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UMC Repository: Recent submissions

  • Contemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist 
    Robba, Chiara; Busl, Katharina M; Claassen, Jan; Diringer, Michael N; Helbok, Raimund; Park, Soojin; Rabinstein, Alejandro; Treggiari, Miriam; Vergouwen, Mervyn D I; Citerio, Giuseppe (Springer-Verlag, 2024-05)
    Aneurysmal subarachnoid haemorrhage (aSAH) is a rare yet profoundly debilitating condition associated with high global case fatality and morbidity rates. The key determinants of functional outcome include early brain injury, ...
  • Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial 
    SABATO study group (Elsevier Limited, 2024-05)
    Background: Staphylococcus aureus bloodstream infection is treated with at least 14 days of intravenous antimicrobials. We assessed the efficacy and safety of an early switch to oral therapy in patients at low risk for ...
  • Exploring the interplay between psychotic experiences, functional somatic symptoms and health anxiety in childhood and adolescence - A longitudinal cohort study 
    Rimvall, Martin Køster; Rask, Charlotte Ulrikka; Jensen, Jens Søndergaard; Olsen, Else Marie; Clemmensen, Lars; Skovgaard, Anne Mette; Verhulst, Frank; van Os, Jim; Jeppesen, Pia (Elsevier, 2024-05)
    BACKGROUND: Similarities exist between contemporary explanatory models underlying psychosis development, functional somatic symptoms, and health anxiety. The current study aimed to examine the potential interplay between ...
  • Psychosocial factors, health behaviors and risk of cancer incidence: Testing interaction and effect modification in an individual participant data meta-analysis 
    Basten, Maartje; Pan, Kuan Yu; van Tuijl, Lonneke A.; de Graeff, Alexander; Dekker, Joost; Hoogendoorn, Adriaan W.; Lamers, Femke; Ranchor, Adelita V.; Vermeulen, Roel; Portengen, Lützen; Voogd, Adri C.; Abell, Jessica; Awadalla, Philip; Beekman, Aartjan T.F.; Bjerkeset, Ottar; Boyd, Andy; Cui, Yunsong; Frank, Philipp; Galenkamp, Henrike; Garssen, Bert; Hellingman, Sean; Huisman, Martijn; Huss, Anke; Keats, Melanie R.; Kok, Almar A.L.; Krokstad, Steinar; van Leeuwen, Flora E.; Luik, Annemarie I.; Noisel, Nolwenn; Payette, Yves; Penninx, Brenda W.J.H.; Rissanen, Ina; Roest, Annelieke M.; Rosmalen, Judith G.M.; Ruiter, Rikje; Schoevers, Robert A.; Soave, David; Spaan, Mandy; Steptoe, Andrew; Stronks, Karien; Sund, Erik R.; Sweeney, Ellen; Twait, Emma L.; Teyhan, Alison; Verschuren, W. M.Monique; van der Willik, Kimberly D.; Geerlings, Mirjam I. (John Wiley & Sons Inc., 2024-05-15)
    Depression, anxiety and other psychosocial factors are hypothesized to be involved in cancer development. We examined whether psychosocial factors interact with or modify the effects of health behaviors, such as smoking ...
  • Predictive Performance of a Gentamicin Pharmacokinetic Model in Term Neonates with Perinatal Asphyxia Undergoing Controlled Therapeutic Hypothermia 
    PharmaCool study group (Lippincott Williams & Wilkins, 2024-06-01)
    BACKGROUND: Model validation procedures are crucial when population pharmacokinetic (PK) models are used to develop dosing algorithms and to perform model-informed precision dosing. We have previously published a population ...
  • Hypertensive disorders of pregnancy and cardiovascular disease risk: a Mendelian randomisation study 
    Tschiderer, Lena; van der Schouw, Yvonne T; Burgess, Stephen; Bloemenkamp, Kitty W M; Seekircher, Lisa; Willeit, Peter; Onland-Moret, Charlotte; Peters, Sanne A E (BMJ Publishing Group, 2024-05-01)
    OBJECTIVE: Observational studies show that hypertensive disorders of pregnancy (HDPs) are related to unfavourable maternal cardiovascular disease (CVD) risk profiles later in life. We investigated whether genetic liability ...
