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UMC Repository: Recent submissions

  • Abdominal Pain and Cola-Colored Serum 
    Tiel Groenestege, Wouter M.; Wijnen, Ella J.; Janssen, Marcel J.W. (Oxford University Press, 2023-02-01)
  • Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response 
    Dekkers, Koen F.; Slieker, Roderick C.; Ioan-Facsinay, Andreea; van Iterson, Maarten; Ikram, M. Arfan; van Greevenbroek, Marleen M.J.; Veldink, Jan H.; Franke, Lude; Boomsma, Dorret I.; Slagboom, P. Eline; Jukema, J. Wouter; Heijmans, Bastiaan T.; BIOS Consortium (Nature Publishing Group, 2023-12)
    Immune cell function can be altered by lipids in circulation, a process potentially relevant to lipid-associated inflammatory diseases including atherosclerosis and rheumatoid arthritis. To gain further insight in the ...
  • Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus. 
    Hundscheid, Tim; Onland, Wes; Kooi, Elisabeth M.W.; Vijlbrief, Daniel C.; De Vries, Willem B.; Dijkman, Koen P.; Van Kaam, Anton H.; Villamor, Eduardo; Kroon, André A.; Visser, Remco; Mulder-De Tollenaer, Susanne M.; De Bisschop, Barbara; Dijk, Peter H.; Avino, Daniela; Hocq, Catheline; Zecic, Alexandra; Meeus, Marisse; De Baat, Tessa; Derriks, Frank; Henriksen, Tine B.; Kyng, Kasper J.; Donders, Rogier; Nuytemans, Debbie H.G.M.; Van Overmeire, Bart; Mulder, Antonius L.; De Boode, Willem P. (Massachussetts Medical Society, 2023)
    Background Cyclooxygenase inhibitors are commonly used in infants with patent ductus arteriosus (PDA), but the benefit of these drugs is uncertain. Methods In this multicenter, noninferiority trial, we randomly assigned ...
  • Feasibility of telementoring during robot-assisted minimally invasive esophagectomy 
    den Boer, Robin B; de Jongh, Cas; van Boxel, Gijs I; Rouanet, Philippe; Mourregot, Anne; Ruurda, Jelle P; van Hillegersberg, Richard (S. Karger AG, 2025)
    Introduction: Telementoring could increase the quality, reduce the time, and increase cost efficiency of the proctoring program for robot-assisted minimally invasive esophagectomy (RAMIE). However, feasibility is unclear ...
  • Sublingual microcirculatory assessment on admission independently predicts the outcome of old intensive care patients suffering from shock 
    Bruno, Raphael Romano; Schemmelmann, Mara; Hornemann, Johanna; Moecke, Helene Mathilde Emilie; Demirtas, Filiz; Palici, Lina; Marinova, Radost; Kanschik, Dominika; Binnebößel, Stephan; Spomer, Armin; Guidet, Bertrand; Leaver, Susannah; Flaatten, Hans; Szczeklik, Wojciech; Mikiewicz, Maciej; De Lange, Dylan W; Quenard, Stanislas; Beil, Michael; Kelm, Malte; Jung, Christian (Nature Publishing Group, 2024-10-27)
    Shock is a life-threatening condition. This study evaluated if sublingual microcirculatory perfusion on admission is associated with 30-day mortality in older intensive care unit (ICU) shock patients. This trial prospectively ...
  • Breast cancer survival prediction using an automated mitosis detection pipeline 
    Stathonikos, Nikolas; Aubreville, Marc; de Vries, Sjoerd; Wilm, Frauke; Bertram, Christof A; Veta, Mitko; van Diest, Paul J (Wiley-Blackwell Publishing Ltd, 2024-11)
    Mitotic count (MC) is the most common measure to assess tumor proliferation in breast cancer patients and is highly predictive of patient outcomes. It is, however, subject to inter- and intraobserver variation and ...
  • The Molecular Classification of Pheochromocytomas and Paragangliomas: Discovering the Genomic and Immune Landscape of Metastatic Disease 
    de Bresser, Carolijn J M; de Krijger, Ronald R (Humana Press, 2024-12)
    Pheochromocytomas (PCCs) and paragangliomas (PGLs, together PPGLs) are the most hereditary tumors known. PPGLs were considered benign, but the fourth edition of the World Health Organisation (WHO) classification redefined ...
  • Autoimmune Encephalitis and Paraneoplastic Neurologic Syndromes: A Nationwide Study on Epidemiology and Antibody Testing Performance 
    Kerstens, Jeroen; Schreurs, Marco W J; de Vries, Juna M; Neuteboom, Rinze F; Brenner, Juliette; Crijnen, Yvette S; van Steenhoven, Robin W; de Bruijn, Marienke A A M; van Sonderen, Agnes; van Coevorden-Hameete, Marleen H; Bastiaansen, Anna E M; Vermeiren, Marie R; Damoiseaux, Jan G M C; Otten, Henny G; Frijns, Catharina J M; Meek, Bob; Platteel, Anouk C M; van de Mortel, Alina; Delnooz, Cathérine C S; Broeren, Maarten A C; Verbeek, Marcel M; Hoff, Erik I; Boukhrissi, Sanae; Franken, Suzanne C; Nagtzaam, Mariska M P; Paunovic, Manuela; Veenbergen, Sharon; Sillevis Smitt, Peter A E; Titulaer, Maarten J (Lippincott Williams & Wilkins, 2024-11)
    BACKGROUND AND OBJECTIVES: Autoimmune encephalitis (AIE) and paraneoplastic neurologic syndromes (PNSs) encompass a heterogeneous group of antibody-associated disorders. Both the number of syndromes and commercially available ...
