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UMC Repository: Recent submissions

  • Goedegebuur, J.; Abbel, D.; Accassat, S.; Achterberg, W. P.; Akbari, A.; Arfuch, V. M.; Baddeley, E.; Bax, J. J.; Becker, D.; Bergmeijer, B.; Bertoletti, L.; Blom, J. W.; Calvetti, A.; Cannegieter, S. C.; Castro, L.; Chavannes, N. H.; Coma-Auli, N.; Couffignal, C.; Edwards, A.; Edwards, M.; Enggaard, H.; Font, C.; Gava, A.; Geersing, G. J.; Geijteman, E. C.T.; Greenley, S.; Gregory, C.; Gussekloo, J.; Hoffmann, I.; Højen, A. A.; van den Hout, W. B.; Huisman, M. V.; Jacobsen, S.; Jagosh, J.; Johnson, M. J.; Jørgensen, L.; Juffermans, C. C.M.; Kempers, E. K.; Konstantinides, S.; Kroder, A. F.; Kruip, M. J.H.A.; Lafaie, L.; Langendoen, J. W.; Larsen, T. B.; Lifford, K.; van der Linden, Y. M.; Mahé, I.; Maiorana, L.; Maraveyas, A.; Martens, E. S.L.; Mayeur, D.; van Mens, T. E.; Mohr, K.; Mooijaart, S. P.; Murtagh, F. E.M.; Nelson, A.; Nielsen, P. B.; Ording, A. G.; Ørskov, M.; Pearson, M.; Poenou, G.; Portielje, J. E.A.; Raczkiewicz, D.; Rasmussen, K.; Trinks-Roerdink, E.; Schippers, I.; Seddon, K.; Sexton, K.; Sivell, S.; Skjøth, F.; Søgaard, M.; Szmit, S.; Trompet, S.; Vassal, P.; Visser, C.; van Vliet, L. M.; Wilson, E.; Klok, F. A.; Noble, S. I.R. (Elsevier Limited, 2023-08)
    Background: Even though antithrombotic therapy has probably little or even negative effects on the well-being of people with cancer during their last year of life, deprescribing antithrombotic therapy at the end of life ...
  • Mol, Sander; Gaakeer, Menno I.; Van Der Linden, M. Christien; Baan-Kooman, E. C.Margré; Backus, Barbra E.; De Ridder, Victor A. (2023-08-01)
  • Zanovello, Matteo; Ibáñez, Kristina; Brown, Anna Leigh; Sivakumar, Prasanth; Bombaci, Alessandro; Santos, Liana; van Vugt, Joke J.F.A.; Narzisi, Giuseppe; Karra, Ramita; Scholz, Sonja W.; Ding, Jinhui; Gibbs, J. Raphael; Chiò, Adriano; Dalgard, Clifton; Weisburd, Ben; Hanna, Michael G.; Greensmith, Linda; Phatnani, Hemali; Veldink, Jan H.; Traynor, Bryan J.; Polke, James; Houlden, Henry; Fratta, Pietro; Tucci, Arianna; The American Genome Center (TAGC) consortium; Genomics England Research Consortium; Project MinE ALS Sequencing Consortium; The NYGC ALS Consortium (Oxford University Press, 2023-07-01)
    CAG repeat expansions in exon 1 of the AR gene on the X chromosome cause spinal and bulbar muscular atrophy, a male-specific progressive neuromuscular disorder associated with a variety of extra-neurological symptoms. The ...
  • Bouwens, Elke; Vanmaele, Alexander; Hoeks, Sanne E.; Verhagen, Hence J.M.; Fioole, Bram; Moelker, Adriaan; ten Raa, Sander; Hussain, Burhan; Oliveira-Pinto, José; Bastos Gonçalves, Frederico; Ijpma, Arne S.; Hoefer, Imo E.; van Lier, Felix; Akkerhuis, K. Martijn; Majoor-Krakauer, Danielle F.; Boersma, Eric; Kardys, Isabella (SAGE Publications Ltd, 2023-10)
    Background: Surveillance programs in abdominal aortic aneurysms (AAA) are mainly based on imaging and leave room for improvement to timely identify patients at risk for AAA growth. Many biomarkers are dysregulated in ...
  • Jensen, Märit; Al-Shahi Salman, Rustam; Ng, G. Andre; van der Worp, H. Bart; Loh, Peter; Campbell, Bruce C.V.; Kalman, Jonathan M.; Hill, Michael D.; Sposato, Luciano A.; Andrade, Jason G.; Metzner, Andreas; Kirchhof, Paulus; Thomalla, Götz (BioMed Central Ltd., 2023-12)
    Background: Patients with ischemic stroke and atrial fibrillation (AF) are at particularly high risk for recurrent stroke and cardiovascular events. Early rhythm control has been shown to be superior to usual care for the ...
