Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

Now showing items 2621-2640 of 40729

Rationale and Design of a Multi-National Study of Physicians' Opinions, Attitudes, and Practices Regarding Influenza Vaccination in Patients with Cardiovascular Diseases: A Mixed Methods Designs. The FLUence Project

Garcia-Zamora, Sebastián; Koh, Angela S.; Stoica, Svetlana; Sepehrvand, Nariman; Ranjani, Harish; Ishaku, Salisu; Herz, Naomi; Kandoole-Kabwere, Vanessa; Perel, Pablo; Banerjee, Amitava; Warren-Gash, Charlotte; Taylor, Sean; Piñeiro, Daniel José; Sosa-Liprandi, María Inés; Sosa-Liprandi, Álvaro (Elsevier Science & Technology, 2024-10-15)

Infections, particularly those involving the respiratory tract, are associated with an increased incidence of cardiovascular events, both de novo and as exacerbations of pre-existing cardiovascular diseases. Influenza ...
The impact of tau-PET in a selected memory clinic cohort: rationale and design of the TAP-TAU study

Vermeiren, Marie R.; Somsen, Joost; Luurtsema, Gert; Reesink, Fransje E.; Verwey, Nicolaas A.; Hempenius, Liesbeth; Tolboom, Nelleke; Biessels, Geert Jan; Biesbroek, J. Matthijs; Vernooij, Meike W.; Veldhuijzen van Zanten, Sophie E.M.; Seelaar, Harro; Coomans, Emma M.; Teunissen, Charlotte E.; Lemstra, Afina W.; van Harten, Argonde C.; Visser, Leonie N.C.; van der Flier, Wiesje M.; van de Giessen, Elsmarieke; Ossenkoppele, Rik (BioMed Central, 2024-10-19)

Background: Tau-PET is a diagnostic tool with high sensitivity and specificity for discriminating Alzheimer’s disease (AD) dementia from other neurodegenerative disorders in well-controlled research environments. The role ...
Description and functional validation of human enteroendocrine cell sensors

Beumer, Joep; Geurts, Maarten H.; Geurts, Veerle; Andersson-Rolf, Amanda; Akkerman, Ninouk; Völlmy, Franziska; Krueger, Daniel; Busslinger, Georg A.; Martínez-Silgado, Adriana; Boot, Charelle; Yousef Yengej, Fjodor A.; Puschhof, Jens; Van de Wetering, Wiline J.; Knoops, Kevin; López-Iglesias, Carmen; Peters, Peter J.; Vivié, Judith A.; Mooijman, Dylan; van Es, Johan H.; Clevers, Hans (American Association for the Advancement of Science, 2024-10-18)

Enteroendocrine cells (EECs) are gut epithelial cells that respond to intestinal contents by secreting hormones, including the incretins glucagon-like peptide 1 (GLP-1) and gastric inhibitory protein (GIP), which regulate ...
Biomarker pathway heterogeneity of amyloid-positive individuals

Prosser, Lloyd; Sudre, Carole H.; Oxtoby, Neil P.; Young, Alexandra L.; Malone, Ian B.; Manning, Emily N.; Pemberton, Hugh; Walsh, Phoebe; Barkhof, Frederik; Biessels, Geert Jan; Cash, David M.; Barnes, Josephine; for the Alzheimer's Disease Neuroimaging Initiative (John Wiley & Sons Inc., 2024-12)

INTRODUCTION: In amyloid-positive individuals, disease-related biomarker heterogeneity is understudied. METHODS: We used Subtype and Stage Inference (SuStaIn) to identify data-driven subtypes among cerebrospinal fluid (CSF) ...
TUBectomy with delayed oophorectomy as an alternative to risk-reducing salpingo-oophorectomy in high-risk women to assess the safety of prevention: The TUBA-WISP II study protocol

the TUBA-WISP II consortium (Lippincott Williams & Wilkins, 2023-06-01)

Background Risk-reducing salpingectomy with delayed oophorectomy has gained interest for individuals at high risk for tubo-ovarian cancer as there is compelling evidence that especially high-grade serous carcinoma originates ...
Development of new Kir2.1 channel openers from propafenone analogues

Li, Encan; Boujeddaine, Najla; Houtman, Marien J.C.; Maas, Renee G.C.; Sluijter, Joost P.G.; Ecker, Gerhard F.; Stary-Weinzinger, Anna; van Ham, Willem B.; van der Heyden, Marcel A.G. (John Wiley & Sons Inc., 2025-02)

Background and Purposes: Reduced inward rectifier potassium channel (Kir2.1) functioning is associated with heart failure and may cause Andersen-Tawil Syndrome, among others characterized by ventricular arrhythmias. Most ...
RENOIR Trial - RSVpreF Vaccine Efficacy over Two Seasons

