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UMC Repository: Recent submissions

  • Bone Regeneration in A Large Animal Model Featuring A Modular Off-The-Shelf Soft Callus Mimetic 
    de Silva, Leanne; Longoni, Alessia; Staubli, Flurina; Nurmohamed, Silke; Duits, Anneli; Rosenberg, Antoine Jwp; Gawlitta, Debby (John Wiley & Sons Inc., 2023-11-22)
    Implantation of engineered cartilage with soft callus features triggers remodeling to bone tissue via endochondral bone regeneration (EBR). Thus far, EBR has not progressed to the level of large animals on the axis of ...
  • Enhanced low-threshold motor unit capacity during endurance tasks in patients with spinal muscular atrophy using pyridostigmine 
    Habets, Laura E; Bartels, Bart; Jeneson, Jeroen A L; Asselman, Fay-Lynn; Stam, Marloes; Wijngaarde, Camiel A; Wadman, Renske I; van Eijk, Ruben P A; Stegeman, Dick F; Ludo van der Pol, W (Elsevier Ireland Ltd, 2023-10)
    Objective: To investigate the electrophysiological basis of pyridostigmine enhancement of endurance performance documented earlier in patients with spinal muscular atrophy (SMA). Methods: We recorded surface electromyography ...
  • Safety of BCG vaccination and revaccination in healthcare workers 
    Villanueva, Paola; Crawford, Nigel W; Garcia Croda, Mariana; Collopy, Simone; Araújo Jardim, Bruno; de Almeida Pinto Jardim, Tyane; Marshall, Helen; Prat-Aymerich, Cristina; Sawka, Alice; Sharma, Ketaki; Troeman, Darren; Wadia, Ushma; Warris, Adilia; Wood, Nicholas; Messina, Nicole L; Curtis, Nigel; Pittet, Laure F (Landes Bioscience, 2023-08-01)
    BCG vaccination and revaccination are increasingly being considered for the protection of adolescents and adults against tuberculosis and, more broadly, for the off-target protective immunological effects against other ...
  • Vascular Access Challenges in Thoracic Endovascular Aortic Repair: A Literature Review 
    Mandigers, Tim J; Lomazzi, Chiara; Domanin, Maurizio; Pirrelli, Stefano; Piffaretti, Gabriele; van Herwaarden, Joost A; Trimarchi, Santi (Elsevier, 2023-08)
    BACKGROUND: This review aims to comprehensively summarize access challenges in thoracic endovascular aortic repair (TEVAR) by describing vascular access routes, associated risks, outcomes, and complications. METHODS: A ...
  • Safety and pharmacodynamic efficacy of eculizumab in aneurysmal subarachnoid hemorrhage (CLASH): A phase 2a randomized clinical trial 
    Koopman, Inez; Tack, Reinier Wp; Wunderink, Herman F; Bruns, Anke Hw; van der Schaaf, Irene C; Cianci, Daniela; Gelderman, Kyra A; van de Ridder, Inge M; Hol, Elly M; Rinkel, Gabriel Je; Vergouwen, Mervyn DI (SAGE Publications Inc., 2023-12)
    Introduction: Complement C5 antibodies reduce brain injury after experimental subarachnoid hemorrhage. Patients and methods: In this randomized, controlled, open-label, phase 2a clinical trial with blinded-outcome assessment, ...
  • Genetic inhibition of CARD9 accelerates the development of atherosclerosis in mice through CD36 dependent-defective autophagy 
    Zhang, Yujiao; Vandestienne, Marie; Lavillegrand, Jean Rémi; Joffre, Jeremie; Santos-Zas, Icia; Lavelle, Aonghus; Zhong, Xiaodan; Le Goff, Wilfried; Guérin, Maryse; Al-Rifai, Rida; Laurans, Ludivine; Bruneval, Patrick; Guérin, Coralie; Diedisheim, Marc; Migaud, Melanie; Puel, Anne; Lanternier, Fanny; Casanova, Jean Laurent; Cochain, Clément; Zernecke, Alma; Saliba, Antoine Emmanuel; Mokry, Michal; Silvestre, Jean Sebastien; Tedgui, Alain; Mallat, Ziad; Taleb, Soraya; Lenoir, Olivia; Vindis, Cécile; Camus, Stéphane M.; Sokol, Harry; Ait-Oufella, Hafid (Nature Publishing Group, 2023-08)
    Caspase recruitment-domain containing protein 9 (CARD9) is a key signaling pathway in macrophages but its role in atherosclerosis is still poorly understood. Global deletion of Card9 in Apoe -/- mice as well as hematopoietic ...
