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UMC Repository: Recent submissions

  • Vertebrate centromere architecture: from chromatin threads to functional structures 
    Andrade Ruiz, Lorena; Kops, Geert J.P.L.; Sacristan, Carlos (Springer Science and Business Media Deutschland GmbH, 2024-07)
    Centromeres are chromatin structures specialized in sister chromatid cohesion, kinetochore assembly, and microtubule attachment during chromosome segregation. The regional centromere of vertebrates consists of long regions ...
  • Hypothermic and cryogenic preservation of cardiac tissue-engineered constructs 
    Janssen, Jasmijn; Chirico, Nino; Ainsworth, Madison J; Cedillo-Servin, Gerardo; Viola, Martina; Dokter, Inge; Vermonden, Tina; Doevendans, Pieter A; Serra, Margarida; Voets, Ilja K; Malda, Jos; Castilho, Miguel; van Laake, Linda W; Sluijter, Joost P G; Sampaio-Pinto, Vasco; van Mil, Alain (Royal Society of Chemistry, 2024-07-23)
    Cardiac tissue engineering (cTE) has already advanced towards the first clinical trials, investigating safety and feasibility of cTE construct transplantation in failing hearts. However, the lack of well-established ...
  • Virological failure after switch to long-acting cabotegravir and rilpivirine injectable therapy: an in-depth analysis 
    van Welzen, Berend J; Van Lelyveld, Steven F L; Ter Beest, Gerjanne; Gisolf, Jet H; Geerlings, Suzanne E; Prins, Jan M; Van Twillert, Gitte; Van Nieuwkoop, Cees; Van der Valk, Marc; Burger, David; Wensing, Annemarie M J (Oxford University Press, 2024-07-15)
    Background. Long-acting (LA) injectable therapy with cabotegravir (CAB) and rilpivirine (RPV) is currently used as maintenance treatment for human immunodeficiency virus type 1, and has a low risk for virological failure ...
  • Mitochondrial Transport from Mesenchymal Stromal Cells to Chondrocytes Increases DNA Content and Proteoglycan Deposition In Vitro in 3D Cultures 
    Korpershoek, Jasmijn V.; Rikkers, Margot; Wallis, Fleur S.A.; Dijkstra, Koen; te Raa, Marije; de Knijff, Peter; Saris, Daniel B.F.; Vonk, Lucienne A. (SAGE Publications Inc., 2022-12)
    Objective: Allogeneic mesenchymal stromal cells (MSCs) are used in the 1-stage treatment of articular cartilage defects. The aim of this study is to investigate whether transport of mitochondria exists between chondrocytes ...
  • Prevotella timonensis Bacteria Associated With Vaginal Dysbiosis Enhance Human Immunodeficiency Virus Type 1 Susceptibility Of Vaginal CD4 + T Cells 
    van Teijlingen, Nienke H; van Smoorenburg, Marleen Y; Sarrami-Forooshani, Ramin; Zijlstra-Willems, Esther M; van Hamme, John L; Borgdorff, Hanneke; van de Wijgert, Janneke Hhm; van Leeuwen, Elisabeth; van der Post, Joris A M; Strijbis, Karin; Ribeiro, Carla M S; Geijtenbeek, Teunis B H (Oxford University Press, 2024-07-15)
    Dysbiosis of the vaginal microbiome poses a serious risk for sexual human immunodeficiency virus type 1 (HIV-1) transmission. Prevotella spp are abundant during vaginal dysbiosis and associated with enhanced HIV-1 ...
  • Detection of acute coronary occlusion with a novel mobile electrocardiogram device: a pilot study 
    Zepeda Echavarria, Alejandra; van de Leur, Rutger; Vessies, Melle; de Vries, Nynke M; van Sleuwen, Meike; Hassink, Rutger; Wildbergh, Thierry X.; Doevendans, PA; Jaspers, JEN; van Es, René (Oxford University Press, 2024-03)
    Aims Many portable electrocardiogram (ECG) devices have been developed to monitor patients at home, but the majority of these devices are single lead and only intended for rhythm disorders. We developed the miniECG, a ...
  • A view from the clinic – Perspectives from Dutch patients and professionals on high myopia care 
    Ravenstijn, Monica; du Bois, Gerlof; Jansen, Ritsert C.; Liu, Chang; Luyten, Gregorius P.M.; van Leeuwen, Redmer; Dickman, Mor M.; Reus, Nic J.; Yzer, Suzanne; Klaver, Caroline C.W. (Wiley-Blackwell, 2023-05)
    Purpose: To understand and compare perspectives of patients and professionals on current ophthalmologic care for high myopia, and to identify challenges and future opportunities. Methods: Self-reported data were collected ...
