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UMC Repository: Recent submissions

  • Standards of fracture care in polytrauma: results of a Europe-wide survey by the ESTES polytrauma section 
    Scherer, Julian; Coimbra, Raul; Mariani, Diego; Leenen, Luke; Komadina, Radko; Peralta, Ruben; Fattori, Luka; Marzi, Ingo; Wendt, Klaus; Gaarder, Christine; Pape, Hans-Christoph; Pfeifer, Roman (Springer International Publishing AG, 2024-06)
    INTRODUCTION: Fixation of major fractures plays a pivotal role in the surgical treatment of polytrauma patients. In addition to ongoing discussions regarding the optimal timing in level I trauma centers, it appears that ...
  • The role of the specialist nurse in comprehensive care for bleeding disorders in Europe: An integrative review 
    Mulders, Greta; Uitslager, Nanda; Kavanagh, Mary; Birkedal, Maj Friberg; Nicolo, Gabriella; Fenton, Renester; Westesson, Linda Myrin (Wiley-Blackwell, 2024-05)
    Introduction: Managing bleeding disorders (BDs) is complex, requiring a comprehensive approach coordinated by a multidisciplinary team (MDT). Haemophilia nurses (HNs) play a central role in the MDT, frequently coordinating ...
  • Reciprocal association between pain and quality of life after newly acquired spinal cord injury 
    Westphal, Maren; Carrard, Valerie; Braunwalder, Céline; Debnar, Caroline; Post, Marcel; Fekete, Christine; Galvis, Mayra; Scheel-Sailer, Anke (Springer Netherlands, 2024-05)
    Purpose: Pain is highly prevalent in spinal cord injury (SCI) and a key determinant of quality of life (QoL). This is the first study to examine reciprocal associations between pain and QoL in patients undergoing their ...
  • The Image Biomarker Standardization Initiative: Standardized Convolutional Filters for Reproducible Radiomics and Enhanced Clinical Insights 
    Whybra, Philip; Zwanenburg, Alex; Andrearczyk, Vincent; Schaer, Roger; Apte, Aditya P.; Ayotte, Alexandre; Baheti, Bhakti; Bakas, Spyridon; Bettinelli, Andrea; Boellaard, Ronald; Boldrini, Luca; Buvat, Irène; Cook, Gary J.R.; Dietsche, Florian; Dinapoli, Nicola; Gabryś, Hubert S.; Goh, Vicky; Guckenberger, Matthias; Hatt, Mathieu; Hosseinzadeh, Mahdi; Iyer, Aditi; Lenkowicz, Jacopo; Loutfi, Mahdi A.L.; Löck, Steffen; Marturano, Francesca; Morin, Olivier; Nioche, Christophe; Orlhac, Fanny; Pati, Sarthak; Rahmim, Arman; Rezaeijo, Seyed Masoud; Rookyard, Christopher G.; Salmanpour, Mohammad R.; Schindele, Andreas; Shiri, Isaac; Spezi, Emiliano; Tanadini-Lang, Stephanie; Tixier, Florent; Upadhaya, Taman; Valentini, Vincenzo; van Griethuysen, Joost J.M.; Yousefirizi, Fereshteh; Zaidi, Habib; Müller, Henning; Vallières, Martin; Depeursinge, Adrien (Radiological Society of North America Inc., 2024-02)
    Filters are commonly used to enhance specific structures and patterns in images, such as vessels or peritumoral regions, to enable clinical insights beyond the visible image using radiomics. However, their lack of ...
  • Primary Failure of Dental Eruption Due to Variants Parathyroid Hormone Receptor 1: Retrospective Study and Proposal of Guidelines Treatment 
    Thuaire, Antoine; Delebarre, Hélène; Marsili, Luisa; Colson, Cindy; Vanlerberghe, Clemence; Lauwers, Ludovic; Raoul, Gwenael; Touzet-Roumazeille, Sandrine; Ferri, Joël (Lippincott Williams & Wilkins, 2024-03)
    Objective: Primary failure of eruption is characterized by a nonsyndromic defect in tooth eruption in the absence of mechanical obstruction. It is correlated to rare heterozygous variants in the parathyroid hormone receptor ...
  • Respiratory Syncytial Virus–Associated Hospitalization in Adults With Comorbidities in 2 European Countries: A Modeling Study 
    Osei-Yeboah, Richard; Johannesen, Caroline Klint; Egeskov-Cavling, Amanda Marie; Chen, Junru; Lehtonen, Toni; Fornes, Arantxa Urchueguía; Paget, John; Fischer, Thea K.; Wang, Xin; Nair, Harish; Campbell, Harry; Bont, Louis; PROMISE investigators (Oxford University Press, 2024-03-15)
    Background. Individuals with comorbidities are at increased risk of severe respiratory syncytial virus (RSV) infection. We estimated RSV-associated respiratory hospitalization among adults aged ≥45 years with comorbidities ...
