences in the association between major risk factors and the risk of stroke in the UK Biobank cohort study

Peters, Sanne A E; Carcel, Cheryl; Millett, Elizabeth R C; Woodward, Mark (Lippincott Williams & Wilkins, 2020-11-17)

OBJECTIVE: To determine whether there are sex differences in the association between risk factors and incident stroke, including stroke subtypes. METHODS: A total of 471,971 (56% women) UK Biobank participants without a ...
Covid-19: Male disadvantage highlights the importance of sex disaggregated data

Womersley, Kate; Ripullone, Katherine; Peters, Sanne Ae; Woodward, Mark (BMJ Publishing Group, 2020-07-20)
Essential Issues for Pregnancy Counseling in Renal Transplant Women

van Buren, Marleen; Lely, Titia; van de Wetering, Jacqueline (Lippincott Williams & Wilkins, 2018-06-01)
Is microbiota research advancing our understanding of infection?

Paganelli, Fernanda L.; Ekkelenkamp, Miquel B. (Oxford University Press, 2019-04-08)
Autoantibodies in idiopathic inflammatory myopathies: Clinical associations and laboratory evaluation by mono- and multispecific immunoassays

Damoiseaux, Jan; Vulsteke, Jean-Baptiste; Tseng, Chih-Wei; Platteel, Anouk C M; Piette, Yves; Shovman, Ora; Bonroy, Carolien; Hamann, Dörte; De Langhe, Ellen; Musset, Lucille; Chen, Yi-Hsing; Shoenfeld, Yehuda; Allenbach, Yves; Bossuyt, Xavier (Elsevier, 2019-03)

Idiopathic inflammatory myopathies (IIM) are a group of diseases characterized by immune-mediated muscular lesions that may be associated with extra-muscular manifestations involving skin, lungs, heart or joints. Four main ...
Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls

BBMRI-NL Metabolomics Consortium (Elsevier, 2020-03-01)

BACKGROUND: Depression has been associated with metabolic alterations, which adversely impact cardiometabolic health. Here, a comprehensive set of metabolic markers, predominantly lipids, was compared between depressed and ...
Early career investigator highlight: April

Tataranno, Maria Luisa (Lippincott Williams & Wilkins, 2018-04-01)
Clinical epidemiology: Detrusor voiding contraction maximum power, related to ageing

Rosier, P. F.W.M.; Donkelaar, C. S.Ten; De Kort, L. M. (Elsevier, 2019-09)
Bacterial killing by complement requires membrane attack complex formation via surface-bound C5 convertases

Heesterbeek, Dani A.C.; Bardoel, Bart W.; Parsons, Edward S.; Bennett, Isabel; Ruyken, Maartje; Doorduijn, Dennis J.; Gorham, Ronald D.; Berends, Evelien T.M.; Pyne, Alice L.B.; Hoogenboom, Bart W.; Rooijakkers, Suzan H.M. (Springer Science and Business Media Deutschland GmbH, 2019-02-15)

The immune system kills bacteria by the formation of lytic membrane attack complexes (MACs), triggered when complement enzymes cleave C5. At present, it is not understood how the MAC perturbs the composite cell envelope ...
Local structural plasticity of the Staphylococcus aureus evasion protein EapH1 enables engagement with multiple neutrophil serine proteases

Herdendorf, Timothy J.; Stapels, Daphne A.C.; Rooijakkers, Suzan H.M.; Geisbrecht, Brian V. (American Society for Biochemistry and Molecular Biology Inc., 2020-05-28)

Members of the EAP family of Staphylococcus aureus immune evasion proteins potently inhibit the neutrophil serine proteases (NSPs) neutrophil elastase, cathepsin-G, and proteinase-3. Previously, we determined a 1.8 A ...
Bacterial killing by complement requires direct anchoring of membrane attack complex precursor C5b-7

Doorduijn, Dennis J.; Bardoel, Bart W.; Heesterbeek, Dani A.C.; Ruyken, Maartje; Benn, Georgina; Parsons, Edward S.; Hoogenboom, Bart W.; Suzan, Suzan H. (Public Library of Science, 2020-06)

An important effector function of the human complement system is to directly kill Gram-negative bacteria via Membrane Attack Complex (MAC) pores. MAC pores are assembled when surface-bound convertase enzymes convert C5 ...
How the Membrane Attack Complex Damages the Bacterial Cell Envelope and Kills Gram-Negative Bacteria

Doorduijn, Dennis J.; Rooijakkers, Suzan H.M.; Heesterbeek, Dani A.C. (John Wiley & Sons Inc., 2019-10-01)

The human immune system can directly lyse invading micro-organisms and aberrant host cells by generating pores in the cell envelope, called membrane attack complexes (MACs). Recent studies using single-particle cryoelectron ...
Functional characterization of alternative and classical pathway C3/C5 convertase activity and inhibition using purified models

Zwarthoff, Seline A.; Berends, Evelien T.M.; Mol, Sanne; Ruyken, Maartje; Aerts, Piet C.; Józsi, Mihály; de Haas, Carla J.C.; Rooijakkers, Suzan H.M.; Gorham, Ronald D. (Frontiers Media S. A., 2018-07-23)

Complement is essential for the protection against infections; however, dysregulation of complement activation can cause onset and progression of numerous inflammatory diseases. Convertase enzymes play a central role in ...

Now showing items 3581-3600 of 40729