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UMC Repository: Recent submissions

  • The association between aberrant salience and psychotic experiences in general population twins, and genetic vulnerability as a modifier 
    Drukker, Marjan; Todor, Tatvan; Bongaarts, Jelle; Broggi, Eleonora; Kelkar, Mihika; Wigglesworth, Thomas; Verhiel, Kayle; van Leeuwen, Karel; Koster, Meinte; Derom, Catherine; Thiery, Evert; De Hert, Marc; Menne-Lothmann, Claudia; Decoster, Jeroen; Collip, Dina; van Winkel, Ruud; Jacobs, Nele; Guloksuz, Sinan; Rutten, Bart; van Os, Jim (BioMed Central, 2024-10-26)
    Background: Previous studies assessing the hypothesis that the construct of ‘aberrant salience’ is associated with psychosis and psychotic symptoms showed conflicting results. For this reason, the association between ...
  • Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data 
    Saez-Atienzar, Sara; Souza, Cleide dos Santos; Chia, Ruth; Beal, Selina N.; Lorenzini, Ileana; Huang, Ruili; Levy, Jennifer; Burciu, Camelia; Ding, Jinhui; Gibbs, J. Raphael; Jones, Ashley; Dewan, Ramita; Pensato, Viviana; Peverelli, Silvia; Corrado, Lucia; van Vugt, Joke J.F.A.; van Rheenen, Wouter; Tunca, Ceren; Bayraktar, Elif; Xia, Menghang; The International ALS Genomics Consortium; ITALSGEN Consortium; SLAGEN Consortium; Project MinE ALS Sequencing Consortium (Cell Press, 2024-11-13)
    Repeat expansions in the C9orf72 gene are the most common genetic cause of (ALS) and frontotemporal dementia (FTD). Like other genetic forms of neurodegeneration, pinpointing the precise mechanism(s) by which this mutation ...
  • Use of antithrombotic therapy and the risk of cardiovascular outcomes and bleeding in cancer patients at the end of life: a Danish nationwide cohort study 
    Søgaard, Mette; Ørskov, Marie; Jensen, Martin; Goedegebuur, Jamilla; Kempers, Eva K.; Visser, Chantal; Geijteman, Eric C.T.; Abbel, Denise; Mooijaart, Simon P.; Geersing, Geert Jan; Portielje, Johanneke; Edwards, Adrian; Aldridge, Sarah J.; Akbari, Ashley; Højen, Anette A.; Klok, Frederikus A.; Noble, Simon; Cannegieter, Suzanne; Ording, Anne Gulbech (Wiley-Blackwell, 2025-01)
    Background: Despite uncertain benefit-risk profile near the end of life, antithrombotic therapy (ATT) is prevalent in patients with terminal cancer. Objectives: To examine adherence and persistence with ATT in terminally ...
  • Short-term impact of cardiovascular screening by traditional risk assessment or coronary artery calcium score on health-related quality of life: The ROBINSCA trial 
    Moldovanu, Dana; De Koning, Harry J.; Vonder, Marleen; Gratama, Jan Willem C.; Adriaansen, Henk J.; Roeters Van Lennep, Jeanine E.; Vliegenthart, Rozemarijn; Van Der Harst, Pim; Braam, Richard L.; Van Dijkman, Paul R.M.; Oudkerk, Matthijs; Van Der Aalst, Carlijn M. (Oxford University Press, 2024-09-01)
    Aims: Evidence on the impact of screening for cardiovascular diseases (CVDs) on health-related quality of life (HRQoL) is important for policy decisions about screening implementation and to uncover teachable moments to ...
  • Clinical knowledge modeling: An essential step in the digital transformation of healthcare 
    Edelman, Eric; Tijssen, Fabian; Munniksma, Popke Rein; Bast, Wim; Bohmer, Harold ten; van Eldik, Nicole; Spreeuwenberg, Marieke; Buhre, Wolfgang; van Merode, Frits (2024-11-04)
  • Effect of intrapartum azithromycin on gut microbiota development in early childhood: A post hoc analysis of a double-blind randomized trial 
    Sanyang, Bakary; de Silva, Thushan I.; Camara, Bully; Beloum, Nathalie; Kanteh, Abdoulie; Manneh, Jarra; de Steenhuijsen Piters, Wouter A.A.; Bogaert, Debby; Sesay, Abdul Karim; Roca, Anna (Elsevier, 2024-09-20)
    Intrapartum azithromycin prophylaxis has shown the potential to reduce maternal infections but showed no effect on neonatal sepsis and mortality. Antibiotic exposure early in life may affect gut microbiota development, ...
