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UMC Repository: Recent submissions

  • Abrocitinib effect on patient-reported outcomes in patients with moderate-to-severe atopic dermatitis: Results from phase 3 studies, including the long-term extension JADE EXTEND study 
    Reich, K.; Silverberg, J. I.; Papp, K. A.; Deleuran, M.; Katoh, N.; Strober, B.; Beck, L. A.; de Bruin-Weller, M.; Werfel, T.; Zhang, F.; Biswas, P.; DiBonaventura, M. D.; Chan, G.; Farooqui, S. A.; Kerkmann, U.; Clibborn, C. (Wiley-Blackwell, 2023-10)
    Background: Abrocitinib improved signs and symptoms of moderate-to-severe atopic dermatitis (AD) at Weeks 12 and 16 in phase 3 studies, with a manageable safety profile. Patient-reported outcomes with long-term abrocitinib ...
  • Levensbedreigende behandelingen: inzicht in morele spanningen onder verpleegkundigen 
    Arends, Susanne; Steenbergen, Milou; Jongerden, Irene; Francke, Anneke (Vereniging van Oncologie Verpleegkundigen, 2022-12-16)
    In hoeverre ervaren verpleegkundigen morele spanning bij het uitvoeren van mogelijk levensverlengende behandelingen bij volwassen patiënten in het ziekenhuis? Maakt het uit of ze betrokken zijn bij de besluitvorming rond ...
  • The quality of OpenStreetMap food-related point-of-interest data for use in epidemiological research 
    Pinho, Maria Gabriela M.; Flueckiger, Benjamin; Valentin, Antonia; Kasdagli, Maria Iosifina; Kyriakou, Kalliopi; Lakerveld, Jeroen; Mackenbach, Joreintje D.; Beulens, Joline W.J.; de Hoogh, Kees (Elsevier, 2023-09)
    We assessed the quality of food-related OpenStreetMap (OSM) data in urban areas of five European countries. We calculated agreement statistics between point-of-interests (POIs) from OSM and from Google Street View (GSV) ...
  • Susceptibility and disease modifier genes in amyotrophic lateral sclerosis: from genetic associations to therapeutic implications 
    Willemse, Sean W.; Van Es, Michael A. (Lippincott Williams & Wilkins, 2023-08-01)
    Purpose of reviewAmyotrophic lateral sclerosis (ALS) is a severe disease characterized by the degeneration of motor neurons. Large-scale genetic studies have now identified over 60 genes that are associated with ALS, which ...
  • Morele spanningen 
    Steenbergen, Milou; Arends, Susanne; Jongerden, Irene; Francke, Anneke (Bohn Stafleu van Loghum, 2022-10-08)
    Verpleegkundigen ervaren morele spanningen rondom mogelijk levensverlengende behandelingen van volwassenen met een korte levensverwachting
  • Early and intensive Motor Training for people with spinal cord injuries (the SCI-MT Trial): description of the intervention 
    Ben, M.; Glinsky, J. V.; Chu, J.; Spooren, A. I.; Roberts, S.; Chen, L. W.; Denis, S.; Lorusso, M.; Jorgensen, V.; Gollan, E. J.; Agostinello, J.; Van Laake-Geelen, C. C.M.; Lincoln, C.; Stolwijk, J. M.; Bell, C.; Paddison, S.; Rainey, D.; Tranter, K.; Ilha, J.; Oostra, K.; Sherrington, C.; Harvey, L. A. (Springer Nature, 2023-11)
    Study design: Descriptive. Objectives: The primary objective is to describe the intervention that will be provided in a large multi-centre randomised controlled trial titled: Early and Intensive Motor Training for people ...
  • Verplegingswetenschapper, en dan? 