Walsh, Edward E.; Pérez Marc, Gonzalo; Falsey, Ann R.; Jiang, Qin; Eiras, Daniel; Patton, Michael; Polack, Fernando P.; Llapur, Conrado; Doreski, Pablo A.; Zareba, Agnieszka M.; Ilangovan, Kumar; Rämet, Mika; Fukushima, Yasushi; Hussen, Nazreen; Bont, Louis J.; Cardona, Jose; DeHaan, Elliot; Mikati, Tarek; Shah, Rupal N.; Schneider, Katherine; Cooper, David; Koury, Kenneth; Lino, Maria Maddalena; Anderson, Annaliesa S.; Jansen, Kathrin U.; Swanson, Kena A.; Gruber, William C.; Schmoele-Thoma, Beate; Gurtman, Alejandra (Massachussetts Medical Society, 2024-10-17)
Biofabricated osteoblast-derived nanovesicles as extracellular vesicle mimics for bone repair

Brunet, Mathieu Y.; Man, Kenny; Jones, Marie Christine; Cox, Sophie C. (Academic Press Inc., 2024-11-26)

Osteoblast-derived extracellular vesicles (EVs) have demonstrated therapeutic utility for bone repair as transporters of key biomolecules capable of accelerating biomineralisation and tissue repair. The clinical translation ...
Implementation of a tailored multifaceted antibiotic stewardship intervention to improve antibiotic prescribing for urinary tract infections in frail older adults (ImpresU) in four European countries: a process evaluation alongside a pragmatic cluster randomized controlled trial

Hartman, Esther A.R.; Groen, Wim G.; Heltveit-Olsen, Silje Rebekka; Lindbæk, Morten; Høye, Sigurd; Lithén, Sara Sofia; Sundvall, Pär Daniel; Sundvall, Sofia; Snaebjörnsson Arnljots, Egill; Gunnarsson, Ronny; Kowalczyk, Anna; Godycki-Cwirko, Maciej; van de Pol, Alma C.; Platteel, Tamara N.; Monnier, Annelie A.; Verheij, Theo J.M.; Hertogh, Cees M.P.M. (BioMed Central, 2024-10-18)

BACKGROUND: We previously performed a pragmatic cluster randomized controlled trial (RCT) in general practices and older adult care organizations in Poland, the Netherlands, Norway, and Sweden. We found that a multifaceted ...
Early Prediction and Impact Assessment of CYP3A4-Related Drug-Drug Interactions for Small-Molecule Anticancer Drugs Using Human-CYP3A4-Transgenic Mouse Models

Damoiseaux, David; Beijnen, Jos H.; Huitema, Alwin D.R.; Dorlo, Thomas P.C. (Elsevier, 2024-10-16)

Early detection of drug-drug interactions (DDIs) can facilitate timely drug development decisions, prevent unnecessary restrictions on patient enrollment, resulting in clinical study populations that are not representative ...
Phenolization of the sinus tract in recurrent sacrococcygeal pilonidal sinus disease: long-term results of a prospective cohort study

de Kort, Jochem; Pronk, Akke; Vriens, Menno R.; Smakman, Niels; Furnee, Edgar J.B. (Springer-Verlag, 2024-10-18)

Aim: In recent years, the paradigm for the treatment of sacrococcygeal pilonidal sinus disease (SPSD) has shifted from surgical excision toward more minimally invasive techniques. Although extensive research has been ...
Color-map recommendation for MR relaxometry maps

Fuderer, Miha; Wichtmann, Barbara; Crameri, Fabio; de Souza, Nandita M.; Baeßler, Bettina; Gulani, Vikas; Wang, Meiyun; Poot, Dirk; de Boer, Ruud; Cashmore, Matt; Keenan, Kathryn E.; Ma, Dan; Pirkl, Carolin; Sollmann, Nico; Weingärtner, Sebastian; Mandija, Stefano; Golay, Xavier (John Wiley & Sons Inc., 2025-02)

Purpose: To harmonize the use of color for MR relaxometry maps and therefore recommend the use of specific color-maps for representing (Formula presented.), (Formula presented.), and (Formula presented.) maps and their ...
Optimised treatment of patients with enlarged lateral lymph nodes in rectal cancer: protocol of an international, multicentre, prospective registration study after extensive multidisciplinary training (LaNoReC)

van Geffen, Eline G.M.; Sluckin, Tania C.; Hazen, Sanne Marije J.A.; Horsthuis, Karin; Intven, Martijn; van Dieren, Susan; Beets, Geerard; Lange, Marilyne M.; Taggart, Melissa W.; Beets-Tan, Regina G.H.; Marijnen, Corrie A.M.; Konishi, Tsuyoshi; Tanis, Pieter J.; Kusters, Miranda; LaNoReC study group (BMJ Publishing Group, 2024-10-16)

Introduction Inadequate treatment of enlarged lateral lymph nodes (LLNs) in rectal cancer patients is associated with an increased lateral local recurrence (LLR) risk, despite neoadjuvant treatment and total mesorectal ...
Author Correction: Digital consults in heart failure care: a randomized controlled trial(Nature Medicine, 10.1038/s41591-024-03238-6)

