Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

  • Leisure time physical activity is associated with improved diastolic heart function and is partly mediated by unsupervised quantified metabolic health 
    Klarenberg, Hugo; van der Velde, Jeroen Hpm; Peeters, Carel Fw; Dekkers, Ilona A; de Mutsert, R; Jukema, J Wouter; Rosendaal, Frits R; Leiner, Tim; Froeling, Martijn; Jorstad, Harald; Boekholdt, S Matthijs; Strijkers, Gustav J; Lamb, Hildo J (BMJ Publishing Group, 2024-02-06)
    Objectives To investigate the association between leisure time physical activity (LTPA) and MRI-based diastolic function and the mediating role of metabolic health. Methods This cross-sectional analysis comprised 901 ...
  • Optimising surgical anastomosis in ileocolic resection for Crohn's disease with respect to recurrence and functionality: two international parallel randomized controlled trials comparing handsewn (END-to-end or Kono-S) to stapled anastomosis (HAND2END and the End2End STUDIES) 
    Haanappel, Anouck E G; Bellato, Vittoria; Buskens, Christianne J; Armuzzi, Alessandro; van der Bilt, Jarmila D W; de Boer, Nanne K H; Danese, Silvio; van der Does de Willebois, Eline M L; Duijvestein, Marjolijn; van der Horst, Daniëlle; Pellino, Gianluca; Richir, Milan C; Selvaggi, Francesco; Spinelli, Antonino; Vignali, Andrea; Rosati, Riccardo; Bemelman, Willem A (BioMed Central, 2024-02-26)
    BACKGROUND: The most common intestinal operation in Crohn's disease (CD) is an ileocolic resection. Despite optimal surgical and medical management, recurrent disease after surgery is common. Different types of anastomoses ...
  • Imaging of intracranial arterial disease: a comparison between MRI and unenhanced CT 
    Lucci, Carlo; Rissanen, Ina; Takx, Richard A P; van der Kolk, Anja G; Harteveld, Anita A; Dankbaar, Jan W; Geerlings, Mirjam I; de Jong, Pim A; Hendrikse, Jeroen (Frontiers Media SA, 2024-02-15)
    BACKGROUND AND PURPOSE: Arterial calcifications on unenhanced CT scans and vessel wall lesions on MRI are often used interchangeably to portray intracranial arterial disease. However, the extent of pathology depicted with ...
  • Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy in Patients With Advanced Ovarian Cancer (OVHIPEC-1): Final Survival Analysis of a Randomised, Controlled, Phase 3 Trial 
    Aronson, S. Lot; Lopez-Yurda, Marta; Koole, Simone N.; Schagen Van Leeuwen, Jules H.; Schreuder, Hendrik W.R.; Hermans, Ralph H.M.; De Hingh, Ignace H.J.T.; Van Gent, Mignon D.J.M.; Arts, Henriëtte J.G.; Van Ham, Maaike A.P.C.; Van Dam, Peter A.; Vuylsteke, Peter; Aalbers, Arend G.J.; Verwaal, Victor J.; Van De Vijver, Koen K.; Aaronson, Neil K.; Sonke, Gabe S.; Van Driel, Willemien J. (Lippincott Williams & Wilkins, 2024-02-01)
    Although the 5-year survival of patients with advanced ovarian cancer has improved, overall survival at 10 years remains approximately 13%. Hyperthermic intraperitoneal chemotherapy (HIPEC) involves the delivery of ...
  • ICS educational module: The practice of uroflowmetry in adults 
    Tarcan, Tufan; Acar, Omer; Agarwal, Mayank Mohan; Rubilotta, Emanuele; De Nunzio, Cosimo; Rosier, Peter (2024-03)
    Aim: To present the body of evidence behind the International Continence Society (ICS) educational module on “Practice of uroflowmetry in adults” which consists of a PowerPoint® presentation. Methods: This evidence review ...
  • Healthcare professionals’ perceived barriers in providing palliative care in primary care and nursing homes: a survey study 
    Kochems, Katrin; de Graaf, Everlien; Hesselmann, Ginette M.; Ausems, Marieke J.E.; Teunissen, Saskia C.C.M. (SAGE Publications Ltd, 2023-01-01)
    Background: Palliative care in primary care and nursing home settings is becoming increasingly important. A multidimensional palliative care approach, provided by a multiprofessional team, is essential to meeting patients’ ...
  • Impact of age on pneumococcal colonization of the nasopharynx and oral cavity: an ecological perspective 
    Miellet, Willem R; Mariman, Rob; van Veldhuizen, Janieke; Badoux, Paul; Wijmenga-Monsuur, Alienke J; Litt, David; Bosch, Thijs; Miller, Elizabeth; Fry, Norman K; van Houten, Marianne A; Rots, Nynke Y; Sanders, Elisabeth A M; Trzciński, Krzysztof (2024-01)
    Pneumococcal carriage studies have suggested that pneumococcal colonization in adults is largely limited to the oral cavity and oropharynx. In this study, we used total abundance-based β-diversity (dissimilarity) and ...
