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How Smart are Smart Materials? A Conceptual and Ethical Analysis of Smart Lifelike Materials for the Design of Regenerative Valve Implants

de Kanter, Anne Floor J.; Jongsma, Karin R.; Bouten, Carlijn V.C.; Bredenoord, Annelien L. (Springer Netherlands, 2023-09-05)

It may soon become possible not just to replace, but to re-grow healthy tissues after injury or disease, because of innovations in the field of Regenerative Medicine. One particularly promising innovation is a regenerative ...
Opportunities and Challenges of Prognostic Models for Extremely Preterm Infants

de Boer, Angret; van Beek, Pauline E; Andriessen, Peter; Groenendaal, Floris; Hogeveen, Marije; Meijer, Julia S; Obermann-Borst, Sylvia A; Onland, Wes; Scheepers, Liesbeth H C J; Vermeulen, Marijn J; Verweij, E J T Joanne; De Proost, Lien; Geurtzen, Rosa (MDPI AG, 2023-10-21)

Predicting the short- and long-term outcomes of extremely preterm infants remains a challenge. Multivariable prognostic models might be valuable tools for clinicians, parents, and policymakers for providing accurate outcome ...
Authors' Reply to Juergen O Kirchner's Comment on "Incidence Rates of Autoimmune Diseases in European Healthcare Databases: A Contribution of the ADVANCE Project"

Willame, Corinne; Weibel, Daniel; Sturkenboom, Miriam C J M (Adis, 2023-08)
Stimulating solidarity to improve knowledge on medications used during pregnancy: A contribution from the ConcePTION project

Hollestelle, Marieke J; van der Graaf, Rieke; Sturkenboom, Miriam Cjm; van Delden, Johannes Jm (BioMed Central, 2023-06-27)

BACKGROUND: Pregnant people have been overlooked or excluded from clinical research, resulting in a lack of scientific knowledge on medication safety and efficacy during pregnancy. Thus far, both the opportunities to ...
Variations across Europe in hospitalization and management of pregnant women with SARS-CoV-2 during the initial phase of the pandemic: Multi-national population-based cohort study using the International Network of Obstetric Survey Systems (INOSS)

INOSS COVID-19 Working Group (Wiley-Blackwell, 2023-11)

INTRODUCTION: The majority of data on COVID-19 in pregnancy are not from sound population-based active surveillance systems. MATERIAL AND METHODS: We conducted a multi-national study of population-based national or regional ...
Exploring intrinsic variability between cultured nasal and bronchial epithelia in cystic fibrosis

Rodenburg, Lisa W; Metzemaekers, Mieke; van der Windt, Isabelle S; Smits, Shannon M A; den Hertog-Oosterhoff, Loes A; Kruisselbrink, Evelien; Brunsveld, Jesse E; Michel, Sabine; de Winter-de Groot, Karin M; van der Ent, Cornelis K; Stadhouders, Ralph; Beekman, Jeffrey M; Amatngalim, Gimano D (Nature Publishing Group, 2023-10-30)

The nasal and bronchial epithelium are unified parts of the respiratory tract that are affected in the monogenic disorder cystic fibrosis (CF). Recent studies have uncovered that nasal and bronchial tissues exhibit intrinsic ...
Organoid-guided synergistic treatment of minimal function CFTR mutations with CFTR modulators, roflumilast and simvastatin: a personalised approach

Spelier, Sacha; de Winter-de Groot, Karin; Keijzer-Nieuwenhuijze, Natascha; Liem, Yves; van der Ent, Kors; Beekman, Jeffrey; Kamphuis, Lieke S. (European Respiratory Society, 2024-01-01)
Beyond gene-disease validity: capturing structured data on inheritance, allelic requirement, disease-relevant variant classes, and disease mechanism for inherited cardiac conditions

Josephs, Katherine S; Roberts, Angharad M; Theotokis, Pantazis; Walsh, Roddy; Ostrowski, Philip J; Edwards, Matthew; Fleming, Andrew; Thaxton, Courtney; Roberts, Jason D; Care, Melanie; Zareba, Wojciech; Adler, Arnon; Sturm, Amy C; Tadros, Rafik; Novelli, Valeria; Owens, Emma; Bronicki, Lucas; Jarinova, Olga; Callewaert, Bert; Peters, Stacey; Lumbers, Tom; Jordan, Elizabeth; Asatryan, Babken; Krishnan, Neesha; Hershberger, Ray E; Chahal, C Anwar A; Landstrom, Andrew P; James, Cynthia; McNally, Elizabeth M; Judge, Daniel P; van Tintelen, Peter; Wilde, Arthur; Gollob, Michael; Ingles, Jodie; Ware, James S (BioMed Central, 2023-12)

BACKGROUND: As the availability of genomic testing grows, variant interpretation will increasingly be performed by genomic generalists, rather than domain-specific experts. Demand is rising for laboratories to accurately ...
2023 ESC Guidelines for the management of cardiomyopathies: Developed by the task force on the management of cardiomyopathies of the European Society of Cardiology (ESC)

ESC Scientific Document Group (Oxford University Press, 2023-10-01)
Generation and characterization of novel human induced pluripotent stem cell (iPSC) lines originating from five asymptomatic individuals carrying the PLN-R14del pathogenic variant and a non-carrier relative

