Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

Now showing items 9701-9720 of 40729

Mesenchymal stem/stromal cells-derived extracellular vesicles as a potentially more beneficial therapeutic strategy than MSC-based treatment in a mild metabolic osteoarthritis model

Warmink, Kelly; Rios, Jaqueline L.; Varderidou-Minasian, Suzy; Torres-Torrillas, Marta; van Valkengoed, Devin R.; Versteeg, Sabine; Eijkelkamp, Niels; Weinans, Harrie; Korthagen, Nicoline M.; Lorenowicz, Magdalena J. (BioMed Central, 2023-12)

Background: Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) hold promise as a disease modifying treatment in osteoarthritis (OA). Obesity, and its associated inflammation, contribute ...
Microbubble-Assisted Ultrasound for Drug Delivery to the Retina in an Ex Vivo Eye Model

Rousou, Charis; van Kronenburg, Nicky; Sonnen, Andreas F P; van Dijk, Marijke; Moonen, Chrit; Storm, Gert; Mastrobattista, Enrico; Deckers, Roel (Multidisciplinary Digital Publishing Institute, 2023-04-11)

Drug delivery to the retina is one of the major challenges in ophthalmology due to the biological barriers that protect it from harmful substances in the body. Despite the advancement in ocular therapeutics, there are many ...
Ultrasound and Microbubbles Mediated Bleomycin Delivery in Feline Oral Squamous Cell Carcinoma-An In Vivo Veterinary Study

de Maar, Josanne S; Zandvliet, Maurice M J M; Veraa, Stefanie; Tobón Restrepo, Mauricio; Moonen, Chrit T W; Deckers, Roel (Multidisciplinary Digital Publishing Institute, 2023-04-06)

To investigate the feasibility and tolerability of ultrasound and microbubbles (USMB)-enhanced chemotherapy delivery for head and neck cancer, we performed a veterinary trial in feline companion animals with oral squamous ...
Associations between N-Acetylaspartate and white matter integrity in individuals with schizophrenia and unaffected relatives

Roberts, Dominic; Rösler, Lara; Wijnen, Jannie P.; Thakkar, Katharine N. (Elsevier Ireland Ltd, 2023-04)

Compromised white matter has been reported in schizophrenia; however, few studies have investigated neurochemical abnormalities underlying microstructural differences. N-acetylaspartate (NAA) is used to synthesize myelin ...
Primary tumor resection or systemic treatment as palliative treatment for patients with isolated synchronous colorectal cancer peritoneal metastases in a nationwide cohort study

Rijken, Anouk; van de Vlasakker, Vincent C J; Simkens, Geert A; Rovers, Koen P; van Erning, Felice N; Koopman, Miriam; Verhoef, Cornelis; de Wilt, Johannes H W; de Hingh, Ignace H J T (Springer Netherlands, 2023-08)

Limited data are available to guide the decision-making process for clinicians and their patients regarding palliative treatment options for patients with isolated synchronous colorectal cancer peritoneal metastases (CRC-PM). ...
Physical and mental health of breast cancer patients and survivors before and during successive SARS-CoV-2-infection waves

Bargon, Claudia A.; Mink van der Molen, Dieuwke R.; Batenburg, Marilot C.T.; van Stam, Lilianne E.; van Dam, Iris E.; Baas, Inge O.; Veenendaal, Liesbeth M.; Maarse, Wiesje; Sier, Maartje; Schoenmaeckers, Ernst J.P.; Burgmans, Josephina P.J.; Bijlsma, Rhodé M.; van der Leij, Femke; Doeksen, Annemiek; Young-Afat, Danny A.; Verkooijen, Helena M. (Springer Netherlands, 2023-08)

Purpose: During the first SARS-CoV-2-infection wave, a deterioration in emotional well-being and increased need for mental health care were observed among patients treated or being treated for breast cancer. In this follow-up ...
Learning from long-term adolescent and young adult (AYA) cancer survivors regarding their age-specific care needs to improve current AYA care programs

Janssen, Silvie H.M.; Vlooswijk, Carla; Manten-Horst, Eveliene; Sleeman, Sophia H.E.; Bijlsma, Rhodé M.; Kaal, Suzanne E.J.; Kerst, Jan Martijn; Tromp, Jacqueline M.; Bos, Monique E.M.M.; van der Hulle, Tom; Lalisang, Roy I.; Nuver, Janine; Kouwenhoven, Mathilde C.M.; van der Graaf, Winette T.A.; Husson, Olga (John Wiley & Sons Inc., 2023-06)

