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UMC Repository: Recent submissions

  • Leveraging FHIR in Federated Learning Environments: A Data Harmonization Framework for Cohort Studies 
    Cadavid, Héctor; Arends, Bauke (IOS Press, 2024-08-22)
    MyDigiTwin is a scientific initiative for the development of a platform for the early detection and prevention of cardiovascular diseases. This platform, which is supported by prediction models trained in a federated fashion ...
  • Practice variation in home care nursing: mapping potential explanations through a scoping review of the literature 
    Brabers, A E M; Meijer, M A M; Groenewegen, P P; Bleijenberg, N; Zwakhalen, S; de Jong, J D (2024-08-21)
    Needs assessment is the starting point of good home care as it determines which care is necessary, based on the needs of patients, their personal situation, and social context. There are indications that practice variation ...
  • Evaluation of risk prediction models to select lung cancer screening participants in Europe: a prospective cohort consortium analysis 
    Feng, Xiaoshuang; Goodley, Patrick; Alcala, Karine; Guida, Florence; Kaaks, Rudolf; Vermeulen, Roel; Downward, George S; Bonet, Catalina; Colorado-Yohar, Sandra M; Albanes, Demetrius; Weinstein, Stephanie J; Goldberg, Marcel; Zins, Marie; Relton, Caroline; Langhammer, Arnulf; Skogholt, Anne Heidi; Johansson, Mattias; Robbins, Hilary A (Elsevier, 2024-09)
    BACKGROUND: Lung cancer risk prediction models might efficiently identify individuals who should be offered lung cancer screening. However, their performance has not been comprehensively evaluated in Europe. We aimed to ...
  • A cross-sectional study in 18 patients with typical and mild forms of nemaline myopathy in the Netherlands 
    van Kleef, Esmee S B; van de Camp, Sanne A J H; Groothuis, Jan T; Erasmus, Corrie E; Gaytant, Michael A; Vosse, Bettine A H; de Weerd, Willemien; Verschuuren-Bemelmans, Corien C; Medici-Van den Herik, Evita G; Wallgren-Pettersson, Carina; Küsters, Benno; Schouten, Meyke; van Engelen, Baziel G M; Ottenheijm, Coen A C; Doorduin, Jonne; Voermans, Nicol C (Elsevier Limited, 2024-10)
    Nemaline myopathy (NM) is a congenital myopathy with generalised muscle weakness, most pronounced in neck flexor, bulbar and respiratory muscles. The aim of this cross-sectional study was to assess the Dutch NM patient ...
  • On the design and development of a handheld electrocardiogram device in a clinical setting 
    Zepeda-Echavarria, Alejandra; Ratering Arntz, Niek C M; Westra, Albert H; van Schelven, Leonard J; Euwe, Froukje E; Noordmans, Herke Jan; Vessies, Melle; van de Leur, Rutger R; Hassink, Rutger J; Wildbergh, Thierry X; van der Zee, Rien; Doevendans, Pieter A; van Es, René; Jaspers, Joris E N (Frontiers Media S. A., 2024-08-09)
    Cardiovascular diseases (CVDs) are a global burden that requires attention. For the detection and diagnosis of CVDs, the 12-lead ECG is a key tool. With technological advancements, ECG devices are becoming smaller and ...
  • Heterozygous missense CSF1R variants hamper in vitro CD34+-derived dendritic cell generation but not in vivo dendritic cell development 
    Beerepoot, Shanice; Wolf, Nicole I; van der Knaap, Marjo S; Nierkens, Stefan; Plantinga, Maud (Elsevier Limited, 2024-10)
    Colony stimulating factor 1 receptor (CSF1R) is an essential receptor for both colony stimulating factor 1 (CSF1) and interleukin (IL) 34 signaling expressed on monocyte precursors and myeloid cells, including monocytes, ...
