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UMC Repository: Recent submissions

  • VCA supercooling in a swine partial hindlimb model 
    Berkane, Yanis; Filz von Reiterdank, Irina; Tawa, Pierre; Charlès, Laura; Goutard, Marion; Dinicu, Antonia T.; Toner, Mehmet; Bertheuil, Nicolas; Mink van der Molen, Aebele B.; Coert, J. Henk; Lellouch, Alexandre G.; Randolph, Mark A.; Cetrulo, Curtis L.; Uygun, Korkut (Nature Publishing Group, 2024-06-01)
    Vascularized composite allotransplantations are complex procedures with substantial functional impact on patients. Extended preservation of VCAs is of major importance in advancing this field. It would result in improved ...
  • Healthy lifestyle change and all-cause and cancer mortality in the European Prospective Investigation into Cancer and Nutrition cohort 
    Matta, Komodo; Viallon, Vivian; Botteri, Edoardo; Peveri, Giulia; Dahm, Christina; Nannsen, Anne Østergaard; Olsen, Anja; Tjønneland, Anne; Elbaz, Alexis; Artaud, Fanny; Marques, Chloé; Kaaks, Rudolf; Katzke, Verena; Schulze, Matthias B.; Llanaj, Erand; Masala, Giovanna; Pala, Valeria; Panico, Salvatore; Tumino, Rosario; Ricceri, Fulvio; Derksen, Jeroen W.G.; Nøst, Therese Haugdahl; Sandanger, Torkjel M.; Borch, Kristin Benjaminsen; Quirós, J. Ramón; Castro-Espin, Carlota; Sánchez, Maria José; Atxega, Amaia Aizpurua; Cirera, Lluís; Guevara, Marcela; Manjer, Jonas; Tin Tin, Sandar; Heath, Alicia; Touvier, Mathilde; Goldberg, Marcel; Weiderpass, Elisabete; Gunter, Marc J.; Freisling, Heinz; Riboli, Elio; Ferrari, Pietro (BioMed Central Ltd., 2024-05-29)
    Background: Healthy lifestyles are inversely associated with the risk of noncommunicable diseases, which are leading causes of death. However, few studies have used longitudinal data to assess the impact of changing lifestyle ...
  • AmiA and AliA peptide ligands, found in Klebsiella pneumoniae, are imported into pneumococci and alter the transcriptome 
    Lux, Janine; Sánchez García, Lucía; Chaparro Fernández, Patricia; Laloli, Laura; Licheri, Manon F.; Gallay, Clement; Hermans, Peter W.M.; Croucher, Nicholas J.; Veening, Jan Willem; Dijkman, Ronald; Straume, Daniel; Hathaway, Lucy J. (Nature Publishing Group, 2024-05-30)
    Klebsiella pneumoniae releases the peptides AKTIKITQTR and FNEMQPIVDRQ, which bind the pneumococcal proteins AmiA and AliA respectively, two substrate-binding proteins of the ABC transporter Ami-AliA/AliB oligopeptide ...
  • SARS-CoV-2-specific immune responses converge in kidney disease patients and controls with hybrid immunity 
    Aguilar-Bretones, Muriel; den Hartog, Yvette; van Dijk, Laura L.A.; Malahe, S. Reshwan K.; Dieterich, Marjolein; Mora, Héctor Tejeda; Mueller, Yvonne M.; Koopmans, Marion P.G.; Reinders, Marlies E.J.; Baan, Carla C.; van Nierop, Gijsbert P.; de Vries, Rory D.; Abrahams, Alferso C.; Baas, Marije C.; Hemmelder, Marc H.; Bouwmans, Pim; ten Dam, Marc A.G.J.; Gommers, Lennert; de Vries, Aiko P.J. (Nature Publishing Group, 2024-05-28)
    Healthy individuals with hybrid immunity, due to a SARS-CoV-2 infection prior to first vaccination, have stronger immune responses compared to those who were exclusively vaccinated. However, little is known about the ...
  • Safe Stop IPI-NIVO trial: early discontinuation of nivolumab upon achieving a complete or partial response in patients with irresectable stage III or metastatic melanoma treated with first-line ipilimumab-nivolumab – study protocol 
    Janssen, J. C.; van Dijk, B.; de Joode, K.; Aarts, M. J.B.; van den Berkmortel, F. W.P.J.; Blank, C. U.; Boers-Sonderen, M. J.; van den Eertwegh, A. J.M.; de Groot, J. W.B.; Jalving, M.; de Jonge, M. J.A.; Joosse, A.; Kapiteijn, E.; Kamphuis-Huismans, A. M.; Naipal, K. A.T.; Piersma, D.; Rikhof, B.; Westgeest, H. M.; Vreugdenhil, G.; Oomen-de Hoop, E.; Mulder, E. E.A.P.; van der Veldt, Astrid A.M. (BioMed Central, 2024-05-23)
    Background: Patients with irresectable stage III or metastatic melanoma presenting with poor prognostic factors are usually treated with a combination of immune checkpoint inhibitors (ICIs), consisting of ipilimumab and ...
