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Now showing items 6521-6540 of 40729

Incidence, survival, and mortality of cancer in children and young adolescents in Belgium and the Netherlands in 2004–2015: A comparative population-based study

Peirelinck, Hanne; Schulpen, Maya; Hoogendijk, Raoull; Van Damme, An; Pieters, Rob; Henau, Kris; Van Damme, Nancy; Karim-Kos, Henrike E. (John Wiley & Sons Inc., 2024-07-15)

International comparisons of cancer surveillance measures may provide insight into inequalities in registration practices, etiological factors, and treatment strategies. This study aimed to compare incidence, survival, and ...
Tacrolimus versus mycophenolate for AutoImmune hepatitis patients with incompLete response On first-line therapy (TAILOR study): a study protocol for a phase III, open-label, multicentre, randomised controlled trial

Stoelinga, Anna E.C.; Tushuizen, Maarten E.; van den Hout, Wilbert B.; Girondo, Mar D.M.Rodriguez; de Vries, Elsemieke S.; Levens, Amar D.; Moes, Dirk Jan A.R.; Gevers, Tom J.G.; van der Meer, Suzanne; Brouwer, Hans T.; de Jonge, Hendrik J.M.; de Boer, Ynte S.; Beuers, Ulrich H.W.; van der Meer, Adriaan J.; van den Berg, Aad P.; Guichelaar, Maureen M.J.; Drenth, Joost P.H.; van Hoek, Bart; on behalf of the Dutch Autoimmune Hepatitis Group (BioMed Central, 2024-01-17)

Background: Autoimmune hepatitis (AIH) is a rare, chronic inflammatory disease of the liver. The treatment goal is reaching complete biochemical response (CR), defined as the normalisation of aspartate and alanine ...
A multipurpose, adolescent idiopathic scoliosis-specific, short MRI protocol: A feasibility study in volunteers

Shcherbakova, Yulia M.; Lafranca, Peter P.G.; Foppen, Wouter; van der Velden, Tijl A.; Nievelstein, Rutger A.J.; Castelein, Rene M.; Ito, Keita; Seevinck, Peter R.; Schlosser, Tom P.C. (Elsevier Ireland Ltd, 2024-08)

Introduction: Visualization of scoliosis typically requires ionizing radiation (radiography and CT) to visualize bony anatomy. MRI is often additionally performed to screen for neural axis abnormalities. We propose a ...
Development and validation of an ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of the antimalarial drug pyronaridine in human whole blood

Schouten, Wietse M.; Roseboom, Ignace C.; Lucas, Luc; Kabalu Tshiongo, Japhet; Muhindo Mavoko, Hypolite; Kayentao, Kassoum; Rosing, Hilde; Huitema, Alwin D.R.; Beijnen, Jos H.; Dorlo, Thomas P.C. (Elsevier, 2024-08-01)

Malaria remains a major health concern, aggravated by emerging resistance of the parasite to existing treatments. The World Health Organization recently endorsed the use of artesunate-pyronaridine to treat uncomplicated ...
Binucleated human hepatocytes arise through late cytokinetic regression during endomitosis M phase

Darmasaputra, Gabriella S.; Geerlings, Cindy C.; Chuva de Sousa Lopes, Susana M.; Clevers, Hans; Galli, Matilde (Rockefeller University Press, 2024-08-05)

Binucleated polyploid cells are common in many animal tissues, where they arise by endomitosis, a non-canonical cell cycle in which cells enter M phase but do not undergo cytokinesis. Different steps of cytokinesis have ...
Identifying factors in the provision of intravenous stroke thrombolysis in Malaysia: a multiple case study from the healthcare providers’ perspective

Hwong, Wen Yea; Ng, Sock Wen; Tong, Seng Fah; Ab Rahman, Norazida; Law, Wan Chung; Wong, Sing Keat; Puvanarajah, Santhi Datuk; Mohd Norzi, Aisyah; Lian, Fiona Suling; Sivasampu, Sheamini (BioMed Central, 2024-01-05)

Background: Translation into clinical practice for use of intravenous thrombolysis (IVT) for the management of ischemic stroke remains a challenge especially across low- and middle-income countries, with regional inconsistencies ...
Trial Participation in Neurodegenerative Diseases: Barriers and Facilitators: A Systematic Review and Meta-Analysis

Weemering, Daphne N.; Beelen, Anita; Kliest, Tessa; van Leeuwen, Lucie A.G.; van den Berg, Leonard H.; van Eijk, Ruben P.A. (Lippincott Williams & Wilkins, 2024-07-09)

BACKGROUND AND OBJECTIVES: Clinical trials in neurodegenerative diseases often encounter selective enrollment and under-representation of certain patient populations. This delays drug development and substantially limits ...
Intentional intoxication with monkshood plant leading to atrioventricular dissociation and ventricular ectopy in a 17-year-old female: a case report

