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No effect of danazol treatment in patients with advanced idiopathic pulmonary fibrosis

Hoffman, Thijs W; van Moorsel, Coline H M; van der Vis, Joanne J; Biesma, Douwe H; Grutters, Jan C (European Respiratory Society, 2023-09)

BACKGROUND: Telomere dysfunction can underly the development of idiopathic pulmonary fibrosis (IPF), and recent work suggests that patients with telomere syndromes might benefit from treatment with androgens, such as ...
Simultaneous Assessment of mTORC1, JAK/STAT, and NLRP3 Inflammasome Activation Pathways in Patients with Sarcoidosis

Kraaijvanger, Raisa; Ambarus, Carmen A.; Damen, Jan; van der Vis, Joanne J.; Kazemier, Karin M.; Grutters, Jan C.; van Moorsel, Coline H.M.; Veltkamp, Marcel (Multidisciplinary Digital Publishing Institute (MDPI), 2023-08)

The unknown etiology of sarcoidosis, along with the variability in organ involvement and disease course, complicates the effective treatment of this disease. Based on recent studies, the cellular inflammatory pathways ...
Involvement of the systemic microcirculation in pediatric uveitis

Kouwenberg, Carlyn V.; Spierings, Julia; de Groot, Evianne L.; de Boer, Joke H.; Kalinina Ayuso, Viera (BioMed Central Ltd., 2023-10-02)

BACKGROUND: Pediatric uveitis is a severe inflammatory ocular condition that can lead to sight-threatening complications and can negatively impact quality of life. The retinal microcirculation is often affected in intermediate ...
Desmopressin to prevent and treat bleeding in pregnant women with an inherited bleeding disorder: A systematic literature review

SYMPHONY consortium (Wiley-Blackwell, 2024-01)

Background: Although desmopressin (DDAVP) is an accessible and inexpensive hemostatic drug, its use in pregnancy is still debated due to safety uncertainties. Objectives: We aimed to review the safety and effectiveness of ...
Associations between psychotropic drugs and rsEEG connectivity and network characteristics: a cross-sectional study in hospital-admitted psychiatric patients

Zandstra, Melissa G; Meijs, Hannah; Somers, Metten; Stam, Cornelis J; de Wilde, Bieke; van Hecke, Jan; Niemegeers, Peter; Luykx, Jurjen J; van Dellen, Edwin (Frontiers Media S. A., 2023-09-15)

INTRODUCTION: Resting-state EEG (rsEEG) characteristics, such as functional connectivity and network topology, are studied as potential biomarkers in psychiatric research. However, the presence of psychopharmacological ...
The performance of ChatGPT in generating answers to clinical questions in psychiatry: a two-layer assessment

Luykx, Jurjen J.; Gerritse, Frank; Habets, Philippe C.; Vinkers, Christiaan H. (Wiley-Blackwell, 2023-10)
GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors

VA Million Veteran Program (MVP) (American Psychiatric Association, 2023-10-01)

Objective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and crossvalidated genome-wide significant (GWS) loci for suicide ...
Research letter: Clonidine is associated with faster first resolution of incident ICU delirium than antipsychotics

Wu, Ting Ting; Steiger, Gillian; Smith, Louisa; Devlin, John W; Slooter, Arjen J C (Elsevier, 2024-02)
Toxicity-specific peripheral blood T and B cell dynamics in anti-PD-1 and combined immune checkpoint inhibition

UNICIT consortium (Springer Science and Business Media Deutschland GmbH, 2023-12)

Abstract: Immune checkpoint inhibitors (ICI) have revolutionized the treatment landscape of advanced malignancies, but come with a diverse spectrum of immune-related adverse events (irAEs). Mechanistic studies can aid the ...
Jaw Bone Invasion of Oral Squamous Cell Carcinoma Is Associated with Osteoclast Count and Expression of Its Regulating Proteins in Patients and Organoids

de Kort, Willem W B; Haakma, Wisse E; van Es, Robert J J; Gawlitta, Debby; Driehuis, Else; Gansevoort, Merel; Willems, Stefan M (Multidisciplinary Digital Publishing Institute (MDPI), 2023-09-18)

AIMS: Oral squamous cell carcinoma (OSCC) frequently invades the jaw. The exact mechanism of bone invasion remains unclear. This study investigates (premature) osteoclasts and the expression of its differentiation regulating ...
ESDE-MIE fellowship: a descriptive analysis of the first experiences

Talavera-Urquijo, Eider; Gantxegi, Amaia; Garbarino, Giovanni M.; Capovilla, Giovanni; Van Boxel, Gijs I.; Grimminger, Peter P.; Luyer, Misha D.; Markar, Sheraz R.; Svendsen, Lars B.; Van Hillegersberg, Richard (Wiley-Blackwell, 2023-08-01)

Esophageal resection is a high-risk and technically demanding procedure, with a long proficiency-gain curve. The European Society Diseases of the Esophagus (ESDE)-Minimally Invasive Esophagectomy (MIE) training program was ...
Water diffusion and T2 quantification in transient-state MRI: the effect of RF pulse sequence.

