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UMC Repository: Recent submissions

  • Cytokine Storm Syndrome Associated with Systemic Juvenile Idiopathic Arthritis 
    Vastert, Sebastiaan J.; Canny, Susan P.; Canna, Scott W.; Schneider, Rayfel; Mellins, Elizabeth D. (Springer New York, 2024-08-09)
    The cytokine storm syndrome (CSS) associated with systemic juvenile idiopathic arthritis (sJIA) has widely been referred to as macrophage activation syndrome (MAS). In this chapter, we use the term sJIA-associated CSS ...
  • Per- and polyfluoroalkyl substances (PFAS) exposure and thyroid cancer: Systematic review and meta-analysis 
    van Gerwen, Maaike; Chung, Tony; Monaghan, Mathilda; Vermeulen, Roel; Petrick, Lauren; Leung, Angela M. (Elsevier, 2024-08)
    Per- and polyfluoroalkyl substances (PFAS) exposure is a potential risk factor for thyroid cancer and may be a contributor to the increasing thyroid cancer incidence rates. A systematic review and meta-analysis was performed ...
  • Determining Perioperative Mortality in Patients with Ruptured Abdominal Aortic Aneurysm: Insights from a Retrospective Cohort Study 
    Prapassaro, Tossapol; Chinsakchai, Khamin; Techarattanaprasert, Somkiat; Wongwanit, Chumpol; Ruangsetakit, Chanean; Hongku, Kiattisak; Hahtapornsawan, Suteekhanit; Puangpunngam, Nattawut; Sermsathanasawadi, Nuttawut; Tongsai, Sasima; Moll, Frans L.; Mutirangura, Pramook (2024-08-01)
    Objective: This retrospective cohort study analyzed factors determining perioperative mortality in patients with ruptured abdominal aortic aneurysm (rAAA) undergoing open surgical repair (OSR) or endovascular aneurysm ...
  • Long-Term Survival in Patients With Advanced Melanoma 
    van Not, Olivier J; van den Eertwegh, Alfons J M; Groningen, University; Bloem, Manja; Haanen, John B; van Rijn, Rozemarijn S; Aarts, Maureen J B; van den Berkmortel, Franchette W P J; Blank, Christian U; Boers-Sonderen, Marye J; de Groot J W B, Jan Willem; Hospers, Geke A P; Kapiteijn, Ellen; Leeneman, Brenda; D, Piersma; Stevense-den Boer, Marion; van der Veldt, Astrid A M; Vreugdenhil G, Gerard; Wouters, Michel W J M; Blokx, Willeke A M; Suijkerbuijk, Karijn P M (American Medical Association, 2024-08-01)
    IMPORTANCE: Long-term survival data from clinical trials show that survival curves of patients with advanced melanoma treated with immune checkpoint inhibitors (ICIs) gradually reach a plateau, suggesting that patients ...
  • Adjuvant treatment with anti-PD-1 in acral melanoma: A nationwide study 
    Bloem, Manja; van Not, Olivier J.; Aarts, Maureen J.B.; van den Berkmortel, Franchette W.P.J.; Blank, Christian U.; Blokx, Willeke A.M.; Boers-Sonderen, Marye J.; Bonenkamp, Johannes J.; de Groot, Jan Willem B.; Haanen, John B.; Hospers, Geke A.P.; Kapiteijn, Ellen W.; de Meza, Melissa M.; Piersma, Djura; van Rijn, Rozemarijn S.; Stevense-den Boer, Marion A.M.; van der Veldt, Astrid A.M.; Vreugdenhil, Gerard; van den Eertwegh, Alfons J.M.; Suijkerbuijk, Karijn P.M.; Wouters, Michel W.J.M. (John Wiley & Sons Inc., 2024-10-15)
    Previous studies demonstrated limited efficacy of immune checkpoint inhibitors in unresectable acral melanoma (AM); it remains unclear how this translates to the adjuvant setting. This study investigates clinical outcomes ...
  • The Hypotension Prediction Index is equally effective in predicting intraoperative hypotension during non-cardiac surgery compared to a mean arterial pressure threshold: a prospective observational study 
    Mulder, Marijn P; Harmannij-Markusse, Mirjam; Fresiello, Libera; Donker, Dirk W; Potters, Jan-Willem (Lippincott Williams & Wilkins, 2024-09-01)
    Background: The Hypotension Prediction Index is designed to predict intraoperative hypotension in a timely manner and is based on arterial waveform analysis using machine learning. It has recently been suggested that this ...
  • Mechanisms of myocardial reverse remodelling and its clinical significance: A scientific statement of the ESC Working Group on Myocardial Function 
    Falcão-Pires, Inês; Ferreira, Ana Filipa; Trindade, Fábio; Bertrand, Luc; Ciccarelli, Michele; Visco, Valeria; Dawson, Dana; Hamdani, Nazha; Van Laake, Linda W.; Lezoualc'h, Frank; Linke, Wolfgang A.; Lunde, Ida G.; Rainer, Peter P.; Abdellatif, Mahmoud; Van der Velden, Jolanda; Cosentino, Nicola; Paldino, Alessia; Pompilio, Giulio; Zacchigna, Serena; Heymans, Stephane; Thum, Thomas; Tocchetti, Carlo Gabriele (Oxford University Press, 2024-07)
    Cardiovascular disease (CVD) is the leading cause of morbimortality in Europe and worldwide. CVD imposes a heterogeneous spectrum of cardiac remodelling, depending on the insult nature, that is, pressure or volume overload, ...