  • Two-year post-distraction cartilage-related structural improvement is accompanied by increased serum full-length SIRT1 
    Marco, Miya; Jansen, Mylène; van der Weiden, Goran; Reich, Eli; Maatuf, Yonathan H.; Mastbergen, Simon C.; Dvir-Ginzberg, Mona (BioMed Central Ltd., 2024-05-24)
    Background: Previously, fragments from Sirtuin 1 (SIRT1) were identified in preclinical and clinical samples to display an increase in serum levels for N-terminal (NT) SIRT1 vs. C-terminal (CT) SIRT1, indicative of early ...
  • Parameter subset reduction for imaging-based digital twin generation of patients with left ventricular mechanical discoordination 
    Koopsen, Tijmen; van Osta, Nick; van Loon, Tim; Meiburg, Roel; Huberts, Wouter; Beela, Ahmed S.; Kirkels, Feddo P.; van Klarenbosch, Bas R.; Teske, Arco J.; Cramer, Maarten J.; Bijvoet, Geertruida P.; van Stipdonk, Antonius; Vernooy, Kevin; Delhaas, Tammo; Lumens, Joost (BioMed Central, 2024-05-13)
    Background: Integration of a patient’s non-invasive imaging data in a digital twin (DT) of the heart can provide valuable insight into the myocardial disease substrates underlying left ventricular (LV) mechanical ...
  • Increased vascular inflammation on PET/CT in psoriatic arthritis patients in comparison with controls 
    Kleinrensink, Nienke J; Spierings, Julia; Vonkeman, Harald E; Seddiqi, Negina; Herman, Amin; Suijkerbuijk, Karijn P M; Heijstek, Marloes W; Jansen, Mylène P; de Jong, Pim A; Foppen, Wouter (BMJ Publishing Group, 2024-01-30)
    Background Patients with psoriatic arthritis (PsA) have an increased risk of cardiovascular disease, possibly due to a chronic inflammatory state. Objectives The main objective of this study was to investigate the difference ...
  • Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci 
    Hodonsky, Chani J; Turner, Adam W; Khan, Mohammad Daud; Barrientos, Nelson B; Methorst, Ruben; Ma, Lijiang; Lopez, Nicolas G; Mosquera, Jose Verdezoto; Auguste, Gaëlle; Farber, Emily; Ma, Wei Feng; Wong, Doris; Onengut-Gumuscu, Suna; Kavousi, Maryam; Peyser, Patricia A; van der Laan, Sander W; Leeper, Nicholas J; Kovacic, Jason C; Björkegren, Johan L M; Miller, Clint L (Cell Press, 2024-01-10)
    Genome-wide association studies (GWASs) have identified hundreds of risk loci for coronary artery disease (CAD). However, non-European populations are underrepresented in GWASs, and the causal gene-regulatory mechanisms ...
  • Critical care beyond organ support: the importance of geriatric rehabilitation 
    Jacobs, Jeremy M.; Rahamim, Ana; Beil, Michael; Guidet, Bertrand; Vallet, Helene; Flaatten, Hans; Leaver, Susannah K.; de Lange, Dylan; Szczeklik, Wojciech; Jung, Christian; Sviri, Sigal (Springer-Verlag GmbH and Co. KG, 2024-05-10)
    Very old critically ill patients pose a growing challenge for intensive care. Critical illness and the burden of treatment in the intensive care unit (ICU) can lead to a long-lasting decline of functional and cognitive ...
  • Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth 
    Hendriks, Delilah; Artegiani, Benedetta; Margaritis, Thanasis; Zoutendijk, Iris; Chuva de Sousa Lopes, Susana; Clevers, Hans (Nature Publishing Group, 2024-05-13)
    Mechanisms underlying human hepatocyte growth in development and regeneration are incompletely understood. In vitro, human fetal hepatocytes (FH) can be robustly grown as organoids, while adult primary human hepatocyte ...
  • Factors influencing presentation delay among cancer patients: a cross-sectional study in Malaysia 
    Gyeltshen, Tshewang; Teh, Hoon Shien; Loo, Ching Ee; Hing, Nicholas Yee Liang; Lim, Wei Yin; Subramaniam, Shridevi; Wong, Wen Jun; Wong, Zoie Shui Yee; Hwong, Wen Yea (BioMed Central, 2024-05-08)
    Background: Cancer represents a significant global public health challenge, with escalating incidence rates straining healthcare systems. Malaysia, like many nations, has witnessed a rise in cancer cases, particularly among ...
  • A novel likely pathogenetic variant p.(Cys235Arg) of the MEN1 gene in multiple endocrine neoplasia type 1 with multifocal glucagonomas 
    Smirne, C; Giacomini, G M; Berton, A M; Pasini, B; Mercalli, F; Prodam, F; Caputo, M; Brosens, L A A; Mollero, E L M; Pitino, R; Pirisi, M; Aimaretti, G; Ghigo, E (Springer Science and Business Media Deutschland GmbH, 2024)
    PURPOSE: Multiple endocrine neoplasia type 1 (MEN1) is a hereditary endocrine syndrome caused by pathogenic variants in MEN1 tumor suppressor gene. Diagnosis is commonly based on clinical criteria and confirmed by genetic ...