  • The importance of understanding pelvic inflammatory disease as a polymicrobial infection -authors’ reply 
    Alexiou, Zoïe W.; Hoenderboom, Bernice M.; Hoebe, Christian J.P.A.; Dukers-Muijrers, Nicole H.T.M.; Götz, Hannelore M.; van der Sande, Marianne A.B.; de Vries, Henry J.C.; den Hartog, Janneke E.; Morré, Servaas A.; van Benthem, Birgit H.B. (Elsevier, 2024-12)
  • Heart disease detection using an acceleration-deceleration curve-based neural network with consumer-grade smartwatch data 
    Naseri, Arman; Tax, David M.J.; Reinders, Marcel; van der Bilt, Ivo (Elsevier, 2024-11-15)
    Cardiovascular disease (CVD) is the most important cause of morbidity and mortality worldwide. Early detection, prevention or even prediction is of pivotal importance to reduce the burden of cardiovascular disease and its ...
  • Complex structural variation is prevalent and highly pathogenic in pediatric solid tumors 
    van Belzen, Ianthe A.E.M.; van Tuil, Marc; Badloe, Shashi; Janse, Alex; Verwiel, Eugène T.P.; Santoso, Marcel; de Vos, Sam; Baker-Hernandez, John; Kerstens, Hindrik H.D.; Solleveld-Westerink, Nienke; Meister, Michael T.; Drost, Jarno; van den Heuvel-Eibrink, Marry M.; Merks, Johannes H.M.; Molenaar, Jan J.; Peng, Weng Chuan; Tops, Bastiaan B.J.; Holstege, Frank C.P.; Kemmeren, Patrick; Hehir-Kwa, Jayne Y. (Cell Press, 2024-11-13)
    In pediatric cancer, structural variants (SVs) and copy-number alterations contribute to cancer initiation as well as progression, thereby aiding diagnosis and treatment stratification. Although suggested to be of importance, ...
  • The effect of polygenic risk score and childhood adversity on transdiagnostic symptom dimensions at first-episode psychosis: evidence for an affective pathway to psychosis 
    Alameda, Luis; Rodriguez, Victoria; Di Forti, Marta; Spinazzola, Edoardo; Trotta, Giulia; Arango, Celso; Arrojo, Manuel; Bernardo, Miguel; Bobes, Julio; de Haan, Lieuwe; Del-Ben, Cristina Marta; Gayer-Anderson, Charlotte; Sideli, Lucia; Jones, Peter B.; Kirkbride, James B.; La Cascia, Caterina; Tripoli, Giada; Ferraro, Laura; La Barbera, Daniele; Lasalvia, Antonio; Tosato, Sarah; Llorca, Pierre Michel; Menezes, Paulo Rossi; van Os, Jim; Rutten, Bart P.; Santos, Jose Luis; Sanjuán, Julio; Selten, Jean Paul; Szöke, Andrei; Tarricone, Ilaria; Tortelli, Andrea; Velthorst, Eva; Jongsma, Hannah E.; Vassos, Evangelos; Quattrone, Diego; Murray, Robin M.; Aas, Monica (Nature Publishing Group, 2024-10-26)
    Childhood adversity is associated with various clinical dimensions in psychosis; however, how genetic vulnerability shapes the adversity-associated psychopathological signature is yet to be studied. We studied data of 583 ...
  • Haemodiafiltration versus haemodialysis for kidney failure: an individual patient data meta-analysis of randomised controlled trials 
    Vernooij, Robin W M; Hockham, Carinna; Strippoli, Giovanni; Green, Suetonia; Hegbrant, Jörgen; Davenport, Andrew; Barth, Claudia; Canaud, Bernard; Woodward, Mark; Blankestijn, Peter J; Bots, Michiel L; CONVINCE scientific committee (Elsevier, 2024-11-02)
    BACKGROUND: High-dose haemodiafiltration has been shown, in a randomised clinical trial, to result in a 23% lower risk of mortality for patients with kidney failure when compared with conventional high-flux haemodialysis. ...
  • Cardiac Amyloidosis Screening and Management in Patients With Heart Failure With Preserved Ejection Fraction: an International Survey 
    Shchendrygina, Anastasia; Mewton, Nathan; Niederseer, David; Kida, Keisuke; Guidetti, Federica; Duval, Antoine Jobbe; Milinkovic, Ivan; Oerlemans, Marish I F J; Zaleska-Kociecka, Marta; de Gracia, Sydney Goldfeder; Palacio, Maria Isabel; Giverts, Ilya; Komarova, Irina; Rustamova, Yasmin; Bahouth, Fadel; Mežnar, Anja Zupan; Mapelli, Massimo; Suvorov, Alexandr; Dyachuk, Irina; Shutov, Michail; Sitnikova, Violetta; Garnier-Crussard, Antoine; Barasa, Anders; Loncar, Goran; Tokmakova, Mariya; Skouri, Hadi; Ruschitzka, Frank; Saldarriaga, Clara (Elsevier, 2025-02)
    Cardiac amyloidosis (CA) is still an underdiagnosed cause of heart failure (HF) and early disease recognition and timely disease-modifying therapy (DMT) administration translate to better outcomes. We aimed to assess CA ...