Klokman, V. W.; Tempelaar, S.; Kuipers, B.C.W.; van Dijk, I. A.G.; Moviat, M. A.M. (Springer London, 2024-02-08)

Background: Monkshood, a toxic plant containing a potent cardio- and neurotoxin called aconitine, can lead to a range of symptoms, including nausea, vomiting, dizziness, seizures, and cardiac arrhythmias. Mortality associated ...
Pseudoxanthoma elasticum – Genetics, pathophysiology, and clinical presentation

Pfau, Kristina; Lengyel, Imre; Ossewaarde-van Norel, Jeannette; van Leeuwen, Redmer; Risseeuw, Sara; Leftheriotis, Georges; Scholl, Hendrik P.N.; Feltgen, Nicolas; Holz, Frank G.; Pfau, Maximilian (Elsevier Limited, 2024-09)

Pseudoxanthoma elasticum (PXE) is an autosomal-recessively inherited multisystem disease. Mutations in the ABCC6-gene are causative, coding for a transmembrane transporter mainly expressed in hepatocytes, which promotes ...
The effects of achievement goal instructions in game-based learning on students’ achievement goals, performance, and achievement emotions

Hu, Yuanyuan; Wouters, Pieter; van der Schaaf, Marieke; Kester, Liesbeth (Elsevier, 2024-10)

Background: Achievement goal instructions are instructions that assign the learners’ achievement goals beforehand, such as mastery-approach goal instructions that emphasize “to learn as much as possible” and performance-approach ...
Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

COVID Human Genetic Effort; COVIDeF Study Group; French COVID Cohort Study Group; CoV-Contact Cohort; COVID-STORM Clinicians; COVID Clinicians; Orchestra Working Group; Amsterdam UMC COVID-19 Biobank; NIAID-USUHS COVID Study Group (Elsevier, 2024-07-18)

Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and ...
ELISA assay for the quantification of ipilimumab in human serum, plasma, milk, and cerebrospinal fluid

Pluim, Dick; Buitelaar, Pauline; de Jong, Karen A.M.; Rosing, Hilde; Brandsma, Dieta; Huitema, Alwin D.R.; Beijnen, Jos H. (Elsevier, 2024-08-01)

Ipilimumab is an immune checkpoint inhibitor of the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Ipilimumab has become part of the standard of care for different types of cancer. The efficacy of these treatments ...
Health-related quality of life one year after refractory cardiac arrest treated with conventional or extracorporeal CPR; a secondary analysis of the INCEPTION-trial

van de Koolwijk, Anina F.; Delnoij, Thijs S.R.; Suverein, Martje M.; Essers, Brigitte A.B.; Hermanides, Renicus C.; Otterspoor, Luuk C.; Elzo Kraemer, Carlos V.; Vlaar, Alexander P.J.; van der Heijden, Joris J.; Scholten, Erik; den Uil, Corstiaan A.; Dos Reis Miranda, Dinis; Akin, Sakir; de Metz, Jesse; van der Horst, Iwan C.C.; Winkens, Bjorn; Maessen, Jos G.; Lorusso, Roberto; van de Poll, Marcel C.G.; INCEPTION-investigators (2024-09)

Background: Prospective, trial-based data comparing health-related quality of life (HRQoL) in patients surviving out-of-hospital cardiac arrest (OHCA) through extracorporeal cardiopulmonary resuscitation (ECPR) or conventional ...
Navigating meaningful engagement: lessons from partnering with youth and families in brain-based disability research

Nguyen, Linda; Pozniak, Kinga; Strohm, Sonya; Havens, Jessica; Dawe-McCord, Claire; Thomson, Donna; Putterman, Connie; Arafeh, Dana; Galuppi, Barb; Ley, Alicia Via Dufresne; Doucet, Shelley; Amaria, Khush; Kovacs, Adrienne H.; Marelli, Ariane; Rozenblum, Ronen; Gorter, Jan Willem; CHILD-BRIGHT READYorNot™ Brain-Based Disabilities Trial Study Group (BioMed Central Ltd., 2024-02-05)

Background: While patient and family engagement in research has become a widespread practice, meaningful and authentic engagement remains a challenge. In the READYorNot™ Brain-Based Disabilities Study, we developed the ...
Role of the vessel morphology on the lenticulostriate arteries hemodynamics during atrial fibrillation: A CFD-based multivariate regression analysis

Saglietto, Andrea; Tripoli, Francesco; Zwanenburg, Jaco; Biessels, Geert Jan; De Ferrari, Gaetano Maria; Anselmino, Matteo; Ridolfi, Luca; Scarsoglio, Stefania (Elsevier Ireland Ltd, 2024-09)

