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UMC Repository: Recent submissions

  • Towards better culturally tailored cardiometabolic prevention among the South-Asian Surinamese in the Netherlands 
    Voogdt-Pruis, Helene; van den Brekel, Lieke; Wispelweij, Lian; Jawalapershad, Laxmie; Narain, Soerin; Vaartjes, Ilonca; Grobbee, Diederick; Klipstein-Grobusch, Kerstin (Frontiers Media S. A., 2023-11-28)
    Objectives: To gain insight in the motives and determinants for the uptake of healthy lifestyles by South-Asian Surinamese people to identify needs and engagement strategies for healthy lifestyle support. Methods: We used ...
  • Multi-class glioma segmentation on real-world data with missing MRI sequences: comparison of three deep learning algorithms 
    Pemberton, Hugh G.; Wu, Jiaming; Kommers, Ivar; Müller, Domenique M.J.; Hu, Yipeng; Goodkin, Olivia; Vos, Sjoerd B.; Bisdas, Sotirios; Robe, Pierre A.; Ardon, Hilko; Bello, Lorenzo; Rossi, Marco; Sciortino, Tommaso; Nibali, Marco Conti; Berger, Mitchel S.; Hervey-Jumper, Shawn L.; Bouwknegt, Wim; Van den Brink, Wimar A.; Furtner, Julia; Han, Seunggu J.; Idema, Albert J.S.; Kiesel, Barbara; Widhalm, Georg; Kloet, Alfred; Wagemakers, Michiel; Zwinderman, Aeilko H.; Krieg, Sandro M.; Mandonnet, Emmanuel; Prados, Ferran; de Witt Hamer, Philip; Barkhof, Frederik; Eijgelaar, Roelant S. (Nature Publishing Group, 2023-12)
    This study tests the generalisability of three Brain Tumor Segmentation (BraTS) challenge models using a multi-center dataset of varying image quality and incomplete MRI datasets. In this retrospective study, DeepMedic, ...
  • Segmentation of glioblastomas in early post-operative multi-modal MRI with deep neural networks 
    Helland, Ragnhild Holden; Ferles, Alexandros; Pedersen, André; Kommers, Ivar; Ardon, Hilko; Barkhof, Frederik; Bello, Lorenzo; Berger, Mitchel S.; Dunås, Tora; Nibali, Marco Conti; Furtner, Julia; Hervey-Jumper, Shawn; Idema, Albert J.S.; Kiesel, Barbara; Tewari, Rishi Nandoe; Mandonnet, Emmanuel; Müller, Domenique M.J.; Robe, Pierre A.; Rossi, Marco; Sagberg, Lisa M.; Sciortino, Tommaso; Aalders, Tom; Wagemakers, Michiel; Widhalm, Georg; Witte, Marnix G.; Zwinderman, Aeilko H.; Majewska, Paulina L.; Jakola, Asgeir S.; Solheim, Ole; Hamer, Philip C.De Witt; Reinertsen, Ingerid; Eijgelaar, Roelant S.; Bouget, David (Nature Publishing Group, 2023-12)
    Extent of resection after surgery is one of the main prognostic factors for patients diagnosed with glioblastoma. To achieve this, accurate segmentation and classification of residual tumor from post-operative MR images ...
  • Study protocol for a multicenter randomised controlled trial on the (cost)effectiveness of biopsy combined with same-session MR-guided LITT versus biopsy alone in patients with primary irresectable glioblastoma (EMITT trial) 
    Neutel, Céline L.G.; Viozzi, Ilaria; Overduin, Christiaan G.; Rijpma, Anne; Grutters, Janneke P.C.; Hannink, Gerjon; van Eijsden, Pieter; Robe, Pierre A.; Rovers, Maroeska M.; ter Laan, Mark (BioMed Central, 2023-12)
    Background: Glioblastoma (GBM) is the most common primary, malignant brain tumour with a 5-year survival of 5%. If possible, a glioblastoma is resected and further treated with chemoradiation therapy (CRT), but resection ...
  • Effectiveness and Cost-Effectiveness of a Stratified Blended Physiotherapy Intervention Compared With Face-to-Face Physiotherapy in Patients With Nonspecific Low Back Pain: Cluster Randomized Controlled Trial 
    Koppenaal, Tjarco; van Dongen, Johanna M.; Kloek, Corelien Jj; Arensman, Remco M.; Veenhof, Cindy; Pisters, Martijn F.; Ostelo, Raymond Wjg (Journal of medical Internet Research, 2023-11-24)
    Background: Nonspecific low back pain (LBP) is a leading contributor to disability worldwide, and its socioeconomic burden is substantial. Self-management support is an important recommendation in clinical guidelines for ...
  • Evolution in Laparoscopic Gastrectomy from a Randomized Controlled Trial through National Clinical Practice 
    LOGICA Study group, Dutch Upper Gastrointestinal Cancer Audit Group (Lippincott Williams & Wilkins, 2024-03-01)
    OBJECTIVE: To examine the influence of the LOGICA RCT (randomized controlled trial) upon the practice and outcomes of laparoscopic gastrectomy within the Netherlands. BACKGROUND: Following RCTs the dissemination of complex ...
  • Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer 
    International Childhood Cancer Outcome Project participants (Nature Research, 2024-02)
  • Making meaning of trauma in psychosis 
    van Sambeek, Nienke; Franssen, Gaston; van Geelen, Stefan; Scheepers, Floortje (Frontiers Research Foundation, 2023-11-03)
    Background: Finding new meaning and identity in the aftermath of trauma has been identified as a key process of mental health recovery. However, research indicates that this meaning-making process is compromised in people ...
  • Molecular EPISTOP, a comprehensive multi-omic analysis of blood from Tuberous Sclerosis Complex infants age birth to two years 
    Huschner, Franz; Głowacka-Walas, Jagoda; Mills, James D; Klonowska, Katarzyna; Lasseter, Kathryn; Asara, John M; Moavero, Romina; Hertzberg, Christoph; Weschke, Bernhard; Riney, Kate; Feucht, Martha; Scholl, Theresa; Krsek, Pavel; Nabbout, Rima; Jansen, Anna C; Petrák, Bořivoj; van Scheppingen, Jackelien; Zamecnik, Josef; Iyer, Anand; Anink, Jasper J; Mühlebner, Angelika; Mijnsbergen, Caroline; Lagae, Lieven; Curatolo, Paolo; Borkowska, Julita; Sadowski, Krzysztof; Domańska-Pakieła, Dorota; Blazejczyk, Magdalena; Jansen, Floor E; Janson, Stef; Urbanska, Malgorzata; Tempes, Aleksandra; Janssen, Bart; Sijko, Kamil; Wojdan, Konrad; Jozwiak, Sergiusz; Kotulska, Katarzyna; Lehmann, Karola; Aronica, Eleonora; Jaworski, Jacek; Kwiatkowski, David J (Nature Publishing Group, 2023-12)
    We present a comprehensive multi-omic analysis of the EPISTOP prospective clinical trial of early intervention with vigabatrin for pre-symptomatic epilepsy treatment in Tuberous Sclerosis Complex (TSC), in which 93 infants ...
  • Prenatal exposure to persistent organic pollutants and changes in infant growth and childhood growth trajectories 
    Cai, Anran; Portengen, Lützen; Govarts, Eva; Martin, Laura Rodriguez; Schoeters, Greet; Legler, Juliette; Vermeulen, Roel; Lenters, Virissa; Remy, Sylvie (Elsevier Limited, 2023-02)
    Background: Children are born with a burden of persistent organic pollutants (POPs) which may have endocrine disrupting properties and have been postulated to contribute to the rise in childhood obesity. The current evidence ...
  • Associations between lifestyle factors and levels of per- and polyfluoroalkyl substances (PFASs), phthalates and parabens in follicular fluid in women undergoing fertility treatment 
    Hallberg, Ida; Björvang, Richelle D.; Hadziosmanovic, Nermin; Koekkoekk, Jacco; Pikki, Anne; van Duursen, Majorie; Lenters, Virissa; Sjunnesson, Ylva; Holte, Jan; Berglund, Lars; Persson, Sara; Olovsson, Matts; Damdimopoulou, Pauliina (Springer Nature, 2023-09)
    Background: Concerns have been raised whether exposure to endocrine-disrupting chemicals (EDCs) can alter reproductive functions and play a role in the aetiology of infertility in women. With increasing evidence of adverse ...
  • Prenatal Exposure to Metabolism-Disrupting Chemicals, Cord Blood Transcriptome Perturbations, and Birth Weight in a Belgian Birth Cohort 
    Cai, Anran; Portengen, Lützen; Ertaylan, Gökhan; Legler, Juliette; Vermeulen, Roel; Lenters, Virissa; Remy, Sylvie (Multidisciplinary Digital Publishing Institute (MDPI), 2023-04)
    Prenatal exposure to metabolism-disrupting chemicals (MDCs) has been linked to birth weight, but the molecular mechanisms remain largely unknown. In this study, we investigated gene expressions and biological pathways ...
  • Perspectives of patients with metastatic breast cancer on physical exercise programs: results from a survey in five European countries 
    Sweegers, Maike G.; Depenbusch, Johanna; Kampshoff, Caroline S.; Aaronson, Neil K.; Hiensch, Anouk; Wengström, Yvonne; Backman, Malin; Gunasekara, Nadira; Clauss, Dorothea; Pelaez, Mireia; Lachowicz, Milena; May, Anne M.; Steindorf, Karen; Stuiver, Martijn M. (Springer-Verlag, 2023-11-13)
    Background: To successfully implement exercise programs for patients with metastatic breast cancer (MBC), services and patient education should consider patients’ knowledge, preferences, values, and goals. Hence, gaining ...