  • N6-Methyladenosine Directly Regulates CD40L Expression in CD4+ T Lymphocytes 
    van Vroonhoven, Ellen C.N.; Picavet, Lucas W.; Scholman, Rianne C.; van den Dungen, Noortje A.M.; Mokry, Michal; Evers, Anouk; Lebbink, Robert J.; Calis, Jorg J.A.; Vastert, Sebastiaan J.; van Loosdregt, Jorg (MDPI Multidisciplinary Digital Publishing Institute, 2023-07)
    T cell activation is a highly regulated process, modulated via the expression of various immune regulatory proteins including cytokines, surface receptors and co-stimulatory proteins. N6-methyladenosine (m6A) is an RNA ...
  • Locational memory of macrovessel vascular cells is transcriptionally imprinted 
    Spanjersberg, Talitha C F; Oosterhoff, Loes A; Kruitwagen, Hedwig S; van den Dungen, Noortje A M; Vernooij, Johannes C M; Asselbergs, Folkert W; Mokry, Michal; Spee, Bart; Harakalova, Magdalena; van Steenbeek, Frank G (Nature Publishing Group, 2023-08-10)
    Vascular pathologies show locational predisposition throughout the body; further insights into the transcriptomics basis of this vascular heterogeneity are needed. We analyzed transcriptomes from cultured endothelial cells ...
  • Transcriptome analysis reveals tumor microenvironment changes in glioblastoma 
    Hoogstrate, Youri; Draaisma, Kaspar; Ghisai, Santoesha A.; van Hijfte, Levi; Barin, Nastaran; de Heer, Iris; Coppieters, Wouter; van den Bosch, Thierry P.P.; Bolleboom, Anne; Gao, Zhenyu; Vincent, Arnaud J.P.E.; Karim, Latifa; Deckers, Manon; Taphoorn, Martin J.B.; Kerkhof, Melissa; Weyerbrock, Astrid; Sanson, Marc; Hoeben, Ann; Lukacova, Slávka; Lombardi, Giuseppe; Leenstra, Sieger; Hanse, Monique; Fleischeuer, Ruth E.M.; Watts, Colin; Angelopoulos, Nicos; Gorlia, Thierry; Golfinopoulos, Vassilis; Bours, Vincent; van den Bent, Martin J.; Robe, Pierre A.; French, Pim J. (Cell Press, 2023-04-10)
    A better understanding of transcriptional evolution of IDH-wild-type glioblastoma may be crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq) (n = 322 test, n = 245 validation) on paired primary-recurrent ...
  • Between-hospital variation in time to glioblastoma surgery: a report from the Quality Registry Neuro Surgery in the Netherlands 
    De Swart, Merijn E.; Müller, Domenique M.J.; Ardon, Hilko; Balvers, Rutger K.; Bosscher, Lisette; Bouwknegt, Wim; van den Brink, Wimar A.; Hovinga, Koos; Kloet, Alfred; Koopmans, Jan; Ter Laan, Mark; Nabuurs, Rob; Tewarie, Rishi Nandoe; Robe, Pierre A.; van der Veer, Olivier; Viozzi, Ilaria; Wagemakers, Michiel; Zwinderman, Aeilko H.; De Witt Hamer, Philip C. (American Association of Neurological Surgeons, 2022-11)
    OBJECTIVE Patients with glioblastoma are often scheduled for urgent elective surgery. Currently, the impact of the waiting period until glioblastoma surgery is undetermined. In this national quality registry study, the ...
  • TRIB1 confers therapeutic resistance in GBM cells by activating the ERK and Akt pathways 
    Singh, Karnika; Han, Chunhua; Fleming, Jessica L; Becker, Aline P; McElroy, Joseph; Cui, Tiantian; Johnson, Benjamin; Kumar, Ashok; Sebastian, Ebin; Showalter, Christian A; Schrock, Morgan S; Summers, Matthew K; Becker, Valesio; Tong, Zhen-Yue; Meng, Xiaomei; Manring, Heather R; Venere, Monica; Bell, Erica H; Robe, Pierre A; Grosu, A L; Haque, S Jaharul; Chakravarti, Arnab (Nature Publishing Group, 2023-08-01)
    GBM (Glioblastoma) is the most lethal CNS (Central nervous system) tumor in adults, which inevitably develops resistance to standard treatments leading to recurrence and mortality. TRIB1 is a serine/threonine pseudokinase ...
  • Cosmetic satisfaction and patient-reported outcome measures following cranioplasty after craniectomy - A prospective cohort study 
    Klieverik, Vita M; Robe, Pierre A; Muradin, Marvick S M; Woerdeman, Peter A (Elsevier, 2023-01)
    INTRODUCTION: Evaluating patient-reported outcomes (PROMs) helps optimize preoperative counseling and psychosocial care for patients who underwent cranioplasty. RESEARCH QUESTION: This study aimed to evaluate cosmetic ...
