Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

  • Omnigene-Guttm ensures fecal microbiome stability in the pediatric population 
    Hoogendijk, Raoull; van den Broek, Thijs J.M.; Lee, Hyunju; Mueller, Sabine; Kline, Cassie; Bianco, John; Top, Janetta; de Zoete, Marcel R.; Kester, Lennart; Calkoen, Friso; van der Lugt, Jasper (2024-12-06)
    Increasing evidence exists that the gut microbiome influences toxicity as well as outcomes in a variety of cancers. To investigate the role of the gut microbiome in pediatric neuro-oncology, microbiome analysis has been ...
  • Imaging in acute percutaneous mechanical circulatory support in adults: A clinical consensus statement of the Association for Acute CardioVascular Care (ACVC) of the ESC, the European Association of Cardiovascular Imaging (EACVI) of the ESC and the European branch of the Extracorporeal Life Support Organization (EuroELSO) 
    Tavazzi, Guido; Price, Susanna; Beitnes, Jan Otto; Bleakley, Caroline; Balik, Martin; Lochy, Stijn; Moller, Jacob Eifer; Guarracino, Fabio; Donal, Erwan; Donker, Dirk W.; Belohlavek, Jan; Hassager, Christian (Oxford University Press, 2024-12-01)
    The use of temporary mechanical circulatory support (tMCS) in cardiogenic shock patients has increased during the last decades with most management strategies relying on observational studies and expert opinion, including ...
  • Long-term follow-up of sacrococcygeal pilonidal sinus disease after previous abscess drainage: a retrospective cohort study 
    de Kort, Jochem; Pronk, Anne Akke; Vriens, Menno R.; Smakman, Niels; Furnee, Edgar J.B. (Springer New York, 2025-02)
  • Surgical specialists face higher a risk for malpractice compared to their non-surgical colleagues 
    Dronkers, Wouter J.; van Rees, Jan M.; Klemann, Désirée; Buis, Dennis R.; Amelink, Quirine J.M.A.; Grünhagen, Dirk J.; Mokhles, Mostafa; Vandertop, W. Peter; Broekman, Marike L.B.; Hendriks, Aart C.; Boersma, Eric; Dirven, Clemens M.F.; Klimek, Markus; Spoor, Jochem K.H. (Nature Publishing Group, 2024-12-05)
    In previous studies, surgical specialties accounted for most malpractice claims. The objective of the present study was to determine the risk for malpractice claims for physicians working in hospitals. A retrospective ...
  • RANK drives structured intestinal epithelial expansion during pregnancy 
    Onji, Masahiro; Sigl, Verena; Lendl, Thomas; Novatchkova, Maria; Ullate-Agote, Asier; Andersson-Rolf, Amanda; Kozieradzki, Ivona; Koglgruber, Rubina; Pai, Tsung Pin; Lichtscheidl, Dominic; Nayak, Komal; Zilbauer, Matthias; Carranza García, Natalia A.; Sievers, Laura Katharina; Falk-Paulsen, Maren; Cronin, Shane J.F.; Hagelkruys, Astrid; Sawa, Shinichiro; Osborne, Lisa C.; Rosenstiel, Philip; Pasparakis, Manolis; Ruland, Jürgen; Takayanagi, Hiroshi; Clevers, Hans; Koo, Bon Kyoung; Penninger, Josef M. (Nature Research, 2025-01-02)
    During reproduction, multiple species such as insects and all mammals undergo extensive physiological and morphological adaptions to ensure health and survival of the mother and optimal development of the offspring. Here ...
  • Temporal Transitions of the Hyperinflammatory and Hypoinflammatory Phenotypes in Critical Illness 
    van Amstel, Rombout B E; Bartek, Brian; Vlaar, Alexander P J; Gay, Elizabeth; van Vught, Lonneke A; Cremer, Olaf L; Van der Poll, Tom; Shapiro, Nathan I; Matthay, Michael A; Calfee, Carolyn S; Sinha, Pratik; Bos, Lieuwe D J; on behalf of the MARS Consortium and NHLBI PETAL Network (American Thoracic Society, 2025-03)
    Rationale: Systemic molecular phenotypes of critical illness are prognostically informative, yet their temporal kinetics and implications of changing phenotypes remain incompletely understood. Objectives: To determine the ...