  • Oxygen gradient ektacytometry-derived biomarkers are associated with acute complications in sickle cell disease 
    Rab, Minke A E; Kanne, Celeste K; Boisson, Camille; Bos, Jennifer; van Oirschot, Brigitte A; Houwing, Maite; Renoux, Céline; Bartels, Marije; Rijneveld, Anita W; Nur, Erfan; Cnossen, Marjon H; Joly, Philippe; Nader, Elie; Fort, Romain; Connes, Philippe; van Wijk, Richard; Sheehan, Vivien A; van Beers, Eduard J (The American Society of Hematology, 2024-01-23)
    We investigated the potential of the point of sickling (PoS; the pO2 tension at which red cells start to sickle), determined by oxygen gradient ektacytometry to serve as a biomarker associated with the incidence of acute ...
  • Home-based initiatives for acute management of COVID-19 patients needing oxygen: differences across The Netherlands 
    Boeijen, Josi A.; van de Pol, Alma C.; van Uum, Rick T.; Smit, Karin; Ahmad, Abeer; van Rijswijk, Eric; van Apeldoorn, Marjan J.; van Thiel, Eric; de Graaf, Netty; Menkveld, R. Michiel; Mantingh, Martijn R.; Geertman, Silke; Couzijn, Nicolette; van Groenendael, Leon; Schers, Henk; Bont, Jettie; Bonten, Tobias N.; Rutten, Frans H.; Zwart, Dorien L.M. (BioMed Central, 2023-11-15)
    Objective: During the COVID-19 pandemic new collaborative-care initiatives were developed for treating and monitoring COVID-19 patients with oxygen at home. Aim was to provide a structured overview focused on differences ...
  • RSPO3 Furin domain-conjugated liposomes for selective drug delivery to LGR5-high cells 
    van Kerkhof, Peter; Kralj, Tomica; Spanevello, Francesca; van Bloois, Louis; Jordens, Ingrid; van der Vaart, Jelte; Jamieson, Cara; Merenda, Alessandra; Mastrobattista, Enrico; Maurice, Madelon M. (Elsevier, 2023-04)
    The transmembrane receptor LGR5 potentiates Wnt/β-catenin signaling by binding both secreted R-spondin (RSPOs) and the Wnt tumor suppressors RNF43/ZNRF3, directing clearance of RNF43/ZNRF3 from the cell surface. Besides ...
  • A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance 
    van der Krift, Felix; Zijlmans, Dick W.; Shukla, Rhythm; Javed, Ali; Koukos, Panagiotis I.; Schwarz, Laura L.E.; Timmermans-Sprang, Elpetra P.M.; Maas, Peter E.M.; Gahtory, Digvijay; van den Nieuwboer, Maurits; Mol, Jan A.; Strous, Ger J.; Bonvin, Alexandre M.J.J.; van der Stelt, Mario; Veldhuizen, Edwin J.A.; Weingarth, Markus; Vermeulen, Michiel; Klumperman, Judith; Maurice, Madelon M. (Life Science Alliance, LLC, 2023-11)
    Cancer cells make extensive use of the folate cycle to sustain increased anabolic metabolism. Multiple chemotherapeutic drugs interfere with the folate cycle, including methotrexate and 5-fluorouracil that are commonly ...
  • Separable mixing: The general formulation and a particular example focusing on mask efficiency 
    Bootsma, M. C.J.; Chan, K. M.D.; Diekmann, O.; Inaba, H. (American Institute of Mathematical Sciences, 2023)
    The aim of this short note is twofold. First, we formulate the general Kermack-McKendrick epidemic model incorporating static heterogeneity and show how it simplifies to a scalar Renewal Equation (RE) when separable mixing ...
  • Genome-wide association reveals host-specific genomic traits in Escherichia coli 
    Tiwari, Sumeet K; van der Putten, Boas C L; Fuchs, Thilo M; Vinh, Trung N; Bootsma, Martin; Oldenkamp, Rik; La Ragione, Roberto; Matamoros, Sebastien; Hoa, Ngo T; Berens, Christian; Leng, Joy; Álvarez, Julio; Ferrandis-Vila, Marta; Ritchie, Jenny M; Fruth, Angelika; Schwarz, Stefan; Domínguez, Lucas; Ugarte-Ruiz, María; Bethe, Astrid; Huber, Charlotte; Johanns, Vanessa; Stamm, Ivonne; Wieler, Lothar H; Ewers, Christa; Fivian-Hughes, Amanda; Schmidt, Herbert; Menge, Christian; Semmler, Torsten; Schultsz, Constance (BioMed Central Ltd., 2023-12)
    BACKGROUND: Escherichia coli is an opportunistic pathogen which colonizes various host species. However, to what extent genetic lineages of E. coli are adapted or restricted to specific hosts and the genomic determinants ...
  • Perioperative Brain Injury in Relation to Early Neurodevelopment among Children with Severe Congenital Heart Disease: Results from a European Collaboration 
    European Association Brain in Congenital Heart Disease (EU-ABC) consortium (Mosby Inc., 2024-03)
    Objective: To examine the relationship between perioperative brain injury and neurodevelopment during early childhood in patients with severe congenital heart disease (CHD). Study design: One hundred and seventy children ...