  • Three Prospective Case Studies Examining Mifepristone's Efficacy in Patients with Treatment-Resistant PTSD 
    van Minnen, Agnes; Vos, Lizelotte; Bet, Pierre M; de Jongh, Ad; Linsen, Felix; van Marle, Hein J F; Meijer, Onno C; Otte, Willem M; Russcher, Marije; Vinkers, Christiaan H (John Wiley & Sons Inc., 2024)
    Despite the availability of various treatment approaches for patients with posttraumatic stress disorder (PTSD), some patients do not respond to these therapies, and novel treatment approaches are needed. This study ...
  • "An invitation to think differently": a narrative medicine intervention using books and films to stimulate medical students' reflection and patient-centeredness 
    Leijenaar, Elsemarijn; Eijkelboom, Charlotte; Milota, Megan (BioMed Central, 2023-08-11)
    BACKGROUND: Narrative medicine purports to improve medical students' communication skills, self-reflection, empathy and professional development. These interpersonal skills and attitudes can facilitate more patient-centered ...
  • Ultra-fast deep-learned CNS tumour classification during surgery 
    Vermeulen, C.; Pagès-Gallego, M.; Kester, L.; Kranendonk, M. E.G.; Wesseling, P.; Verburg, N.; de Witt Hamer, P.; Kooi, E. J.; Dankmeijer, L.; van der Lugt, J.; van Baarsen, K.; Hoving, E. W.; Tops, B. B.J.; de Ridder, J. (Nature Research, 2023-10-26)
    Central nervous system tumours represent one of the most lethal cancer types, particularly among children1. Primary treatment includes neurosurgical resection of the tumour, in which a delicate balance must be struck between ...
  • Angiogenic factors and the lectin pathway of complement in women with secondary recurrent pregnancy loss 
    Krog, M. C.; Flachs, E. M.; Kolte, A. M.; de Jager, W.; Meyaard, L.; Christiansen, O. B.; Steffensen, R.; Vomstein, K.; Garred, P.; Nielsen, H. S. (Elsevier Ireland Ltd, 2024-06)
    The poor remodeling of placental spiral arteries seen in preeclampsia is also discussed to contribute to recurrent pregnancy loss (RPL) preceded by abnormal angiogenesis and excessive complement activation. Low levels of ...
  • Intracellular localisation and extracellular release of Y RNA and Y RNA binding proteins 
    Driedonks, Tom A P; Ressel, Sarah; Tran Ngoc Minh, Thi; Buck, Amy H; Nolte-'t Hoen, Esther N M (John Wiley & Sons Inc., 2024-01-16)
    Cells can communicate via the release and uptake of extracellular vesicles (EVs), which are nano-sized membrane vesicles that can transfer protein and RNA cargo between cells. EVs contain microRNAs and various other types ...
  • A patient’s perspective on care decisions: a qualitative interview study 
    Briedé, Saskia; Brandwijk, Odila N; van Charldorp, Tessa; Kaasjager, Karin (BioMed Central, 2023-12-01)
    Background and Objectives Discussing treatment wishes and limitations during medical consultations aims to enable patients to define goals and preferences for future care. Patients and physicians, however, face multiple ...
  • Patient-reported needs for coping with worry or fear about cancer recurrence and the extent to which they are being met: a survey study 
    Luigjes-Huizer, Yvonne L.; van der Lee, Marije L.; Richel, Carol; Masselink, Roel A.; de Wit, Niek J.; Helsper, Charles W. (Springer, 2024-06)
    Purpose: Many cancer patients and survivors experience fear or worry about cancer recurrence (FCR). Evidence suggests support for FCR is their largest unmet need. We aimed to assess which types of support are needed, which ...
