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A Prolonged Outbreak of Enteric Fever Associated With Illegal Miners in the City of Matlosana, South Africa, November 2020-September 2022

Sekwadi, Phuti; Smith, Anthony Marius; Maruma, Wellington; Mongologa, Gift; Tsele, Grace; Ngomane, Mimmy; Tau, Nomsa; Williams, Shannon; Disenyeng, Bolele; Sebiloane, Mahlaku; Johnston, Leigh; Erasmus, Linda; Thomas, Juno (Oxford University Press, 2024-03)

Background. In South Africa, the annual incidence of enteric fever averaged 0.1 per 100 000 persons between 2003 and 2018. During 2021 an increase in the number of enteric fever cases was observed. An outbreak investigation ...
Nutrition security and traditional food markets in Africa: gender insights

de Kanter, Emilie; Trevenen-Jones, Ann; Billiard, Charlie M.J. (Frontiers Media SA, 2024-03-07)

Malnutrition is a major global challenge. Multiple forms, from underweight to obesity, exist, and several forms coexist within communities and households. Traditional food markets, also known as wet, local, or informal ...
Barriers and facilitators to the delivery of age-friendly health services in Primary Health Care centres in southwest, Nigeria: A qualitative study

Ogunyemi, Adedoyin O.; Balogun, Mobolanle R.; Ojo, Adedayo E.; Welch, Sarah B.; Onasanya, Oluwatosin O.; Yesufu, Victoria O.; Omotayo, Abisola T.; Hirschhorn, Lisa R. (Public Library of Science, 2024-03-19)

Background With the rapid growth of Nigeria's older population, it has become important to establish age-friendly healthcare systems that support care for older people. This study aimed to explore the barriers and facilitators ...
Health-related quality of life and symptom burden in patients on haemodialysis

DOMESTICO study group (Oxford University Press, 2024-03)

Background. Patients on haemodialysis (HD) generally experience poor health-related quality of life (HRQoL) and a broad range of physical and mental symptoms, but it is unknown whether this differs between younger and older ...
Combining Genomic Biomarkers to Guide Immunotherapy in Non-Small Cell Lung Cancer

Van De Haar, Joris; Mankor, Joanne M.; Hummelink, Karlijn; Monkhorst, Kim; Smit, Egbert F.; Wessels, Lodewyk F.A.; Cuppen, Edwin; Aerts, Joachim G.J.V.; Voest, Emile E. (American Association for Cancer Research Inc., 2024-04-01)

Purpose: The clinical value of STK11, KEAP1, and EGFR alterations for guiding immune checkpoint blockade (ICB) therapy in non-small cell lung cancer (NSCLC) remains controversial, as some patients with these proposed ...
Moving across disorders: A cross-sectional study of cognition in early onset ataxia and dystonia

Coenen, Maraike A.; Sival, Deborah; Brandsma, Rick; Eggink, Hendriekje; Timmerman, Marieke E.; Tijssen, Marina A.; Spikman, Jacoba M. (W.B. Saunders Ltd, 2024-03)

Background: Early onset ataxia (EOA) and Early Onset Dystonia (EOD) are movement disorders developing in young people (age <25 per definition). These disorders result from dysfunctional networks involving the cerebellum ...
Explainable machine learning using echocardiography to improve risk prediction in patients with chronic coronary syndrome

Molenaar, Mitchel A.; Bouma, Berto J.; Asselbergs, Folkert W.; Verouden, Niels J.; Selder, Jasper L.; Chamuleau, Steven A.J.; Schuuring, Mark J. (Oxford University Press, 2024-03)

Aims: The European Society of Cardiology guidelines recommend risk stratification with limited clinical parameters such as left ventricular (LV) function in patients with chronic coronary syndrome (CCS). Machine learning ...
Enhancing dialogue: Introducing ‘Letters to the Editor’

van der Harst, Pim (Bohn Stafleu van Loghum, 2024-04)
Longitudinal analysis of serum neurofilament light chain levels as marker for neuronal damage in hereditary transthyretin amyloidosis