Balducci, Valentina; Scardigli, Francesco; Harakalova, Magdalena; Peter. van Tintelen, J.; Doevendans, Pieter A.; Costa, Kevin D.; Turnbull, Irene C.; P. G. Sluijter, Joost; Stillitano, Francesca (Elsevier, 2023-10)

The rare genetic alteration PLN-c.(40_42delAGA), leading to the deletion of arginine 14 (p.R14del) in phospholamban, is associated with dilated and arrhythmogenic cardiomyopathies occurring in early-adulthood. However, ...
IKs Activator ML277 Mildly Affects Repolarization and Arrhythmic Outcome in the CAVB Dog Model.

van Bavel, Joanne J A; Beekman, Henriëtte D M; Smoczyńska, Agnieszka; van der Heyden, Marcel A G; Vos, Marc A (MDPI AG, 2023-04-11)

Long QT syndrome type 1 with affected IKs is associated with a high risk for developing Torsade de Pointes (TdP) arrhythmias and eventually sudden cardiac death. Therefore, it is of high interest to explore drugs that ...
Acceptance and Commitment Therapy and white matter plasticity in individuals with subclinical depression and psychotic experiences: A Randomised Controlled Trial

Michielse, Stijn; Bakker, Jindra; Lange, Iris; Batink, Tim; Goossens, Liesbet; Wichers, Marieke; Lieverse, Ritsaert; Myin-Germeys, Inez; Schruers, Koen; van Amelsvoort, Therese; Viechtbauer, Wolfgang; van Os, Jim; Marcelis, Machteld (Elsevier, 2023-12)

Background: Research indicates that Acceptance and Commitment Therapy in Daily Life (ACT-DL) is effective in reducing symptoms of depression, anxiety and psychosis. During adolescence, vulnerability to psychopathology ...
Revealing the impact of psychiatric comorbidities on treatment outcome in early psychosis using counterfactual model explanation

van Dee, Violet; Kia, Seyed Mostafa; Winter-van Rossum, Inge; Kahn, René S; Cahn, Wiepke; Schnack, Hugo G (Frontiers Research Foundation, 2023-10-12)

INTRODUCTION: Psychiatric comorbidities have a significant impact on the course of illness in patients with schizophrenia spectrum disorders. To accurately predict outcomes for individual patients using computerized ...
Postoperative Staphylococcus aureus Infections in Patients With and Without Preoperative Colonization

ASPIRE-SSI Study Team (American Medical Association, 2023-10-02)

IMPORTANCE: Staphylococcus aureus surgical site infections (SSIs) and bloodstream infections (BSIs) are important complications of surgical procedures for which prevention remains suboptimal. Contemporary data on the ...
Incidence of Air Leaks in Critically Ill Patients with Acute Hypoxemic Respiratory Failure Due to COVID-19

The PRoVENT-Covid And PRoAcT-Covid Investigators (MDPI AG, 2023-03-17)

Subcutaneous emphysema, pneumothorax and pneumomediastinum are well-known complications of invasive ventilation in patients with acute hypoxemic respiratory failure. We determined the incidences of air leaks that were ...
Optimal Dosing and Timing of High-Dose Corticosteroid Therapy in Hospitalized Patients With COVID-19: Study Protocol for a Retrospective Observational Multicenter Study (SELECT)

PRoVENT- and PRoAcT-COVID Collaborative Group (JMIR Publications Inc., 2023-06-02)

Background: In hospitalized patients with COVID-19, the dosing and timing of corticosteroids vary widely. Low-dose dexamethasone therapy reduces mortality in patients requiring respiratory support, but it remains unclear ...
Beyond patterns: how to assign biological meaning to ARDS and sepsis phenotypes

de Grooth, Harm-Jan; Cremer, Olaf L (Elsevier Limited, 2023-11)
Uncovering heterogeneity in sepsis: a comparative analysis of subphenotypes

van Amstel, Rombout B E; Kennedy, Jason N; Scicluna, Brendon P; Bos, Lieuwe D J; Peters-Sengers, Hessel; Butler, Joe M; Cano-Gamez, Eddie; Knight, Julian C; Vlaar, Alexander P J; Cremer, Olaf L; Angus, Derek C; van der Poll, Tom; Seymour, Christopher W; van Vught, Lonneke A; MARS Consortium (Springer-Verlag, 2023-11)

PURPOSE: The heterogeneity in sepsis is held responsible, in part, for the lack of precision treatment. Many attempts to identify subtypes of sepsis patients identify those with shared underlying biology or outcomes. To ...
Prediction of the Proximal Humerus Morphology Based on a Statistical Shape Model with Two Parameters: Comparison to Contralateral Registration Method

van Schaardenburgh, Florianne E.; Nguyen, H. Chien; Magré, Joëll; Willemsen, Koen; van Rietbergen, Bert; Nijs, Stefaan (MDPI AG, 2023-10-13)

(1) Background: Complex proximal humerus fractures often result in complications following surgical treatment. A better understanding of the full 3D displacement would provide insight into the fracture morphology. Repositioning ...
Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: the EuRIDICE randomized clinical trial

EuRIDICE study group (Springer Science + Business Media, 2023-10-30)

BACKGROUND: The role of haloperidol as treatment for ICU delirium and related symptoms remains controversial despite two recent large controlled trials evaluating its efficacy and safety. We sought to determine whether ...

Now showing items 8781-8800 of 40729