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The network of cardiac KIR2.1: its function, cellular regulation, electrical signaling, diseases and new drug avenues

Li, Encan; van der Heyden, Marcel A.G. (Springer-Verlag, 2024-09)

The functioning of the human heart relies on complex electrical and communication systems that coordinate cardiac contractions and sustain rhythmicity. One of the key players contributing to this intricate system is the ...
Antibiotic use by clinical presentation across all healthcare providers in rural Burkina Faso: a healthcare visit exit survey

Valia, Daniel; Ingelbeen, Brecht; Nassa, Guétawendé Job Wilfried; Kaboré, Bérenger; Kiemdé, François; Rouamba, Toussaint; Compaoré, Adélaïde; Kouanda, Juste Stéphane; Robert, Annie; Rodriguez-Villalobos, Hector; Van Der Sande, Marianne A B; Tinto, Halidou (Oxford University Press, 2024-10-01)

BACKGROUND: To guide antibiotic stewardship interventions, understanding for what indications antibiotics are used is essential. METHODS: In rural Burkina Faso, we measured antibiotic dispensing across all healthcare ...
Direct correlation of MR-DWI and histopathology of Wilms’ tumours through a patient-specific 3D-printed cutting guide

van der Beek, Justine N.; Fitski, Matthijs; de Krijger, Ronald R.; Vermeulen, Marijn A.; Nikkels, Peter G.J.; Maat, Arie; Buser, Myrthe A.D.; Wijnen, Marc H.W.A.; Hendrikse, Jeroen; van den Heuvel-Eibrink, Marry M.; van der Steeg, Alida F.W.; Littooij, Annemieke S. (Springer-Verlag, 2025-02)

Objectives: The International Society of Paediatric Oncology-Renal Tumour Study Group (SIOP-RTSG) discourages invasive procedures to determine the histology of paediatric renal neoplasms at diagnosis. Therefore, the ...
The CONVINCE randomized trial found positive effects on quality of life for patients with chronic kidney disease treated with hemodiafiltration

Rose, Matthias; Fischer, Felix H.; Liegl, Gregor; Strippoli, Giovanni F.M.; Hockham, Carina; Vernooij, Robin W.M.; Barth, Claudia; Canaud, Bernard; Covic, Adrian; Cromm, Krister; Cucui, Andrea M.; Davenport, Andrew; Fischer, Kathrin I.; Hegbrant, Jörgen; Jaha, Hanna; Schappert, Anna; Török, Marietta; Woodward, Mark; Bots, Michiel L.; Blankestijn, Peter J.; CONVINCE Scientific Committee and CONVINCE Investigators (Elsevier, 2024-11)

In the CONVINCE trial, the primary analysis demonstrated a survival benefit for patients receiving high-dose hemodiafiltration (HDF) as compared with high-flux hemodialysis (HD). A secondary objective was to evaluate effects ...
Using a measurement type-independent metric to compare patterns of determinants between patient-reported versus performance-based physical function in hemodialysis patients

Liegl, Gregor; Fischer, Felix H; Canaud, Bernard; Woodward, Mark; Barth, Claudia; Davenport, Andrew; Török, Marietta; Strippoli, Giovanni F M; Hegbrant, Jörgen; Cromm, Krister; Bots, Michiel L; Blankestijn, Peter J; Fischer, Kathrin I; Rose, Matthias; CONVINCE scientific committee (Springer Netherlands, 2024-11)

PURPOSE: We applied a previously established common T-score metric for patient-reported and performance-based physical function (PF), offering the unique opportunity to directly compare measurement type-specific patterns ...
Toward a Useful and Cost-Effective Workup in Chronic Polyneuropathy: The EXPRESS Study Protocol

Wiersma, Madde; van der Star, Gerjan M; Eftimov, Filip; van Eijk, Ruben P A; Frederix, Geert W J; van Doorn, Pieter A; Notermans, Nicolette C; Vrancken, Alexander F J E (S. Karger AG, 2025)

BACKGROUND: Knowledge gaps exist about the usefulness and extent of blood tests and nerve conduction studies in the workup of polyneuropathy. We hypothesize that a limited workup improves costs spent on diagnostics without ...
Differences in corneal nerve fiber density and fiber length in patients with painful chronic idiopathic axonal polyneuropathy and diabetic polyneuropathy

Nieuwenhoff, Mariska D.; Nguyen, Hoang Ton; Niehof, Sjoerd P.; Huygen, Frank J.P.M.; Verma, Ajay; Klaassen, Erica S.; Bechakra, Malik; Geelhoed, Wouter J.; Jongen, Joost L.M.; Moll, Annette C.; Vrancken, Alexander F.J.E.; Petzold, Axel; Groeneveld, Geert Jan (John Wiley & Sons Inc., 2024-10)

