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UMC Repository: Recent submissions

  • Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease 
    Van Der Made, Thomas K.; Fedecostante, Michele; Scotcher, Daniel; Rostami-Hodjegan, Amin; Sastre Toranõ, Javier; Middel, Igor; Koster, Andries S.; Gerritsen, Karin G.; Jankowski, Vera; Jankowski, Joachim; Hoenderop, Joost G.J.; Masereeuw, Rosalinde; Galetin, Aleksandra (American Chemical Society, 2019-11-04)
    Indoxyl sulfate (IxS), a highly albumin-bound uremic solute, accumulates in chronic kidney disease (CKD) due to reduced renal clearance. This study was designed to specifically investigate the role of human serum albumin ...
  • Kidney-based in vitro models for drug-induced toxicity testing 
    Faria, João; Ahmed, Sabbir; Gerritsen, Karin G.F.; Mihaila, Silvia M.; Masereeuw, Rosalinde (Springer Heidelberg, 2019-12-01)
    The kidney is frequently involved in adverse effects caused by exposure to foreign compounds, including drugs. An early prediction of those effects is crucial for allowing novel, safe drugs entering the market. Yet, in ...
  • Urea removal strategies for dialysate regeneration in a wearable artificial kidney 
    van Gelder, Maaike K.; Jong, Jacobus A.W.; Folkertsma, Laura; Guo, Yong; Blüchel, Christian; Verhaar, Marianne C.; Odijk, Mathieu; Van Nostrum, Cornelus F.; Hennink, Wim E.; Gerritsen, Karin G.F. (Elsevier, 2020-03)
    The availability of a wearable artificial kidney (WAK) that provides dialysis outside the hospital would be an important advancement for dialysis patients. The concept of a WAK is based on regeneration of a small volume ...
  • Influence of dialysate temperature on creatinine peritoneal clearance in peritoneal dialysis patients: a randomized trial 
    Fontana, Francesco; Torelli, Chiara; Giovanella, Silvia; Ligabue, Giulia; Alfano, Gaetano; Gerritsen, Karin; Selgas, Rafael; Cappelli, Gianni (BioMed Central, 2020-12-01)
    Background: Patients on continuous ambulatory peritoneal dialysis (PD) are encouraged to warm dialysate to 37 °C before peritoneal infusion; main international PD guidelines do not provide specific recommendation, and ...
  • A cautionary note on the use of the missing indicator method for handling missing data in prediction research 
    van Smeden, Maarten; Groenwold, Rolf H.H.; Moons, Karel GM (Elsevier, 2020-09)
  • COVID-19 prediction models should adhere to methodological and reporting standards 
    Collins, Gary S.; van Smeden, Maarten; Riley, Richard D. (European Respiratory Society, 2020-09-01)
  • Systematic evaluation and external validation of 22 prognostic models among hospitalised adults with COVID-19: An observational cohort study 
    Gupta, Rishi K; Marks, Michael; Samuels, Thomas H A; Luintel, Akish; Rampling, Tommy; Chowdhury, Humayra; Quartagno, Matteo; Nair, Arjun; Lipman, Marc; Abubakar, Ibrahim; van Smeden, Maarten; Wong, Wai Keong; Williams, Bryan; Noursadeghi, Mahdad; UCLH COVID-19 Reporting Group (European Respiratory Society, 2020-12-01)
    The number of proposed prognostic models for coronavirus disease 2019 (COVID-19) is growing rapidly, but it is unknown whether any are suitable for widespread clinical implementation. We independently externally validated ...
  • Pediatric oncology as a Learning Health System: Ethical implications for best available treatment protocols 
    van der Graaf, Rieke; Dekking, Sara A.; de Vries, Martine C.; Zwaan, Christian Michel; van Delden, Johannes J.M. (John Wiley & Sons Inc., 2018-04)
    Introduction: Pediatric oncology is often considered as a field in which research and care are highly integrated. We believe that this integration can be seen as a so-called Learning Health System, a system in which research ...
  • Ethical issues in the design and conduct of stepped-wedge cluster randomized trials in low-resource settings 
    Joag, Kaustubh; Ambrosio, Guillermo; Kestler, Edgar; Weijer, Charles; Hemming, Karla; Van Der Graaf, Rieke (BioMed Central, 2019-12-19)
    Background: Stepped-wedge cluster randomized trials (SW-CRTs) are increasingly popular in health-related research in both high- and low-resource settings. There may be specific ethical issues that researchers face when ...
  • Learning health care systems: Highly needed but challenging 
    Wouters, Roel H.P.; van der Graaf, Rieke; Voest, Emile E.; Bredenoord, Annelien L. (John Wiley & Sons Inc., 2020-07-01)
    Background: Learning health care systems (LHSs) have the potential to transform health care. However, this transformation process faces significant challenges. Materials and methods: Based on proposals and early examples ...
  • Low-risk trials for children and pregnant women threatened by unnecessary strict regulations. Does the coming EU Clinical Trial Regulation offer a solution? 
    Knaapen, Max; Ploem, Martine Corrette; Kruijt, Maya; Oudijk, Martijn A.; van der Graaf, Rieke; Bet, Pierre M.; Bakx, Roel; van Heurn, L. W.Ernst; Gorter, Ramon R.; van der Lee, Johanna H. (Springer-Verlag, 2020-08-01)
    Investigator-initiated clinical trials are crucial for improving quality of care for children and pregnant women as they are often excluded from industry-initiated trials. However, trials have become increasingly time-consuming ...
