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Now showing items 9861-9880 of 40729

Patient-Level Pooled Analysis of Ultrasound Renal Denervation in the Sham-Controlled RADIANCE II, RADIANCE-HTN SOLO, and RADIANCE-HTN TRIO Trials

the RADIANCE Investigators and Collaborators (American Medical Association, 2023-05-01)

IMPORTANCE Ultrasound renal denervation (uRDN) was shown to lower blood pressure (BP) in patients with uncontrolled hypertension (HTN). Establishing the magnitude and consistency of the uRDN effect across the HTN spectrum ...
Anatomical predictors for suture-based closure of the patent foramen ovale: A multicenter experience

Witte, Lars S.; Renkens, Mick P.L.; Gąsecka, Aleksandra; el Bouziani, Abdelhak; de Winter, Robbert J.; Tijssen, Jan G.P.; Stella, Pieter R.; Leibundgut, Gregor; Voskuil, Michiel (John Wiley & Sons Inc., 2023-08-01)

Background: NobleStitch EL is a novel suture-based technique used for patent foramen ovale (PFO) closure and an alternative to traditional double-disc devices without the need for antithrombotic therapy. However, successful ...
Reactive astrogliosis in the era of single-cell transcriptomics

Matusova, Zuzana; Hol, Elly M.; Pekny, Milos; Kubista, Mikael; Valihrach, Lukas (Frontiers Media S. A., 2023)

Reactive astrogliosis is a reaction of astrocytes to disturbed homeostasis in the central nervous system (CNS), accompanied by changes in astrocyte numbers, morphology, and function. Reactive astrocytes are important in ...
Clinical consequences of off-label reduced dosing of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: a systematic review and meta-analysis

Joosten, Linda P T; van Maanen, Rosanne; van den Dries, Carline J; Rutten, Frans H; Hoes, Arno W; Granger, Christopher B; Hemels, Martin E W; Geersing, Geert-Jan; van Doorn, Sander (BMJ Publishing Group, 2023-05-11)

OBJECTIVE: Postmarketing observational studies report that a substantial percentage of patients with atrial fibrillation (AF) receive a reduced non-vitamin K antagonist oral anticoagulant (NOAC) dose without a clear ...
Relatives' experiences of the transition from intensive care to home for acutely admitted intensive care patients—A qualitative study

Meiring-Noordstra, Aaltje; van der Meulen, Ingeborg C.; Onrust, Marisa; Hafsteinsdóttir, Thóra B.; Luttik, Marie Louise (Wiley-Blackwell, 2024-01)

Background: Acute admission to an intensive care unit (ICU) can negatively affect quality of life for patients and their relatives. Relatives play an important caregiving role after the patient's admission. More knowledge ...
Nurses' motivations to leave the nursing profession: A qualitative meta-aggregation

Bahlman-van Ooijen, Wilmieke; Malfait, Simon; Huisman-de Waal, Getty; Hafsteinsdóttir, Thóra B. (Wiley-Blackwell, 2023-05-20)

Aim: To systematically provide an overview of the qualitative evidence available on the motivations for nurses to leave the nursing profession. Design: A qualitative systematic review using the meta-aggregation design of ...
Self-stigma and cognitive insight in individuals at ultra-high risk for psychosis

Sportel, Bouwina Esther; van Enthoven, Mirjam; van Donkersgoed, Rozanne J M; Kuis, Daan Jan; van de Giessen, Tara; Lysaker, Paul H; Hasson-Ohayon, Ilanit; de Jong, Steven; Boonstra, Nynke; Pijnenborg, Gerdina H M (Frontiers Research Foundation, 2023-04-13)

BACKGROUND: Impaired cognitive insight and increased self-stigma have been consistently reported in individuals diagnosed with schizophrenia spectrum disorders, but little is known about its presence in individuals at ...
Measuring recovery in participants with a schizophrenia spectrum disorder: validation of the Individual Recovery Outcomes Counter (I.ROC)

Sportel, B Esther; Aardema, Hettie; Boonstra, Nynke; Arends, Johannes; Rudd, Bridey; Metz, Margot J; Castelein, Stynke; Pijnenborg, Gerdina H M (BioMed Central, 2023-04-28)

