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Dilemmas concerning heart procurement in controlled donation after circulatory death

Kaffka Genaamd Dengler, S E; Vervoorn, M T; Brouwer, M; de Jonge, Jeroen; van der Kaaij, N P (Frontiers Media S. A., 2023-07-31)

With an expanding population at risk for heart failure and the resulting increase in patients admitted to the waiting list for heart transplantation, the demand of viable organs exceeds the supply of suitable donor hearts. ...
Assessing the Well-Being at Work of Nurses and Doctors in Hospitals: Protocol for a Scoping Review of Monitoring Instruments

Boskma, Amber; van der Braak, Kim; Ansari, Neda; Hooft, Lotty; Wietasch, Götz; Franx, Arie; van der Laan, Maarten (JMIR Publications Inc., 2023-08-25)

Background: Well-being at work can be defined as “creating an environment to promote a state of contentment which allows an employee to flourish and achieve their full potential for the benefit of themselves and their ...
Combination therapy with crizotinib and vinblastine for relapsed or refractory pediatric ALK-positive anaplastic large cell lymphoma

Knörr, Fabian; Schellekens, Kim P.J.; Schoot, Reineke A.; Landman-Parker, Judith; Teltschik, Heiko Manuel; Förster, Jan; Riquelme, Amambay; Huitema, Alwin D.R.; van Eijkelenburg, Natasha K.A.; Beishuizen, Auke; Zwaan, C. Michel; Woessmann, Wilhelm; van der Lugt, Jasper (Ferrata Storti Foundation, 2023-05)
Development of a Therapeutic Drug Monitoring Strategy for the Optimization of Vincristine Treatment in Pediatric Oncology Populations in Africa

Van Der Heijden, Lisa T.; Nijstad, A. Laura; Uittenboogaard, Aniek; Beijnen, Jos H.; Dorlo, Thomas P.C.; Kaspers, Gertjan J.L.; Huitema, Alwin D.R. (Lippincott Williams & Wilkins, 2023-06-01)

Background:Recent studies have reported ethnic differences in vincristine exposure and outcomes such as toxicity. This resulted in the hypothesis of subtherapeutic dosing in African children. To optimize individual treatment, ...
Influence of germline variations in drug transporters ABCB1 and ABCG2 on intracerebral osimertinib efficacy in patients with non-small cell lung cancer

Veerman, G D Marijn; Boosman, Rene J; Jebbink, Merel; Oomen-de Hoop, Esther; van der Wekken, Anthonie J; Bahce, Idris; Hendriks, Lizza E L; Croes, Sander; Steendam, Christi M J; de Jonge, Evert; Koolen, Stijn L W; Steeghs, Neeltje; van Schaik, Ron H N; Smit, Egbert F; Dingemans, Anne-Marie C; Huitema, Alwin D R; Mathijssen, Ron H J (Elsevier, 2023-05)

BACKGROUND: Central nervous system (CNS) metastases are present in approximately 40% of patients with metastatic epidermal growth factor receptor-mutated ( EGFRm+) non-small cell lung cancer (NSCLC). The EGFR-tyrosine ...
Predicting Chemotherapy Distribution into Breast Milk for Breastfeeding Women Using a Population Pharmacokinetic Approach

Damoiseaux, David; Centanni, Daniel; Beijnen, Jos H; Amant, Frédéric; Huitema, Alwin D R; Dorlo, Thomas P C (Adis, 2023-07)

BACKGROUND AND OBJECTIVE: Information on the distribution of chemotherapeutic drugs to breast milk is scarce, and reports are limited to small sample sizes. Anecdotal pharmacokinetic data have typically been acquired from ...
Design and statistics of pharmacokinetic drug-drug, herb-drug, and food-drug interaction studies in oncology patients

Lanser, Daan A C; Van der Kleij, Maud B A; Veerman, G D Marijn; Steeghs, Neeltje; Huitema, Alwin D R; Mathijssen, Ron H J; Oomen-de Hoop, Esther (Elsevier Masson, 2023-07)