  • de Klerk, Huub H.; Verweij, Lukas P.E.; Sierevelt, Inger N.; Priester-Vink, Simone; Hilgersom, Nick F.J.; Eygendaal, Denise; van den Bekerom, Michel P.J. (W.B. Saunders, 2023-11)
    Purpose: To perform a systematic review of complications associated with elbow arthroscopy in adults and children. Methods: A literature search was performed in the PubMed, EMBASE, and Cochrane databases. Studies reporting ...
  • Loots, Feike (Bohn Stafleu van Loghum, 2023-07)
    Tijdige herkenning en behandeling van sepsis kan veel sterfte voorkomen. Vooral kwetsbare ouderen hebben een verhoogd risico en juist bij hen zijn de symptomen vaak subtiel of aspecifiek. Er is een nieuwe sepsisscore voor ...
  • van der Veen, Suzanne W; Dijkstra, Jelmer J; Willemsen, Ellen C L; Houtman, René; Milona, Alexandra; Marchet, Nikolas; Spit, Maureen; Hollman, Danielle; Zwartkruis, Fried J T; Vermeulen, Michiel; Ramos Pittol, Jose M; van Mil, Saskia W C (Oxford University Press, 2025-02-08)
    The farnesoid X receptor (FXR) is a nuclear receptor (NR) known to obligately heterodimerize with the retinoid X receptor (RXR). FXR is expressed as four isoforms (α1-α4) that drive transcription from IR-1 (inverted repeat-1) ...
  • Rademaker, Emma; Vernooij, Lisette M; van der Poll, Tom; Bonten, Marc J M; Leavis, Helen; Cremer, Olaf L; Derde, Lennie P G (Springer Science + Business Media, 2024-12-05)
    Background: Low endogenous immunoglobulin(Ig)-levels are common in critically ill patients with sepsis, but it is unknown whether low Ig-levels are associated with poor outcome, and in which patients Ig-replacement therapy ...
  • Koenderman, Leo; Vrisekoop, Nienke (Springer Nature, 2025)
    The view of neutrophils has shifted from simple phagocytic cells, whose main function is to kill pathogens, to very complex cells that are also involved in immune regulation and tissue repair. These cells are essential for ...
  • Chaturvedi, Madhav; Köster, Denise; Bossuyt, Patrick M; Gerke, Oke; Jurke, Annette; Kretzschmar, Mirjam E; Lütgehetmann, Marc; Mikolajczyk, Rafael; Reitsma, Johannes B; Schneiderhan-Marra, Nicole; Siebert, Uwe; Stekly, Carina; Ehret, Christoph; Rübsamen, Nicole; Karch, André; Zapf, Antonia (Springer Nature, 2024-12-10)
    Evaluating diagnostic test accuracy during epidemics is difficult due to an urgent need for test availability, changing disease prevalence and pathogen characteristics, and constantly evolving testing aims and applications. ...
  • Reitenbach, Andreas; Sartori, Fabio; Banisch, Sven; Golovin, Anastasia; Calero Valdez, André; Kretzschmar, Mirjam; Priesemann, Viola; Maes, Michael (IOP Publishing Ltd., 2024-12-16)
    To comprehend the dynamics of infectious disease transmission, it is imperative to incorporate human protective behavior into models of disease spreading. While models exist for both infectious disease and behavior dynamics ...
  • White, Susan M.; Bhoj, Elizabeth; Nellåker, Christoffer; Lachmeijer, Augusta M.A.; Marshall, Aren E.; Boycott, Kym M.; Li, Dong; Smith, Wendy; Hartley, Taila; McBride, Arran; Ernst, Michelle E.; May, Alison S.; Wieczorek, Dagmar; Abou Jamra, Rami; Koch-Hogrebe, Margarete; Õunap, Katrin; Pajusalu, Sander; van Gassen, K. L.I.; Sadedin, Simon; Ellingwood, Sara; Tan, Tiong Yang; Christodoulou, John; Barea, Jaime; Lockhart, Paul J.; Nezarati, Marjan M.; Kernohan, Kristin D.; Care4Rare Canada Consortium (Cell Press, 2021-04-01)
    The DNA damage-binding protein 1 (DDB1) is part of the CUL4–DDB1 ubiquitin E3 ligase complex (CRL4), which is essential for DNA repair, chromatin remodeling, DNA replication, and signal transduction. Loss-of-function ...
