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UMC Repository: Recent submissions

  • Developing Clinical Prediction Models Using Primary Care Electronic Health Record Data: The Impact of Data Preparation Choices on Model Performance 
    van Os, Hendrikus J.A.; Kanning, Jos P.; Wermer, Marieke J.H.; Chavannes, Niels H.; Numans, Mattijs E.; Ruigrok, Ynte M.; van Zwet, Erik W.; Putter, Hein; Steyerberg, Ewout W.; Groenwold, Rolf H.H. (Frontiers Media SA, 2022)
    Objective: To quantify prediction model performance in relation to data preparation choices when using electronic health records (EHR). Study Design and Setting: Cox proportional hazards models were developed for predicting ...
  • The association of pre-operative biomarkers of endothelial dysfunction with the risk of post-operative neurocognitive disorders: results from the BioCog study 
    Moazzen, Sara; Janke, Jürgen; Slooter, Arjen J C; Winterer, Georg; Spies, Claudia; Pischon, Tobias; Feinkohl, Insa (BioMed Central, 2024-10-08)
    INTRODUCTION: Endothelial dysfunction (ED) promotes the development of atherosclerosis, and studies suggest an association with age-related neurocognitive disorders. It is currently unclear whether ED is also associated ...
  • The Role of Language in Remote Healthcare Triage: A Meta-Aggregative Review 
    Spek, Michelle; van Braak, Marije; Erkelens, Daphne C A; Rutten, Frans H; Venekamp, Roderick P; Zwart, Dorien L; de Groot, Esther (Wiley-Blackwell, 2025-04)
    AIM(S): To provide an overview of evidence on the role of language in remote healthcare services prioritisation, from now on termed triage. This study synthesises literature, to better understand how language affects triage ...
  • Multidimensional profiling of human T cells reveals high CD38 expression, marking recent thymic emigrants and age-related naive T cell remodeling 
    Bohacova, Pavla; Terekhova, Marina; Tsurinov, Petr; Mullins, Riley; Husarcikova, Kamila; Shchukina, Irina; Antonova, Alina Ulezko; Echalar, Barbora; Kossl, Jan; Saidu, Adam; Francis, Thomas; Mannie, Chelsea; Arthur, Laura; Harridge, Stephen D R; Kreisel, Daniel; Mudd, Philip A; Taylor, Angela M; McNamara, Coleen A; Cella, Marina; Puram, Sidharth V; van den Broek, Theo; van Wijk, Femke; Eghtesady, Pirooz; Artyomov, Maxim N (Cell Press, 2024-10-08)
    Thymic involution is a key factor in human immune aging, leading to reduced thymic output and a decline in recent thymic emigrant (RTE) naive T cells in circulation. Currently, the precise definition of human RTEs and their ...
  • How to meet coping strategies and preferences of children during invasive medical procedures: perspectives of healthcare professionals 
    Segers, Elisabeth W; van den Hoogen, Agnes; Schoonhoven, Lisette; van de Putte, Elise M; Ketelaar, Marjolijn (Springer-Verlag, 2024-12)
    Children with negative procedural experiences have an increased risk of fear and distress, with psychological consequences for subsequent procedures and future healthcare behaviors. Gaining control and feeling trust are ...
  • A Perspective on the Added Value of Red Blood Cells during Cardiac Hypothermic Oxygenated Perfusion 
    Vervoorn, Mats T; Ballan, Elisa M; Kaffka Genaamd Dengler, Selma E; Meijborg, Veronique M F; de Jager, Saskia C A; Van Wijk, Richard; van der Kaaij, Niels P (Elsevier, 2025-02)
    Hypothermic oxygenated perfusion (HOPE) is an emerging technique for donor heart preservation that is currently being studied in multiple clinical trials with promising results. When compared to HOPE for other organs, ...
  • Time-varying exposure to food retailers and cardiovascular disease hospitalization and mortality in the netherlands: a nationwide prospective cohort study 
    Pinho, Maria Gabriela M; Koop, Yvonne; Mackenbach, Joreintje D; Lakerveld, Jeroen; Simões, Mariana; Vermeulen, Roel; Wagtendonk, Alfred J; Vaartjes, Ilonca; Beulens, Joline W J (BioMed Central Ltd., 2024-10-08)
    BACKGROUND: Very few studies to date investigated the prospective association of changes in exposure to the food environment with cardiovascular disease (CVD) risk. We aim to explore if time-varying exposure to the food ...
  • Midostaurin added to 10-day decitabine, for patients unfit for intensive chemotherapy with AML and higher risk MDS, irrespective of FLT3 mutational status, does not improve outcome 
    Huls, Gerwin; Chitu, Dana A; Tick, Lidwine; Boersma, Rinske; Breems, Dimitri; Herbers, Alexandra; Klein, Saskia K; de Jonge, Suzan; Westerweel, Peter E; Cruijsen, Marjan; Hoogendoorn, Mels; Cuijpers, Marlous; Deeren, Dries; Bailly, Benjamin; Visser, Otto; van Rhenen, Anna; Posthuma, Eduard F M; Valk, Peter J M; Cloos, Jacqueline; Ammatuna, Emanuele; Refos, Jeannine M; Fakkert, R; Löwenberg, Bob; Ossenkoppele, Gert J (Springer-Verlag, 2025-01)
    The treatment of older patients with acute myeloid leukemia (AML) considered unfit for receiving intensive chemotherapy is challenging. Based on the hypothesis that addition of the broad tyrosine kinase inhibitor (TKI) ...
