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UMC Repository: Recent submissions

  • HFrEF subphenotypes based on 4210 repeatedly measured circulating proteins are driven by different biological mechanisms 
    Petersen, Teun B.; de Bakker, Marie; Asselbergs, Folkert W.; Harakalova, Magdalena; Akkerhuis, K. Martijn; Brugts, Jasper J.; van Ramshorst, Jan; Lumbers, R. Thomas; Ostroff, Rachel M.; Katsikis, Peter D.; van der Spek, Peter J.; Umans, Victor A.; Boersma, Eric; Rizopoulos, Dimitris; Kardys, Isabella (Elsevier, 2023-07)
    Background: HFrEF is a heterogenous condition with high mortality. We used serial assessments of 4210 circulating proteins to identify distinct novel protein-based HFrEF subphenotypes and to investigate underlying dynamic ...
  • Cost-Effectiveness of SGLT2 Inhibitors in a Real-World Population: A MICADO Model-Based Analysis Using Routine Data from a GP Registry 
    Li, Xinyu; Hoogenveen, Rudolf; El Alili, Mohamed; Knies, Saskia; Wang, Junfeng; Beulens, Joline W.J.; Elders, Petra J.M.; Nijpels, Giel; van Giessen, Anoukh; Feenstra, Talitha L. (Adis International Ltd, 2023-10)
    Objective: Sodium–glucose cotransporter 2 inhibitors (SGLT2i) have been shown to reduce the risk of cardiovascular complications, which largely drive diabetes’ health and economic burdens. Trial results indicated that ...
  • Comparison between Speckle Plethysmography and Photoplethysmography during Cold Pressor Test Referenced to Finger Arterial Pressure 
    Herranz Olazabal, Jorge; Lorato, Ilde; Kling, Jesse; Verhoeven, Marc; Wieringa, Fokko; Van Hoof, Chris; Verkruijsse, Willem; Hermeling, Evelien (Multidisciplinary Digital Publishing Institute (MDPI), 2023-06)
    Speckle Plethysmography (SPG) and Photoplethysmography (PPG) are different biophotonics technologies that allow for measurement of haemodynamics. As the difference between SPG and PPG under low perfusion conditions is not ...
  • Intensive specialised multi-family therapy for multi-stressed families: Therapeutic alliance as predictor for effectiveness 
    van Beek, Yolanda; Hessen, David; Levelt, Lisa; Beijer, Daniëla; Rijnberk, Corine; Maras, Athanasios; Overbeek, Mathilde M. (Wiley-Blackwell Publishing Ltd, 2023-08)
    The effectiveness of intense specialised multi-family therapy (ISMFT) for 111 multi-stressed families, and the therapeutic alliance as a possible predictor of outcome, were examined. A repeated measures design was used, ...
  • Effect of Cell Age and Membrane Rigidity on Red Blood Cell Shape in Capillary Flow 
    Nouaman, Mohammed; Darras, Alexis; John, Thomas; Simionato, Greta; Rab, Minke A.E.; van Wijk, Richard; Laschke, Matthias W.; Kaestner, Lars; Wagner, Christian; Recktenwald, Steffen M. (Multidisciplinary Digital Publishing Institute (MDPI), 2023-06)
    Blood flow in the microcirculatory system is crucially affected by intrinsic red blood cell (RBC) properties, such as their deformability. In the smallest vessels of this network, RBCs adapt their shapes to the flow ...
  • Non-invasive prenatal testing (NIPT) in twin pregnancies affected by early single fetal demise: A systematic review of NIPT and vanishing twins 
    van Eekhout, Jacintha C.A.; Bekker, Mireille N.; Bax, Caroline J.; Galjaard, Robert Jan H. (John Wiley & Sons Inc., 2023-06)
    The screening performance of non-invasive prenatal testing (NIPT) in vanishing twin (VT) pregnancies is relatively unknown. To close this knowledge gap, we conducted a systematic review of the available literature. Studies ...