  • The Diagnostic Value of microRNA Expression Analysis in Detecting Intraductal Papillomas in Patients with Pathological Nipple Discharge 
    Makineli, Seher; Vriens, Menno R.; Witkamp, Arjen J.; van Diest, Paul J.; Moelans, Cathy B. (Multidisciplinary Digital Publishing Institute (MDPI), 2024-02)
    Patients with pathological nipple discharge (PND) often undergo local surgical procedures because standard radiologic imaging fails to identify the underlying cause. MicroRNA (MiRNA) expression analysis of nipple fluid ...
  • A novel composition of endogenous metabolic modulators improves red blood cell properties in sickle cell disease 
    van Dijk, Myrthe J; Traets, Marissa J M; van Oirschot, Brigitte A; Ruiter, Titine J J; de Wilde, Jonathan R A; Bos, Jennifer; van Solinge, Wouter W; Koziel, Margaret J; Jans, Judith J M; Wani, Revati; van Beers, Eduard J; van Wijk, Richard; Rab, Minke A E (2024-02)
    The most common forms of sickle cell disease (SCD) are sickle cell anemia (SCA; HbSS) and HbSC disease. In both, especially the more dense, dehydrated and adherent red blood cells (RBCs) with reduced deformability are prone ...
  • Machine-learning algorithms in screening for type 2 diabetes mellitus: Data from Fasa Adults Cohort Study 
    Karmand, Hanieh; Andishgar, Aref; Tabrizi, Reza; Sadeghi, Alireza; Pezeshki, Babak; Ravankhah, Mahdi; Taherifard, Erfan; Ahmadizar, Fariba (Wiley-Blackwell Publishing Ltd, 2024-03)
    INTRODUCTION: The application of machine learning (ML) is increasingly growing in biomedical sciences. This study aimed to evaluate factors associated with type 2 diabetes mellitus (T2DM) and compare the performance of ML ...
  • A Federated Database for Obesity Research: An IMI-SOPHIA Study 
    Delfin, Carl; Dragan, Iulian; Kuznetsov, Dmitry; Tajes, Juan Fernandez; Smit, Femke; Coral, Daniel E; Farzaneh, Ali; Haugg, André; Hungele, Andreas; Niknejad, Anne; Hall, Christopher; Jacobs, Daan; Marek, Diana; Fraser, Diane P; Thuillier, Dorothee; Ahmadizar, Fariba; Mehl, Florence; Pattou, Francois; Burdet, Frederic; Hawkes, Gareth; Arts, Ilja C W; Blanch, Jordi; Van Soest, Johan; Fernández-Real, José-Manuel; Boehl, Juergen; Fink, Katharina; van Greevenbroek, Marleen M J; Kavousi, Maryam; Minten, Michiel; Prinz, Nicole; Ipsen, Niels; Franks, Paul W; Ramos, Rafael; Holl, Reinhard W; Horban, Scott; Duarte-Salles, Talita; Tran, Van Du T; Raverdy, Violeta; Leal, Yenny; Lenart, Adam; Pearson, Ewan; Sparsø, Thomas; Giordano, Giuseppe N; Ioannidis, Vassilios; Soh, Keng; Frayling, Timothy M; Le Roux, Carel W; Ibberson, Mark (Multidisciplinary Digital Publishing Institute (MDPI), 2024-02-16)
    Obesity is considered by many as a lifestyle choice rather than a chronic progressive disease. The Innovative Medicines Initiative (IMI) SOPHIA (Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy) ...
  • Perspectives and Concerns on Late Effects Regarding Sexuality among Adolescents and Young Adults Treated for Testicular Germ Cell Tumor: The PRICELESS-Study-A Qualitative Study 
    Kuiper, Stefan T; Zweers, Daniëlle; Suelmann, Britt B M; Meijer, Richard P; Vervoort, Sigrid C J M (Multidisciplinary Digital Publishing Institute (MDPI), 2024-02-08)
    This study aimed to explore perspectives and concerns regarding sexuality among adolescents and young adults (AYAs) possibly experiencing late effects after testicular germ cell tumor (TGCT) treatment. A qualitative study ...
