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UMC Repository: Recent submissions

  • Effect of a prediction tool and communication skills training on communication of treatment outcomes: a multicenter stepped wedge clinical trial (the SOURCE trial) 
    van de Water, L. F.; Kuijper, S. C.; Henselmans, I.; van Alphen, E. N.; Kooij, E. S.; Calff, M. M.; Beerepoot, L. V.; Buijsen, J.; Eshuis, W. J.; Geijsen, E. D.; Havenith, S. H.C.; Heesakkers, F. F.B.M.; Mook, S.; Muller, K.; Post, H. C.; Rütten, H.; Slingerland, M.; van Voorthuizen, T.; van Laarhoven, H. W.M.; Smets, E. M.A. (Elsevier, 2023-10)
    Background: For cancer patients to effectively engage in decision making, they require comprehensive and understandable information regarding treatment options and their associated outcomes. We developed an online prediction ...
  • Refining critical structure contouring in STereotactic Arrhythmia Radioablation (STAR): Benchmark results and consensus guidelines from the STOPSTORM.eu consortium 
    Balgobind, Brian V; Visser, Jorrit; Grehn, Melanie; Marquard Knap, Marianne; de Ruysscher, Dirk; Levis, Mario; Alcantara, Pino; Boda-Heggemann, Judit; Both, Marcus; Cozzi, Salvatore; Cvek, Jakub; Dieleman, Edith M T; Elicin, Olgun; Giaj-Levra, Niccolò; Jumeau, Raphaël; Krug, David; Algara López, Manuel; Mayinger, Michael; Mehrhof, Felix; Miszczyk, Marcin; Pérez-Calatayud, Maria José; van der Pol, Luuk H G; van der Toorn, Peter-Paul; Vitolo, Viviana; Postema, Pieter G; Pruvot, Etienne; Verhoeff, Joost C; Blanck, Oliver (Elsevier Ireland Ltd, 2023-12)
    BACKGROUND AND PURPOSE: In patients with recurrent ventricular tachycardia (VT), STereotactic Arrhythmia Radioablation (STAR) shows promising results. The STOPSTORM.eu consortium was established to investigate and harmonise ...
  • Recurrences of ventricular tachycardia after stereotactic arrhythmia radioablation arise outside the treated volume: analysis of the Swiss cohort 
    Herrera Siklody, Claudia; Schiappacasse, Luis; Jumeau, Raphaël; Reichlin, Tobias; Saguner, Ardan M; Andratschke, Nicolaus; Elicin, Olgun; Schreiner, Frederic; Kovacs, Boldizsar; Mayinger, Michael; Huber, Adrian; Verhoeff, Joost J C; Pascale, Patrizio; Solana Muñoz, Jorge; Luca, Adrian; Domenichini, Giulia; Moeckli, Raphael; Bourhis, Jean; Ozsahin, Esat M; Pruvot, Etienne (Oxford University Press, 2023-10-05)
    Aims Stereotactic arrhythmia radioablation (STAR) has been recently introduced for the management of therapy-refractory ventricular tachycardia (VT). VT recurrences have been reported after STAR but the mechanisms remain ...
  • Interobserver variability in target definition for stereotactic arrhythmia radioablation 
    van der Ree, Martijn H.; Cuculich, Phillip S.; van Herk, Marcel; Hugo, Geoffrey D.; Balt, Jippe C.; Bates, Matthew; Ho, Gordon; Pruvot, Etienne; Herrera-Siklody, Claudia; Hoeksema, Wiert F.; Lee, Justin; Lloyd, Michael S.; Kemme, Michiel J.B.; Sacher, Frederic; Tixier, Romain; Verhoeff, Joost J.C.; Balgobind, Brian V.; Robinson, Clifford G.; Rasch, Coen R.N.; Postema, Pieter G. (Frontiers Media S. A., 2023-09-20)
    Background: Stereotactic arrhythmia radioablation (STAR) is a potential new therapy for patients with refractory ventricular tachycardia (VT). The arrhythmogenic substrate (target) is synthesized from clinical and ...
  • Hyperperfusion profiles after recanalization differentially associate with outcomes in a rat ischemic stroke model 
    Franx, Bart A.A.; van Tilborg, Geralda A.F.; Taha, Aladdin; Bobi, Joaquim; van der Toorn, Annette; Van Heijningen, Caroline L.; van Beusekom, Heleen M.M.; Wu, Ona; Dijkhuizen, Rick M. (SAGE Publications Inc., 2024-02)
    Futile recanalization hampers prognoses of ischemic stroke after successful mechanical thrombectomy, hypothetically through post-recanalization perfusion deficits, onset-to-groin delays and sex effects. Clinically, acute ...
