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UMC Repository: Recent submissions

  • Improving home haemodialysis: Stability evaluation of routine clinical chemistry analytes in blood samples of haemodialysis patients 
    Nonkes, Lourens J.P.; Van Gelder, Maaike K.; Kemperman, Hans; Abrahams, Alferso C.; Boereboom, Frans T.J.; ten Berg, Maarten J.; Gerritsen, Karin G.F. (Biochemia Medica, Editorial Office, 2019-02-15)
    Introduction: A growing number of dialysis patients is treated with home haemodialysis. Our current pre-analytical protocols require patients to centrifuge the blood sample and transfer the plasma into a new tube at home. ...
  • Attributable mortality of infections caused by carbapenem-resistant Enterobacterales: results from a prospective, multinational case-control-control matched cohorts study (EURECA) 
    Paniagua-García, María; Bravo-Ferrer, Jose M; Pérez-Galera, Salvador; Kostyanev, Tomislav; de Kraker, Marlieke E A; Feifel, Jan; Palacios-Baena, Zaira R; Schotsman, Joost; Cantón, Rafael; Daikos, George L; Carevic, Biljana; Dragovac, Gorana; Tan, Lionel K; Raka, Lul; Hristea, Adriana; Viale, Pierluigi; Akova, Murat; Cano, Ángela; Reguera, Jose María; Bartoloni, Alessandro; Florescu, Simin-Aysel; Benea, Serban; Bukarica, Ljiljana; Asensio, Ángel; Korten, Volkan; Grundmann, Hajo; Goossens, Herman; Bonten, Marc J; Gutiérrez-Gutiérrez, Belén; Rodríguez-Baño, Jesús; COMBACTE-CARE-EURECA Team (Elsevier, 2024-02)
    OBJECTIVES: To assess the mortality attributable to infections caused by carbapenem-resistant Enterobacterales (CRE) and to investigate the effect of clinical management on differences in observed outcomes in a multinational ...
  • Fetal fibronectin status and cervical length in women with threatened preterm labor and the effectiveness of maintenance tocolysis 
    Roos, Carolien; Vis, Jolande Y; Scheepers, Hubertina C J; Bloemenkamp, Kitty W M; Duvekot, Hans J J; van Eyck, Jim; de Groot, Christianne; Kok, Joke H; Opmeer, Brent C; Oudijk, Martijn A; Papatsonis, Dimitri N M; Porath, Martina M; Sollie, Krystyna; Spaanderman, Marc E A; Lotgering, Fred K; van der Post, Joris A M; Mol, Ben Willem J (Informa Healthcare, 2016)
    OBJECTIVE: To assess the effect of maintenance tocolysis in women who are at high or low risk for preterm delivery according to fetal fibronectin (fFN) status and cervical length (CL). STUDY DESIGN: We compared the risk ...
  • Comparing human and animal antimicrobial usage: a critical appraisal of the indicators used is needed 
    Sanders, Pim; van Geijlswijk, Ingeborg; Bonten, Marc; Mughini-Gras, Lapo; van Hout, Jobke; Heederik, Dick (Oxford, 2024-02-01)
    Comparisons between antimicrobial usage (AMU) in humans and food-producing animals are regularly made. The accuracy of such comparisons depends on the indicators used to quantify AMU. Indicators for AMU quantitatively ...