Berends, Milou; Brunger, Anne F.; Bijzet, Johan; Kroesen, Bart Jan; Drost, Gea; Lange, Fiete; Teunissen, Charlotte E.; in ‘t Veld, Sjors; Vrancken, Alexander F.J.E.; Gans, Reinold O.B.; Hazenberg, Bouke P.C.; van der Zwaag, Paul A.; Nienhuis, Hans L.A. (Informa Healthcare, 2024-06)

Objective: To evaluate serum neurofilament light chain (sNfL) as biomarker of disease onset, progression and treatment effect in hereditary transthyretin (ATTRv) amyloidosis patients and TTR variant (TTRv) carriers. Methods: ...
The impact of patient-reported frailty on cardiovascular outcomes in elderly patients after non-ST-acute coronary syndrome

van den Broek, W. W.A.; Gimbel, M. E.; Hermanides, R. S.; Runnett, C.; Storey, R. F.; Knaapen, P.; Emans, M. E.; Oemrawsingh, R. M.; Cooke, J.; Galasko, G.; Walhout, R.; Stoel, M. G.; von Birgelen, C.; van Bergen, Paul F.M.M.; Brinckman, S. L.; Aksoy, I.; Liem, A.; van't Hof, A. W.J.; Jukema, J. W.; Heestermans, A. A.C.M.; Nicastia, D.; Alber, H.; Austin, D.; Nasser, A.; Deneer, V.; ten Berg, J. M. (Elsevier Ireland Ltd, 2024-06-15)

Background: As life expectancy increases, the population of older individuals with coronary artery disease and frailty is growing. We aimed to assess the impact of patient-reported frailty on the treatment and prognosis ...
Assessing the clinical benefit of systemic anti-cancer treatments in the Netherlands: The impact of different thresholds for effectiveness

Leeneman, Brenda; Xander, Nicolas S.H.; Fiets, W. Edward; de Jong, Wouter K.; Uyl, Nathalie E.M.; Wymenga, A. N.Machteld; Reyners, An K.L.; Uyl-de Groot, Carin A. (Elsevier Limited, 2024-05)

Background: In the Netherlands, the clinical benefit of systemic anti-cancer treatments (SACTs) is assessed by the Committee for the Evaluation of Oncological Agents (cieBOM). For non-curative SACTs, the assessment is based ...
Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

Harlianto, Netanja I.; Kayode, Gbenga A.; GBD 2021 Nervous System Disorders Collaborators (Elsevier Limited, 2024-04)

Background: Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous ...
Technical considerations for isolated limb perfusion: A consensus paper

Hayes, Andrew J.; Coker, David J.; Been, Lukas; Boecxstaens, Veerle WSM; Bonvalot, Sylvie; De Cian, Franco; de la Cruz-Merino, Luis; Duarte, Carlos; Center München, Munich, Germany, Comprehensive; Farricha, Victor; Fiore, Marco; Grünhagen, Dirk; Grützmann, Robert; Honoré, Charles; Jakob, Jens; Hocevar, Marko; van Houdt, Winan; Klauzner, Joseph; Kettelhack, Christoph; Märten, Angela; Martinez-Said, Hector; Matter, Maurice; Michot, Audrey; Niethard, Maya; Pennacchioli, Elisabetta; Podleska, Lars E.; Rabago, Gregorio; Rastrelli, Marco; Reijers, Sophie; Ribeiro, Matilde; Schwarzbach, Matthias; Snow, Hayden A.; Spacek, Miroslav; Stoldt, Stephan; Testori, Alessandro; Zoras, Odysseas; Olofsson Bagge, Roger (W.B. Saunders Ltd, 2024-06)

Background: Isolated limb perfusion (ILP) is a well-established surgical procedure for the administration of high dose chemotherapy to a limb for the treatment of advanced extremity malignancy. Although the technique of ...
The Assessment of Burden of ColoRectal Cancer (ABCRC)-tool; a validity and reliability study

Thomassen, Britt J.M.; Kimman, Merel L.; Somers, Anne M.J.; Ponds, Rudolf W.H.M.; Dekker, Jan Willem T.; van Leiden, Barbara L.; Vink, Geraldine R.; de Groot, Jan Willem B.; Melenhorst, Jarno; Reynders, Kim M.M.W.; Gielen, Christel M.J.; Weerts, Tom H.A.; Lutke Holzik, Martijn F.; van Kuijk, Sander M.J.; Breukink, Stéphanie O.; Gidding-Slok, Annerika H.M. (W.B. Saunders Ltd, 2024-04)