Fuderer, Miha; van der Heide, Oscar; Liu, Hongyan; van den Berg, Cornelis A T; Sbrizzi, Alessandro (John Wiley & Sons Inc., 2024-01)

In quantitative measurement of the (Formula presented.) value of tissues, the diffusion of water molecules has been recognized as a confounder. This is most notably so for transient-state quantitative mapping techniques, ...
Meningococcal carriage in children and young adults: a cross-sectional and longitudinal study, Iceland, 2019 to 2021

Kristinsdottir, Iris; Visser, Linda J; Miellet, Willem R; Mariman, Rob; Pluister, Gerlinde; Haraldsson, Gunnsteinn; Haraldsson, Asgeir; Trzciński, Krzysztof; Thors, Valtyr (Centre Europeen pour la Surveillance Epidemiologique du SIDA, 2023-09-28)

Background Neisseria meningitidis is a commensal bacterium which can cause invasive disease. Colonisation studies are important to guide vaccination strategies.AimThe study's aim was to determine the prevalence of meningococcal ...
Childhood infection burden, recent antibiotic exposure and vascular phenotypes in preschool children

Yu, Angela; Jansen, Maria A.C.; Dalmeijer, Geertje W.; Bruijning-Verhagen, Patricia; van der Ent, Cornelis K.; Grobbee, Diederick E.; Burgner, David P.; Uiterwaal, Cuno S.P.M. (Public Library of Science, 2023-09)

BACKGROUND: Severe childhood infection has a dose-dependent association with adult cardiovascular events and with adverse cardiometabolic phenotypes. The relationship between cardiovascular outcomes and less severe childhood ...
ASO Author Reflections: Clinical Outcome After Upfront Curative-Intent Local Treatment of Metastases in Patient with Deficient Mismatch Repair Versus Proficient Mismatch Repair Metastatic Colorectal Cancer

Zwart, Koen; Roodhart, Jeanine (Springer New York, 2023-10)
Consensus molecular subtype transition during progression of colorectal cancer

van de Weerd, Simone; Torang, Arezo; Zwager, Liselotte W.; Koelink, Pim J.; Koster, Jan; Bastiaansen, Barbara A.J.; Lammers, Veerle; Longobardi, Ciro; Roodhart, Jeanine M.L.; van Krieken, J. Han; Farina Sarasqueta, Arantza; Dekker, Evelien; Medema, Jan Paul (John Wiley & Sons Inc., 2023-11)

The consensus molecular subtype (CMS) classification divides colorectal cancer (CRC) into four distinct subtypes based on RNA expression profiles. The biological differences between CMSs are already present in CRC precursor ...
Therapeutic drug monitoring of methotrexate in patients with Crohn's disease

Dutch Initiative on Crohn and Colitis (ICC) (Wiley-Blackwell, 2023-12)

BACKGROUND: Therapeutic drug monitoring (TDM) has the potential to improve efficacy and diminish side effects. Measuring methotrexate-polyglutamate (MTX-PG) in erythrocytes might enable TDM for methotrexate in patients ...
Cord blood transplantation for AML: Comparable LFS in patients with de novo versus secondary AML in CR1, an ALWP/EBMT study

Baron, Frédéric; Nagler, Arnon; Galimard, Jacques-Emmanuel; Sanz, Jaime; Versluis, Jurjen; Forcade, Edouard; Chevallier, Patrice; Sirvent, Anne; Anthias, Chloe; Kuball, Jürgen; Furst, Sabine; Rambaldi, Alessandro; Sierra, Jorge; von dem Borne, Peter A; Gallego Hernanz, Maria Pilar; Cluzeau, Thomas; Robinson, Stephen; Raiola, Anna Maria; Labussière-Wallet, Hélène; Byrne, Jenny L; Malfuson, Jean-Valère; Ruggeri, Annalisa; Mohty, Mohamad; Ciceri, Fabio (Wiley-Blackwell, 2024-01)

We investigated whether secondary versus de novo acute myeloid leukaemia (AML) would be associated with poor outcomes in adult acute AML patients in first complete remission (CR1) receiving unrelated cord blood transplantation ...
Evolution of the MOMENTUM Study for Evidence-Based Implementation of MR-Guided Radiotherapy Using the 1.5 Tesla MR-Linac

Daamen, L A; Westerhoff, J M; Christodouleas, J P; Orrling, K; Eggert, D; Choudhury, A; Fuller, C D; van der Heide, U; Sahgal, A; Schultz, C J; Schytte, T; Tersteeg, JHA; Tree, A; Hall, W A; Verkooijen, H (Elsevier, 2023-10-01)

PURPOSE/OBJECTIVE(S): The international prospective 'Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac' (MOMENTUM) study (NCT04075305) was initiated in 2019 by seven hospitals and industry partner precision ...
MRI-based inter- and intrafraction motion analysis of the pancreatic tail and spleen as preparation for adaptive MRI-guided radiotherapy in neuroblastoma

Van Ommen, Fasco; le Quellenec, Gaelle A T; Willemsen-Bosman, Mirjam E; van Noesel, Max M; van den Heuvel-Eibrink, Marry M; Seravalli, Enrica; Kroon, Petra S; Janssens, Geert O (BioMed Central, 2023-10-02)

BACKGROUND: In pediatric radiotherapy treatment planning of abdominal tumors, dose constraints to the pancreatic tail/spleen are applied to reduce late toxicity. In this study, an analysis of inter- and intrafraction motion ...

Now showing items 9001-9020 of 40729