Introduction/Aims: Corneal confocal microscopy (CCM) detects small nerve fiber loss and correlates with skin biopsy findings in diabetic neuropathy. In chronic idiopathic axonal polyneuropathy (CIAP) this correlation is ...
A New Case Series Suggests That SCA48 (ATX/STUB1) Is Primarily a Monogenic Disorder

van Prooije, Teije H.; Pennings, Maartje; Dorresteijn, Lucille; Gardeitchik, Thatjana; Odekerken, Vincent J.J.; Oosterloo, Mayke; Pedersen, Annie; Verschuuren-Bemelmans, Corien C.; Vrancken, Alexander; Kamsteeg, Erik Jan; van de Warrenburg, Bart P.C. (John Wiley & Sons Inc., 2024-09)

Background: Monoallelic, pathogenic STUB1 variants cause autosomal dominant cerebellar ataxia (ATX-STUB1/SCA48). Recently, a genetic interaction between STUB1 variants and intermediate or high-normal CAG/CAA repeats in TBP ...
How to follow up patients with brachial plexus birth palsy in the long term: a survey of expert opinion

de Joode, Stijn G.C.J.; Schotanus, Martijn G.M.; van Rhijn, Lodewijk W.; Samijo, Steven K. (SAGE Publications Ltd, 2024-12)

There is no generally accepted diagnostic, treatment and follow-up algorithm for brachial plexus birth palsy in the current literature. This study evaluates the opinion of experts in the field of brachial plexus birth palsy ...
Are we ready to cure post-stroke cognitive impairment?: Many key prerequisites can be achieved quickly and easily

Godefroy, Olivier; Aarabi, Ardalan; Béjot, Yannick; Biessels, Geert Jan; Glize, Bertrand; Mok, Vincent Ct; Schotten, Michel Thiebaut de; Sibon, Igor; Chabriat, Hugues; Roussel, Martine (SAGE Publications Inc., 2025-03)

PURPOSE: Post-stroke (PS) cognitive impairment (CI) is frequent and its devastating functional and vital consequences are well known. Despite recent guidelines, they are still largely neglected. A large number of recent ...
Repurposing CD19-directed immunotherapies for pediatric t(8;21) acute myeloid leukemia

Barneh, Farnaz; Koedijk, Joost B; Wijnen, Noa E; Meulendijks, Tom; Ashtiani, Minoo; Dunnebach, Ester; Dautzenberg, Noël; Cornel, Annelisa M; Krippner-Heidenreich, Anja; Klein, Kim; Zwaan, Michel C; Kuball, Jürgen; Nierkens, Stefan; Cloos, Jacqueline; Kaspers, Gertjan J L; Heidenreich, Olaf (Ferrata Storti Foundation, 2024-12-01)

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Exploring the contribution of genetic variants to high sunitinib exposure in patients with cancer

Giraud, Eline L.; Krens, Stefanie D.; Böhringer, Stefan; Desar, Ingrid M.E.; Vermeulen, Sita H.; Kiemeney, Lambertus A.; Huitema, Alwin D.R.; Steeghs, Neeltje; van Erp, Nielka P.; Swen, Jesse J. (Wiley-Blackwell, 2025-02)

Aims: Sunitinib exhibits considerable interindividual variability in exposure. While the target total plasma concentration of sunitinib and its active metabolite is 50–87.5 ng/mL for the intermittent dosing schedule, ~10–21% ...
Sexual functioning in men with haemophilia: Data from the haemophilia in the Netherlands-6 study

van Gastel, Tessa C.M.; Teela, Lorynn; Mauser-Bunschoten, Evelien P.; Coppens, Michiel; Peters, Marjolein; Fijnvandraat, Karin C.J.; Haverman, Lotte; Gouw, Samantha C. (Wiley-Blackwell, 2024-09)
Treatments affecting splenic function as a risk factor for valvular heart disease in Childhood Cancer Survivors: A DCCSS-LATER study

Houtman, Bente M; Walraven, Iris; Kapusta, Livia; Teske, Arco J; van Dulmen-den Broeder, Eline; Tissing, Wim J E; van den Heuvel-Eibrink, Marry M; Versluys, A B Birgitta; Bresters, Dorine; van der Heiden-van der Loo, Margriet; Ronckers, Cécile; Kok, Wouter E M; van der Pal, Helena J H; Pluijm, Saskia M F; Janssens, Geert O; Blijlevens, Nicole M A; Kremer, Leontien C M; Loonen, Jacqueline J; Feijen, E A M Lieke (Wiley-Liss Inc., 2024-11)

PURPOSE: Splenectomy might be a risk factor for valvular heart disease (VHD) in adult Hodgkin lymphoma survivors. As this risk is still unclear for childhood cancer survivors (CCS), the aim of this study is to evaluate the ...
Are immunosenescent T cells really senescent?