  • Predicting the next pandemic: VACCELERATE ranking of the World Health Organization's Blueprint for Action to Prevent Epidemics 
    Salmanton-García, Jon; Wipfler, Pauline; Leckler, Janina; Nauclér, Pontus; Mallon, Patrick W.; Bruijning-Verhagen, Patricia C.J.L.; Schmitt, Heinz Joseph; Bethe, Ullrich; Olesen, Ole F.; Stewart, Fiona A.; Albus, Kerstin; Cornely, Oliver A.; Busch, Martin; Seifert, Ulrike; Widmer, Andreas; Nagao, Miki; Rello, Jordi; Todorova, Tatina; Cviljević, Sabina; Heath, Christopher H.; Jančorienė, Ligita; Fischer, Thea Koelsen; Orth, Hans Martin; Johansen, Isik Somuncu; Doymaz, Mehmet; Tragiannidis, Athanasios; Löscher, Thomas; Xu, Jin Fu; Husa, Petr; Oteo, José Antonio; Issack, Mohammad I.; Zeitlinger, Markus; Le Grand, Roger; Zdziarski, Przemysław; Demirkan, Fatih; Amador, Paloma Merino; García-Lozano, Tomás; Cao, Qing; Vázquez, Lourdes; Caeiro, Juan Pablo; Hermans, Peter; Nahrwar, Shahroch; Avsar, Korkut; Kumar, Deepak; Fernández, Norma; Mardani, Masoud; Segal, Esther; Pan, Angelo; Gkentzi, Despoina; Gioula, Georgia; Cortés, Jorge Alberto; Oliveira, Joaquim; van Damme, Pierre; Bin Mohd Zaili, Mohd Zaki; Antinori, Spinello; Zablockienė, Birutė; Papazisis, Georgios; Aneke, Chioma Inyang; Valerio, Maricela; McConkey, Samuel; Aujayeb, Avinash; Azzini, Anna Maria; Roganović, Jelena; Greve-Isdahl Mohn, Kristin; Kremsner, Peter; Gkrania-Klotsas, Effrossyni; Corzo, Dora; Khanna, Nina; Smiatacz, Tomasz; Scheithauer, Simone; Merelli, Maria; Klempa, Boris; Vrḫovac, Radovan; Ruggiero, Antonio; Chaudhary, Pankaj; Maquera-Afaray, Julio; Ekkelenkamp, Miquel; Jindra, Pavel; Pantić, Nikola; Guerra, Gemma Jiménez; Weiss, Guenter; Roohi, Behrad; Argyropoulos, Christos D.; Silfverdal, Sven Aprne; van Praet, Jens; Bal, Zumrut Sahbudak; Kanj, Souha; Young, Barnaby; Pana, Zoi Dorothea; Roilides, Emmanuel; Stearns, Stephen C.; Wauters, Joost; Baño, Jesús Rodríguez; Pletz, Mathias W.; Travar, Maja; Kühn, Steven; Riera, Fernando; Cornely, Daniel; Laura, Vlad Jeni; Koehler, Philipp; Eley, Brian; Nair, Pravin K.; Ciesek, Sandra; Olaru, Ioana Diana; Marques, Laura; Pontali, Emanuele; Naunheim, Alexandra; Lieb, Adrian; Gerhard, Markus; Farooqi, Joveria Qais; Turtle, Lance; Méndez, Gustavo Adolfo; Cox, Rebecca Jane; Goodman, Nigel; Caceca, Billie; Pemán, Javier; Dawood, Halima; Askling, Helena Hervius; Fomsgaard, Anders; Hernández, Alejandra Calderón; Staehelin, Cornelia; Liu, Chia Ying; Icardi, Giancarlo; Castagnola, Elio; Salzer, Helmut J.F.; Lundgren, Jens; Javadli, Samir; Forghieri, Fabio (Elsevier, 2024-01-01)
    Introduction: The World Health Organization (WHO)'s Research and Development (R&D) Blueprint for Action to Prevent Epidemics, a plan of action, highlighted several infectious diseases as crucial targets for prevention. ...