  • Clinical outcome of subdural versus subgaleal drain after burr-hole drainage for chronic subdural hematoma 
    Carter, Sophie H; de Rooij, Maud J; Ahmadian, Narjes; de Wit, Anouk; van der Zwan, Albert; Robe, Pierre A J T (Springer, 2024-11-01)
    BACKGROUND: Chronic subdural hematoma (CSDH) is commonly treated by burr-hole drainage with subgaleal or subdural drain insertion, mostly based on surgeon's preference. We analyzed the recurrence rate and clinical outcomes ...
  • Evaluating methods for identifying and quantifying Streptococcus pneumoniae co-colonization using next-generation sequencing data. 
    Hackman, Jada; Hibberd, Martin L; Swarthout, Todd D; Hinds, Jason; Ashall, James; Sheppard, Carmen; Tonkin-Hill, Gerry; Gould, Kate; Brown, Comfort; Msefula, Jacquline; Mataya, Andrew A; Toizumi, Michiko; Yoshida, Lay-Myint; French, Neil; Heyderman, Robert S; Flasche, Stefan; Kwambana, Brenda; Hué, Stéphane (American Society for Microbiology, 2024-12-05)
    Detection of multiple pneumococcal serotype carriage can enhance monitoring of pneumococcal vaccine impact, particularly among high-burden childhood populations. We assessed methods for identifying co-carriage of pneumococcal ...
  • Adolescents’ dietary patterns, their drivers and association with double burden of malnutrition in adolescents: a cross-sectional study in Kenya’s urban slums 
    Wanjohi, Milkah N.; Kimani-Murage, Elizabeth Wambui; Asiki, Gershim; Holdsworth, Michelle; Pradeilles, Rebecca; Langat, Nelson; Amugsi, Dickson A.; Wilunda, Calistus; Klipstein-Grobusch, Kerstin (2024-11-06)
    Background: The double burden of malnutrition (DBM) during adolescence is associated with growth and developmental impairment and risk of non-communicable diseases. There is limited evidence on adolescent’s dietary patterns ...
  • Bulging after DIEP Breast Reconstruction: New Insights Concerning Rectus Diastasis and Medial Perforator Harvest 
    Nelissen, Sophie H.; Krijnen, Nienke A.; Tsehaie, Jonathan; Schellekens, Pascal P.A.; Paes, Emma C.; Simmermacher, Rogier K.J.; Maarse, Wiesje (Lippincott Williams and Wilkins Ltd., 2023-03-08)
    Background: The aim of this study was to evaluate the association between flap harvest technique and occurrence of abdominal bulging. Methods: A retrospective analysis of 159 patients undergoing DIEP flap breast reconstruction ...
  • European standard clinical practice – Key issues for the medical care of individuals with familial leukemia 
    Förster, Alisa; Davenport, Claudia; Duployez, Nicolas; Erlacher, Miriam; Ferster, Alina; Fitzgibbon, Jude; Göhring, Gudrun; Hasle, Henrik; Jongmans, Marjolijn C.; Kolenova, Alexandra; Kronnie, Geertruijte; Lammens, Tim; Mecucci, Cristina; Mlynarski, Wojciech; Niemeyer, Charlotte M.; Sole, Francesc; Szczepanski, Tomasz; Waanders, Esmé; Biondi, Andrea; Wlodarski, Marcin; Schlegelberger, Brigitte; Ripperger, Tim (Elsevier Masson SAS, 2023-04)
    Although hematologic malignancies (HM) are no longer considered exclusively sporadic, additional awareness of familial cases has yet to be created. Individuals carrying a (likely) pathogenic germline variant (e.g., in ETV6, ...
  • Harmen Tiddens (1923–2002): A butterfly’s impact on medical education 
    ten Cate, Olle; Jason, Hilliard (Springer Netherlands, 2023-10)
    The history of medical education scholarship is often overlooked. Moreover, although productive educational researchers are often recognized for their scholarly contributions in peer-reviewed publications, the impact of ...
  • The role of proximal tibial osteotomy in joint preservation 
    Husen, Martin; Custers, Roel J.H.; Hevesi, Mario; Krych, Aaron J.; Saris, Daniel B.F. (2023-03)
    Introduction: Tibial osteotomy has a role in various aspects of joint preservation. Proper diagnosis and addressing all aspects of alignment both for focal cartilage lesions to support restorative repair procedures as well ...
  • Elective Ascending Aortic Aneurysm Surgery in the Elderly 
    Memis, Feyza; Thijssen, Carlijn G.E.; Gökalp, Arjen L.; Notenboom, Maximiliaan L.; Meccanici, Frederike; Mokhles, Mohammad Mostafa; van Kimmenade, Roland R.J.; Veen, Kevin M.; Geuzebroek, Guillaume S.C.; Sjatskig, Jelena; ter Woorst, Franciscus J.; Bekkers, Jos A.; Takkenberg, Johanna J.M.; Roos-Hesselink, Jolien W. (Multidisciplinary Digital Publishing Institute (MDPI), 2023-03)
    Background. No clear guidelines exist for performing preventive surgery for ascending aortic (AA) aneurysm in elderly patients. This study aims to provide insights by: (1) evaluating patient and procedural characteristics ...