  • Radiographically confirmed pneumonia in Malawian children and associated pneumococcal carriage after introduction of the 13-valent pneumococcal conjugate vaccine 
    Mzumara, Grace; Chirombo, James; Swarthout, Todd D; Bar-Zeev, Naor; Harawa, Philliness Prisca; Jalloh, Mohamed Sanusi; Kirolos, Amir; Mukhula, Victoria; Newberry, Laura; Ogunlade, Olawale; Wachepa, Richard; French, Neil; Heyderman, Robert S; Iroh Tam, Pui-Ying (2024-10-05)
    BACKGROUND: The 13-valent pneumococcal conjugate vaccine (PCV-13) was introduced in Malawi in 2011 with an expected impact of reducing pneumococcal pneumonia in children. We aimed to describe clinical characteristics and ...
  • Efficacy and safety in early-phase clinical trials for refractory colorectal cancer: A meta-analysis 
    Smabers, Lidwien P; Huismans, Maarten A; van Nieuwenhuijzen, Niels; Minnema, Monique C; Kranenburg, Onno; Koopman, Miriam; Snippert, Hugo J G; May, Anne M; Roodhart, Jeanine M L (Elsevier Limited, 2024-11)
    Background: Despite recent metastatic colorectal cancer (mCRC) therapeutic innovations a comprehensive synthesis of patient outcome and risk-benefit assessment of phase 1/2 trials is missing. The aim of this meta-analysis ...
  • Systemic determinants of brain health in ageing 
    Smith, Eric E; Biessels, Geert Jan; Gao, Virginia; Gottesman, Rebecca F; Liesz, Arthur; Parikh, Neal S; Iadecola, Costantino (Nature Research, 2024-11)
    Preservation of brain health is a worldwide priority. The traditional view is that the major threats to the ageing brain lie within the brain itself. Consequently, therapeutic approaches have focused on protecting the brain ...
  • Tuft cells act as regenerative stem cells in the human intestine 
    Huang, Lulu; Bernink, Jochem H.; Giladi, Amir; Krueger, Daniel; van Son, Gijs J.F.; Geurts, Maarten H.; Busslinger, Georg; Lin, Lin; Begthel, Harry; Zandvliet, Maurice; Buskens, Christianne J.; Bemelman, Willem A.; López-Iglesias, Carmen; Peters, Peter J.; Clevers, Hans (Nature Research, 2024-10)
    In mice, intestinal tuft cells have been described as a long-lived, postmitotic cell type. Two distinct subsets have been identified: tuft-1 and tuft-2 (ref. 1). By combining analysis of primary human intestinal resection ...
  • Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells 
    Sáez-Cirión, Asier; Mamez, Anne Claire; Avettand-Fenoel, Véronique; Nabergoj, Mitja; Passaes, Caroline; Thoueille, Paul; Decosterd, Laurent; Hentzien, Maxime; Perdomo-Celis, Federico; Salgado, Maria; Nijhuis, Monique; Mélard, Adeline; Gardiennet, Elise; Lorin, Valérie; Monceaux, Valérie; Chapel, Anaïs; Gourvès, Maël; Lechartier, Marine; Mouquet, Hugo; Wensing, Annemarie; Martinez-Picado, Javier; Yerly, Sabine; Rougemont, Mathieu; Calmy, Alexandra (Nature Research, 2024-12)
    HIV cure has been reported for five individuals who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) with cells from CCR5Δ32 homozygous donors. By contrast, viral rebound has occurred in other people ...
  • European Society of Intensive Care Medicine guidelines on end of life and palliative care in the intensive care unit 
    Kesecioglu, Jozef; Rusinova, Katerina; Alampi, Daniela; Arabi, Yaseen M; Benbenishty, Julie; Benoit, Dominique; Boulanger, Carole; Cecconi, Maurizio; Cox, Christopher; van Dam, Marjel; van Dijk, Diederik; Downar, James; Efstathiou, Nikolas; Endacott, Ruth; Galazzi, Alessandro; van Gelder, Fiona; Gerritsen, Rik T; Girbes, Armand; Hawyrluck, Laura; Herridge, Margaret; Hudec, Jan; Kentish-Barnes, Nancy; Kerckhoffs, Monika; Latour, Jos M; Malaska, Jan; Marra, Annachiara; Meddick-Dyson, Stephanie; Mentzelopoulos, Spyridon; Mer, Mervyn; Metaxa, Victoria; Michalsen, Andrej; Mishra, Rajesh; Mistraletti, Giovanni; van Mol, Margo; Moreno, Rui; Nelson, Judith; Suñer, Andrea Ortiz; Pattison, Natalie; Prokopova, Tereza; Puntillo, Kathleen; Puxty, Kathryn; Qahtani, Samah Al; Radbruch, Lukas; Rodriguez-Ruiz, Emilio; Sabar, Ron; Schaller, Stefan J; Siddiqui, Shahla; Sprung, Charles L; Umbrello, Michele; Vergano, Marco; Zambon, Massimo; Zegers, Marieke; Darmon, Michael; Azoulay, Elie (Springer-Verlag, 2024-11)
    The European Society of Intensive Care Medicine (ESICM) has developed evidence-based recommendations and expert opinions about end-of-life (EoL) and palliative care for critically ill adults to optimize patient-centered ...