  • System Genetics Analysis Reveals Sex Differences in Human Aortic Smooth Muscle Gene Expression 
    Meng, Sarah L.; Anane-Wae, Rita; Benavente, Ernest Diez; Aherrahrou, Redouane (Libertas Academica Ltd., 2024-11-28)
    Background: Coronary artery disease (CAD) is one of the leading causes of death worldwide. The buildup of atherosclerotic plaque, including lipids and cellular waste, characterizes this disease. Smooth muscle cells (SMCs) ...
  • Global vaccination against hepatitis E virus: position paper from the European society of clinical microbiology and infectious diseases viral hepatitis study group 
    Dudman, Susanne; Zerja, Arjana; Hasanoğlu, İmran; Ruta, Simona; van Welzen, Berend; Nicolini, Laura Ambra; Yonga, Paul; Øverbø, Joakim; Rawat, Sumit; Habibovic, Selma; Kim, Tan Bou; Rivero-Juarez, Antonio; ESGVH members (Elsevier, 2025-02)
    Scope: Hepatitis E virus (HEV) is a significant global health issue, impacting both low- and middle-income countries and industrialized nations. HEV genotypes 1 and 2, primarily transmitted through contaminated water, are ...
  • Vigabatrin-associated brain magnetic resonance imaging abnormalities and clinical symptoms in infants with tuberous sclerosis complex 
    Stevering, Carmen; Lequin, Maarten; Szczepaniak, Kinga; Sadowski, Krzysztof; Ishrat, Saba; De Luca, Alberto; Leemans, Alexander; Otte, Willem; Kwiatkowski, David J.; Curatolo, Paolo; Weschke, Bernhard; Riney, Kate; Feucht, Martha; Krsek, Pavel; Nabbout, Rima; Jansen, Anna; Wojdan, Konrad; Sijko, Kamil; Glowacka-Walas, Jagoda; Borkowska, Julita; Domanska-Pakiela, Dorota; Moavero, Romina; Hertzberg, Christoph; Hulshof, Hanna; Scholl, Theresa; Petrák, Bořivoj; Maminak, Miroslav; Aronica, Eleonora; De Ridder, Jessie; Lagae, Lieven; Jozwiak, Sergiusz; Kotulska, Katarzyna; Braun, Kees; Jansen, Floor (Wiley-Blackwell, 2025-02)
    Objective: Previous retrospective studies have reported vigabatrin-associated brain abnormalities on magnetic resonance imaging (VABAM), although clinical impact is unknown. We evaluated the association between vigabatrin ...
  • Coronary Artery Calcium Scores After Prophylactic Premenopausal Bilateral Salpingo-Oophorectomy 
    Beekman, Maarten J.; Terra, Lara; Heemskerk-Gerritsen, Bernadette A.M.; van der Aalst, Carlijn M.; Roeters van Lennep, Jeanine E.; van Beurden, Marc; van Doorn, Helena C.; de Hullu, Joanne A.; van Dorst, Eleonora B.L.; Mom, Constantijne H.; Mourits, Marian J.E.; Slangen, Brigitte F.M.; Bartels-Rutten, Annemarieke; Budde, Ricardo P.J.; Snoeren, Miranda M.; Leiner, Tim; de Jong, Pim A.; Vliegenthart, Rozemarijn; Planken, R. Nils; Mihl, Casper; Vonder, Marleen; Oudkerk, Matthijs; Gaarenstroom, Katja N.; Gratama, Jan Willem C.; van Engelen, Klaartje; van der Kolk, Lizet E.; Collée, J. Margriet; Wevers, Marijke R.; Ausems, Margreet G.E.M.; Berger, Lieke P.V.; Gomez Garcia, Encarna B.; van Asperen, Christi J.; Hooning, Maartje J.; de Koning, Harry J.; Maas, Angela H.E.M.; van Leeuwen, Flora E. (Elsevier, 2024-12)
    Background: Premenopausal risk-reducing salpingo-oophorectomy (RRSO) in women at high familial risk of ovarian cancer leads to immediate menopause. Although early natural menopause is associated with increased cardiovascular ...
