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UMC Repository: Recent submissions

  • Aberrant neurodevelopment in human iPS cell-derived models of Alexander disease 
    Matusova, Zuzana; Dykstra, Werner; de Pablo, Yolanda; Zetterdahl, Oskar G; Canals, Isaac; van Gelder, Charlotte A G H; Vos, Harmjan R; Pérez-Sala, Dolores; Kubista, Mikael; Abaffy, Pavel; Ahlenius, Henrik; Valihrach, Lukas; Hol, Elly M; Pekny, Milos (John Wiley & Sons Inc., 2025-01)
    Alexander disease (AxD) is a rare and severe neurodegenerative disorder caused by mutations in glial fibrillary acidic protein (GFAP). While the exact disease mechanism remains unknown, previous studies suggest that mutant ...
  • Craniotubular Dysplasia Ikegawa Type: Further Delineation of the Phenotype 
    van Ommeren, Babeth; Hoekstra, Maud; van Gassen, Koen; van Jaarsveld, Richard; van Haaften, Gijs; Mathijssen, Irene; Dammers, Ruben; van Veelen, Marie Lise; Baars, Rolanda; Giltay, Jacques C (John Wiley & Sons Inc., 2025-02)
    Craniotubular Dysplasia Ikegawa type is a sclerosing bone disorder recently identified in five patients from four independent Indian families. It is caused by homozygous or compound heterozygous mutations in TMEM53. Deficient ...
  • TBI related death has become the new epidemic in polytrauma: a 10-year prospective cohort analysis in severely injured patients 
    van Wessem, Karlijn J.P.; Benders, Kim E.M.; Leenen, Luke P.H.; Hietbrink, Falco (Springer International Publishing AG, 2024-12)
    Introduction: Advances in trauma care have attributed to a decrease in mortality and change in cause of death. Consequently, exsanguination and traumatic brain injury (TBI) have become the most common causes of death. ...
  • Roadmap to a Global Template for Implementation of Ototoxicity Management for Cancer Treatment 
    Fernandez, Katharine; Hoetink, Alex; Konrad-Martin, Dawn; Berndtson, Deborah; Clark, Khaya; Dreisbach, Laura; Geller, James I.; Goffi-Gomez, Maria Valeria; Grosnik, Amy; Jamis, Carmen; Knight, Kristin; Lee, David S.; Lee, John; Liberman, Patricia Helena Pecora; Milnes, Trisha; Meijer, Annelot J.M.; Ortiz, Candice E.; Rooker, Jennessa; Sanchez, Victoria A.; van den Heuvel-Eibrink, Mary M.; Brewer, Carmen C.; Poling, Gayla L. (Lippincott Williams & Wilkins, 2025-03)
    Ototoxicity is among the adverse events related to cancer treatment that can have far-reaching consequences and negative impacts on quality-of-life for cancer patients and survivors of all ages. Ototoxicity management ...
  • Diagnostic performance of pupil perimetry in detecting hemianopia under standard and virtual reality viewing conditions 
    Portengen, Brendan; Imhof, Saskia; Naber, Marnix; Porro, Giorgio (Springer-Verlag, 2025-02)
    Purpose: To determine the diagnostic performance and reliability of two pupil perimetry (PP) methods in homonymous hemianopia. Methods: This cross-sectional monocenter cohort study performed gaze-contingent flicker PP ...
  • Historical Perspectives on the Evolution of Spino-Pelvic Fixation and its Implications on Clinical Care A Narrative Review 
    von Glinski, Alexander; Yilmaz, Emre; Godolias, Periklis; Benneker, Lorin; Oner, F. C.; Kandziora, Frank; Schroeder, Gregory; Schnake, Klaus; Dvorak, Marcel; Rajasekaran, Shanmuganathan; El-Sharkawi, Mohammad; Vaccaro, Alexander; Bransford, Richard; Schildhauer, Thomas A.; Chapman, Jens R. (SAGE Publications Inc., 2025-01)
    Study Design: Broad narrative review. Objectives: To review and summarize the evolution of spinopelvic fixation (SPF) and its implications on clinical care. Methods: A thorough review of peer-reviewed literature was performed ...
  • Nutrition Users’ Guides: RCTs Part 2 – structured guide for interpreting and applying study results from randomised controlled trials on therapy or prevention questions 
    Bala, Malgorzata M.; Agarwal, Arnav; Klatt, Kevin C.; Vernooij, Robin W.M.; Alonso-Coello, Pablo; Steen, Jeremy P.; Guyatt, Gordon H.; Duque, Tiffany; Johnston, Bradley C. (BMJ Publishing Group, 2024-12-31)
    This article continues from a prior commentary on evaluating the risk of bias in randomised controlled trials addressing nutritional interventions. Having provided a synopsis of the risk of bias issues, we now address how ...