Background: To improve recovery in mental health, validated instruments are needed. Aims: This study evaluates psychometric properties of the Individual Recovery Outcomes Counter (I.ROC) in a Dutch population of participants ...
The Cutting Edge of Epigenetic Clocks: In Search of Mechanisms Linking Aging and Mental Health

Harvanek, Zachary M.; Boks, Marco P.; Vinkers, Christiaan H.; Higgins-Chen, Albert T. (Elsevier, 2023-11-01)

Individuals with psychiatric disorders are at increased risk of age-related diseases and early mortality. Recent studies demonstrate that this link between mental health and aging is reflected in epigenetic clocks, aging ...
Efficacy of customized corneal crosslinking versus standard corneal crosslinking in patients with progressive keratoconus (C-CROSS study): study protocol for a randomized controlled trial

Vandevenne, Magali M S; Berendschot, Tos T J M; Winkens, Bjorn; van den Biggelaar, Frank J H M; Visser, Nienke; Dickman, Mor M; Wisse, Robert P L; Wijdh, Robert-Jan H J; Roy, Abhijit Sinha; Shetty, Rohit; Nuijts, Rudy M M A (BioMed Central, 2023-12)

BACKGROUND: Keratoconus is a degenerative disorder of the cornea leading to a protrusion and thinning with loss of visual acuity. The only treatment to halt the progression is corneal crosslinking (CXL), which uses riboflavin ...
Development of a primary care screening algorithm for the early detection of patients at risk of primary antibody deficiency

Messelink, Marianne A; Berbers, Roos M; van Montfrans, Joris M; Ellerbroek, Pauline M; Gladiator, André; Welsing, Paco M J; Leavis, Helen (BioMed Central Ltd., 2023-05-27)

BACKGROUND: Primary antibody deficiencies (PAD) are characterized by a heterogeneous clinical presentation and low prevalence, contributing to a median diagnostic delay of 3-10 years. This increases the risk of morbidity ...
Ventricular function and biomarkers in relation to repair and pulmonary valve replacement for tetralogy of Fallot

van der Ven, Jelle P G; Günthel, Marie; van den Bosch, Eva; Kamphuis, Vivian P; Blom, Nicolaas A; Breur, Johannes; Berger, Rolf M F; Bogers, Ad J J C; Koopman, Laurens; Ten Harkel, Arend D J; Christoffels, Vincent; Helbing, Willem A (BMJ Publishing Group, 2023-01)

Objective Cardiac surgery may cause temporarily impaired ventricular performance and myocardial injury. We aim to characterise the response to perioperative injury for patients undergoing repair or pulmonary valve replacement ...
Propranolol or atenolol for the management of infantile hemangioma: Implications for long-term health

Hermans, Mireille M; Pasmans, Suzanne G M A; de Laat, Peter C J; Slieker, Martijn G; Mendels, Elodie J; de Graaf, Marlies; Langeveld, Hester R; Schappin, Renske; Rietman, André B; Breugem, Corstiaan C; Breur, Johannes M P J; de Wildt, Saskia N; Raphael, Martine F (Elsevier, 2023-06)
Benzodiazepine Receptor Agonists Use and Cessation Among Multimorbid Older Adults with Polypharmacy: Secondary Analysis from the OPERAM Trial

Sibille, François-Xavier; de Saint-Hubert, Marie; Henrard, Séverine; Aubert, Carole Elodie; Goto, Namiko Anna; Jennings, Emma; Dalleur, Olivia; Rodondi, Nicolas; Knol, Wilma; O'Mahony, Denis; Schwenkglenks, Matthias; Spinewine, Anne (Adis, 2023-06)

BACKGROUND: Benzodiazepine receptor agonists (BZRAs) are commonly prescribed in older adults despite an unfavorable risk-benefit ratio. Hospitalizations may provide a unique opportunity to initiate BZRA cessation, yet ...
Prevention and Screening for Cardiometabolic Disease Following Hypertensive Disorders in Pregnancy in Low-Resource Settings: A Systematic Review and Delphi Study