  • Built environment and cardiovascular risk 
    Liu, Mingwei (Utrecht University, 2024-09-26)
    This thesis has described the current evidence of the association between the built environment and cardiovascular risk, and has originally investigated this long-term association and its underlying mechanisms. Chapter 1 ...
  • Advanced diagnostics and novel therapeutic strategies in ischemic heart disease 
    van Klarenbosch, Bas (Utrecht University, 2024-09-10)
    Ischemic heart disease remains the leading cause of morbidity and premature mortality worldwide. The incidence of acute myocardial infarction (AMI) is expected to rise in the coming years. Combined with improved survival ...
  • Merging Macro and Micro: Transcriptional landscapes and in-depth studies for understanding heart disease 
    Timmer, Louk Theodoor (Utrecht University, 2024-09-23)
    Various heart diseases can progress to heart failure in the long term. Heart failure is defined as a clinical syndrome caused by structural and/or functional abnormalities of the heart resulting in increased intracardiac ...
  • Pathobiological signatures of dysbiotic lung injury in pediatric patients undergoing stem cell transplantation 
    Zinter, Matt S.; Dvorak, Christopher C.; Mayday, Madeline Y.; Reyes, Gustavo; Simon, Miriam R.; Pearce, Emma M.; Kim, Hanna; Shaw, Peter J.; Rowan, Courtney M.; Auletta, Jeffrey J.; Martin, Paul L.; Godder, Kamar; Duncan, Christine N.; Lalefar, Nahal R.; Kreml, Erin M.; Hume, Janet R.; Abdel-Azim, Hisham; Hurley, Caitlin; Cuvelier, Geoffrey D.E.; Keating, Amy K.; Qayed, Muna; Killinger, James S.; Fitzgerald, Julie C.; Hanna, Rabi; Mahadeo, Kris M.; Quigg, Troy C.; Satwani, Prakash; Castillo, Paul; Gertz, Shira J.; Moore, Theodore B.; Hanisch, Benjamin; Abdel-Mageed, Aly; Phelan, Rachel; Davis, Dereck B.; Hudspeth, Michelle P.; Yanik, Greg A.; Pulsipher, Michael A.; Sulaiman, Imran; Segal, Leopoldo N.; Versluys, Birgitta A.; Lindemans, Caroline A.; Boelens, Jaap J.; DeRisi, Joseph L.; the Pediatric Transplantation and Cell Therapy Consortium (Nature Research, 2024-07)
    Hematopoietic cell transplantation (HCT) uses cytotoxic chemotherapy and/or radiation followed by intravenous infusion of stem cells to cure malignancies, bone marrow failure and inborn errors of immunity, hemoglobin and ...
  • Corrigendum to “Updated clinical recommendations for the management of tuberous sclerosis complex associated epilepsy” [Eur. J. Paediatr. Neurol. 47 (2023) 25-34, (S1090379823001332), (10.1016/j.ejpn.2023.08.005)] 
    Specchio, Nicola; Nabbout, Rima; Aronica, Eleonora; Auvin, Stephane; Benvenuto, Arianna; de Palma, Luca; Feucht, Martha; Jansen, Floor; Kotulska, Katarzyna; Sarnat, Harvey; Lagae, Lieven; Jozwiak, Sergiusz; Curatolo, Paolo (W.B. Saunders Ltd, 2024-07)
    The authors regret to inform you that the following updated should be considered in the text of the manuscript. Paragraph on Pre-symptomatic treatment. Very recently results from the PREVeNT study have been published: this ...
  • Risk calculators for the detection of prostate cancer: a systematic review 
    Denijs, Frederique B.; van Harten, Meike J.; Meenderink, Jonas J.L.; Leenen, Renée C.A.; Remmers, Sebastiaan; Venderbos, Lionne D.F.; van den Bergh, Roderick C.N.; Beyer, Katharina; Roobol, Monique J. (Springer Nature, 2024-09)
    Background: Prostate cancer (PCa) (early) detection poses significant challenges, including unnecessary testing and the risk of potential overdiagnosis. The European Association of Urology therefore suggests an individual ...
  • Early life exposure to environmental hazards and infant health 
    Soesanti, F (Utrecht University, 2024-10-15)
    The impact of harmful environmental factors on human health has become a major concern, especially during the prenatal and early postnatal stages of development. Exposure to these factors can result in long-term effects ...
  • Electrospinning Lysine-Polypeptide Copolymers: Creating Microfiber Meshes for Biomedical Applications 
    Salas-Ambrosio, Pedro; Morales-Patlan, Enikar; Cedillo-Servin, Gerardo; Tronnet, Antoine; Villavicencio, Katia Pamela; Gómez-Lizárraga, Karla; Benítez-Martínez, Jorge A.; Sanchez-Arevalo, Francisco Manuel; Velasquillo, Cristina; Ceapă, Corina Diana; Vera-Graziano, Ricardo; Bonduelle, Colin (American Chemical Society, 2024-08-09)
    Polylysine is a synthetic polymer used in biology to promote cell proliferation. However, due to its high solubility in water, its incorporation into stable substrates is difficult to achieve using processes that enable ...