  • Adjuvant therapy for stage II melanoma: the need for further studies 
    Lee, Rebecca; Mandala, Mario; Long, Georgina V.; Eggermont, Alexander M.M.; van Akkooi, Alexander C.J.; Sandhu, Shahneen; Garbe, Claus; Lorigan, Paul (Elsevier Limited, 2023-08)
    Immunotherapy with checkpoint inhibitors has revolutionised the outcomes for melanoma patients. In the metastatic setting, patients treated with nivolumab and ipilimumab have an expected 5-year survival of> 50%. For patients ...
  • Extending the Mann–Kendall test to allow for measurement uncertainty 
    Nikolakopoulos, Stavros; Cator, Eric; Janssen, Mart P. (Taylor and Francis Ltd., 2023)
    The Mann–Kendall test for trend has gained a lot of attention in a range of disciplines, especially in the environmental sciences. One of the drawbacks of the Mann–Kendall test when applied to real data is that no distinction ...
  • Lexicale achterstand van kinderen met farmacoresistente epilepsie is leeftijdsafhankelijk Een onderzoek naar benoemen van afbeeldingen 
    de Koning, Trudi; Versnel, Huib; Meekes, Joost; Braams, Olga; Jennekens-Schinkel, Aag (Swets & Zeitlinger, 2023)
    Background and aim Generally, children with epilepsy perform worse in language tests than do healthy peers. To understand the abnormality better, we compared confrontation naming - as an index of the lexicon - between ...
  • Targeting NETs using dual-active DNase1 variants 
    Englert, Hanna; Göbel, Josephine; Khong, Danika; Omidi, Maryam; Wolska, Nina; Konrath, Sandra; Frye, Maike; Mailer, Reiner K.; Beerens, Manu; Gerwers, Julian C.; Preston, Roger J.S.; Odeberg, Jacob; Butler, Lynn M.; Maas, Coen; Stavrou, Evi X.; Fuchs, Tobias A.; Renné, Thomas (Frontiers Media S. A., 2023)
    Background: Neutrophil Extracellular Traps (NETs) are key mediators of immunothrombotic mechanisms and defective clearance of NETs from the circulation underlies an array of thrombotic, inflammatory, infectious, and ...
  • Crosstalk between TLR8 and RIG-I-like receptors enhances antiviral immune responses 
    Vlaming, Killian E.; van Wijnbergen, Kelly; Kaptein, Tanja M.; Nijhuis, Monique; Kootstra, Neeltje J.; de Bree, Godelieve J.; Geijtenbeek, Teunis B. (Frontiers Media S. A., 2023)
    Background: Toll-like receptor (TLR) agonists have been investigated due to their potential dual effects as latency reverting agents and immune modulatory compounds in people living with HIV (PLWH). Here, we investigated ...
  • Novel emm4 lineage associated with an upsurge in invasive group A streptococcal disease in the Netherlands, 2022 
    van der Putten, Boas C.L.; Bril-Keijzers, Wendy C.M.; Rumke, Lidewij W.; Vestjens, Stefan M.T.; Koster, Linda A.M.; Willemsen, Marloes; van Houten, Marlies A.; Rots, Nynke Y.; Vlaminckx, Bart J.M.; de Gier, Brechje; van Sorge, Nina M. (Microbiology Society, 2023-06-01)
    Invasive group A streptococcal (iGAS) disease cases increased in the first half of 2022 in the Netherlands, with a remarkably high proportion of emm4 isolates. Whole-genome sequence analysis of 66 emm4 isolates, 40 isolates ...