  • Determination of the clinical relevance of donor epitope-specific HLA-antibodies in kidney transplantation 
    Kardol-Hoefnagel, Tineke; Senejohnny, Danial Mohammadi; Kamburova, Elena G; Wisse, Bram W; Reteig, Leon; Gruijters, Maartje L; Joosten, Irma; Allebes, Wil A; van der Meer, Arnold; Hilbrands, Luuk B; Baas, Marije C; Spierings, Eric; Hack, Cornelis E; van Reekum, Franka E; van Zuilen, Arjan D; Verhaar, Marianne C; Bots, Michiel L; Drop, Adriaan C A D; Plaisier, Loes; Melchers, Rowena C A; Seelen, Marc A J; Sanders, Jan Stephan; Hepkema, Bouke G; Lambeck, Annechien J A; Bungener, Laura B; Roozendaal, Caroline; Tilanus, Marcel G J; Voorter, Christina E; Wieten, Lotte; van Duijnhoven, Elly M; Gelens, Mariëlle A C J; Christiaans, Maarten H L; van Ittersum, Frans J; Nurmohamed, Shaikh A; Lardy, Neubury M; Swelsen, Wendy; van der Pant, Karlijn A M I; van der Weerd, Neelke C; Ten Berge, Ineke J M; Hoitsma, Andries; van der Boog, Paul J M; de Fijter, Johan W; Betjes, Michiel G H; Roelen, Dave L; Claas, Frans H; Bemelman, Frederike J; Senev, Aleksandar; Naesens, Maarten; Heidt, Sebastiaan; Otten, Henny G (Wiley-Blackwell, 2024-01)
    In kidney transplantation, survival rates are still partly impaired due to the deleterious effects of donor specific HLA antibodies (DSA). However, not all luminex-defined DSA appear to be clinically relevant. Further ...
  • The cycle effect quantified: reduced tumour uptake in subsequent cycles of [177Lu]Lu-HA-DOTATATE during peptide receptor radionuclide therapy 
    Siebinga, H.; Hendrikx, J. J.M.A.; de Vries-Huizing, D. M.V.; Huitema, A. D.R.; de Wit-van der Veen, B. J. (Springer-Verlag, 2024-02)
    Background: Clear evidence regarding the effect of reduced tumour accumulation in later peptide receptor radionuclide therapy (PRRT) cycles is lacking. Therefore, we aimed to quantify potential cycle effects for patients ...
  • A comparison of full model specification and backward elimination of potential confounders when estimating marginal and conditional causal effects on binary outcomes from observational data 
    Luijken, Kim; Groenwold, Rolf H.H.; van Smeden, Maarten; Strohmaier, Susanne; Heinze, Georg (Wiley-VCH Verlag, 2024-01)
    A common view in epidemiology is that automated confounder selection methods, such as backward elimination, should be avoided as they can lead to biased effect estimates and underestimation of their variance. Nevertheless, ...
  • Author reply 
    Vandenberghe, Griet; Vierin, Anne; Bloemenkamp, Kitty; Berlage, Silvia; Colmorn, Lotte; Deneux-Tharaux, Catherine; Donati, Serena; Gissler, Mika; Knight, Marian; Langhoff-Roos, Jens; Lindqvist, Pelle G; Maier, Barbara; van Roosmalen, Jos; Zwart, Joost; Roelens, Kristien; INOSS (the International Network of Obstetrics Survey Systems) (Wiley-Blackwell, 2024-01)
  • Availability of evidence and comparative effectiveness for surgical versus drug interventions: an overview of systematic reviews and meta-analyses 
    Zavalis, Emmanuel A; Rameau, Anaïs; Saraswathula, Anirudh; Vist, Joachim; Schuit, Ewoud; Ioannidis, John P (BMJ Publishing Group, 2024-01-09)
    OBJECTIVES: This study aims to examine the prevalence of comparisons of surgery to drug regimens, the strength of evidence of such comparisons and whether surgery or the drug intervention was favoured. DESIGN: Systematic ...
  • The relationship between ischaemic brain lesions and cognitive outcome after aneurysmal subarachnoid haemorrhage 
    Huenges Wajer, I. M.C.; Hendriks, M. E.; Witkamp, T. D.; Hendrikse, J.; Rinkel, G. J.E.; Visser-Meily, J. M.A.; van Zandvoort, M. J.E.; Vergouwen, M. D.I.; de Vis, J. B. (Springer Science and Business Media Deutschland GmbH, 2019-09-01)
    Background: Cerebral ischaemia is thought to be an important determinant of cognitive outcome after aneurysmal subarachnoid haemorrhage (aSAH), but the exact relationship is unclear. We studied the effect of ischaemic brain ...