  • Progressive demyelinating polyneuropathy after hematopoietic cell transplantation in metachromatic leukodystrophy: a case series 
    Beerepoot, Shanice; Boelens, Jaap Jan; Lindemans, Caroline; de Witte, Moniek A; Nierkens, Stefan; Vrancken, Alexander F J E; van der Knaap, Marjo S; Bugiani, Marianna; Wolf, Nicole I (Springer Science and Business Media Deutschland GmbH, 2024-07)
    Metachromatic leukodystrophy (MLD) is a neuro-metabolic disorder due to arylsulfatase A deficiency, causing demyelination of the central and peripheral nervous system. Hematopoietic cell transplantation (HCT) can provide ...
  • Estimating Surgical Urethral Length on Intraoperative Robot-Assisted Prostatectomy Images using Artificial Intelligence Anatomy Recognition 
    Bakker, Franciscus Hendericus Aäron; de Nijs, Joris V; Jaspers, Tim J M; de With, Peter H N; Beulens, Alexander J W; van der Poel, Henk; van der Sommen, Fons; Brinkman, Willem M (Mary Ann Liebert Inc., 2024-07)
    Objective: To construct a convolutional neural network (CNN) model that can recognize and delineate anatomic structures on intraoperative video frames of robot-assisted radical prostatectomy (RARP) and to use these annotations ...
  • The Global Reading Room: A Patient With Neuroendocrine Liver Metastases After Pancreaticoduodenectomy 
    Braat, A J A T; Kim, Hyo-Cheol; Vogl, Thomas J; White, Sarah B (American Roentgen Ray Society, 2024-06)
  • Dupilumab provides sustained effectiveness on patient-reported outcomes and favorable safety in patients with moderate-to-severe atopic dermatitis: up to 5-year results from the daily practice BioDay Registry 
    Zhang, Junfen; Boesjes, Celeste M; Loman, Laura; Kamphuis, Esmé; Romeijn, Margreet L E; Spekhorst, Lotte S; Haeck, Inge; van der Gang, Lian F; Dekkers, Coco C; van der Rijst, Lisa P; Oosting, Albert J; van Lumig, Paula; van Lynden-van Nes, Anneke M T; Tupker, Ron A; Nijssen, Annieke; Flinterman, Annebeth; Politiek, Klaziena; Touwslager, Wouter R H; Christoffers, Wianda A; Stewart, Shiarra M; Kamsteeg, Marijke; de Graaf, Marlies; de Bruin-Weller, Marjolein S; Schuttelaar, Marie-Louise A (Mosby Inc., 2024-08)
    Background: Long-term daily practice data on patient-reported benefits of dupilumab for atopic dermatitis (AD) remains limited. Objective: To evaluate patient-reported outcome measures (PROMs) and the safety of dupilumab ...
  • Atherosclerotic plaque-specific methylation biomarkers in plasma cell-free DNA of female and male patients with coronary artery disease 
    Diez Benavente, Ernest; Sakkers, Tim R; van der Harst, Pim; den Ruijter, Hester M (Oxford University Press, 2024-07-21)
  • Rare and common genetic determinants of mitochondrial function determine severity but not risk of amyotrophic lateral sclerosis 
    Harvey, Calum; Weinreich, Marcel; Lee, James A.K.; Shaw, Allan C.; Ferraiuolo, Laura; Mortiboys, Heather; Zhang, Sai; Hop, Paul J.; Zwamborn, Ramona A.J.; van Eijk, Kristel; Julian, Thomas H.; Moll, Tobias; Iacoangeli, Alfredo; Al Khleifat, Ahmad; Quinn, John P.; Pfaff, Abigail L.; Kõks, Sulev; Poulton, Joanna; Battle, Stephanie L.; Arking, Dan E.; Snyder, Michael P.; Veldink, Jan H.; Kenna, Kevin P.; Shaw, Pamela J.; Cooper-Knock, Johnathan; Project MinE ALS Sequencing Consortium (Elsevier, 2024-02-15)
    Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving selective vulnerability of energy-intensive motor neurons (MNs). It has been unclear whether mitochondrial function is an upstream driver ...
  • Patient-reported outcomes after free muscle flap coverage for therapy-resistant neuropathic pain from the ulnar nerve 
    List, Emile B.; Boers, Nadine; Martin, Enrico; Krijgh, David D.; Henk Coert, J. (SAGE Publications Ltd, 2024-02)
    Extensive microsurgical neurolysis followed by free gracilis muscle flap coverage can be performed as a last resort for patients with persistent neuropathic pain of the ulnar nerve. All patients who had this surgery between ...
  • Predicting the risks and recognizing the signs: a two-year prospective population-based study on pregnant women with uterine rupture in The Netherlands 
    Overtoom, E. M.; Huynh, T. N.; Rosman, A. N.; Zwart, J. J.; Schaap, T. P.; Vogelvang, T. E.; van den Akker, T.; Bloemenkamp, K. W.M. (Informa Healthcare, 2024-12)
    Objective: To estimate the incidence of uterine rupture in the Netherlands and evaluate risk indicators prelabour and during labor of women with adverse maternal and/or perinatal outcome. Methods: This is a population-based ...