  • Whole-genome sequencing confirms a persistent candidaemia clonal outbreak due to multidrug-resistant Candida parapsilosis 
    Daneshnia, Farnaz; Hilmioğlu-Polat, Süleyha; Ilkit, Macit; Fuentes, Diego; Lombardi, Lisa; Binder, Ulrike; Scheler, Jakob; Hagen, Ferry; Mansour, Michael K.; Butler, Geraldine; Lass-Flörl, Cornelia; Gabaldon, Toni; Arastehfar, Amir (Oxford University Press, 2023-06-01)
    Objectives: Although perceived as a rare clinical entity, recent studies have noted the emergence of MDR C. parapsilosis (MDR-Cp) isolates from single patients (resistant to both azole and echinocandins). We previously ...
  • A scoring tool to predict mortality and dependency after cerebral venous thrombosis 
    Lindgren, Erik; Krzywicka, Katarzyna; de Winter, Maria A.; Sánchez Van Kammen, Mayte; Heldner, Mirjam R.; Hiltunen, Sini; Aguiar de Sousa, Diana; Mansour, Maryam; Canhão, Patrícia; Ekizoğlu, Esme; Rodrigues, Miguel; Martins Silva, Elisa; Garcia-Esperon, Carlos; Arnao, Valentina; Aridon, Paolo; Simaan, Naaem Moin; Silvis, Suzanne M.; Zuurbier, Susanna M.; Scutelnic, Adrian; Sezgin, Mine; Alasheev, Andrey Marisovich; Smolkin, Andrey; Guisado-Alonso, Daniel; Yesilot, Nilufer; Barboza, Miguel; Ghiasian, Masoud; Leker, Ronen R.; Arauz, Antonio; Arnold, Marcel; Putaala, Jukka; Tatlisumak, Turgut; Coutinho, Jonathan M.; Jood, Katarina (Wiley-Blackwell, 2023-08)
    Background and purpose: A prognostic score was developed to predict dependency and death after cerebral venous thrombosis (CVT) to identify patients for targeted therapy in future clinical trials. Methods: Data from the ...
  • A qualitative study on the perspectives of mothers who had been diagnosed with primary carnitine deficiency through newborn screening of their child 
    van den Heuvel, Lieke M.; Kater-Kuipers, Adriana; van Dijk, Tessa; Crefcoeur, Loek L.; Visser, Gepke; Langeveld, Mirjam; Henneman, Lidewij (BioMed Central, 2023-06)
    Background: Primary carnitine deficiency is an inborn error of metabolism, which can lead to life-threating complications early in life. Low carnitine levels can be detected by newborn bloodspot screening (NBS). However, ...
  • Regional and national antimicrobial stewardship activities: a survey from the Joint Programming Initiative on Antimicrobial Resistance - Primary Care Antibiotic Audit and Feedback Network (JPIAMR-PAAN) 
    Michalsen, Benedikte Olsen; Xu, Alice X.T.; Alderson, Sarah L.; Bjerrum, Lars; Brehaut, Jamie; Bucher, Heiner C.; Clarkson, Janet; Duncan, Eilidh; Grimshaw, Jeremy; Gunnarsson, Ronny; Høye, Sigurd; Ivers, Noah; Lecky, Donna M.; Lindbæk, Morten; Llor, Carl; Lundgren, Pia Touboul; O'connor, Denise; Pulcini, Celiné; Ramsay, Craig; Sundvall, Pär Daniel; Verheij, Theo; Schwartz, Kevin L.; JPIAMR-PAAN (Oxford, 2023-04-01)
    Background: Antibiotic overuse and misuse in primary care are common, highlighting the importance of antimicrobial stewardship (AMS) efforts in this setting. Audit and feedback (A&F) interventions can improve professional ...
  • Eversion technique versus traditional carotid endarterectomy with patch angioplasty: a systematic review with meta-analyses and trial sequential analysis 
    Marsman, Martijn S.; Wetterslev, Jørn; Vriens, Patrick W.H.E.; Bleys, Ronald L.A.W.; Jahrome, Abdelkarime Kh; Moll, Frans L.; Keus, Frederik; Reijnen, Michel M.P.J.; Koning, Giel G. (Elsevier, 2023-06)
    Introduction: The use of an ‘eversion’ technique is not unequivocally proven to be superior to carotid endarterectomy with patch angioplasty. An up-to-date systematic review is needed for evaluation of benefits and harms ...