Background: Despite growing (inter)national awareness and appreciation, age-specific care is still not always self-evident and accepted as standard of care for adolescent and young adult (AYA) cancer patients. It is unknown ...
Een vrouw met kanker en een opvallende venetekening

Franken, Mira D.; Röckmann-Helmbach, Heike; Bijlsma, Rhodé M. (Bohn Stafleu van Loghum, 2023-04-19)

A 71-year-old female was treated with carboplatin and paclitaxel for an endometrial carcinosarcoma. The patient demonstrated an unusual type 1 allergic reaction on carboplatin, which started with an erythematous urticarial ...
Lutetium-177-PSMA bij gemetastaseerd prostaatcarcinoom

van Golen, Larissa W.; Vogel, Wouter; Lam, Marnix G.E.H. (Bohn Stafleu van Loghum, 2023-03-16)

Lutetium-177 coupled with a ligand for Prostate Specific Membrane Antigen ([177Lu]Lu-PSMA) is a new treatment in The Netherlands. Patients with metastasized castration resistant prostate carcinoma and progressive disease ...
Radiofrequency localization of nonpalpable breast cancer in a multicentre prospective cohort study: feasibility, clinical acceptability, and safety

Christenhusz, Anke; den Dekker, Bianca M; van Dalen, Thijs; Jongen, Lisa; van der Schaaf, Margreet C; Alic, Lejla; Ten Haken, Bennie; Pijnappel, Ruud M; Dassen, Anneriet E (Springer New York, 2023-08)

PURPOSE: In breast conserving surgery, accurate lesion localization is essential for obtaining adequate surgical margins. Preoperative wire localization (WL) and radioactive seed localization (RSL) are widely accepted ...
International Interobserver Variability of Breast Density Assessment

Portnow, Leah H; Choridah, Lina; Kardinah, Kardinah; Handarini, Triwulan; Pijnappel, Ruud; Bluekens, Adriana M J; Duijm, Lucien E M; Schoub, Peter K; Smilg, Pamela S; Malek, Liat; Leung, Jessica W T; Raza, Sughra (Elsevier, 2023-07)

Purpose: The aim of this study was to determine variability in visually assessed mammographic breast density categorization among radiologists practicing in Indonesia, the Netherlands, South Africa, and the United States. ...
The dilemma of recalling well-circumscribed masses in a screening population: A narrative literature review and exploration of Dutch screening practice

Geertse, Tanya D.; van der Waal, Daniëlle; Vreuls, Willem; Tetteroo, Eric; Duijm, Lucien E.M.; Pijnappel, Ruud M.; Broeders, Mireille J.M. (Churchill Livingstone, 2023-06)

Background: In Dutch breast cancer screening, solitary, new or growing well-circumscribed masses should be recalled for further assessment. This results in cancers detected but also in false positive recalls, especially ...
Deep learning for automated contouring of neurovascular structures on magnetic resonance imaging for prostate cancer patients

van den Berg, Ingeborg; Savenije, Mark H F; Teunissen, Frederik R; van de Pol, Sandrine M G; Rasing, Marnix J A; van Melick, Harm H E; Brink, Wyger M; de Boer, Johannes C J; van den Berg, Cornelis A T; van der Voort van Zyp, Jochem R N (Elsevier, 2023-04)

Background and purpose: Manual contouring of neurovascular structures on prostate magnetic resonance imaging (MRI) is labor-intensive and prone to considerable interrater disagreement. Our aim is to contour neurovascular ...
Plasma Level of Pyrophosphate Is Low in Pseudoxanthoma Elasticum Owing to Mutations in the ABCC6 Gene, but It Does Not Correlate with ABCC6 Genotype

Kozák, Eszter; Bartstra, Jonas W.; de Jong, Pim A.; Mali, Willem P.T.M.; Fülöp, Krisztina; Tőkési, Natália; Pomozi, Viola; Risseeuw, Sara; Norel, Jeannette Ossewaarde van; van Leeuwen, Redmer; Váradi, András; Spiering, Wilko (Multidisciplinary Digital Publishing Institute (MDPI), 2023-02)