  • Cerebroplacental ratio in low-risk pregnancies: the RATIO37 trial 
    Meijerink, Lotte; Terstappen, Fieke; Depmann, Martine; Bekker, Mireille; Lely, Titia (Elsevier Limited, 2024-08-24)
  • Omega-3 supplementation changes the physical properties of leukocytes but not erythrocytes in healthy individuals: An exploratory trial 
    Schuchardt, Jan Philipp; Kräter, Martin; Schlögel, Maximilian; Guck, Jochen; van Oirschot-Hermans, Brigitte A.; Bos, Jennifer; van Wijk, Richard; Tintle, Nathan L.; Westra, Jason; Kerlikowsky, Felix; Hahn, Andreas; Harris, William S. (Churchill Livingstone, 2024-03)
    n3-PUFA impact health in several ways, including cardiovascular protection and anti-inflammatory effects, but the underlying mechanisms are not fully understood. In this exploratory study involving 31 healthy subjects, we ...
  • From diagnosis to dialogue – reconsidering the DSM as a conversation piece in mental health care: a hypothesis and theory 
    Veldmeijer, Lars; Terlouw, Gijs; van Os, Jim; te Meerman, Sanne; van ‘t Veer, Job; Boonstra, Nynke (Frontiers Research Foundation, 2024-08-06)
    The Diagnostic and Statistical Manual of Mental Disorders, abbreviated as the DSM, is one of mental health care’s most commonly used classification systems. While the DSM has been successful in establishing a shared language ...
  • Editorial: The ethics of speech ownership in the context of neural control of augmented assistive communication 
    Freudenburg, Zachary; Berezutskaya, Julia; Herbert, Cornelia (Frontiers Research Foundation, 2024-08-06)
  • MR-OCTAVIUS 4D with 1500 MR and 1600 MR arrays is suitable for plan QA in a 1.5 T MRI-linac 
    Gorobets, Viktoriia; Vries, Wilfred de; Brand, Nicole; Foppen, Thomas; Wopereis, André J.M.; Woodings, Simon (IOP Publishing Ltd., 2024-09-07)
    To ensure the accuracy of radiation delivery to patients in a 1.5 T MRI-linac, the implementation of quality assurance (QA) devices compatible with MR technology is essential. The OCTAVIUS 4D MR, made by PTW (Freiburg, ...
  • Genome-wide methylation analysis in patients with proximal hypospadias–a pilot study and review of the literature 
    van Bever, Yolande; Boers, Ruben G.; Brüggenwirth, Hennie T.; van IJcken, Wilfred Fj; Magielsen, Frank J.; de Klein, Annelies; Boers, Joachim B.; Looijenga, Leendert Hj; Brosens, Erwin; Gribnau, Joost; Hannema, Sabine E. (Landes Bioscience, 2024-09)
    In patients with proximal hypospadias, often no genetic cause is identified despite extensive genetic testing. Many genes involved in sex development encode transcription factors with strict timing and dosing of the gene ...
  • Association of body shape phenotypes and body fat distribution indexes with inflammatory biomarkers in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank 
    González-Gil, Esther M.; Peruchet-Noray, Laia; Sedlmeier, Anja M.; Christakoudi, Sofia; Biessy, Carine; Navionis, Anne Sophie; Mahamat-Saleh, Yahya; Jaafar, Rola F.; Baurecht, Hansjörg; Guevara, Marcela; Etxezarreta, Pilar Amiano; Verschuren, W. M.Monique; Boer, Jolanda M.A.; Olsen, Anja; Tjønneland, Anne; Simeon, Vittorio; Castro-Espin, Carlota; Aune, Dagfinn; Heath, Alicia K.; Gunter, Marc; Colorado-Yohar, Sandra M.; Zilhão, Nuno R.; Dahm, Christina C.; Llanaj, Erand; Schulze, Matthias B.; Petrova, Dafina; Sieri, Sabina; Ricceri, Fulvio; Masala, Giovanna; Key, Tim; Viallon, Vivian; Rinaldi, Sabina; Freisling, Heinz; Dossus, Laure (BioMed Central, 2024-08-15)
    Background: The allometric body shape index (ABSI) and hip index (HI), as well as multi-trait body shape phenotypes, have not yet been compared in their associations with inflammatory markers. The aim of this study was to ...