  • Glucose phosphate isomerase deficiency demasked by whole-genome sequencing: a case report 
    Holme, Sissel; van Wijk, Richard; Rasmussen, Andreas Ørslev; Petersen, Jesper; Glenthøj, Andreas (BioMed Central, 2024-03-28)
    Background: Glucose-6-phosphate isomerase deficiency is a rare genetic disorder causing hereditary nonspherocytic hemolytic anemia. It is the second most common glycolytic enzymopathy in red blood cells. About 90 cases are ...
  • A genotype-guided strategy for oral P2Y12 inhibitors in primary PCI 
    Claassens, Daniel M.F.; Vos, Gerrit J.A.; Bergmeijer, Thomas O.; Hermanides, Renicus S.; Van’t Hof, Arnoud W.J.; Van Der Harst, Pim; Barbato, Emanuele; Morisco, Carmine; Tjon Joe Gin, Richard M.; Asselbergs, Folkert W.; Mosterd, Arend; Herrman, Jean Paul R.; Dewilde, Willem J.M.; Janssen, Paul W.A.; Kelder, Johannes C.; Postma, Maarten J.; De Boer, Anthonius; Boersma, Cornelis; Deneer, Vera H.M.; ten Berg, Jurriën M. (Massachussetts Medical Society, 2019-10-24)
    BACKGROUND: It is unknown whether patients undergoing primary percutaneous coronary intervention (PCI) benefit from genotype-guided selection of oral P2Y 12 inhibitors. METHODS: We conducted a randomized, open-label, ...
  • Limited Role of the Apparent Diffusion Coefficient (ADC) for Tumor Grade and Overall Survival in Resectable Pancreatic Ductal Adenocarcinoma 
    Riviere, Deniece M.; Maas, Marnix C.; Brosens, Lodewijk A.A.; Stommel, Martijn W.J.; van Laarhoven, Cornelis J.H.M.; Hermans, John J. (MDPI AG, 2024-03)
    This study evaluated the relationship between apparent diffusion coefficient (ADC) values in pancreatic ductal adenocarcinoma (PDAC) and tumor grades based on WHO, Adsay, and Kalimuthu classifications, using whole-mount ...
  • Bivalent binding on cells varies between anti-CD20 antibodies and is dose-dependent 
    Bondza, Sina; ten Broeke, Toine; University, Marika; Leusen, Jeanette; Buijs, Jos (Landes Bioscience, 2020-08-04)
    Based on their mechanism of action, two types of anti-CD20 antibodies are distinguished: Type I, which efficiently mediate complement-dependent cytotoxicity, and Type II, which instead are more efficient in inducing direct ...
  • Corticosteroids and other immunosuppressants for immune-related adverse events and checkpoint inhibitor effectiveness in melanoma 
    Verheijden, Rik J.; Burgers, Femke H.; Janssen, Josephine C.; Putker, Anouk E.; Veenstra, Sophie P.G.R.; Hospers, Geke A.P.; Aarts, Maureen J.B.; Hehenkamp, Karel W.; Doornebosch, Veerle L.E.; Verhaert, Marthe; van den Berkmortel, Franchette W.P.J.; Chatzidionysiou, Katerina; Llobell, Arturo; Barros, Milton; Maria, Alexandre T.J.; Takeji, Akari; García Morillo, José Salvador; Lidar, Merav; van Eijs, Mick J.M.; Blank, Christian U.; Aspeslagh, Sandrine; Piersma, Djura; Kapiteijn, Ellen; Labots, Mariette; Boers-Sonderen, Marye J.; van der Veldt, Astrid A.M.; Haanen, John B.A.G.; May, Anne M.; Suijkerbuijk, Karijn P.M. (Elsevier Limited, 2024-08)
    Background: Recent studies indicate an association between immunosuppression for immune-related adverse events (irAEs) and impaired survival in patients who received immune checkpoint inhibitors. Whether this is related ...
  • Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells 
    Hernández-López, Patricia; van Diest, Eline; Brazda, Peter; Heijhuurs, Sabine; Meringa, Angelo; Hoorens van Heyningen, Lauren; Riillo, Caterina; Schwenzel, Caroline; Zintchenko, Marina; Johanna, Inez; Nicolasen, Mara J T; Cleven, Astrid; Kluiver, Thomas A; Millen, Rosemary; Zheng, Jiali; Karaiskaki, Froso; Straetemans, Trudy; Clevers, Hans; de Bree, Remco; Stunnenberg, Hendrik G; Peng, Weng Chuan; Roodhart, Jeanine; Minguet, Susana; Sebestyén, Zsolt; Beringer, Dennis X; Kuball, Jürgen (Nature Research, 2024-01)
    Few cancers can be targeted efficiently by engineered T cell strategies. Here, we show that γδ T cell antigen receptor (γδ TCR)-mediated cancer metabolome targeting can be combined with targeting of cancer-associated stress ...
  • The efficacy of hyperbaric oxygen therapy related to the clinical stage of osteoradionecrosis of the mandible 
    Dieleman, F. J.; Phan, T.T.T.; van den Hoogen, F.J.A.; Kaanders, Johannes H A M; Merkx, Matthias A W (Churchill Livingstone, 2017-04-01)
    This study aimed to evaluate the success of hyperbaric oxygen therapy (HBOT) and surgery in the treatment of mandibular osteoradionecrosis (ORN) in relation to the extent of the ORN. Twenty-seven patients with ORN were ...
  • Impact of radiation-induced toxicities on quality of life of patients treated for head and neck cancer 
    van der Laan, Hans Paul; Van den Bosch, Lisa; Schuit, Ewoud; Steenbakkers, Roel J H M; van der Schaaf, Arjen; Langendijk, Johannes A (Elsevier Ireland Ltd, 2021-07)
    PURPOSE: The aim of this study is to establish the relative impact of physician-rated toxicities and patient-rated symptoms in head and neck cancer (HNC) on quality of life (QOL) and to weigh the various toxicities and ...
  • Low breastfeeding continuation to 6 months for very preterm infants: A European multiregional cohort study 
    Bonnet, Camille; Blondel, Béatrice; Piedvache, Aurélie; Wilson, Emilija; Bonamy, Anna Karin Edstedt; Gortner, L.; Rodrigues, Carina; van Heijst, Arno; Draper, Elizabeth S.; Cuttini, M.; Zeitlin, J.; Martens, E.; Martens, G.; Van Reempts, P.; Boerch, K.; Hasselager, A.; Huusom, L.; Pryds, O.; Weber, T.; Toome, L.; Varendi, H.; Ancel, P. Y.; Blondel, B.; Burguet, A.; Jarreau, P. H.; Truffert, P.; Maier, R. F.; Misselwitz, B.; Schmidt, S.; Gortner, L.; Baronciani, D.; Gargano, G.; Agostino, R.; DiLallo, D.; Franco, F.; Carnielli, V.; Cuttini, M.; Koopman-Esseboom, C.; Van Heijst, A.; Nijman, J.; Gadzinowski, J.; Mazela, J.; Graça, L. M.; Machado, M. C.; Rodrigues, Carina; Rodrigues, T.; Barros, H.; Bonamy, A. K.; Norman, M.; Wilson, E.; the EPICE Research Group (Wiley-Blackwell Publishing Ltd, 2019-01)
    Breastfeeding confers multiple benefits for the health and development of very preterm infants, but there is scarce information on the duration of breastfeeding after discharge from the neonatal intensive care unit (NICU). ...
  • Entry-level career paths in the life sciences: generic skills in Dutch job postings 
    van Ravenswaaij, Heleen; ter Meulen-de Jong, Sanne; de Kleijn, Renske A.M.; Dilaver, Gonul; van der Schaaf, Marieke F.; van Rijen, Harold V.M. (Taylor and Francis Ltd., 2024)
    The importance of generic skills for life scientists is commonly recognised by employers, graduates, and higher education institutes. As it remains unclear which generic skills are relevant for different life sciences ...