  • The ethics of deferred consent in times of pandemics 
    van der Graaf, Rieke; Hoogerwerf, Marie Astrid; de Vries, Martine C. (Nature Research, 2020-09-01)
  • Ethics of alternative trial designs and methods in low-resource settings 
    Van Der Graaf, Rieke; Cheah, Phaik Yeong (BioMed Central, 2019-12-19)
    This editorial introduces articles in this Special Issue, which are based on presentations given at the 2017 meeting of the Global Forum of Bioethics in Research meeting. The main themes presented at the meeting were the ...
  • Between-hospital variation in mortality and survival after glioblastoma surgery in the Dutch Quality Registry for Neuro Surgery 
    on behalf of the Quality Registry Neuro Surgery glioblastoma working group from the Dutch Society of Neurosurgery (Kluwer Academic Publishers, 2019-09-01)
    Purpose: Standards for surgical decisions are unavailable, hence treatment decisions can be personalized, but also introduce variation in treatment and outcome. National registrations seek to monitor healthcare quality. ...
  • “I had lost the sense of direction on my left body part”, proprioception and awake brain surgery: A case report 
    Ruis, Carla; Smits, Anouk; Robe, Pierre; Dijkerman, Chris; van Zandvoort, Martine (Masson SpA, 2019-12)
  • The Cerebellar Cognitive Affective Syndrome: a Meta-analysis 
    Ahmadian, Narjes; van Baarsen, Kirsten; van Zandvoort, Martine; Robe, Pierre A. (Springer New York, 2019-10-01)
    The cerebellar cognitive affective syndrome (CCAS) was first described by Schmahmann and Sherman in 1998. Despite their clear depiction of the syndrome, it is our experience that the CCAS has not yet found solid ground as ...
  • GFAP alternative splicing regulates glioma cell–ECM interaction in a DUSP4-dependent manner 
    van Bodegraven, Emma J.; van Asperen, Jessy V.; Sluijs, Jacqueline A.; van Deursen, Coen B.J.; van Strien, Miriam E.; Stassen, Oscar M.J.A.; Robe, Pierre A.J.; Hol, Elly M. (John Wiley & Sons Inc., 2019-11-01)
    Gliomas are the most common primary brain tumors. Their highly invasive character and the heterogeneity of active oncogenic pathways within single tumors complicate the development of curative therapies and cause poor ...
  • GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes 
    Franceschini, Nora; Giambartolomei, Claudia; de Vries, Paul S.; Finan, Chris; Bis, Joshua C.; Huntley, Rachael P.; Lovering, Ruth C.; Tajuddin, Salman M.; Winkler, Thomas W.; Graff, Misa; Kavousi, Maryam; Dale, Caroline; Smith, Albert V.; Hofer, Edith; van Leeuwen, Elisabeth M.; Nolte, Ilja M.; Lu, Lingyi; Scholz, Markus; Sargurupremraj, Muralidharan; Pitkänen, Niina; Franzén, Oscar; Joshi, Peter K.; Noordam, Raymond; Marioni, Riccardo E.; Hwang, Shih Jen; Musani, Solomon K.; Schminke, Ulf; Palmas, Walter; Isaacs, Aaron; Correa, Adolfo; Zonderman, Alan B.; Hofman, Albert; Teumer, Alexander; Cox, Amanda J.; Uitterlinden, André G.; Wong, Andrew; Smit, Andries J.; Newman, Anne B.; Britton, Annie; Ruusalepp, Arno; Sennblad, Bengt; Hedblad, Bo; Pasaniuc, Bogdan; Penninx, Brenda W.; Langefeld, Carl D.; Franco, Oscar H.; van der Laan, Sander W.; de Bakker, Paul I.W.; Pulit, Sara L.; van der Harst, Pim; MEGASTROKE Consortium (Nature Publishing Group, 2018-12-01)
    Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide ...
  • Do IL-7 R+ innate cells orchestrate autoimmune pathology? 
    Hinrichs, Anneline C.; van Roon, Joel A.G. (Nature Research, 2019-11-01)
  • Estimating the Risk of Severe Peanut Allergy Using Clinical Background and IgE Sensitization Profiles 
    Datema, Mareen R.; Lyons, Sarah A.; Fernández-Rivas, Montserrat; Ballmer-Weber, Barbara; Knulst, André C.; Asero, Riccardo; Barreales, Laura; Belohlavkova, Simona; de Blay, Frédéric; Clausen, Michael; Dubakiene, Ruta; Fernández-Perez, Cristina; Fritsche, Philipp; Gislason, David; Hoffmann-Sommergruber, Karin; Jedrzejczak-Czechowicz, Monika; Jongejan, Laurian; Kowalski, Marek L.; Kralimarkova, Tanya Z.; Lidholm, Jonas; Papadopoulos, Nikolaos G.; Popov, Todor A.; Prado, Nayade del; Purohit, Ashok; Reig, Isabel; Seneviratne, Suranjith L.; Sinaniotis, Athanassios; Vassilopoulou, Emilia; Versteeg, Serge A.; Vieths, Stefan; Welsing, Paco M.J.; Mills, E. N.Clare; Le, Thuy My; Zwinderman, Aeilko H.; van Ree, Ronald (Frontiers Media S. A., 2021)
    Background: It is not well-understood why symptom severity varies between patients with peanut allergy (PA). Objective: To gain insight into the clinical profile of subjects with mild-to-moderate and severe PA, and investigate ...