  • Translational strategies to uncover the etiology of congenital anomalies of the kidney and urinary tract 
    Vendrig, Lisanne M; Ten Hoor, Mayke A C; König, Benthe H; Lekkerkerker, Iris; Renkema, Kirsten Y; Schreuder, Michiel F; van der Zanden, Loes F M; van Eerde, Albertien M; Groen In 't Woud, Sander; Mulder, Jaap; Westland, Rik; ArtDECO consortium (Springer-Verlag, 2025-03)
    While up to 50% of children requiring kidney replacement therapy have congenital anomalies of the kidney and urinary tract (CAKUT), they represent only a fraction of the total patient population with CAKUT. The extreme ...
  • Clinical aspects of a large group of adults with Angelman syndrome 
    den Besten, Inge; de Jong, Rianne F; Geerts-Haages, Amber; Bruggenwirth, Hennie T; Koopmans, Marije; Brooks, Alice; Elgersma, Ype; Festen, Dederieke A M; Valstar, Marlies J; ENCORE Expertise Center for AS 18+ (John Wiley & Sons Inc., 2021-01)
    Descriptions of the clinical features of Angelman syndrome (AS) have mainly been focused on children. Here, we describe the evolution of the clinical phenotypes of AS in adulthood, using clinical data from 95 individuals ...
  • Augmented Reality Implementation in Minimally Invasive Surgery for Future Application in Pulmonary Surgery: A Systematic Review 
    Doornbos, Marie-Claire J; Peek, Jette J; Maat, Alexander P W M; Ruurda, Jelle P; De Backer, Pieter; Cornelissen, Bart M W; Mahtab, Edris A F; Sadeghi, Amir H; Kluin, Jolanda (SAGE Publications Inc., 2024-12)
    OBJECTIVE: This systematic review investigates of Augmented Reality (AR) systems used in minimally invasive surgery of deformable organs, focusing on initial registration, dynamic tracking, and visualization. The objective ...
  • Adjuvant immunotherapy in older patients with stage III and resected stage IV melanoma: Toxicity and recurrence-free survival outcomes from the Dutch melanoma treatment registry 
    Özkan, A; Kapiteijn, E; van den Bos, F; Aarts, M J B; van den Berkmortel, F W P J; Blank, C U; Bloem, M; Blokx, W A M; Boers-Sonderen, M J; Bonenkamp, J J; van den Eertwegh, A J M; de Groot, J W B; Haanen, J B; Holtslag, C E; Hospers, G A P; Piersma, D; van Rijn, R S; Stevense-den Boer, A M; Suijkerbuijk, K P M; van der Veldt, A A M; Vreugdenhil, G; Wouters, M W J M; Portielje, J E A; de Glas, N A (Elsevier Limited, 2024-11)
    BACKGROUND: Adjuvant anti-PD-1 therapy improves relapse free survival in stage III melanoma, but also leads to immune-related adverse events (irAEs). Older patients are of particular interest due to comorbidities and ...
  • Long-Term Risk of Subsequent Neoplasms in 5-Year Survivors of Childhood Neuroblastoma: A Dutch Childhood Cancer Survivor Study-LATER 3 Study 
    Westerveld, Aimée S R; Tytgat, Godelieve A M; van Santen, Hanneke M; van Noesel, Max M; Loonen, Jacqueline; de Vries, Andrica C H; Louwerens, Marloes; Koopman, Maria M W; van der Heiden-van der Loo, Margriet; Janssens, Geert O; de Krijger, Ronald R; Ronckers, Cecile M; van der Pal, Helena J H; Kremer, Leontien C M; Teepen, Jop C (Lippincott Williams & Wilkins, 2025-01-10)
    PURPOSE: Neuroblastoma survivors have an increased risk of developing subsequent malignant neoplasms (SMNs), but the risk of subsequent nonmalignant neoplasms (SNMNs) and risk factors are largely unknown. We analyzed the ...
  • Examining the applicability of virtual battle space for stress management training in military personnel: A validation study 
    Schilder, Frank P.M.; Withagen, Frederique M.; de Weijer, Antoin D.; Bruinsma, Bastiaan; Geuze, Elbert (2024-12)
    Military personnel are often exposed to high levels of both physical and psychological challenges in their work environment and therefore it is important to be trained on how to handle stressful situations. The primary aim ...