    Steenbergen, Milou; Grootscholten, Emerentia; Hoitinga, Gercora; van Glansbeek-Schutijser, Bernadette; Bouma, Joanne; de Groot, Kim; Henderik, Suzan (Bohn Stafleu van Loghum, 2023-10-05)
  • A germline PDGFRB splice site variant associated with infantile myofibromatosis and resistance to imatinib 
    Boulouadnine, Boutaina; Filser, Mathilde; Leducq, Camille; Losole, Taylor; Bies, Joshua; Smetsers, Stephanie; Kouwenberg, Dorus; de Lange, Iris; Mensenkamp, Arjen; Kordes, Uwe Richard; Minard-Colin, Véronique; Orbach, Daniel; Brichard, Bénédicte; de Krijger, Ronald; Masliah-Planchon, Julien; Demoulin, Jean Baptiste (Lippincott Williams & Wilkins, 2025-02)
    Purpose: Infantile myofibromatosis is characterized by the development of myofibroblastic tumors in young children. In most cases, the disease is caused by somatic gain-of-function variants in platelet-derived growth factor ...
  • CTGCT, Centre of Excellence for the Technologies of Gene and Cell Therapy: Collaborative translation of scientific discoveries into advanced treatments for neurological rare genetic diseases and cancer 
    Marolt Presen, Darja; Lainšček, Duško; Kinghorn, Jane; Sebestyen, Zsolt; Kuball, Jurgen; Amini, Leila; Reinke, Petra; Fuchs, Anke; Jerala, Roman; Benčina, Mojca (Elsevier, 2025-01)
    The emerging field of precision medicine relies on scientific breakthroughs to understand disease mechanisms and develop cutting-edge technologies to overcome underlying genetic and functional aberrations. The establishment ...
  • The nationwide Dietary Intake after Diagnosis and Colorectal Cancer Outcomes (PLCRC-PROTECT) cohort: Study design, clinical characteristics and baseline health behaviors 
    Derksen, Jeroen W.G.; Smit, Karel C.; Hoeven, Irene W.F.; Sijtsma, Femke P.C.; Koopman, Miriam; May, Anne M. (Elsevier, 2025-02)
    Purpose: The nationwide Dietary Intake After Diagnosis and Colorectal Cancer Outcomes (PROTECT) study is a prospective cohort study investigating how lifestyle-related factors including dietary intake and physical activity ...
  • The convoluted path leading to neuronal circuit formation 
    Silva, Carla G. (Elsevier Limited, 2025-02)
    A limiting step of neuronal circuit formation is the extensive migration of interneurons from their birthplace to populate territories formed by excitatory neurons. Interneuron dynamics in the developing brain culminates ...
  • Methodological quality assessment tools for diagnosis and prognosis research: overview and guidance 
    Kaul, Tabea; Kellerhuis, Bas E.; Damen, Johanna A.A.; Schuit, Ewoud; Jenniskens, Kevin; van Smeden, Maarten; Reitsma, Johannes B.; Hooft, Lotty; Moons, Karel G.M.; Yang, Bada (Elsevier, 2025-01)
    Background and Objectives: Multiple tools exist for assessing the methodological quality of diagnosis and prognosis research. It can be challenging to decide on when to use which tool. We aimed to provide an overview of ...
  • Prospective Analysis of Confocal Laser Endomicroscopy for Assessment of the Resection Bed for Bladder Tumor 
    de Ruiter, Ben Max; Freund, Jan E.; Dilara Savci-Heijink, C.; van Hattum, Jons W.; Remmelink, Marinka J.; de Reijke, Theo M.; Baard, Joyce; Kamphuis, Guido M.; de Bruin, D. Martijn; Oddens, Jorg R. (Elsevier, 2025-01)
    Background and objective: Urothelial bladder cancer (UCB) care requires frequent follow-up cystoscopy and surgery. Confocal laser endomicroscopy (CLE), a probe-based optical technique for real-time microscopic evaluation, ...