  • m6A Reader YTHDC1 Impairs Respiratory Syncytial Virus Infection by Downregulating Membrane CX3CR1 Expression 
    Picavet, Lucas W.; van Vroonhoven, Ellen C.N.; Scholman, Rianne C.; Smits, Yesper T.H.; Banerjee, Rupa; Besteman, Sjanna B.; Viveen, Mattheus C.; van der Vlist, Michiel M.; Tanenbaum, Marvin E.; Lebbink, Robert J.; Vastert, Sebastiaan J.; van Loosdregt, Jorg (Multidisciplinary Digital Publishing Institute (MDPI), 2024-05)
    Respiratory syncytial virus (RSV) is the most prevalent cause of acute lower respiratory infection in young children. Currently, the first RSV vaccines are approved by the FDA. Recently, N6-methyladenosine (m6A) RNA ...
  • Past or Present; Which Exposures Predict Metabolomic Aging Better?: The Doetinchem Cohort Study 
    Smit, Annelot P; Herber, Gerrie-Cor M; Kuiper, Lieke M; Loef, Bette; Picavet, H Susan J; Verschuren, W M Monique (Oxford University Press, 2024-02-01)
    People age differently. Differences in aging might be reflected by metabolites, also known as metabolomic aging. Predicting metabolomic aging is of interest in public health research. However, the added value of longitudinal ...
  • The effect of six-month oral vitamin K supplementation on calcification propensity time in individuals with type 2 diabetes mellitus: A post hoc analysis of a randomized, double-blind, placebo-controlled trial 
    Meer, R.; Romero Prats, M. L.; Vervloet, M. G.; van der Schouw, Y. T.; de Jong, P. A.; Beulens, J. W.J. (Elsevier, 2024-07)
    Background and aims: Experimental studies suggested that vitamin K supplementation may retard arterial calcification. Recently, serum calcification propensity time (T50) has been suggested as a functional biomarker for ...
  • Histological chorioamnionitis and funisitis as new risk factors for retinopathy of prematurity: a meta-analysis 
    El Emrani, Salma; Smit-Jansen, Esther; Goeman, Jelle; Lopriore, Enrico; Termote, Jacqueline; Schalij-Delfos, Nicoline; Van Der Meeren, Lotte (Thieme Medical Publishers, 2024-05)
    Objective The role of placental inflammation in neonatal morbidities is underestimated due to lack of placental examination. This meta-analysis aims to assess the association between histological chorioamnionitis (HCA) ...
  • Pharmacokinetics, pharmacodynamics, efficacy, and safety of ravulizumab in pediatric paroxysmal nocturnal hemoglobinuria 
    Chonat, Satheesh; Kulagin, Alexander; Maschan, Alexey; Bartels, Marije; Buechner, Jochen; Punzalan, Rowena; Richards, Michael; Ogawa, Masayo; Hicks, Eden; Yu, Ji; Baruchel, André; Kulasekararaj, Austin G (The American Society of Hematology, 2024-06-11)
    Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disease of uncontrolled terminal complement activation leading to intravascular hemolysis, thrombotic events and increased morbidity and mortality. This phase ...
  • Metabolic blood profile and response to treatment with the pyruvate kinase activator mitapivat in patients with sickle cell disease 
    van Dijk, Myrthe J; Ruiter, Titine J J; van der Veen, Sigrid; Rab, Minke A E; van Oirschot, Brigitte A; Bos, Jennifer; Derichs, Cleo; Rijneveld, Anita W; Cnossen, Marjon H; Nur, Erfan; Biemond, Bart J; Bartels, Marije; Schutgens, Roger E G; van Solinge, Wouter W; Jans, Judith J M; van Beers, Eduard J; van Wijk, Richard (Wolters Kluwer Health, 2024-06)
    Mitapivat is an investigational, oral, small-molecule allosteric activator of pyruvate kinase (PK). PK is a regulatory glycolytic enzyme that is key in providing the red blood cell (RBC) with sufficient amounts of adenosine ...