  • A database for MR-based electrical properties tomography with in silico brain data—ADEPT 
    Meerbothe, T. G.; Meliado, E. F.; Stijnman, P. R.S.; van den Berg, C. A.T.; Mandija, S. (John Wiley & Sons Inc., 2024-03)
    Purpose: Several reconstruction methods for MR-based electrical properties tomography (EPT) have been developed. However, the lack of common data makes it difficult to objectively compare their performances. This is, ...
  • Long COVID and the cardiovascular system - elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases 
    Gyöngyösi, Mariann; Alcaide, Pilar; Asselbergs, Folkert W.; Brundel, Bianca J.J.M.; Camici, Giovanni G.; Da Costa Martins, Paula; Ferdinandy, Péter; Fontana, Marianna; Girao, Henrique; Gnecchi, Massimiliano; Gollmann-Tepeköylü, Can; Kleinbongard, Petra; Krieg, Thomas; Madonna, Rosalinda; Paillard, Melanie; Pantazis, Antonis; Perrino, Cinzia; Pesce, Maurizio; Schiattarella, Gabriele G.; Sluijter, Joost P.G.; Steffens, Sabine; Tschöpe, Carsten; Van Linthout, Sophie; Davidson, Sean M. (Oxford University Press, 2023-02-01)
    Long COVID has become a world-wide, non-communicable epidemic, caused by long-lasting multiorgan symptoms that endure for weeks or months after SARS-CoV-2 infection has already subsided. This scientific document aims to ...
  • Circular RNAs in Cardiovascular Diseases: Regulation and Therapeutic Applications 
    Wang, Lijun; Xu, Gui E.; Spanos, Michail; Li, Guoping; Lei, Zhiyong; Sluijter, Joost P.G.; Xiao, Junjie (American Association for the Advancement of Science, 2023-01)
    Cardiovascular disease is one of the leading causes of mortality worldwide. Recent studies have shown that circular RNAs (circRNAs) have emerged as important players in the prevention and treatment of cardiovascular diseases. ...
  • Methods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles 
    Davidson, Sean M.; Boulanger, Chantal M.; Aikawa, Elena; Badimon, Lina; Barile, Lucio; Binder, Christoph J.; Brisson, Alain; Buzas, Edit; Emanueli, Costanza; Jansen, Felix; Katsur, Miroslava; Lacroix, Romaric; Lim, Sai Kiang; Mackman, Nigel; Mayr, Manuel; Menasché, Philippe; Nieuwland, Rienk; Sahoo, Susmita; Takov, Kaloyan; Thum, Thomas; Vader, Pieter; Wauben, Marca H.M.; Witwer, Kenneth; Sluijter, Joost P.G. (Oxford University Press, 2023-01-01)
    Extracellular vesicles (EVs) are nanosized vesicles with a lipid bilayer that are released from cells of the cardiovascular system, and are considered important mediators of intercellular and extracellular communications. ...
  • Cyclic strain has antifibrotic effects on the human cardiac fibroblast transcriptome in a human cardiac fibrosis-on-a-chip platform 
    Bracco Gartner, Tom C.L.; Wang, Ye; Leiteris, Laurynas; van Adrichem, Iris; Marsman, Judith; Goumans, Marie José; Bouten, Carlijn V.C.; Sluijter, Joost P.G.; den Toonder, Jaap M.J.; Suyker, Willem J.L.; Hjortnaes, Jesper (Elsevier, 2023-08)
    In cardiac fibrosis, in response to stress or injury, cardiac fibroblasts deposit excessive amounts of collagens which contribute to the development of heart failure. The biochemical stimuli in this process have been ...
  • Extracellular vesicle heterogeneity and its impact for regenerative medicine applications 
    Van De Wakker, Simonides Immanuel; Meijers, Fleur Michelle; Sluijter, Joost Petrus Gerardus; Vader, Pieter (Elsevier, 2023-09)
    Extracellular vesicles (EVs) are cell-derived membrane-enclosed particles that are involved in physiologic and pathologic processes. EVs are increasingly being studied for therapeutic applications in the field of regenerative ...
  • Cardiac progenitor cell-derived extracellular vesicles promote angiogenesis through both associated- and co-isolated proteins 
    Roefs, Marieke Theodora; Bauzá-Martinez, Julia; van de Wakker, Simonides Immanuel; Qin, Jiabin; Olijve, Willem Theodoor; Tuinte, Robin; Rozeboom, Marjolein; Snijders Blok, Christian; Mol, Emma Alise; Wu, Wei; Vader, Pieter; Sluijter, Joost Petrus Gerardus (Springer Nature, 2023-08-01)
    Extracellular vesicles (EVs) are cell-derived lipid bilayer-enclosed particles that play a role in intercellular communication. Cardiac progenitor cell (CPC)-derived EVs have been shown to protect the myocardium against ...