  • Prediction of Severe Baseline Asymptomatic Carotid Stenosis and Subsequent Risk of Stroke and Cardiovascular Disease 
    Poorthuis, Michiel H.F.; Hageman, Steven H.J.; Fiolet, Aernoud T.L.; Kappelle, L. Jaap; Bots, Michiel L.; Steg, Ph Gabriel; Visseren, Frank L.J.; Bhatt, Deepak L.; De Borst, Gert J. (Lippincott Williams & Wilkins, 2024-11)
    BACKGROUND: Risk models to identify patients at high risk of asymptomatic carotid artery stenosis (ACAS) can help in selecting patients for screening, but long-term outcomes in these patients are unknown. We assessed the ...
  • 12. vascular pain Ischemic pain in the extremities and Raynaud's syndrome 
    van der Gaag, Antal; Cohen, Steven P.; Stojanovic, Milan P.; Huygen, Frank J.P.M.; Kallewaard, Jan Willem (Wiley-Blackwell, 2025-01)
    Introduction: Peripheral artery diseases (PAD) and Raynaud's syndrome are associated with substantial morbidity. PAD, through the restriction of blood flow to the extremities, may lead to critical limb ischemia with symptoms ...
  • Evaluation of propofol-based procedural sedation in pediatric hemato-oncological patients provided by physician assistants in anesthesia 
    van Langeveld, I.; Aalbers, T.; Prudon, I.; Koning, R.; Dors, N.; Hampsink, B.; Bronkhorst, E. M.; Scheffer, G. J.; Malagon, I.; Hendriks, M. (Wiley-Blackwell, 2025-01)
    Background: Procedural sedation and analgesia are required for painful hemato-oncological procedures such as lumbar and bone marrow punctures. At our institution, sedation with propofol and alfentanil is usually provided ...
  • Deep learning predicted perceived age is a reliable approach for analysis of facial ageing: A proof of principle study 
    Turner, Conor; Pardo, Luba M.; Gunn, David A.; Zillmer, Ruediger; Mekić, Selma; Liu, Fan; Ikram, M. Arfan; Klaver, Caroline C.W.; Croll, Pauline H.; Goedegebure, André; Trajanoska, Katerina; Rivadeneira, Fernando; Kavousi, Maryam; Brusselle, Guy G.O.; Kayser, Manfred; Nijsten, Tamar; Bacardit, Jaume (Wiley-Blackwell, 2024-12)
    Background: Perceived age (PA) has been associated with mortality, genetic variants linked to ageing and several age-related morbidities. However, estimating PA in large datasets is laborious and costly to generate, limiting ...
  • Feasibility of Indocyanine Green Fluorescence Endoscopic Assisted Resection of Sinonasal Tumours 
    Alnemr, Mohamed Abdelmohsen; Rijken, Johannes A.; Braunius, Weibel W.; Donders, Dominique N.V.; de Bree, Remco (Wiley-Blackwell, 2025-01)
  • Cardiac symptomatology and coronary artery disease. A clinical conundrum 
    Jukema, Ruurt A.; Somsen, Yvemarie BO; Hoek, Roel; Nurmohamed, Nick S.; Driessen, Roel S.; Raijmakers, Pieter G.; van der Harst, Pim; Cramer, Maarten J.; Knaapen, Paul; Danad, Ibrahim (Elsevier, 2024-11-01)
  • EULAR/PReS recommendations for the diagnosis and management of Still's disease, comprising systemic juvenile idiopathic arthritis and adult-onset Still's disease 
    Fautrel, Bruno; Mitrovic, Stéphane; De Matteis, Arianna; Bindoli, Sara; Antón, Jordi; Belot, Alexandre; Bracaglia, Claudia; Constantin, Tamàs; Dagna, Lorenzo; Di Bartolo, Alessandro; Feist, Eugen; Foell, Dirk; Gattorno, Marco; Georgin-Lavialle, Sophie; Giacomelli, Roberto; Grom, Alexei A.; Jamilloux, Yvan; Laskari, Katerina; Lazar, Calin; Minoia, Francesca; Nigrovic, Peter A.; Oliveira Ramos, Filipa; Ozen, Seza; Quartier, Pierre; Ruscitti, Piero; Sag, Erdal; Savic, Sinisa; Truchetet, Marie Elise; Vastert, Sebastiaan J.; Wilhelmer, Tanita Christina; Wouters, Carine; Carmona, Loreto; De Benedetti, Fabrizio (Elsevier, 2024-11-14)
    Systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD) are considered the same disease, but a common approach for diagnosis and management is still missing. Methods: In May 2022, EULAR and ...