  • Biological Sample Collection to Advance Research and Treatment: A Fight Osteosarcoma Through European Research and Euro Ewing Consortium Statement 
    Green, Darrell; van Ewijk, Roelof; Tirtei, Elisa; Andreou, Dimosthenis; Baecklund, Fredrik; Baumhoer, Daniel; Bielack, Stefan S.; Botchu, Rajesh; Boye, Kjetil; Brennan, Bernadette; Capra, Michael; Cottone, Lucia; Dirksen, Uta; Fagioli, Franca; Fernandez, Natalia; Flanagan, Adrienne M.; Gambarotti, Marco; Gaspar, Nathalie; Gelderblom, Hans; Gerrand, Craig; Gomez-Mascard, Anne; Hardes, Jendrik; Hecker-Nolting, Stefanie; Kabickova, Edita; Kager, Leo; Kanerva, Jukka; Kester, Lennart A.; Kuijjer, Marieke L.; Laurence, Valérie; Lervat, Cyril; Marchais, Antonin; Marec-Berard, Perrine; Mendes, Cristina; Merks, Johannes H.M.; Ory, Benjamin; Palmerini, Emanuela; Pantziarka, Pan; Papakonstantinou, Evgenia; Piperno-Neumann, Sophie; Raciborska, Anna; Roundhill, Elizabeth A.; Rutkauskaite, Vilma; Safwat, Akmal; Scotlandi, Katia; Staals, Eric L.; Strauss, Sandra J.; Surdez, Didier; Sys, Gwen M.L.; Tabone, Marie Dominique; Toulmonde, Maud; Valverde, Claudia; van de Sande, Michiel A.J.; Wörtler, Klaus; Campbell-Hewson, Quentin; McCabe, Martin G.; Nathrath, Michaela (American Association for Cancer Research Inc., 2024-08-15)
    Osteosarcoma and Ewing sarcoma are bone tumors mostly diagnosed in children, adolescents, and young adults. Despite multimodal therapy, morbidity is high and survival rates remain low, especially in the metastatic disease ...
  • Use of virtual reality in preoperative education of cardiac surgery patients – A feasibility study 
    van Rijn, Michelle M.; de Heer, Linda M.; Nieuwenhuis-Wendt, Jenny; van der Kaaij, Niels P.; Moolenaar, Eveline G.E.; van der Ham, Daan Halle; van der Plank, Lars; Westland, Heleen; Weldam, Saskia W.M. (Elsevier Ireland Ltd, 2024-12)
    Objective: A Virtual Patient Tour (VPT) was developed to inform cardiac surgery patients about their hospitalization from the admission to their postoperative stay on the ward. The objective of our study was to assess the ...
  • In response to Chuong et al. 
    Grimbergen, Guus; Intven, Martijn P.W.; Meijer, Gert J. (Elsevier Ireland Ltd, 2024-09)
  • Association of fibrotic markers with diastolic function after STEMI 
    Al Ali, Lawien; Meijers, Wouter C.; Beldhuis, Iris E.; Groot, Hilde E.; Lipsic, Erik; van Veldhuisen, Dirk J.; Voors, Adriaan A.; van der Horst, Iwan C.C.; de Boer, Rudolf A.; van der Harst, Pim (Nature Publishing Group, 2024-08-18)
    Galectin-3 and Suppression of tumorigenicity-2 (ST2) are known markers of cardiac fibrosis. We investigated the prognostic value of fibrotic markers for the development of diastolic dysfunction and long-term outcome in ...