BACKGROUND AND OBJECTIVE: Atrial fibrillation (AF) is the most common cardiac arrhythmia, inducing accelerated and irregular beating. Beside well-known disabling symptoms - such as palpitations, reduced exercise tolerance, ...
METhodological RadiomICs Score (METRICS): a quality scoring tool for radiomics research endorsed by EuSoMII

Kocak, Burak; Akinci D’Antonoli, Tugba; Mercaldo, Nathaniel; Alberich-Bayarri, Angel; Baessler, Bettina; Ambrosini, Ilaria; Andreychenko, Anna E.; Bakas, Spyridon; Beets-Tan, Regina G.H.; Bressem, Keno; Buvat, Irene; Cannella, Roberto; Cappellini, Luca Alessandro; Cavallo, Armando Ugo; Chepelev, Leonid L.; Chu, Linda Chi Hang; Demircioglu, Aydin; deSouza, Nandita M.; Dietzel, Matthias; Fanni, Salvatore Claudio; Fedorov, Andrey; Fournier, Laure S.; Giannini, Valentina; Girometti, Rossano; Groot Lipman, Kevin B.W.; Kalarakis, Georgios; Kelly, Brendan S.; Klontzas, Michail E.; Koh, Dow Mu; Kotter, Elmar; Lee, Ho Yun; Maas, Mario; Marti-Bonmati, Luis; Müller, Henning; Obuchowski, Nancy; Orlhac, Fanny; Papanikolaou, Nikolaos; Petrash, Ekaterina; Pfaehler, Elisabeth; Pinto dos Santos, Daniel; Ponsiglione, Andrea; Sabater, Sebastià; Sardanelli, Francesco; Seeböck, Philipp; Sijtsema, Nanna M.; Stanzione, Arnaldo; Traverso, Alberto; Ugga, Lorenzo; Vallières, Martin; van Dijk, Lisanne V.; van Griethuysen, Joost J.M.; van Hamersvelt, Robbert W.; van Ooijen, Peter; Vernuccio, Federica; Wang, Alan; Williams, Stuart; Witowski, Jan; Zhang, Zhongyi; Zwanenburg, Alex; Cuocolo, Renato (Springer Science and Business Media Deutschland GmbH, 2024-01-17)

Purpose: To propose a new quality scoring tool, METhodological RadiomICs Score (METRICS), to assess and improve research quality of radiomics studies. Methods: We conducted an online modified Delphi study with a group of ...
Designing tailored maintenance strategies for systematic reviews and clinical practice guidelines using the Portfolio Maintenance by Test-Treatment (POMBYTT) framework

Oerbekke, Michiel S.; Elbers, Roy G.; van der Laan, Maarten J.; Hooft, Lotty (BioMed Central, 2024-02-02)

Background: Organizations face diverse contexts and requirements when updating and maintaining their portfolio, or pool, of systematic reviews or clinical practice guidelines they need to manage. We aimed to develop a ...
The association of obesogenic environments with weight status, blood pressure, and blood lipids: A cross-sectional pooled analysis across five cohorts

Meijer, Paul; Lam, Thao Minh; Vaartjes, Ilonca; Moll van Charante, Eric; Galenkamp, Henrike; Koster, Annemarie; van den Hurk, Katja; den Braver, Nicole R.; Blom, Marieke T.; de Jong, Trynke; Grobbee, Diederick E.; Beulens, Joline WJ; Lakerveld, Jeroen; GECCO Consortium (Academic Press Inc., 2024-09-01)

In this observational cross-sectional study, we investigated the relationship between combined obesogenic neighbourhood characteristics and various cardiovascular disease risk factors in adults, including BMI, systolic ...
Resistance of HNSCC cell models to pan-FGFR inhibition depends on the EMT phenotype associating with clinical outcome

Broghammer, Felix; Korovina, Irina; Gouda, Mahesh; Celotti, Martina; van Es, Johan; Lange, Inga; Brunner, Cornelia; Mircetic, Jovan; Coppes, Robert P.; Gires, Olivier; Dahl, Andreas; Seifert, Michael; Cordes, Nils (BioMed Central, 2024-02-21)

Background: Focal adhesion signaling involving receptor tyrosine kinases (RTK) and integrins co-controls cancer cell survival and therapy resistance. However, co-dependencies between these receptors and therapeutically ...
From signalling oscillations to somite formation

Meijer, Wilke H.M.; Sonnen, Katharina F. (Elsevier, 2024-12)

Periodic segmentation of vertebrate embryos or somitogenesis is regulated by a dynamic network of signalling pathways. Signalling gradients determine the spacing of the forming segments, while signalling oscillations, ...

Now showing items 6521-6540 of 40729