Polypharmacy is becoming increasingly prevalent in society. Patients with polypharmacy are at greater risk for drug-drug interactions, which can influence the efficacy of treatment. Especially, in oncology this is a concern ...
CYP3A4*22 Genotype-Guided Dosing of Kinase Inhibitors in Cancer Patients

Dutch Pharmacology Oncology Group (Adis, 2023-08)

INTRODUCTION: A genetic variant explaining a part of the exposure of many kinase inhibitors (KIs) is the single nucleotide polymorphism (SNP) CYP3A4*22, resulting in less CYP3A4 enzyme activity. The primary aim of this ...
Predicting the effect of different folate doses on [ 68Ga]Ga-PSMA-11 organ and tumor uptake using physiologically based pharmacokinetic modeling.

Siebinga, Hinke; Hendrikx, Jeroen J M A; Huitema, Alwin D R; de Wit-van der Veen, Berlinda J (Springer Berlin, 2023-06-15)

BACKGROUND: Folate intake might reduce [ 68Ga]Ga-PSMA-11 uptake in tissues due to a competitive binding to the PSMA receptor. For diagnostic imaging, this could impact decision making, while during radioligand therapy this ...
Gut Colonization by ESBL-Producing Escherichia coli in Dogs Is Associated with a Distinct Microbiome and Resistome Composition

Stege, Paul B.; Hordijk, Joost; Sandholt, Arnar K.S.; Zomer, Aldert L.; Viveen, Marco C.; Rogers, Malbert R.C.; Salomons, Moniek; Wagenaar, Jaap A.; Mughini-Gras, Lapo; Willems, Rob J.L.; Paganelli, Fernanda L. (American Society for Microbiology, 2023-08-17)

The gut microbiome of humans and animals acts as a reservoir of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC). Dogs are known for having a high prevalence of ESBL-EC in their gut microbiota, although ...
Feasibility and tolerability of multimodal peripheral electrophysiological techniques in a cohort of patients with spinal muscular atrophy

Ros, Leandra A.A.; Sleutjes, Boudewijn T.H.M.; Stikvoort García, Diederik J.L.; Goedee, H. Stephan; Asselman, Fay Lynn; van den Berg, Leonard H.; van der Pol, W. Ludo; Wadman, Renske I. (Elsevier, 2023-01)

Objective: Electrophysiological techniques are emerging as an aid in identifying prognostic or therapeutic biomarkers in patients with spinal muscular atrophy (SMA), but electrophysiological assessments may be burdensome ...
Deep learning based correction of RF field induced inhomogeneities for T2w prostate imaging at 7 T

Harrevelt, Seb D; Meliado, Ettore F M; van Lier, Astrid L H M W; Reesink, Daan; Meijer, Richard P; Pluim, Josien P W; Raaijmakers, Alexander J E (John Wiley & Sons Inc., 2023-12)

At ultrahigh field strengths images of the body are hampered by B 1 -field inhomogeneities. These present themselves as inhomogeneous signal intensity and contrast, which is regarded as a "bias field" to the ideal image. ...
Antibody deficiencies in children are associated with prematurity and a family history of infections

Koenen, Mischa H; van Montfrans, Joris M; Prevaes, Sabine M P J; van Engelen, Martine P; van der Vries, Erhard; Boes, Marianne; Sanders, Elisabeth A M; Bogaert, Debby; Verhagen, Lilly M (Lippincott Williams & Wilkins, 2023-12)

Background: Recurrent respiratory tract infections (rRTIs) frequently affect young children and are associated with antibody deficiencies. We investigated the prevalence of and epidemiological risk factors associated with ...
Nivolumab plus Brentuximab vedotin +/- bendamustine combination therapy: a safe and effective treatment in pediatric recurrent and refractory classical Hodgkin lymphoma

Greve, Patrick; Beishuizen, Auke; Hagleitner, Melanie; Loeffen, Jan; Veening, Margreet; Boes, Marianne; Peperzak, Victor; Diez, Claudius; Meyer-Wentrup, Friederike (Frontiers Media S. A., 2023)