  • Potential causal association between gut microbiome and posttraumatic stress disorder 
    He, Qiang; Wang, Wenjing; Xu, Dingkang; Xiong, Yang; Tao, Chuanyuan; You, Chao; Ma, Lu; Ma, Junpeng; Nievergelt, Caroline M.; Maihofer, Adam X.; Klengel, Torsten; Atkinson, Elizabeth G.; Chen, Chia Yen; Choi, Karmel W.; Coleman, Jonathan R.I.; Dalvie, Shareefa; Duncan, Laramie E.; Logue, Mark W.; Provost, Allison C.; Ratanatharathorn, Andrew; Stein, Murray B.; Torres, Katy; Aiello, Allison E.; Almli, Lynn M.; Amstadter, Ananda B.; Andersen, Søren B.; Andreassen, Ole A.; Arbisi, Paul A.; Ashley-Koch, Allison E.; Austin, S. Bryn; Avdibegovic, Esmina; Babić, Dragan; Bækvad-Hansen, Marie; Baker, Dewleen G.; Beckham, Jean C.; Bierut, Laura J.; Bisson, Jonathan I.; Boks, Marco P.; Bolger, Elizabeth A.; Børglum, Anders D.; Bradley, Bekh; Brashear, Megan; Breen, Gerome; Bryant, Richard A.; Bustamante, Angela C.; Bybjerg-Grauholm, Jonas; Calabrese, Joseph R.; Caldas-de-Almeida, José M.; Dale, Anders M.; Daly, Mark J.; Daskalakis, Nikolaos P.; Deckert, Jürgen; Delahanty, Douglas L.; Dennis, Michelle F.; Disner, Seth G.; Domschke, Katharina; Dzubur-Kulenovic, Alma; Erbes, Christopher R.; Evans, Alexandra; Farrer, Lindsay A.; Feeny, Norah C.; Flory, Janine D.; Forbes, David; Franz, Carol E.; Galea, Sandro; Garrett, Melanie E.; Gelaye, Bizu; Gelernter, Joel; Geuze, Elbert; Gillespie, Charles; Uka, Aferdita Goci; Gordon, Scott D.; Guffanti, Guia; Hammamieh, Rasha; Harnal, Supriya; Hauser, Michael A.; Heath, Andrew C.; Hemmings, Sian M.J.; Hougaard, David Michael; Jakovljevic, Miro; Jett, Marti; Johnson, Eric Otto; Jones, Ian; Jovanovic, Tanja; Qin, Xue Jun; Junglen, Angela G.; Karstoft, Karen Inge; Kaufman, Milissa L.; Kessler, Ronald C.; Khan, Alaptagin; Kimbrel, Nathan A.; King, Anthony P.; Koen, Nastassja; Kranzler, Henry R.; Kremen, William S.; Lawford, Bruce R.; Lebois, Lauren A.M.; Lewis, Catrin E.; Linnstaedt, Sarah D.; Lori, Adriana; Lugonja, Bozo; Luykx, Jurjen J.; Lyons, Michael J.; Maples-Keller, Jessica; Marmar, Charles; Martin, Alicia R.; Martin, Nicholas G.; Maurer, Douglas; Mavissakalian, Matig R.; McFarlane, Alexander; McGlinchey, Regina E.; McLaughlin, Katie A.; McLean, Samuel A.; McLeay, Sarah; Mehta, Divya; Milberg, William P.; Miller, Mark W.; Morey, Rajendra A.; Morris, Charles Phillip; Mors, Ole; Mortensen, Preben B.; Neale, Benjamin M.; Nelson, Elliot C.; Nordentoft, Merete; Norman, Sonya B.; O’Donnell, Meaghan; Orcutt, Holly K.; Panizzon, Matthew S.; Peters, Edward S.; Peterson, Alan L.; Peverill, Matthew; Pietrzak, Robert H.; Polusny, Melissa A.; Rice, John P.; Ripke, Stephan; Risbrough, Victoria B.; Roberts, Andrea L.; Rothbaum, Alex O.; Rothbaum, Barbara O.; Roy-Byrne, Peter; Ruggiero, Ken; Rung, Ariane; Rutten, Bart P.F.; Saccone, Nancy L.; Sanchez, Sixto E.; Schijven, Dick; Seedat, Soraya; Seligowski, Antonia V.; Seng, Julia S.; Sheerin, Christina M.; Silove, Derrick; Smith, Alicia K.; Smoller, Jordan W.; Solovieff, Nadia; Sponheim, Scott R.; Stein, Dan J.; Sumner, Jennifer A.; Teicher, Martin H.; Thompson, Wesley K.; Trapido, Edward; Uddin, Monica; Ursano, Robert J.; van den Heuvel, Leigh Luella; van Hooff, Miranda; Vermetten, Eric; Vinkers, Christiaan H.; Voisey, Joanne; Wang, Yunpeng; Wang, Zhewu; Werge, Thomas; Williams, Michelle A.; Williamson, Douglas E.; Winternitz, Sherry; Wolf, Christiane; Wolf, Erika J.; Wolff, Jonathan D.; Yehuda, Rachel; Young, Keith A.; Young, Ross Mc D.; Zhao, Hongyu; Zoellner, Lori A.; Liberzon, Israel; Ressler, Kerry J.; Haas, Magali; Koenen, Karestan C. (Nature Publishing Group, 2024-01-31)
    Background: The causal effects of gut microbiome and the development of posttraumatic stress disorder (PTSD) are still unknown. This study aimed to clarify their potential causal association using mendelian randomization ...