  • Patient safety incidents in paediatric radiology: how to care for the professional? 
    Nievelstein, Rutger A J; Hennus, Marije P; van Dam, Marjel (Springer-Verlag, 2025-03)
    Patient safety incidents in paediatric radiology have profound impacts not only on the patient and their family, but also on the well-being and professional practice of healthcare professionals. These incidents, which range ...
  • The Definition of Recurrence of Differentiated Thyroid Cancer: A Systematic Review of the Literature 
    van de Berg, Daniël Jacob; Rodriguez Schaap, Pedro Manuel; Jamaludin, Faridi S; van Santen, Hanneke M; Clement, Sarah C; Vriens, Menno R; van Trotsenburg, A S Paul; Mooij, Christiaan F; Bruinstroop, Eveline; Kruijff, Schelto; Peeters, Robin P; Verburg, Frederik A; Netea-Maier, Romana; Nieveen van Dijkum, Els J M; Derikx, Joep P M; Engelsman, Anton F (Mary Ann Liebert Inc., 2024-11)
    Background: Recurrence is a key outcome to evaluate the treatment effect of differentiated thyroid carcinoma (DTC). However, no consistent definition of recurrence is available in current literature or international ...
  • Evaluating the Impact of Post-Esophagectomy Exercise on 2- and 5-Yr Survival: Findings from the PERFECT Trial 
    Binyam, David; van Vulpen, J K; van Hillegersberg, R; Ruurda, J P; Nieuwenhuijzen, G A P; Kouwenhoven, E A; van der Wall, E; Groenendijk, R P R; van der Peet, D L; Rosman, C; Wijnhoven, B P L; van Berge Henegouwen, M I; van Laarhoven, H W M; Siersema, P D; May, Anne M; Hiensch, A E (Lippincott Williams & Wilkins, 2025-02-01)
    Purpose Despite recent treatment advances, esophageal cancer still has poor survival and a high morbidity. Exploratory evidence suggests that exercise can reduce cancer-related mortality and recurrence rates. Here, we ...
  • Physiological control for left ventricular assist devices based on deep reinforcement learning 
    Fernández-Zapico, Diego; Peirelinck, Thijs; Deconinck, Geert; Donker, Dirk W; Fresiello, Libera (Wiley-Blackwell, 2024-12)
    BACKGROUND: The improvement of controllers of left ventricular assist device (LVAD) technology supporting heart failure (HF) patients has enormous impact, given the high prevalence and mortality of HF in the population. ...
  • Outcome after left ventricular assist device exchange 
    Niamat, Jaiel; Ramjankhan, Faiz; Van Der Kaaij, Niels; Gianoli, Monica; Van Laake, Linda; Mokhles, Mostafa (Elsevier, 2024-10)
    OBJECTIVES: Left ventricular assist device (LVAD) therapy has evolved from a short-term bridge-to-transplant strategy into a long-term and often chronic therapy due to long waiting times for heart transplantation and ...
  • Age-related structural remodelling of the coronary circulation 
    Faria, Daniel; Lombardi, Marco; van der Hoeven, Nina; Travieso, Alejandro; Heemelaar, Julius C.; Nijjer, Sukhjinder S.; Mejía-Rentería, Hernán; de Waard, Guus A.; Sen, Sayan; van de Hoef, Tim P.; Petraco, Ricardo; Echavarría-Pinto, Mauro; Piek, Jan J.; Davies, Justin E.; van Royen, Niels; Escaned, Javier (John Wiley & Sons Inc., 2024-11-01)
    Background: While it is broadly accepted that ageing is associated with impairment of coronary microvascular function, little is known about the underlying mechanisms. Aims: We investigated age-related changes in coronary ...
  • Orthostatic hypotension and cerebral small vessel disease: A systematic review 
    Wiersinga, Julia H.I.; Wolters, Frank J.; Peters, Mike J.L.; Rhodius-Meester, Hanneke F.M.; Trappenburg, Marijke C.; Muller, Majon (SAGE Publications Inc., 2025-01)
    Orthostatic hypotension(OH) is highly prevalent in ageing populations and may contribute to cognitive decline through cerebral small vessel disease(CSVD). Research on the association between OH and CSVD is fragmented and ...