  • Lack of complete biochemical response in autoimmune hepatitis leads to adverse outcome: First report of the IAIHG retrospective registry 
    Slooter, Charlotte D.; Van Den Brand, Floris F.; Lleo, Ana; Colapietro, Francesca; Lenzi, Marco; Muratori, Paolo; Kerkar, Nanda; Dalekos, G.; Zachou, Kalliopi; Lucena, M. Isabel; Robles-Díaz, Mercedes; Di Zeo-Sánchez, Daniel E.; Andrade, Raúl J.; Montano-Loza, Aldo J.; Lytvyak, Ellina; Lissenberg-Witte, Birgit I.; Maisonneuve, Patrick; Bouma, Gerd; MacEdo, Guilherme; Liberal, Rodrigo; De Boer, Ynto S.; Van Erpecum, K.; Dutch AIH Study Group; International Autoimmune Hepatitis Group (John Wiley & Sons Inc., 2024-03)
    Background and Aims: The International Autoimmune Hepatitis Group retrospective registry (IAIHG-RR) is a web-based platform with subjects enrolled with a clinical diagnosis of autoimmune hepatitis (AIH). As prognostic ...
  • An omics-based machine learning approach to predict diabetes progression: a RHAPSODY study 
    Slieker, Roderick C.; Münch, Magnus; Donnelly, Louise A.; Bouland, Gerard A.; Dragan, Iulian; Kuznetsov, Dmitry; Elders, Petra J.M.; Rutter, Guy A.; Ibberson, Mark; Pearson, Ewan R.; ’t Hart, Leen M.; van de Wiel, Mark A.; Beulens, Joline W.J. (Springer-Verlag, 2024-05)
    Aims/hypothesis: People with type 2 diabetes are heterogeneous in their disease trajectory, with some progressing more quickly to insulin initiation than others. Although classical biomarkers such as age, HbA1c and diabetes ...
  • ESR Essentials: ten steps to cardiac MR—practice recommendations by ESCR 
    Emrich, Tilman; Wintersperger, Bernd J.; Greco, Fabio Domenico; Suchá, Dominika; Natale, Luigi; Paar, Maja Hrabak; Francone, Marco (Springer-Verlag, 2024-04)
    Abstract: Cardiovascular MR imaging has become an indispensable noninvasive tool in diagnosing and monitoring a broad range of cardiovascular diseases. Key to its clinical success and efficiency are appropriate clinical ...
  • Standards for the care of people with cystic fibrosis (CF); recognising and addressing CF health issues 
    Burgel, Pierre Régis; Southern, Kevin W.; Addy, Charlotte; Battezzati, Alberto; Berry, Claire; Bouchara, Jean Philippe; Brokaar, Edwin; Brown, Whitney; Azevedo, Pilar; Durieu, Isabelle; Ekkelenkamp, Miquel; Finlayson, Felicity; Forton, Julian; Gardecki, Johanna; Hodkova, Pavla; Hong, Gina; Lowdon, Jacqueline; Madge, Su; Martin, Clémence; McKone, Edward; Munck, Anne; Ooi, Chee Y.; Perrem, Lucy; Piper, Amanda; Prayle, Andrew; Ratjen, Felix; Rosenfeld, Margaret; Sanders, Don B.; Schwarz, Carsten; Taccetti, Giovanni; Wainwright, Claire; West, Natalie E.; Wilschanski, Michael; Bevan, Amanda; Castellani, Carlo; Drevinek, Pavel; Gartner, Silvia; Gramegna, Andrea; Lammertyn, Elise; Landau, Eddie (Edwina) C.; Plant, Barry J.; Smyth, Alan R.; van Koningsbruggen-Rietschel, Silke; Middleton, Peter G. (Elsevier, 2024-03)
    This is the third in a series of four papers updating the European Cystic Fibrosis Society (ECFS) standards for the care of people with CF. This paper focuses on recognising and addressing CF health issues. The guidance ...
  • Writing a manuscript for publication in a peer-reviewed scientific journal: Guidance from the European Society of Clinical Pharmacy 
    Wirth, Francesca; Cadogan, Cathal A.; Fialová, Daniela; Hazen, Ankie; Lutters, Monika; Paudyal, Vibhu; Weidmann, Anita E.; Okuyan, Betul; Henman, Martin C. (Springer Netherlands, 2024-02-08)
    Publishing in reputable peer-reviewed journals is an integral step of the clinical pharmacy research process, allowing for knowledge transfer and advancement in clinical pharmacy practice. Writing a manuscript for publication ...