Ishaku, Salisu Mohammed; Adu-Bonsaffoh, Kwame; Housseine, Natasha; Lamptey, Roberta; Franx, Arie; Grobbee, Diederick; Warren, Charlotte E; Obstetrics and Gynecology, University of Ghana Medical School, Korle Bu Teaching Hospital Accra, Ghana, Department (Elsevier Science & Technology, 2023-04-25)

Hypertensive disorders in pregnancy (HDP) and cardiometabolic and kidney diseases are rising in low- and middle-income countries (LMICs). While HDP are risk factors for cardiometabolic and kidney diseases, cost-effective, ...
Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration

Nguyen, Phong D; Gooijers, Iris; Campostrini, Giulia; Verkerk, Arie O; Honkoop, Hessel; Bouwman, Mara; de Bakker, Dennis E M; Koopmans, Tim; Vink, Aryan; Lamers, Gerda E M; Shakked, Avraham; Mars, Jonas; Mulder, Aat A; Chocron, Sonja; Bartscherer, Kerstin; Tzahor, Eldad; Mummery, Christine L; de Boer, Teun P; Bellin, Milena; Bakkers, Jeroen (American Association for the Advancement of Science, 2023-05-19)

Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes. Although the steps leading up to the proliferation of surviving cardiomyocytes have been extensively studied, little is known about the ...
Optimising urinary catecholamine metabolite diagnostics for neuroblastoma

SIOPEN Catecholamine Working Group (Wiley-Liss Inc., 2023-06)

INTRODUCTION: The analysis of urinary catecholamine metabolites is a cornerstone of neuroblastoma diagnostics. Currently, there is no consensus regarding the sampling method, and variable combinations of catecholamine ...
Exploring the Modulatory Effect of High-Fat Nutrition on Lipopolysaccharide-Induced Acute Lung Injury in Vagotomized Rats and the Role of the Vagus Nerve

Seesing, Maarten F J; Janssen, Henricus J B; Geraedts, Tessa C M; Weijs, Teus J; van Ark, Ingrid; Leusink-Muis, Thea; Folkerts, Gert; Garssen, Johan; Ruurda, Jelle P; Nieuwenhuijzen, Grard A P; van Hillegersberg, Richard; Luyer, Misha D P (Multidisciplinary Digital Publishing Institute (MDPI), 2023-05-16)

During esophagectomy, the vagus nerve is transected, which may add to the development of postoperative complications. The vagus nerve has been shown to attenuate inflammation and can be activated by a high-fat nutrition ...
Radiological and long-term clinical response to elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis with advanced lung disease

Aalbers, Bente L.; Mohamed Hoesein, Firdaus A.A.; Hofland, Regina W.; Bronsveld, Inez; Kruijswijk, Marian A.; Schotman, Suzan; Slingerland, Corlien W.; Panhuis, Hannah; van der Ent, C. Kors; Heijerman, Harry G.M. (John Wiley & Sons Inc., 2023-08)

Introduction: A triple combination of CFTR modulators ELE/TEZ/IVA (elexacaftor/tezacaftor/ivacaftor, Trikafta™) has been evaluated in clinical trials for people with cystic fibrosis (pwCF) and was approved to the European ...
WEE1 inhibitor adavosertib in combination with carboplatin in advanced TP53 mutated ovarian cancer: A biomarker-enriched phase II study

Embaby, Alaa; Kutzera, Joachim; Geenen, Jill J; Pluim, Dick; Hofland, Ingrid; Sanders, Joyce; Lopez-Yurda, Marta; Beijnen, Jos H; Huitema, Alwin D R; Witteveen, Petronella O; Steeghs, Neeltje; van Haaften, Gijs; van Vugt, Marcel A T M; de Ridder, Jeroen; Opdam, Frans L (Academic Press Inc., 2023-07)

OBJECTIVE: In the first part of this phase II study (NCT01164995), the combination of carboplatin and adavosertib (AZD1775) was shown to be safe and effective in patients with TP53 mutated platinum-resistant ovarian cancer ...

Now showing items 9861-9880 of 40729