  • Harnessing developmental cues for cardiomyocyte production 
    Maas, Renee G.C.; van den Dolder, Floor W.; Yuan, Qianliang; van der Velden, Jolanda; Wu, Sean M.; Sluijter, Joost P.G.; Buikema, Jan W. (Company of Biologists Ltd, 2023-08)
    Developmental research has attempted to untangle the exact signals that control heart growth and size, with knockout studies in mice identifying pivotal roles for Wnt and Hippo signaling during embryonic and fetal heart ...
  • Antioxidants for adults with chronic kidney disease 
    Colombijn, Julia Mt; Hooft, Lotty; Jun, Min; Webster, Angela C; Bots, Michiel L; Verhaar, Marianne C; Vernooij, Robin Wm (John Wiley & Sons Inc., 2023-11-02)
    BACKGROUND: Chronic kidney disease (CKD) is a significant risk factor for cardiovascular disease (CVD) and death. Increased oxidative stress in people with CKD has been implicated as a potential causative factor. Antioxidant ...
  • Donor pregnancies and transfusion recipient mortality: A role for red blood cell storage? 
    Valk, Sarah J; Caram-Deelder, Camila; Evers, Dorothea; de Vooght, Karen M K; van de Kerkhof, Daan; Wondergem, Marielle J; Péquériaux, Nathalie C V; Hudig, Francisca; Zwaginga, Jaap Jan; de Korte, Dirk; van de Watering, Leo M G; Middelburg, Rutger A; van der Bom, Johanna G (Wiley-Blackwell, 2024-01)
    BACKGROUND AND OBJECTIVES: Donor characteristics have been implicated in transfusion-related adverse events. Uncertainty remains about whether sex, and specifically pregnancy history of the blood donor, could affect patient ...
  • NLRP3 inflammasome activation in sensory neurons promotes chronic inflammatory and osteoarthritis pain 
    Silva Santos Ribeiro, Patrícia; Willemen, Hanneke L D M; Versteeg, Sabine; Martin Gil, Christian; Eijkelkamp, Niels (2023-10-24)
    Pain is one of the most debilitating symptoms in rheumatic diseases. Pain often persists after total knee replacement in osteoarthritis, or when inflammation is minimal/absent in rheumatoid arthritis. This suggests that ...
  • Inflammation-induced mitochondrial and metabolic disturbances in sensory neurons control the switch from acute to chronic pain 
    Willemen, HLDM; Silva Santos Ribeiro, Patrícia; Broeks, Melissa; Meijer, Nils; Versteeg, Sabine; Tiggeler, Annefien; de Boer, Teun; Małecki, Jędrzej; Falnes, Pål Ø; Jans, Judith; Eijkelkamp, Niels (Cell Press, 2023-11-21)
    Pain often persists in patients with an inflammatory disease, even when inflammation has subsided. The molecular mechanisms leading to this failure in pain resolution and the transition to chronic pain are poorly understood. ...
  • Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2) 
    Raja, Aroosha; Kuiper, Jonas J W (Springer Nature, 2023-12)
    Endoplasmic reticulum aminopeptidase 2 (ERAP2) is a proteolytic enzyme involved in adaptive immunity. The ERAP2 gene is highly polymorphic and encodes haplotypes that confer resistance against lethal infectious diseases, ...
  • Systems genomics in age-related macular degeneration 
    den Hollander, Anneke I; Mullins, Robert F; Orozco, Luz D; Voigt, Andrew P; Chen, Hsu-Hsin; Strunz, Tobias; Grassmann, Felix; Haines, Jonathan L; Kuiper, Jonas J W; Tumminia, Santa J; Allikmets, Rando; Hageman, Gregory S; Stambolian, Dwight; Klaver, Caroline C W; Boeke, Jef D; Chen, Hao; Honigberg, Lee; Katti, Suresh; Frazer, Kelly A; Weber, Bernhard H F; Gorin, Michael B (Academic Press Inc., 2022-12)
    Genomic studies in age-related macular degeneration (AMD) have identified genetic variants that account for the majority of AMD risk. An important next step is to understand the functional consequences and downstream effects ...
  • Uncovering the genomic toll of the Black Death 
    Kuiper, Jonas; van Endert, Peter (Elsevier Limited, 2023-02)
    The Black Death, a notorious devastating pandemic caused by Yersinia pestis infection during the 14th century, posed a formidable challenge to human immune defenses. A new article by Klunk et al. reports that a variant in ...