  • Renin-angiotensin System Antagonists and Beta-blockers in Prevention of Anthracycline Cardiotoxicity: a Systematic Review and Meta-analysis 
    Avila, Monica Samuel; Siqueira, Suellen Rodrigues Rangel; Waldeck, Lucas; Ayub-Ferreira, Silvia Moreira; Takx, Richard; Bittencourt, Marcio Sommer; Bocchi, Edimar Alcides (Arquivos Brasileiros de Cardiologia, 2023)
    Background: The evidence supporting the use of renin-angiotensin-aldosterone system (RAAS) inhibitors and beta-blockers for the prevention of anthracycline-induced cardiomyopathy is controversial. Objective: We performed ...
  • Evaluation of the recently established Dutch nationwide Archipelago of Ovarian Cancer Research biobank 
    Zelisse, Hein S.; van Gent, Mignon D.J.M.; Mom, Constantijne H.; de Ridder, Sander; Snijders, Malou L.H.; Heeling, Marlou; Stoter, Matthijs; Broeks, Annegien; Horlings, Hugo M.; Lok, Christianne A.R.; Bosch, Steven L.; Piek, Jurgen M.; Bart, Joost; Reyners, Anna K.L.; Wisman, G. Bea A.; Yigit, Refika; Boere, Ingrid A.; Collée, Margriet; Groenendijk, Floris H.; Jansen, Maurice P.H.M.; Roes, Eva Maria; Hofhuis, Ward; Hoogduin, Klaas J.; Alcalá, Luthy S.M.; Smedts, Huberdina P.M.; Makkus, Alexander C.F.; Nieuwenhuyzen-de Boer, Gatske M.; van Es, Nicole; Vencken, Peggy M.L.H.; van Altena, Anne M.; Simons, Michiel; Hazelbag, Hans Marten; Kagie, Marjolein J.; Aliredjo, Riena; Bonestroo, Tijmen J.J.; Bosse, Tjalling; de Kroon, Cor D.; Brinkhuis, Mariël; Janssen, Marc Jan; Koster, Nils C.; Kruse, Arnold Jan; Gerestein, Cornelis G.; Jonges, Trudy G.N.; Zweemer, Ronald P.; Kooreman, Loes F.S.; Lambrechts, Sandrina; Ebisch, Inge M.W.; de Kievit van der Heijden, Ineke M.; Voorham, Quirinus J.; van der Aa, Maaike A.; Archipelago of Ovarian Cancer Research Consortium (W.B. Saunders, 2025-02)
    Fundamental and translational research in ovarian cancer aims to enhance understanding of disease mechanisms and improve treatment and survival outcomes. To support this, we established the Dutch multicenter, interdisciplinary ...
  • Neurophysiological and psychosocial mechanisms of fibromyalgia: A comprehensive review and call for an integrative model 
    Pinto, Ana Margarida; Luís, Mariana; Geenen, Rinie; Palavra, Filipe; Lumley, Mark A.; Ablin, Jacob N.; Amris, Kirstine; Branco, Jaime; Buskila, Dan; Castelhano, João; Castelo-Branco, Miguel; Crofford, Leslie J.; Fitzcharles, Mary Ann; Häuser, Winfried; Kosek, Eva; Mease, Philip J.; Marques, Tiago Reis; Jacobs, Johannes W.G.; Castilho, Paula; da Silva, José A.P. (Elsevier Limited, 2023-08)
    Research into the neurobiological and psychosocial mechanisms involved in fibromyalgia has progressed remarkably in recent years. Despite this, current accounts of fibromyalgia fail to capture the complex, dynamic, and ...