  • Clinical Updates and Surveillance Recommendations for DNA Replication Repair Deficiency Syndromes in Children and Young Adults 
    Das, Anirban; MacFarland, Suzanne P.; Meade, Julia; Hansford, Jordan R.; Schneider, Kami W.; Kuiper, Roland P.; Jongmans, Marjolijn C.J.; Lesmana, Harry; Schultz, Kris Ann P.; Nichols, Kim E.; Durno, Carol; Zelley, Kristin; Porter, Christopher C.; States, Lisa J.; Ben-Shachar, Shay; Savage, Sharon A.; Kalish, Jennifer M.; Walsh, Michael F.; Scott, Hamish S.; Plon, Sharon E.; Tabori, Uri (American Association for Cancer Research Inc., 2024-08-15)
    Replication repair deficiency (RRD) is a pan-cancer mechanism characterized by abnormalities in the DNA mismatch repair (MMR) system due to pathogenic variants in the PMS2, MSH6, MSH2, or MLH1 genes, and/or in the ...
  • Discovering novel germline genetic variants linked to severe fluoropyrimidine-related toxicity in- and outside DPYD 
    Knikman, Jonathan E.; Zhai, Qinglian; Lunenburg, Carin A.T.C.; Henricks, Linda M.; Böhringer, Stefan; van der Lee, Maaike; de Man, Femke M.; Offer, Steven M.; Shrestha, Shikshya; Creemers, Geert Jan; Baars, Arnold; Dezentjé, Vincent O.; Imholz, Alexander L.T.; Jeurissen, Frank J.F.; Portielje, Johanna E.A.; Jansen, Rob L.H.; Hamberg, Paul; Droogendijk, Helga J.; Koopman, Miriam; Nieboer, Peter; van de Poel, Marlène H.W.; Mandigers, Caroline M.P.W.; van Schaik, Ron H.N.; Gelderblom, Hans; Mathijssen, Ron H.J.; Schellens, Jan H.M.; Cats, Annemieke; Guchelaar, Henk Jan; Swen, Jesse J. (BioMed Central, 2024-08-15)
    Background: The Alpe-DPD study (NCT02324452) demonstrated that prospective genotyping and dose-individualization using four alleles in DPYD (DPYD*2A/rs3918290, c.1236G > A/rs75017182, c.2846A > T/rs67376798 and c.1679 T > ...
  • Metadata for Data dIscoverability aNd Study rEplicability in obseRVAtional Studies (MINERVA): Development and Pilot of a Metadata List and Catalogue in Europe 
    Pajouheshnia, Romin; Gini, Rosa; Gutierrez, Lia; Swertz, Morris A; Hyde, Eleanor; Sturkenboom, Miriam; Arana, Alejandro; Franzoni, Carla; Ehrenstein, Vera; Roberto, Giuseppe; Gil, Miguel; Maciá, Miguel Angel; Schäfer, Wiebke; Haug, Ulrike; Thurin, Nicolas H; Lassalle, Régis; Droz-Perroteau, Cécile; Zaccagnino, Silvia; Busto, Maria Paula; Middelkoop, Bas; Gembert, Karin; Sanchez-Saez, Francisco; Rodriguez-Bernal, Clara; Sanfélix-Gimeno, Gabriel; Hurtado, Isabel; Acosta, Manuel Barreiro de; Poblador-Plou, Beatriz; Carmona-Pírez, Jonás; Gimeno-Miguel, Antonio; Prados-Torres, Alexandra; Schultze, Anna; Jansen, Ella; Herings, Ron; Kuiper, Josine; Locatelli, Igor; Jazbar, Janja; Žerovnik, Špela; Kos, Mitja; Smit, Steven; Lind, Sirje; Metspalu, Andres; Simou, Stefania; Hedenmalm, Karin; Cochino, Ana; Alcini, Paolo; Kurz, Xavier; Perez-Gutthann, Susana (John Wiley & Sons Inc., 2024-08)
    Purpose: Metadata for data dIscoverability aNd study rEplicability in obseRVAtional studies (MINERVA), a European Medicines Agency–funded project (EUPAS39322), defined a set of metadata to describe real-world data sources ...