BACKGROUND: Pseudoxanthoma elasticum (PXE), a monogenic disorder resulting in calcification affecting the skin, eyes and peripheral arteries, is caused by mutations in the ABCC6 gene, and is associated with low plasma ...
Multi-source data approach for personalized outcome prediction in lung cancer screening: update from the NELSON trial

Sidorenkov, Grigory; Stadhouders, Ralph; Jacobs, Colin; Mohamed Hoesein, Firdaus A.A.; Gietema, Hester A.; Nackaerts, Kristiaan; Saghir, Zaigham; Heuvelmans, Marjolein A.; Donker, Hylke C.; Aerts, Joachim G.; Vermeulen, Roel; Uitterlinden, Andre; Lenters, Virissa; van Rooij, Jeroen; Schaefer-Prokop, Cornelia; Groen, Harry J.M.; de Jong, Pim A.; Cornelissen, Robin; Prokop, Mathias; de Bock, Geertruida H.; Vliegenthart, Rozemarijn (Springer Netherlands, 2023-04)

Trials show that low-dose computed tomography (CT) lung cancer screening in long-term (ex-)smokers reduces lung cancer mortality. However, many individuals were exposed to unnecessary diagnostic procedures. This project ...
Robustness of pulmonary nodule radiomic features on computed tomography as a function of varying radiation dose levels—a multi-dose in vivo patient study

Bartholomeus, Gijs A.; van Amsterdam, Wouter A.C.; Harder, Annemarie M.den; Willemink, Martin J.; van Hamersvelt, Robbert W.; de Jong, Pim A.; Leiner, Tim (Springer-Verlag, 2023-10)

Objective: Analysis of textural features of pulmonary nodules in chest CT, also known as radiomics, has several potential clinical applications, such as diagnosis, prognostication, and treatment response monitoring. For ...
SynthRAD2023 Grand Challenge dataset: Generating synthetic CT for radiotherapy

Thummerer, Adrian; van der Bijl, Erik; Galapon, Arthur; Verhoeff, Joost J.C.; Langendijk, Johannes A.; Both, Stefan; van den Berg, Cornelis A.T.; Maspero, Matteo (John Wiley & Sons Inc., 2023-07)

Purpose: Medical imaging has become increasingly important in diagnosing and treating oncological patients, particularly in radiotherapy. Recent advances in synthetic computed tomography (sCT) generation have increased ...
Gaussian Processes for real-time 3D motion and uncertainty estimation during MR-guided radiotherapy

Huttinga, Niek R.F.; Bruijnen, Tom; van den Berg, Cornelis A.T.; Sbrizzi, Alessandro (Elsevier, 2023-08)

Respiratory motion during radiotherapy causes uncertainty in the tumor's location, which is typically addressed by an increased radiation area and a decreased dose. As a result, the treatments’ efficacy is reduced. The ...
Patient Preparation with Esomeprazole Is Comparable to Ranitidine in Meckel Diverticulum Scintigraphy

Ververs, Tessa F; Lobbezoo, Anne-Fleur H; Hobbelink, Monique G; Braat, Arthur J (Society of Nuclear Medicine Inc., 2023-09-01)

To localize ectopic gastric mucosa in patients with unexplained gastrointestinal bleeding and diagnose a Meckel diverticulum, 99mTc-pertechnetate imaging is the standard procedure. H2 inhibitor pretreatment enhances the ...
Retrospective batch analysis to evaluate the diagnostic accuracy of a clinically deployed AI algorithm for the detection of acute pulmonary embolism on CTPA

Langius-Wiffen, Eline; de Jong, Pim A.; Hoesein, Firdaus A.Mohamed; Dekker, Lisette; van den Hoven, Andor F.; Nijholt, Ingrid M.; Boomsma, Martijn F.; Veldhuis, Wouter B. (Springer Science and Business Media Deutschland GmbH, 2023-06-06)

PURPOSE: To generate and extend the evidence on the clinical validity of an artificial intelligence (AI) algorithm to detect acute pulmonary embolism (PE) on CT pulmonary angiography (CTPA) of patients suspected of PE and ...

Now showing items 9701-9720 of 40729