  • Identification and culture of meniscons, meniscus cells with their pericellular matrix 
    Struijk, Caroline; Korpershoek, Jasmijn; Lydon, Katherine L.; Verdonk, Peter; Michielsen, Jozef; Krych, Aaron J.; Vonk, Lucienne A.; Saris, Daniel B.F. (Informa Healthcare, 2025-01)
    Background aims: Meniscus injury is highly debilitating and often results in osteoarthritis. Treatment is generally symptomatic; no regenerative treatments are available. “Chondrons,” articular chondrocytes with preserved ...
  • Correction: A recommendation for the use of electrical biosensing technology in neonatology (Pediatric Research, (2024), 10.1038/s41390-024-03369-z) 
    van Wyk, Lizelle; Austin, Topun; Barzilay, Bernard; Bravo, Maria Carmen; Breindahl, Morten; Czernik, Christoph; Dempsey, Eugene; de Boode, Willem Pieter; de Vries, Willem; Eriksen, Beate Horsberg; Fauchére, Jean Claude; Kooi, Elisabeth M.W.; Levy, Philip T.; McNamara, Patrick J.; Mitra, Subhabrata; Nestaas, Eirik; Rabe, Heike; Rabi, Yacov; Rogerson, Sheryle R.; Savoia, Marilena; Schena, Frederico; Sehgal, Arvind; Schwarz, Christoph E.; Thome, Ulrich; van Laere, David; Zaharie, Gabriela C.; Gupta, Samir; van Wyk, Lizelle; ESPR Special Interest Group on Non-Invasive Cardiac Output Monitoring (Lippincott Williams & Wilkins, 2024-12)
    Correction to: Pediatric Researchhttps://doi.org/10.1038/s41390-024-03369-z, published online 08 July 2024 In the original version of the article, the author’s name Christoph E. Schwarz was incorrectly given as ‘Christop ...
  • A genome-wide association analysis reveals new pathogenic pathways in gout* 
    Major, Tanya J.; Takei, Riku; Matsuo, Hirotaka; Leask, Megan P.; Sumpter, Nicholas A.; Topless, Ruth K.; Shirai, Yuya; Wang, Wei; Cadzow, Murray J.; Phipps-Green, Amanda J.; Li, Zhiqiang; Ji, Aichang; Merriman, Marilyn E.; Morice, Emily; Kelley, Eric E.; Wei, Wen Hua; McCormick, Sally P.A.; Bixley, Matthew J.; Reynolds, Richard J.; Saag, Kenneth G.; Fadason, Tayaza; Golovina, Evgenia; O’Sullivan, Justin M.; Stamp, Lisa K.; Dalbeth, Nicola; Abhishek, Abhishek; Doherty, Michael; Roddy, Edward; Jacobsson, Lennart T.H.; Kapetanovic, Meliha C.; Melander, Olle; Andrés, Mariano; Pérez-Ruiz, Fernando; Torres, Rosa J.; Radstake, Timothy; Jansen, Timothy L.; Janssen, Matthijs; Joosten, Leo A.B.; Liu, Ruiqi; Gaal, Orsolya I.; Crişan, Tania O.; Rednic, Simona; Kurreeman, Fina; Huizinga, Tom W.J.; Toes, René; Lioté, Frédéric; Richette, Pascal; Bardin, Thomas; Ea, Hang Korng; Pascart, Tristan; FAST Study Group; Japan Gout Genomics Consortium; Asia Pacific Gout Consortium; GlobalGout Genetics Consortium; 23andMe Research Team (Nature Research, 2024-11)
    Gout is a chronic disease that is caused by an innate immune response to deposited monosodium urate crystals in the setting of hyperuricemia. Here, we provide insights into the molecular mechanism of the poorly understood ...
  • How do patients with head and neck cancer and low skeletal muscle mass experience cisplatin-based chemoradiotherapy?: A qualitative study 
    Schaeffers, Anouk W M A; van Beers, Maartje A; Devriese, Lot A; Klomp, F W José; Westerink-van den Brink, Chantal F M; Smid, Ernst J; de Bree, Remco; Speksnijder, Caroline M (Springer-Verlag, 2024-11)
    BACKGROUND: Patients with head and neck squamous cell carcinoma (HNSCC) face several physical, emotional, and psychological challenges throughout treatment. Cisplatin-based chemoradiotherapy (CRT) is an effective but toxic ...
  • Study protocol for a multicenter non-inferiority randomized controlled trial to assess functional outcomes and cost-effectiveness of a primarily non-operative treatment strategy with cast immobilization versus immediate operative treatment followed by cast immobilization for patients with complete ulnar collateral ligament ruptures, including Stener lesions: MUSCAT study 
    de Haas, Louise; van Hoorn, Bastiaan; van de Lücht, Veronique; Schep, N; Dijkgraaf, M; van Heijl, M; MUSCAT Trial Collaborator group (BioMed Central, 2024-10-28)
    BACKGROUND: Guidelines recommend operative treatment followed by cast immobilization for acute complete ulnar collateral ligament (UCL) ruptures, including Stener lesions. This recommendation is based on expert opinion, ...