  • Outcome of traumatic thoracolumbar spine fractures in elderly: A systematic review 
    van Tiel, J.; Tan, T.; Tee, J.; Marion, T. E.; Öner, F. C.; Rutges, J. P.H.J. (Elsevier, 2024)
    Introduction: Adequate guidelines for treatment of people over 65 years, suffering traumatic thoracolumbar spine fractures without neurologic deficit, are currently lacking. Research question: The aim of this study was to ...
  • Genotype–phenotype associations in 1018 individuals with SCN1A-related epilepsies 
    Gallagher, Declan; Pérez-Palma, Eduardo; Bruenger, Tobias; Ghanty, Ismael; Brilstra, Eva; Ceulemans, Berten; Chemaly, Nicole; de Lange, Iris; Depienne, Christel; Guerrini, Renzo; Mei, Davide; Møller, Rikke S.; Nabbout, Rima; Regan, Brigid M.; Schneider, Amy L.; Scheffer, Ingrid E.; Schoonjans, An Sofie; Symonds, Joseph D.; Weckhuysen, Sarah; Zuberi, Sameer M.; Lal, Dennis; Brunklaus, Andreas (Wiley-Blackwell, 2024-04)
    Objective: SCN1A variants are associated with epilepsy syndromes ranging from mild genetic epilepsy with febrile seizures plus (GEFS+) to severe Dravet syndrome (DS). Many variants are de novo, making early phenotype ...
  • Offline orbitofrontal cortex reactivation depends on recency of place-reward changes and coheres with hippocampal replay 
    Rusu, Silviu I.; Bos, Jeroen J.; Marchesi, Pietro; Lankelma, Jan V.; Ferreira Pica, Ildefonso; Gentet, Luc J.; Joëls, Marian; Pennartz, Cyriel (Elsevier, 2024-03-15)
    The orbitofrontal cortex, one of the key neocortical areas in valuation and emotion, is critical for cognitive flexibility but its role in the consolidation of recently acquired information remains unclear. Here, we ...
  • Estimation of the infection attack rate of mumps in an outbreak among college students using paired serology 
    van Boven, Michiel; Backer, Jantien A.; Veldhuijzen, Irene; Gomme, Justin; van Binnendijk, Rob; Kaaijk, Patricia (Elsevier, 2024-03)
    Mumps virus is a highly transmissible pathogen that is effectively controlled in countries with high vaccination coverage. Nevertheless, outbreaks have occurred worldwide over the past decades in vaccinated populations. ...
  • Human platelets contain a pool of free zinc in dense granules 
    Kahr, Walter H.A.; Henderson, Sara J.; Pluthero, Fred G.; Heijnen, Harry F.G.; Vaezzadeh, Nima; Stafford, Alan R.; Fredenburgh, James C.; Weitz, Jeffrey I. (Elsevier, 2024-02)
    Background: Activated platelets release procoagulant factors that include Ca2+ and Zn2+. Releasable Ca2+ stores have been identified in platelet dense granules and the dense tubular system, but similar stores of free Zn2+ ...
  • Sex-specific differences in physiological parameters related to SARS-CoV-2 infections among a national cohort (COVI-GAPP study) 
    Grossmann, Kirsten; Risch, Martin; Markovic, Andjela; Aeschbacher, Stefanie; Weideli, Ornella C.; Velez, Laura; Kovac, Marc; Pereira, Fiona; Wohlwend, Nadia; Risch, Corina; Hillmann, Dorothea; Lung, Thomas; Renz, Harald; Twerenbold, Raphael; Rothenbühler, Martina; Leibovitz, Daniel; Kovacevic, Vladimir; Klaver, Paul; Brakenhoff, Timo B.; Franks, Billy; Mitratza, Marianna; Downward, George S.; Dowling, Ariel; Montes, Santiago; Veen, Duco; Grobbee, Diederick E.; Cronin, Maureen; Conen, David; Goodale, Brianna M.; Risch, Lorenz; behalf of the COVID-19 remote early detection (COVID-RED) consortium (Public Library of Science, 2024-03)
    Considering sex as a biological variable in modern digital health solutions, we investigated sex-specific differences in the trajectory of four physiological parameters across a COVID-19 infection. A wearable medical device ...
  • Intracellular proteomics and extracellular vesiculomics as a metric of disease recapitulation in 3D-bioprinted aortic valve arrays 
    Clift, Cassandra L.; Blaser, Mark C.; Gerrits, Willem; Turner, Mandy E.; Sonawane, Abhijeet; Pham, Tan; Andresen, Jason L.; Fenton, Owen S.; Grolman, Joshua M.; Campedelli, Alesandra; Buffolo, Fabrizio; Schoen, Frederick J.; Hjortnaes, Jesper; Muehlschlegel, Jochen D.; Mooney, David J.; Aikawa, Masanori; Singh, Sasha A.; Langer, Robert; Aikawa, Elena (American Association for the Advancement of Science, 2024-03)
    In calcific aortic valve disease (CAVD), mechanosensitive valvular cells respond to fibrosis- and calcification-induced tissue stiffening, further driving pathophysiology. No pharmacotherapeutics are available to treat ...