Introduction: Follow-up care after treatment for colorectal cancer (CRC) is increasingly focused on health-related quality of life (HRQoL) and functional outcomes. The Assessment of Burden of ColoRectal Cancer (ABCRC)-tool ...
Shifting landscape in skin cancer incidence: the rising tide of cutaneous squamous cell carcinoma and potential implications for prevention

Eggermont, Celeste J.; Center München, Munich, Germany, Comprehensive (Wiley-Blackwell, 2024-04)
Alzheimer's disease heterogeneity revealed by neuroanatomical normative modeling

Loreto, Flavia; Verdi, Serena; Kia, Seyed Mostafa; Duvnjak, Aleksandar; Hakeem, Haneen; Fitzgerald, Anna; Patel, Neva; Lilja, Johan; Win, Zarni; Perry, Richard; Marquand, Andre F.; Cole, James H.; Malhotra, Paresh (John Wiley & Sons Inc., 2024-01)

INTRODUCTION: Overlooking the heterogeneity in Alzheimer's disease (AD) may lead to diagnostic delays and failures. Neuroanatomical normative modeling captures individual brain variation and may inform our understanding ...
Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma: Outcomes in histopathologic subgroups from the randomized, double-blind, phase 3 KEYNOTE-716 trial

Schadendorf, Dirk; Luke, Jason John; Ascierto, Paolo A.; Long, Georgina V.; Rutkowski, Piotr; Khattak, Adnan; Del Vecchio, Michele; De La Cruz-Merino, Luis; Mackiewicz, Jacek; Sileni, Vanna Chiarion; Kirkwood, John M.; Robert, Caroline; Grob, Jean Jacques; Dummer, Reinhard; Carlino, Matteo S.; Zhao, Yujie; Kalabis, Mizuho; Krepler, Clemens; Center München, Munich, Germany, Comprehensive; Scolyer, Richard A. (BioMed Central Ltd., 2024-03-13)

Background Adjuvant pembrolizumab significantly improved recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) versus placebo in the phase 3 KEYNOTE-716 study of resected stage IIB or IIC melanoma. At ...
Heterotopic Ossification of Bilateral Hips Post–COVID-19 and Prolonged Immobilization A Case Report

van de Langerijt, Olaf N.; Groot, Olivier Q.; Janssen, Michiel M.A. (Lippincott Williams & Wilkins, 2024-03-14)

Case: A 43-year-old healthy man developed hip pain post–coronavirus disease 2019 (COVID-19) immobilization. Imaging confirmed bilateral bridging heterotopic ossification (HO) of the hips, Brooker Class IV. Bilateral HO ...
Identification of Distinct Brain MRI Phenotypes and Their Association With Long-Term Dementia Risk in Community-Dwelling Older Adults

Keller, Jasmin Annica; Sigurdsson, Sigurdur; Schmitz Abecassis, Bárbara; Kant, Ilse M.J.; Van Buchem, Mark A.; Launer, Lenore J.; van Osch, Matthias J.P.; Gudnason, Vilmundur; de Bresser, Jeroen (Lippincott Williams & Wilkins, 2024-04-09)

BACKGROUND AND OBJECTIVES: Individual brain MRI markers only show at best a modest association with long-term occurrence of dementia. Therefore, it is challenging to accurately identify individuals at increased risk for ...
MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via protein kinase C

Segui-Perez, Celia; Stapels, Daphne A.C.; Ma, Ziliang; Su, Jinyi; Passchier, Elsemieke; Westendorp, Bart; Wubbolts, Richard W.; Wu, Wei; van Putten, Jos P.M.; Strijbis, Karin (Company of Biologists Ltd, 2024-03)

Glycosylated mucin proteins contribute to the essential barrier function of the intestinal epithelium. The transmembrane mucin MUC13 is an abundant intestinal glycoprotein with important functions for mucosal maintenance ...

Now showing items 5501-5520 of 40729