  • Stereotactic body radiotherapy of central lung tumours using a 1.5 T MR-linac: First clinical experiences 
    Merckel, L G; Pomp, Jacquelien; Hackett, S L; van Lier, A L H M W; van den Dobbelsteen, M; Rasing, M J A; Mohamed Hoesein, F A A; Snoeren, L M W; van Es, C A; van Rossum, P S N; Fast, M F; Verhoeff, J J C (Elsevier Ireland Ltd, 2024-03)
    BACKGROUND: MRI-guidance may aid better discrimination between Organs at Risk (OARs) and target volumes in proximity of the mediastinum. We report the first clinical experiences with Stereotactic Body Radiotherapy (SBRT) ...
  • Age-specific transmission dynamics of SARS-CoV-2 during the first 2 years of the pandemic 
    Boldea, Otilia; Alipoor, Amir; Pei, Sen; Shaman, Jeffrey; Rozhnova, Ganna (National Academy of Sciences, 2024-02-01)
    During its first 2 years, the SARS-CoV-2 pandemic manifested as multiple waves shaped by complex interactions between variants of concern, non-pharmaceutical interventions, and the immunological landscape of the population. ...
  • Deep-learning-based joint rigid and deformable contour propagation for magnetic resonance imaging-guided prostate radiotherapy 
    Kolenbrander, Iris D; Maspero, Matteo; Hendriksen, Allard A; Pollitt, Ryan; van der Voort van Zyp, Jochem R N; van den Berg, Cornelis A T; Pluim, Josien P W; van Eijnatten, Maureen A J M (John Wiley & Sons Inc., 2024-04)
    Background: Deep learning-based unsupervised image registration has recently been proposed, promising fast registration. However, it has yet to be adopted in the online adaptive magnetic resonance imaging-guided radiotherapy ...
  • Identification of a gene network driving the attenuated response to lipopolysaccharide of monocytes from hypertensive coronary artery disease patients 
    Lu, Chang; Donners, Marjo M P C; de Baaij, Julius B J; Jin, Han; Otten, Jeroen J T; Manca, Marco; van Zonneveld, Anton Jan; Jukema, J Wouter; Kraaijeveld, Adriaan; Kuiper, Johan; Pasterkamp, Gerard; Mees, Barend; Sluimer, Judith C; Cavill, Rachel; Karel, Joël M H; Goossens, Pieter; Biessen, Erik A L (Frontiers Media S. A., 2024-02-12)
    Introduction: The impact of cardiovascular disease (CVD) risk factors, encompassing various biological determinants and unhealthy lifestyles, on the functional dynamics of circulating monocytes—a pivotal cell type in CVD ...
  • Identifying clinical response to daratumumab therapy in relapsed/refractory multiple myeloma using a patient-derived in vitro model 
    van Nieuwenhuijzen, Niels; Cuenca, Marta; Abbink, Leonie; Jak, Margot; Peperzak, Victor; Minnema, Monique C (2024-02)
    Response to daratumumab in patients with relapsed/refractory multiple myeloma is heterogeneous, and a reliable biomarker of response is lacking. We aimed to develop a method that identifies response to daratumumab therapy. ...
  • Size matters: Functional differences of small extracellular vesicle subpopulations in cardiac repair responses 
    van de Wakker, Simon; Bauzá-Martinez, Julia; Rios Arceo, Carla; Manjikian, Herak; Snijders Blok, Christian J.B.; Roefs, Marieke; Maas, Renee G; Willms, Eduard; Pronker, Matti F.; de Jong, Olivier; Wu, Wei; Görgens, André; Andaloussi, Samir E L; Sluijter, Joost; Vader, Pieter (John Wiley & Sons Inc., 2024-01-13)
    Cardiac progenitor cell (CPC)-derived small extracellular vesicles (sEVs) exhibit great potential to stimulate cardiac repair. However, the multifaceted nature of sEV heterogeneity presents a challenge in understanding the ...
  • Statins affect human iPSC-derived cardiomyocytes by interfering with mitochondrial function and intracellular acidification. 
    Somers , Tim; Siddiqi, Sailay; Maas, Renee G; Sluijter, Joost; Buikema, Jan Willem; H. H. van den Broek, Petra; J Meuwissen, Tanne; J. Morshuis, Wim; G. M. Russel, Frans; J. J. Schirris , Tom (Springer Science and Business Media Deutschland GmbH, 2024-04)
    Statins are effective drugs in reducing cardiovascular morbidity and mortality by inhibiting cholesterol synthesis. These effects are primarily beneficial for the patient's vascular system. A significant number of statin ...