  • Introduction to target trial emulation in rehabilitation: a systematic approach to emulate a randomized controlled trial using observational data 
    Côté, Pierre; Negrini, Stefano; Donzelli, Sabrina; Kiekens, Carlotte; Arienti, Chiara; Ceravolo, Maria G.; Gross, Douglas P.; Battel, Irene; Ferriero, Giorgio; Lazzarini, Stefano G.; Dan, Bernard; Shearer, Heather M.; Wong, Jessica J.; Participants in the 5th Cochrane Rehabilitation Methodological Meeting (Edizioni Minerva Medica S.p.A, 2024-02)
    Rehabilitation providers and policymakers need valid evidence to make informed decisions about the healthcare needs of the population. Whenever possible, these decisions should be informed by randomized controlled trials ...
  • Association between self-reported functional capacity and general postoperative complications: analysis of predefined outcomes of the MET-REPAIR international cohort study 
    Roth, Sebastian; M'Pembele, René; Nienhaus, Johannes; Mauermann, Eckhard; Ionescu, Daniela; Szczeklik, Wojciech; De Hert, Stefan; Filipovic, Miodrag; Beck-Schimmer, Beatrice; Spadaro, Savino; Matute, Purificación; Bolliger, Daniel; Turhan, Sanem C.; van Waes, Judith; Lagarto, Filipa; Theodoraki, Kassiani; Gupta, Anil; Gillmann, Hans Jörg; Guzzetti, Luca; Kotfis, Katarzyna; Wulf, Hinnerk; Larmann, Jan; Corneci, Dan; Chammartin, Frédérique; Howell, Simon J.; Lurati Buse, Giovanna; the MET: Reevaluation for Perioperative Cardiac Risk Investigators (Oxford University Press, 2024-04)
  • Effectiveness of Vaccines and Monoclonal Antibodies Against Respiratory Syncytial Virus: Generic Protocol for Register-Based Cohort Study 
    Poukka, Eero; Roekel, Caren van; Turunen, Topi; Baum, Ulrike; Kramer, Rolf; Begier, Elizabeth; Presser, Lance D.; Teirlinck, Anne C.; Heikkinen, Terho; Knol, Mirjam; Nohynek, Hanna; Bont, Louis; PROMISE investigators (Oxford University Press, 2024-03-15)
    Several immunization products are currently being developed against respiratory syncytial virus (RSV) for children, pregnant females, and older adults, and some products have already received authorization. Therefore, ...
  • A Novel CMR-ECGI Lens Exposes the Electrophysiological Substrate in Subclinical HCM: A Glimmering Future Preview 
    Asatryan, Babken; Muller, Steven A. (Elsevier, 2024-03-19)
  • The ALSFRS-R Summit: a global call to action on the use of the ALSFRS-R in ALS clinical trials 
    Genge, Angela; Cedarbaum, Jesse M.; Shefner, Jeremy; Chio, Adriano; Al-Chalabi, Ammar; Van Damme, Philip; McDermott, Chris; Glass, Jonathan; Berry, James; van Eijk, Ruben P.A.; Fournier, Christina; Grosskreutz, Julian; Andrews, Jinsy; Bertone, Vanessa; Bunte, Tommy M.; Couillard, Mathias; Cummings, Cathy; Kittle, Gale; Polzer, John; Salmon, Kristiana; Straub, Corey; van den Berg, Leonard H. (Informa Healthcare, 2024-05)
    The Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) was developed more than 25 years ago as an instrument to monitor functional change over time in patients with ALS. It has since been revised and extended ...
  • Underreporting and Misclassification of Respiratory Syncytial Virus–Coded Hospitalization Among Adults in Denmark Between 2015–2016 and 2017–2018 
    Egeskov-Cavling, Amanda Marie; Johannesen, Caroline Klint; Lindegaard, Birgitte; Fischer, Thea Kølsen; Bont, Louis; PROMISE investigators (Oxford University Press, 2024-03-15)
    Background. Low awareness and lack of routine testing for respiratory syncytial virus (RSV) infections among adults has led to underreporting in hospital records. This study aimed to assess the underreporting and ...
  • Effectiveness of Immunization Products Against Medically Attended Respiratory Syncytial Virus Infection: Generic Protocol for a Test-Negative Case-Control Study 
    Roekel, Caren Van; Poukka, Eero; Turunen, Topi; Nohynek, Hanna; Presser, Lance; Meijer, Adam; Heikkinen, Terho; Kramer, Rolf; Begier, Elizabeth; Teirlinck, Anne C.; Knol, Mirjam; Bont, Louis; PROMISE investigators (Oxford University Press, 2024-03-15)
    Monitoring the real-life effectiveness of respiratory syncytial virus (RSV) products is of major public health importance. This generic protocol for a test-negative design study aims to address currently envisioned approaches ...