  • Sex differences in social brain neural responses in autism: temporal profiles of configural face-processing within data-driven time windows 
    Del Bianco, Teresa; Lai, Meng Chuan; Mason, Luke; Johnson, Mark H.; Charman, Tony; Loth, Eva; Banaschewski, Tobias; Buitelaar, Jan; Murphy, Declan G.M.; Jones, Emily J.H.; The AIMS-2-TRIALS LEAP Team (Nature Publishing Group, 2024-06-18)
    Face-processing timing differences may underlie visual social attention differences between autistic and non-autistic people, and males and females. This study investigates the timing of the effects of neurotype and sex ...
  • Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions 
    Dareng, Eileen O.; Coetzee, Simon G.; Tyrer, Jonathan P.; Peng, Pei Chen; Rosenow, Will; Chen, Stephanie; Davis, Brian D.; Dezem, Felipe Segato; Seo, Ji Heui; Nameki, Robbin; Reyes, Alberto L.; Aben, Katja K.H.; Anton-Culver, Hoda; Antonenkova, Natalia N.; Aravantinos, Gerasimos; Bandera, Elisa V.; Beane Freeman, Laura E.; Beckmann, Matthias W.; Beeghly-Fadiel, Alicia; Benitez, Javier; Bernardini, Marcus Q.; Bjorge, Line; Black, Amanda; Bogdanova, Natalia V.; Bolton, Kelly L.; Brenton, James D.; Budzilowska, Agnieszka; Butzow, Ralf; Cai, Hui; Campbell, Ian; Cannioto, Rikki; Chang-Claude, Jenny; Chanock, Stephen J.; Chen, Kexin; Chenevix-Trench, Georgia; Chiew, Yoke Eng; Cook, Linda S.; DeFazio, Anna; Dennis, Joe; Doherty, Jennifer A.; Dörk, Thilo; du Bois, Andreas; Dürst, Matthias; Eccles, Diana M.; Ene, Gabrielle; Fasching, Peter A.; Flanagan, James M.; Fortner, Renée T.; Fostira, Florentia; Onland-Moret, N. Charlotte; AOCS Group; OPAL Study Group; The Ovarian Cancer Association Consortium (OCAC) (Cell Press, 2024-06-06)
    To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ovarian cancer (EOC), we performed genome-wide association analysis for 470,825 genotyped and 10,163,797 imputed SNPs in ...
  • Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study 
    van den Berg, Leonard H.; Rothstein, Jeffrey D.; Shaw, Pamela J.; Babu, Suma; Benatar, Michael; Bucelli, Robert C.; Genge, Angela; Glass, Jonathan D.; Hardiman, Orla; Libri, Vincenzo; Mobach, Theodore; Oskarsson, Björn; Pattee, Gary L.; Ravits, John; Shaw, Christopher E.; Weber, Markus; Zinman, Lorne; Jafar-nejad, Paymaan; Rigo, Frank; Lin, Luan; Ferguson, Toby A.; Gotter, Anthony L.; Graham, Danielle; Monine, Michael; Inra, Jennifer; Sinks, Susie; Eraly, Satish; Garafalo, Steve; Fradette, Stephanie (Elsevier Limited, 2024-09)
    Background: Hexanucleotide repeat expansion of C9orf72 is a common genetic cause of amyotrophic lateral sclerosis (ALS). No C9orf72-targeted treatments are available. BIIB078 is an investigational antisense oligonucleotide ...
  • Characteristics, consent patterns, and challenges of randomized trials using the Trials within Cohorts (TwiCs) design - A scoping review 
    Amstutz, Alain; Schönenberger, Christof M.; Speich, Benjamin; Griessbach, Alexandra; Schwenke, Johannes M.; Glasstetter, Jan; James, Sophie; Verkooijen, Helena M.; Nickolls, Beverley; Relton, Clare; Hemkens, Lars G.; Chammartin, Frédérique; Gerber, Felix; Labhardt, Niklaus D.; Schandelmaier, Stefan; Briel, Matthias (Elsevier, 2024-10)
    Objectives: Trials within Cohorts (TwiCs) is a pragmatic design approach that may overcome frequent challenges of traditional randomized trials such as slow recruitment, burdensome consent procedures, or limited external ...
  • Long-term outcomes of chimney endovascular aneurysm repair procedure for complex abdominal aortic pathologies 
    Verlato, Paolo; Foresti, Leonardo; Bloemert-Tuin, Trijntje; Trimarchi, Santi; Hazenberg, Constantijn E.V.B.; van Herwaarden, Joost A. (Mosby Inc., 2024-09)
    Objective: The aim of this study was to update our earlier experience and to evaluate long-term outcomes of chimney endovascular aortic repair performed for selected cases with complex abdominal aortic aneurysm. Methods: ...