  • Douben, Hannie C.W.; Nellist, Mark; van Unen, Leontine; Elfferich, Peter; Kasteleijn, Esmee; Hoogeveen-Westerveld, Marianne; Louwen, Jesse; van Veghel-Plandsoen, Monique; de Valk, Walter; Saris, Jasper J.; Hendriks, Femke; Korpershoek, Esther; Hoefsloot, Lies H.; van Vliet, Margreethe; van Bever, Yolande; van de Laar, Ingrid; Aten, Emmelien; Lachmeijer, Augusta M.A.; Taal, Walter; van den Bersselaar, Lisa; Schuurmans, Juliette; Oostenbrink, Rianne; van Minkelen, Rick; van Ierland, Yvette; van Ham, Tjakko J. (John Wiley & Sons Inc., 2022-12)
    Neurofibromatosis type 1 (NF1) is caused by inactivating mutations in NF1. Due to the size, complexity, and high mutation rate at the NF1 locus, the identification of causative variants can be challenging. To obtain a ...
  • Grant, Matthew P; McCarthy, Damien; Kearney, Chris; Collins, Anna; Sundararajan, Vijaya; Rhee, Joel J; Philip, Jennifer A M; Emery, Jon D (Oxford University Press, 2025-04-01)
    Objectives General practice plays a key role in end-of-life care, yet the extent of this remains largely unknown due to a lack of detailed clinical data. This study aims to describe the care provided by General Practitioners ...
  • Hart, Einar A; Eenhoorn, Paul; Nijkeuter, Mathilde; Ruigrok, Dieuwertje; van der Heijden, Joris J; Voskuil, Michiel; Liu, Tommy K K; Balder, Jan Willem; van de Hoef, Tim P; van der Harst, Pim; Kraaijeveld, Adriaan O; Dickinson, Michael G (Bohn Stafleu van Loghum, 2025)
    BACKGROUND: Pulmonary embolism is an important cause of preventable mortality. Treatment strategies depend on risk stratification. High-risk patients, and some intermediate-high-risk patients, require urgent reperfusion ...
  • van Royen, Niels; Amat-Santos, Ignacio J; Hudec, Martin; Bunc, Matjaz; Ijsselmuiden, Alexander; Laanmets, Peep; Unic, Daniel; Merkely, Béla; Hermanides, Renicus S; Ninios, Vlasis; Protasiewicz, Marcin; Rensing, Benno J W M; Martin, Pedro L; Feres, Fausto; Sousa, Manuel De; Van Belle, Eric; Linke, Axel; Ielasi, Alfonso; Montorfano, Matteo; Webster, Mark; Toutouzas, Konstantinos; Teiger, Emmanuel; Bedogni, Francesco; Voskuil, Michiel; Pan, Manuel; Angerås, Oskar; Kim, Won-Keun; Rothe, Jürgen; Kristić, Ivica; Peral, Vicente; Van den Branden, Ben J L; Westermann, Dirk; Bellini, Barbara; Garcia-Gomez, Mario; Tobe, Akihiro; Tsai, Tsung-Ying; Garg, Scot; Thakkar, Ashokkumar; Chandra, Udita; Morice, Marie-Claude; Soliman, Osama; Onuma, Yoshinobu; Serruys, Patrick W; Baumbach, Andreas (Europa Group, 2025-01-20)
    BACKGROUND: There are limited head-to-head randomised trials comparing the performance of different transcatheter heart valves (THVs). AIMS: We aimed to evaluate the non-inferiority of the balloon-expandable Myval THV ...
  • Verburgt, Esmée; Verhoeven, Jamie I.; Hilkens, Nina A.; Vaartjes, Ilonca; De Leeuw, Frank Erik (Lippincott Williams & Wilkins, 2024-12-24)
    Background and Objectives Multiple studies found a higher ischemic stroke incidence in rural areas compared with urbanized areas, often explained by a low socioeconomic status (SES). However, this has rarely been investigated ...
  • Visser, Maurits R; Voeten, Daan M; Gisbertz, Suzanne S; Ruurda, Jelle P; van Hillegersberg, Richard; van Berge Henegouwen, Mark I; Dutch Upper Gastrointestinal Cancer Audit (DUCA) Group (Springer New York, 2025-04)
    Background: Salvage esophagectomy is more complex and associated with higher postoperative morbidity and mortality than standard resection. This study aimed to investigate short-term outcomes and the influence of hospital ...