  • A timeline of cognitive functioning in glioma patients who undergo awake brain tumor surgery: a response to Mahajan et al. and their letter to the editor 
    de Sain, A M; van Zandvoort, M J E; Mantione, M H M; Huenges Wajer, I M C; Willems, P W A; Robe, P A; Ruis, C (Springer, 2023-09)
  • Awake craniotomy does not lead to increased psychological complaints 
    Wajer, I M C Huenges; Kal, J; Robe, P A; van Zandvoort, M J E; Ruis, C (Springer, 2023-09)
    BACKGROUND: Patients with brain tumours are increasingly treated by using the awake craniotomy technique. Some patients may experience anxiety when subjected to brain surgery while being fully conscious. However, there has ...
  • A timeline of cognitive functioning in glioma patients who undergo awake brain tumor surgery 
    de Sain, A M; Mantione, M H M; Wajer, I M C Huenges; van Zandvoort, M J E; Willems, P W A; Robe, P A; Ruis, C (Springer, 2023-06)
    BACKGROUND: The purpose of awake brain tumor surgery is to maximize the resection of the tumor and to minimize the risk of neurological and cognitive impairments. The aim of this study is to gain understanding of the ...
  • Development of a Prediction Model for Cranioplasty Implant Survival Following Craniectomy 
    Klieverik, Vita M; Robe, Pierre A; Muradin, Marvick S M; Woerdeman, Peter A (Elsevier, 2023-07)
    BACKGROUND: Cranioplasty after craniectomy can result in high rates of postoperative complications. Although determinants of postoperative outcomes have been identified, a prediction model for predicting cranioplasty implant ...
  • A global survey of health care workers' awareness of non-alcoholic fatty liver disease: The AwareNASH survey 
    Driessen, Stan; de Jong, Vivian D; van Son, Koen C; Klompenhouwer, Tatiana; Colardelle, Yann; Alings, Marco; Moreno, Cristophe; Anker, Stefan D; Castro Cabezas, Manuel; Holleboom, Adriaan G; Grobbee, Diederick E; Tushuizen, Maarten E (John Wiley & Sons Inc., 2023-09)
    BACKGROUND: The estimated global prevalence and burden of non-alcoholic fatty liver disease (NAFLD) and its advanced stage, non-alcoholic steatohepatitis (NASH), is increasing. Yet, NAFLD remains largely underdiagnosed. ...
  • Limited wedge resection for T1 colon cancer (LIMERIC-II trial) - rationale and study protocol of a prospective multicenter clinical trial 
    Hanevelt, Julia; Huisman, Jelle F; Leicher, Laura W; Lacle, Miangela M; Richir, Milan C; Didden, Paul; Geesing, Joost M J; Smakman, Niels; Droste, Jochim S Terhaar Sive; Ter Borg, Frank; Talsma, A Koen; Schrauwen, Ruud W M; van Wely, Bob J; Schot, Ingrid; Vermaas, Maarten; Bos, Philip; Sietses, Colin; Hazen, Wouter L; Wasowicz, Dareczka K; Ploeg, David E; Ramsoekh, Dewkoemar; Tuynman, Jurriaan B; Alderlieste, Yasser A; Renger, Rutger-Jan; Schreuder, Ramon-Michel; Bloemen, Johanne G; van Lijnschoten, Ineke; Consten, Esther C J; Sikkenk, Daan J; Schwartz, Matthijs P; Vos, Annelotte; Burger, Jordy P W; Spanier, Bernhard W M; Knijn, Nikki; de Vos Tot Nederveen Cappel, Wouter H; Moons, Leon M G; van Westreenen, Henderik L (BioMed Central, 2023-06-19)
    BACKGROUND: The sole presence of deep submucosal invasion is shown to be associated with a limited risk of lymph node metastasis. This justifies a local excision of suspected deep submucosal invasive colon carcinomas (T1 ...
  • Perioperative or adjuvant mFOLFIRINOX for resectable pancreatic cancer (PREOPANC-3): study protocol for a multicenter randomized controlled trial 
    Dutch Pancreatic Cancer Group (BioMed Central, 2023-12)
    BACKGROUND: Surgical resection followed by adjuvant mFOLFIRINOX (5-fluorouracil with leucovorin, irinotecan, and oxaliplatin) is currently the standard of care for patients with resectable pancreatic cancer. The main concern ...
  • Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms 
    Wood, Laura D; Adsay, N Volkan; Basturk, Olca; Brosens, Lodewijk A A; Fukushima, Noriyoshi; Hong, Seung-Mo; Kim, Sung-Joo; Lee, Jae W; Luchini, Claudio; Noë, Michaël; Pitman, Martha B; Scarpa, Aldo; Singhi, Aatur D; Tanaka, Mariko; Furukawa, Toru (Elsevier, 2023-11)
    BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) are a cystic precursor to pancreatic cancer. IPMNs deemed clinically to be at high-risk for malignant progression are frequently treated with surgical resection, ...