INTRODUCTION: Classical Hodgkin lymphoma (cHL) is the most common pediatric lymphoma. Approximately 10% of patients develop refractory or recurrent disease. These patients are treated with intensive chemotherapy followed ...
Managing juvenile idiopathic arthritis within the context of their life: What we learnt from children and youth living with juvenile idiopathic arthritis and their parents

Currie, G. R.; Kennedy, B. L.; Benseler, S. M.; R. S. M., Yeung; Swart, J. F.; Vastert, S. J.; Wulffraat, N. M.; M. M. A., Kip; MacKean, Gail; Marshall, D. A. (Whurr Publishers Ltd., 2023-12)

Introduction: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children and causes short- and long-term disability. Optimal management requires pharmacologic and non-pharmacologic interventions. ...
Can motor proficiency testing predict sports injuries and sports-induced bleeds in people with haemophilia?

Versloot, Olav; Blokzijl, Johan; Timmer, Merel; Schuuring, Marleen; van Galen, Karin; Kremer Hovinga, Idske; van der Valk, Paul; van Vulpen, Lize; Schutgens, Roger; van Koppenhagen, Casper; van der Net, Janjaap; Fischer, Kathelijn (Wiley-Blackwell, 2023-05)

Introduction: Predicting the risk of sports injuries and sports-induced bleeds (SIBs) in people with haemophilia (PWH) may support clinical counselling. Aim: To assess the association between motor proficiency testing and ...
Clotting factor activity levels and bleeding risk in people with haemophilia playing sports

Versloot, Olav; Kemler, Ellen; Blokzijl, Johan; Timmer, Merel; Schuuring, Marleen; van Galen, Karin P.M.; Kremer Hovinga, Idske Cornelia L.; van der Valk, Paul R.; van Vulpen, Lize F.D.; Schutgens, Roger E.G.; van Koppenhagen, Casper F.; van der Net, Janjaap; Fischer, Kathelijn (Wiley-Blackwell, 2023-07)

Background: Improved treatment options for people with haemophilia (PWH) have increased the possibilities for sports participation, but the risk of sports-induced bleeding (SIB) is still considered considerable by many. ...
Macrovascular and renal microvascular complications in West Africans with intermediate hyperglycemia living in West Africa and Europe: The RODAM study

Bannerman-Williams, Emmanuel; Hayfron-Benjamin, Charles F.; Atiase, Yacoba; Bahendeka, Silver; Meeks, Karlijn; Klipstein-Grobusch, Kerstin; Addo, Juliet; Mockenhaupt, Frank; Schulze, Matthias B.; Beune, Erik; van den Born, Bert-Jan; Agyemang, Charles (Elsevier, 2023-08)

Background: Metabolic conditions, including intermediate hyperglycemia (IH), affect migrants to a greater extent than the populations of origin. Evidence suggests that IH increases the risk of vascular complications, but ...
Screening for intracranial aneurysms in persons ⩾35 years with hypertension and atherosclerotic disease who smoke(d)

Mensing, Liselore A.; van Tuijl, Rick J.; de Kort, Gerard A.; van der Schaaf, Irene C.; Visseren, Frank L.; Rinkel, Gabriel J.E.; Velthuis, Birgitta K.; Ruigrok, Ynte M. (SAGE Publications Inc., 2023-12)

Introduction: Lifetime risk of aneurysmal subarachnoid haemorrhage (aSAH) is high (7%) in persons ⩾35 years with hypertension who smoke(d). Whether screening for intracranial aneurysms (IAs) to prevent aSAH is effective ...
Nationwide treatment and outcomes of intrahepatic cholangiocarcinoma

Dutch Hepatocellular & Cholangiocarcinoma Group (DHCG) (John Wiley & Sons Inc., 2023-11)

Background: Most data on the treatment and outcomes of intrahepatic cholangiocarcinoma (iCCA) derives from expert centers. This study aimed to investigate the treatment and outcomes of all patients diagnosed with iCCA in ...

Now showing items 9321-9340 of 40729