Man, Jelle P.; Koole, Maarten A.C.; Meregalli, Paola G.; Handoko, M. Louis; Stienen, Susan; de Lange, Frederik J.; Winter, Michiel M.; Schijven, Marlies P.; Kok, Wouter E.M.; Kuipers, Dorianne I.; van der Harst, Pim; Asselbergs, Folkert W.; Zwinderman, Aeilko H.; Dijkgraaf, Marcel G.W.; Chamuleau, Steven A.J.; Schuuring, Mark J. (Nature Research, 2024-10)

Correction to: Nature Medicinehttps://doi.org/10.1038/s41591-024-03238-6, published online 31 August 2024. In the version of the article initially published, the traces in Fig. 3 appeared with an incorrect 180° rotation, ...
Paternal HLA-Derived Epitopes and Live Birth in Secondary Recurrent Pregnancy Loss: New Insights From a Clinical Trial

Krog, Maria Christine; Peereboom, Emma T.M.; Geneugelijk, Kirsten; Matern, Benedict M.; Kolte, Astrid Marie; Christiansen, Ole Bjarne; Steffensen, Rudi; Nielsen, Henriette Svarre; Spierings, Eric (Wiley-Blackwell, 2024-10)

Recurrent pregnancy loss (RPL), defined as two or more pregnancy losses before the 24th week of gestation, affects 1%–3% of women worldwide. Approximately, 40% of RPL cases are secondary RPL (sRPL), where women have given ...
Double-strand breaks in facultative heterochromatin require specific movements and chromatin changes for efficient repair

Wensveen, Marieke R.; Dixit, Aditya A.; van Schendel, Robin; Kendek, Apfrida; Lambooij, Jan Paul; Tijsterman, Marcel; Colmenares, Serafin U.; Janssen, Aniek (Nature Publishing Group, 2024-10-17)

DNA double-strand breaks (DSBs) must be properly repaired within diverse chromatin domains to maintain genome stability. Whereas euchromatin has an open structure and is associated with transcription, facultative heterochromatin ...
Randomized phase II dose comparison LITESPARK-013 study of belzutifan in patients with advanced clear cell renal cell carcinoma

Agarwal, N.; Brugarolas, J.; Ghatalia, P.; George, S.; Haanen, J. B.; Gurney, H.; Ravilla, R.; Van der Veldt, A.; Beuselinck, B.; Pokataev, I.; Suelmann, B. B.M.; Tuthill, M. H.; Vaena, D.; Zagouri, F.; Wu, J.; Perini, R. F.; Liu, Y.; Merchan, J.; Atkins, M. B. (Oxford University Press, 2024-12)

Background: Belzutifan is a first-in-class hypoxia-inducible factor subunit 2α (HIF-2α) inhibitor approved at a dose of 120 mg once daily for certain adults with VHL disease and adults with advanced renal cell carcinoma ...
Psychosocial Determinants for Self-Reported Health Status in Hemodialysis Patients: A Cohort Analysis of the CONVINCE Randomized Trial

Cromm, K.; Ngoc Pham, Le Hong; Jaha, Hanna; Fischer, Kathrin I.; Liegl, Gregor; Schappert, Anna; Davenport, A.; Barth, C.; Blankestijn, P. J.; Hegbrant, Jörgen; Fischer, Felix H.; Strippoli, G. F.M.; Rose, Matthias; CONVINCE Scientific Committee and Investigators (Lippincott Williams & Wilkins, 2025-01)

Background We investigated whether psychosocial determinants self-efficacy and social support are associated with health-related quality of life in patients on hemodialysis enrolled in the CONVINCE trial. Methods We used ...
A practical guide to apply AI in childhood cancer: Data collection and AI model implementation

Wen, Shuping; Theobald, Stefan; Gangas, Pilar; Borja Jiménez, Karina C.; Merks, Johannes H.M.; Schoot, Reineke A.; Meyerheim, Marcel; Graf, Norbert (Elsevier, 2024-12)

Childhood cancer is a leading cause of death in children, and the increasing availability of digital healthcare data, coupled with rapid progress in artificial intelligence (AI), brings a transformative opportunity to ...
Stereotactic Body Radiotherapy (SBRT) for the Treatment of Primary Localized Renal Cell Carcinoma: A Systematic Review and Meta-Analysis

Suleja, Agata; Bilski, Mateusz; Laukhtina, Ekaterina; Fazekas, Tamás; Matsukawa, Akihiro; Tsuboi, Ichiro; Mancon, Stefano; Schulz, Robert; Soeterik, Timo F.W.; Przydacz, Mikołaj; Nyk, Łukasz; Rajwa, Paweł; Majewski, Wojciech; Campi, Riccardo; Shariat, Shahrokh F.; Miszczyk, Marcin (Multidisciplinary Digital Publishing Institute (MDPI), 2024-10)

Context: Surgery is the gold standard for the local treatment of primary renal cell carcinoma (RCC), but alternatives are emerging. We conducted a systematic review and meta-analysis to assess the results of prospective ...

Now showing items 2621-2640 of 40729