  • Impact of Adjuvant Chemotherapy on Resected Intraductal Papillary Mucinous Neoplasm-Derived Pancreatic Cancer: Results from an International Multicenter Study 
    Habib, Joseph R.; Kinny-Köster, Benedict; Javed, Ammar A.; Zelga, Poitr; Saadat, Lily V.; Kim, Rachel C.; Gorris, Myrte; Allegrini, Valentina; Watanabe, Shuichi; Sharib, Jeremy; Arcerito, Massimo; Kaiser, Jörg; Lafaro, Kelly J.; Tu, Min; Bhandre, Manish; Shi, Chanjuan; Kim, Michael P.; Correa, Camilo; Daamen, Lois A.; Oberstein, Paul E.; Schmidt, C. Max; Hanna, Nader N.; Allen, Peter; Loos, Martin; Shrikhande, Shailesh V.; Molenaar, I. Quintus; Frigerio, Isabella; Katz, Matthew H.G.; Soares, Kevin C.; Miao, Yi; Del Chiaro, Marco; He, Jin; Hackert, Thilo; Salvia, Roberto; Büchler, Markus W.; Castillo, Carlos Fernandez Del; Besselink, Marc G.; Marchegiani, Giovanni; Wolfgang, Christopher L. (Lippincott Williams & Wilkins, 2024-12-20)
    PURPOSE The benefit of adjuvant therapy for intraductal papillary mucinous neoplasm (IPMN)-derived pancreatic ductal adenocarcinoma (PDAC) remains unclear because of severely limited evidence. Although biologically distinct ...
  • Cost Analysis of Robot-Assisted Versus On-Pump and Off-Pump Coronary Artery Bypass Grafting: A Single-Center Surgical and 30-Day Outcomes Comparison 
    Gianoli, Monica; de Jong, Anne R.; van der Harst, Pim; van der Kaaij, Niels P.; Jacob, Kirolos A.; Suyker, Willem J.L. (Lippincott Williams & Wilkins, 2024-08)
    Objective: Throughout Europe, the interest in implementing robot-assisted minimally invasive direct coronary artery bypass (RA-MIDCAB) has been growing. However, concerns about additional costs have emerged concurrently. ...
  • Combination blood pressure lowering therapy in patients with type 2 diabetes: messages from the ADVANCE trial 
    Wang, Nelson; Chalmers, John; Harris, Katie; Poulter, Neil; Mancia, Giuseppe; Harrap, Stephen; Hamet, Pavel; Grobbee, Diederick E.; Marre, Michel; Woodward, Mark (Lippincott Williams & Wilkins, 2024-12-01)
    The Action in Diabetes and Vascular disease: preterAx and diamicroN Controlled Evaluation (ADVANCE) trial investigated the effects of intensive blood pressure (BP) lowering using a fixed combination of perindopril-indapamide ...
  • Puberty changes the natural history of idiopathic scoliosis: three prediction models for future radiographic curve severity from 1563 consecutive patients 
    Negrini, Stefano; Yaskina, Maryna; Donzelli, Sabrina; Negrini, Alberto; Rebagliati, Giulia; Cordani, Claudio; Zaina, Fabio; Parent, Eric C. (Springer-Verlag, 2024)
    Purpose: Understanding idiopathic scoliosis (IS) natural history during growth is essential for shared decision-making between patients and physicians. We developed a retrospective model with the largest available sample ...
  • Patient-reported outcomes during first-line palliative systemic therapy alternated with pressurized intraperitoneal aerosol chemotherapy for unresectable colorectal peritoneal metastases: a single-arm phase II trial (CRC-PIPAC-II) 
    van de Vlasakker, Vincent C.J.; Rauwerdink, Paulien; Rovers, Koen P.B.; Wassenaar, Emma C.; Creemers, Geert Jan; Los, Maartje; Burger, Jacobus W.A.; Nienhuijs, Simon W.; Kranenburg, Onno; Wiezer, Marinus J.; Lurvink, Robin J.; Boerma, Djamila; de Hingh, Ignace H.J.T. (Springer New York, 2024-11)
    Background: The CRC-PIPAC-II study prospectively assessed bidirectional therapy (BT) consisting of first-line palliative systemic therapy and electrostatic precipitation oxaliplatin-based pressurized intraperitoneal aerosol ...
  • Antagonism between H3K27me3 and genome–lamina association drives atypical spatial genome organization in the totipotent embryo 
    Guerreiro, Isabel; Rang, Franka J.; Kawamura, Yumiko K.; Kroon-Veenboer, Carla; Korving, Jeroen; Groenveld, Femke C.; van Beek, Ramada E.; Lochs, Silke J.A.; Boele, Ellen; Peters, Antoine H.M.F.; Kind, Jop (Nature Research, 2024-10)
    In mammals, early embryonic development exhibits highly unusual spatial positioning of genomic regions at the nuclear lamina, but the mechanisms underpinning this atypical genome organization remain elusive. Here, we ...