  • Advancing toxicovigilance of recreational drugs, including new psychoactive substances, by using data from four European poison centres 
    Kader, Aza; Hermanns-Clausen, Maren; van Riel, Antoinette; Faber, Katrin; Hondebrink, Laura (Informa Healthcare, 2025)
    Introduction: Common recreational drugs and new psychoactive substances pose challenges to public health. This study investigated the feasibility of merging cases of recreational drug poisoning reported to European poison ...
  • Safety, Efficacy, and Biomarker Analysis of Crizotinib in MET-Mutated Non-Small Cell Lung Cancer-Results from the Drug Rediscovery Protocol 
    Verkerk, Karlijn; van der Wel, Tijmen J.W.T.; Zeverijn, Laurien J.; Geurts, Birgit S.; Spiekman, Ilse A.C.; de Wit, Gijs F.; Roepman, Paul; Jansen, Anne M.L.; van der Noort, Vincent; Smit, Egbert F.; Hoeben, Ann; Hendriks, Lizza E.L.; van den Heuvel, Michel M.; Piet, Berber; Herder, Gerarda J.M.; Hashemi, Sayed M.S.; Gelderblom, Hans; Verheul, Henk M.W.; Voest, Emile E.; de Langen, Adrianus J. (2024-12-01)
    Purpose: To provide patients with MET-mutated advanced non-small cell lung cancer (METmut aNSCLC) access to crizotinib, further substantiate evidence of its efficacy and safety in this setting, and find potential biomarkers ...
  • The influence of cardiac substructure dose on survival in a large lung cancer stereotactic radiotherapy cohort using a robust personalized contour analysis 
    van der Pol, Luuk H.G.; Pomp, Jacquelien; Mohamed Hoesein, Firdaus A.A.; Raaymakers, Bas W.; Verhoeff, Joost J.C.; Fast, Martin F. (Elsevier, 2024-10)
    Background/Purpose: Radiation-induced cardiac toxicity in lung cancer patients has received increased attention since RTOG 0617. However, large cohort studies with accurate cardiac substructure (CS) contours are lacking, ...
  • IKZF1 gene deletions drive resistance to cytarabine in B-cell precursor acute lymphoblastic leukemia 
    Vervoort, Britt M.T.; Butler, Miriam; Grünewald, Kari J.T.; van Ingen Schenau, Dorette S.; Tee, Trisha M.; Lucas, Luc; Huitema, Alwin D.R.; Boer, Judith M.; Bornhauser, Beat C.; Bourquin, Jean Pierre; Hoogerbrugge, Peter M.; van der Velden, Vincent H.J.; Kuiper, Roland P.; van der Meer, Laurens T.; van Leeuwen, Frank N. (Ferrata Storti Foundation, 2024-12)
    IKZF1 deletions occur in 10-15% of patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and predict a poor outcome. However, the impact of IKZF1 loss on sensitivity to drugs used in contemporary treatment ...
  • Retinal ganglion cell-derived semaphorin 6A segregates starburst amacrine cell dendritic scaffolds to organize the mouse inner retina 
    James, Rebecca E.; Hamilton, Natalie R.; Huffman, Lola Nicole; Brown, Matthew P.; Neckles, Victoria N.; Pasterkamp, R. Jeroen; Goff, Loyal A.; Kolodkin, Alex L. (Company of Biologists Ltd, 2024-11)
    To form functional circuits, neurons must settle in their appropriate cellular locations, and then project and elaborate neurites to contact their target synaptic neuropils. Laminar organization within the vertebrate retinal ...
  • Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages 
    Andersson-Rolf, Amanda; Groot, Kelvin; Korving, Jeroen; Begthel, Harry; Hanegraaf, Maaike A.J.; VanInsberghe, Michael; Salmén, Fredrik; van den Brink, Stieneke; Lopez-Iglesias, Carmen; Peters, Peter J.; Krueger, Daniel; Beumer, Joep; Geurts, Maarten H.; Alemany, Anna; Gehart, Helmuth; Carlotti, Françoise; de Koning, Eelco J.P.; Chuva de Sousa Lopes, Susana M.; van Oudenaarden, Alexander; van Es, Johan H.; Clevers, Hans (Elsevier, 2024-12-26)
    The mammalian pancreas consists of three epithelial compartments: the acini and ducts of the exocrine pancreas and the endocrine islets of Langerhans. Murine studies indicate that these three compartments derive from a ...
  • Mevalonate kinase deficiency: an updated clinical overview and revision of the SHARE recommendations 
    Lengvári, Lilla; Takács, Kata; Lengyel, Anna; Pálinkás, Annamária; Wouters, Carine Helena; Koné-Paut, Isabelle; Kuemmerle-Deschner, Jasmin; Jeyaratnam, Jerold; Anton, Jordi; Lachmann, Helen Jane; Gattorno, Marco; Hofer, Michael; Toplak, Nataša; Weiser, Peter; Kallinich, Tilmann; Ozen, Seza; Hentgen, Véronique; Uziel, Yosef; Horváth, Zsuzsanna; Szabados, Márton; Brogan, Paul; Constantin, Tamás; Frenkel, Joost (Frontiers Media S. A., 2024-11-12)
    Mevalonate kinase deficiency (MKD), a rare auto-inflammatory disorder, arises from mutations in the MVK gene, disrupting isoprenoid biosynthesis, and affecting cellular processes. This comprehensive review provides an ...
  • Reporting Guidelines for the Early-Phase Clinical Evaluation of Applications Using Extended Reality: RATE-XR Qualitative Study Guideline 
    Vlake, Johan H.; Drop, Denzel LQ; Bommel, Jasper Van; Riva, Giuseppe; Wiederhold, Brenda K.; Cipresso, Pietro; Rizzo, Albert S.; Rothbaum, Barbara O.; Botella, Cristina; Hooft, Lotty; Bienvenu, Oscar J.; Jung, Christian; Geerts, Bart; Wils, Evert Jan; Gommers, Diederik; van Genderen, Michel E.; RATE-XR Expert Group (Journal of medical Internet Research, 2024-11-19)
    Background: Extended reality (XR), encompassing technologies such as virtual reality, augmented reality, and mixed reality, has rapidly gained prominence in health care. However, existing XR research often lacks rigor, ...
  • Comparison of open and endovascular repair of complex abdominal aortic aneurysms 
    Yadavalli, Sai Divya; Rastogi, Vinamr; Mehta, Ambar; Allievi, Sara; Solomon, Yoel; de Bruin, Jorg L.; Arya, Shipra; Stangenberg, Lars; Verhagen, Hence J.M.; Schermerhorn, Marc L. (Mosby Inc., 2025-02)
    Objective: The aim of this study was to compare perioperative and 5-year outcomes following endovascular (FEVAR) and open repair (OAR) of complex abdominal aortic aneurysms (cAAAs) in males and females separately, given ...
  • Interleukin-1β induces trained innate immunity in human hematopoietic progenitor cells in vitro 
    Flores-Gomez, Daniela; Hobo, Willemijn; van Ens, Diede; Kessler, Elise L.; Novakovic, Boris; Schaap, Nicolaas; Rijnen, Wim H.C.; Joosten, Leo A.B.; Netea, Mihai G.; Riksen, Niels P.; Bekkering, Siroon (Cell Press, 2024-12-10)
    Innate immune cells can develop a long-lasting hyperresponsive phenotype, termed trained immunity, mediated by epigenetic and metabolic reprogramming. In mice, exposure to Bacille Calmette-Guérin (BCG), β-glucan, or Western ...