  • Oncologic outcomes of screen-detected and non-screen-detected T1 colorectal cancers 
    van der Schee, Lisa; Haasnoot, Krijn Jan Cornelis; Elias, Sjoerd G; Gijsbers, Kim; Alderlieste, Y A; Backes, Yara; van Berkel, Annemarie M; Boersma, Femke; Ter Borg, F; Breekveldt, Emilie C H; Kessels, Koen; Koopman, Miriam; Lansdorp-Vogelaar, Iris; van Leerdam, Monique E; Rasschaert, Gertjan; Schreuder, Ramon Michel; Schrauwen, R W M; Seerden, Tom C J; Spanier, Marcel B W; Terhaar Sive Droste, Jochim S; Toes-Zoutendijk, Esther; Tuynman, Jurriaan; Vink, Geraldine R; de Vos Tot Nederveen Cappel, Wouter H; Vleggaar, Frank P; Lacle, M M; Moons, Leon Mg (Georg Thieme Verlag, 2024-07-01)
    Background The incidence of T1 colorectal cancer (CRC) has increased with the implementation of CRC screening programs. It is unknown whether the outcomes and risk models for T1 CRC based on non-screen-detected patients ...
  • Multi-energy computed tomography based detection of cardiac sarcoidosis - always on 
    de Jong, P A; Vorselaars, A D M; Suchá, D (Oxford University Press, 2024-07)
  • Current challenges in cell and gene therapy: a joint view from the European Committee of the International Society for Cell & Gene Therapy (ISCT) and the European Society for Blood and Marrow Transplantation (EBMT) 
    Sanchez-Guijo, Fermin; Vives, Joaquim; Ruggeri, Annalisa; Chabannon, Christian; Corbacioglu, Selim; Dolstra, Harry; Farge, Dominique; Gagelmann, Nico; Horgan, Claire; Kuball, Jurgen; Neven, Benedicte; Rintala, Tuula; Rocha, Vanderson; Sanchez-Ortega, Isabel; Snowden, John A; Zwaginga, Jaap Jan; Gnecchi, Massimiliano; Sureda, Anna (Informa Healthcare, 2024-07)
    Cell and gene therapy poses evolving challenges. The current article summarizes the discussions held by European Regional Committee of the International Society for Cell & Gene Therapy and the European Society for Blood ...
  • B-cell precursor acute lymphoblastic leukemia elicits an interferon-α/b response in bone marrow-derived mesenchymal stroma 
    Smeets, Mandy W E; Steeghs, Elisabeth M P; Orsel, Jan; Stalpers, Femke; Vermeeren, Myrthe M P; Veltman, Christina H J; Slenders, Lotte; Nierkens, Stefan; Van de Ven, Cesca; Den Boer, Monique L (Ferrata Storti Foundation, 2024-07)
    B-cell precursor acute lymphoblastic leukemia (BCP-ALL) can hijack the normal bone marrow microenvironment to create a leukemic niche which facilitates blast cell survival and promotes drug resistance. Bone marrow-derived ...
  • ASO Visual Abstract: Multimodal Therapy Versus Primary Surgery for Gastric and Gastroesophageal Junction Diffuse Type Carcinoma, with a Focus on Signet Ring Cell Carcinoma: A Nationwide Study 
    Gertsen, Emma C; van der Veen, Arjen; Brenkman, Hylke J F; Brosens, Lodewijk A A; van der Post, Rachel S; Verhoeven, Rob H A; Luijten, Josianne C H B M; Vissers, Pauline A J; Vegt, Erik; van Hillegersberg, Richard; Siersema, Peter D; Ruurda, Jelle P (Springer New York, 2024)
  • Genomics Research of Lifetime Depression in the Netherlands: The BIObanks Netherlands Internet Collaboration (BIONIC) Project 
    Huider, Floris; Milaneschi, Yuri; Hottenga, Jouke-Jan; Bot, Mariska; Rietman, M Liset; Kok, Almar A L; Galesloot, Tessel E; 't Hart, Leen M; Rutters, Femke; Blom, Marieke T; Rhebergen, Didi; Visser, Marjolein; Brouwer, Ingeborg; Feskens, Edith; Hartman, Catharina A; Oldehinkel, Albertine J; de Geus, Eco J C; Kiemeney, Lambertus A; Huisman, Martijn; Picavet, H Susan J; Verschuren, W M Monique; van Loo, Hanna M; Penninx, Brenda W J H; Boomsma, Dorret I (Cambridge University Press, 2024)
    In this cohort profile article we describe the lifetime major depressive disorder (MDD) database that has been established as part of the BIObanks Netherlands Internet Collaboration (BIONIC). Across the Netherlands we ...
  • Engaging in healthy life activities is inherently valuable 
    Speyer, Helene; van Os, Jim (Elsevier Limited, 2024-06)