  • Physiological versus time based cord clamping in very preterm infants (ABC3): a parallel-group, multicentre, randomised, controlled superiority trial 
    Knol, Ronny; Brouwer, Emma; van den Akker, Thomas; DeKoninck, Philip L.J.; Onland, Wes; Vermeulen, Marijn J.; de Boode, Willem P.; van Kaam, Anton H.; Lopriore, Enrico; Reiss, Irwin K.M.; Hutten, G. Jeroen; Prins, Sandra A.; Mulder, Estelle E.M.; d'Haens, Esther J.; Hulzebos, Christian V.; Bouma, Helene A.; van Sambeeck, Sam J.; Niemarkt, Hendrik J.; van der Putten, Mayke E.; Lebon, Tinta; Zonnenberg, Inge A.; Nuytemans, Debbie H.; Willemsen, Sten P.; Polglase, Graeme R.; Steggerda, Sylke J.; Hooper, Stuart B.; te Pas, Arjan B. (Elsevier, 2025-01)
    Background: Physiological-based cord clamping (PBCC) in preterm infants is beneficial for cardiovascular transition at birth and may optimize placental transfusion. Whether PBCC can improve clinical outcomes is unknown. ...
  • Enhancing fMRI quality control 
    van den Berg, Lennard; Ramsey, Nick; Raemaekers, Mathijs (Elsevier, 2025-03)
    Background: fMRI in clinical settings faces challenges affecting activity maps. Template matching can screen for abnormal results by providing an objective metric of activity map quality. This research tests how sample ...
  • Cold acclimation with shivering improves metabolic health in adults with overweight or obesity 
    Sellers, Adam J.; van Beek, Sten M.M.; Hashim, Dzhansel; Baak, Rosalie; Pallubinsky, Hannah; Moonen-Kornips, Esther; Schaart, Gert; Gemmink, Anne; Jörgensen, Johanna A.; van de Weijer, Tineke; Kalkhoven, Eric; Hooiveld, Guido J.; Kersten, Sander; Hesselink, Matthijs K.C.; Schrauwen, Patrick; Hoeks, Joris; van Marken Lichtenbelt, Wouter D. (Springer Berlin, 2024-12-06)
    Cold acclimation increases insulin sensitivity, and some level of muscle contraction appears to be needed for provoking this effect. Here 15 men and (postmenopausal) women with overweight or obesity, the majority of whom ...
  • Radioimmunotherapy combating biofilm-associated infection in vitro 
    Ye, Zijian; van der Wildt, Berend; Nurmohamed, F. Ruben H.A.; van Duyvenbode, J. Fred F.Hooning; van Strijp, Jos; Vogely, H. Charles; Lam, Marnix G.E.H.; Dadachova, Ekaterina; Weinans, Harrie; van der Wal, Bart C.H.; Poot, Alex J. (Frontiers Media S. A., 2024-11-29)
    Background: Addressing prosthetic joint infections poses a significant challenge within orthopedic surgery, marked by elevated morbidity and mortality rates. The presence of biofilms and infections attributed to Staphylococcus ...
  • Comparative iron management in hemodialysis and peritoneal dialysis patients: a systematic review 
    van Lieshout, Thomas S.; Klerks, Anastasia K.; Mahic, Osman; Vernooij, Robin W.M.; Eisenga, Michele F.; van Jaarsveld, Brigit C.; Abrahams, Alferso C. (Frontiers Media SA, 2024-11-27)
    Background: Patients with kidney failure undergoing dialysis often suffer from anemia. Iron deficiency, along with a shortage in erythropoietin, is a common cause. Peritoneal dialysis (PD) patients may have a different ...
  • Evaluating predictive patterns of antigen-specific B cells by single-cell transcriptome and antibody repertoire sequencing 
    Erlach, Lena; Kuhn, Raphael; Agrafiotis, Andreas; Shlesinger, Danielle; Yermanos, Alexander; Reddy, Sai T. (Cell Press, 2024-12-18)
    The field of antibody discovery typically involves extensive experimental screening of B cells from immunized animals. Machine learning (ML)-guided prediction of antigen-specific B cells could accelerate this process but ...
  • Colposuspension in girls with refractory stress-incontinence, a critical evaluation of a last-resort treatment 
    van Geen, Frank Jan; Nieuwhof-Leppink, Anka; Klijn, Aart; de Kort, Laetitia; Chrzan, Rafal (2024-11-29)
    Introduction: We previously presented promising results with a Burch-type colposuspension (BC) in a heterogeneous group of girls with therapy-resistant daytime incontinence (DUI). In view of our clinical observations, we ...