Slaets, Helena; Veeningen, Naomi; de Keizer, Peter L.J.; Hellings, Niels; Hendrix, Sven (Wiley-Blackwell, 2024-10)

Loss of proper T-cell functioning is a feature of aging that increases the risk of developing chronic diseases. In aged individuals, highly differentiated T cells arise with a reduced expression of CD28 and CD27 and an ...
Progression of Peripapillary and Macular Chorioretinal Atrophy in Multifocal Choroiditis Is Associated with Periatrophic Inflammatory Plumes

Ossewaarde-Van Norel, Jeannette; Spaide, Richard F. (Lippincott Williams & Wilkins, 2024-11-01)

Purpose:To investigate peripapillary atrophy and macular chorioretinal scars in eyes affected by multifocal choroiditis and panuveitis.Methods:This retrospective cohort study reviewed the medical records, fundus photographs, ...
Impact of Preoperative Time Intervals for Neoadjuvant Chemoradiotherapy on Short-term Postoperative Outcomes of Esophageal Cancer Surgery: A Population-Based Study Using the Dutch Upper Gastrointestinal Cancer Audit (DUCA) Data

Wang, Jingpu; de Jongh, Cas; Wu, Zhouqiao; de Groot, Eline M; Alexandre, Challine; Markar, Sheraz R; Brenkman, Hylke J F; Ruurda, Jelle P; van Hillegersberg, Richard; Dutch Upper Gastrointestinal Cancer Audit (DUCA) Group (Lippincott Williams & Wilkins, 2024-11)

Objective: To clarify the impact of the preoperative time intervals on short-term postoperative and pathologic outcomes in patients with esophageal cancer who underwent neoadjuvant chemoradiotherapy (nCRT) followed by ...
Optimal Treatment Strategies for cT2 Staged Adenocarcinoma of the Esophagus and the Gastroesophageal Junction: A Multinational, High-volume Center Retrospective Cohort Analysis

Wirsik, Naita M; Kooij, Cezanne D; Dempster, Niall; Crnovrsanin, Nerma; Donlon, Noel E; Uzun, Eren; Bhanot, Kunal; Nienhüser, Henrik; Polette, Daniela; Kewani, Kammy; Grimminger, Peter; Reim, Daniel; Seyfried, Florian; Fuchs, Hans F; Gisbertz, Suzanne S; Germer, Christoph-Thomas; Ruurda, Jelle P; Klevebro, Fredrik; Schröder, Wolfgang; Nilsson, Magnus; Reynolds, John V; Van Berge Henegouwen, Mark I; Markar, Sheraz; Van Hillegersberg, Richard; Schmidt, Thomas; Bruns, Christiane J (Lippincott Williams & Wilkins, 2024-11)

Objective: To evaluate outcomes after primary surgery (PS) or neoadjuvant treatment followed by surgery (NAT/S) in cT2 staged adenocarcinomas of the esophagus (EAC) and gastroesophageal junction (GEJ), a multinational ...
Inter- and Intrarater Agreement of CT Brain Calcification Scoring in Primary Familial Brain Calcification

Snijders, Birgitta M.G.; Koek, Huiberdina L.; Peters, Mike J.L.; Mali, Willem P.T.M.; van Beek, Michelle M.; Betman, Merel J.C.; Golüke, Nienke M.S.; Kruyswijk, Tijl; de Lange, Stéphanie V.; Lith, Bouke D.W.T.; Pekelharing, Ruth M.; Roos, Marvin J.; Rutgers, Dirk R.; Uniken Venema, Simone M.; Verberne, Wouter R.; Emmelot-Vonk, Marielle H.; de Jong, Pim A. (American Society of Neuroradiology, 2025-01-08)

BACKGROUND AND PURPOSE: The total calcification score (TCS) is a visual rating scale to measure primary familial brain calcification (PFBC)–related calcification severity on CT. We investigated the inter- and intrarater ...
Duplex ultrasound surveillance after femoropopliteal endovascular treatment for peripheral arterial disease: a systematic review and narrative synthesis

Hoitz, Nathalie C C; Nugteren, Michael J; Huizing, Eline; Fioole, Bram; Mees, Barend M E; de Borst, Gert J; Ünlü, Çağdaş (Elsevier, 2025-01)

Background: To review the current literature and establish a consensual recommendation on duplex ultrasound (DUS) surveillance after endovascular treatment of the femoropopliteal tract. Methods: This systematic review ...

Now showing items 3061-3080 of 40729