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Now showing items 4801-4820 of 40729

Host and environmental factors shape upper airway microbiota and respiratory health across the human lifespan

Odendaal, Mari Lee; de Steenhuijsen Piters, Wouter A.A.; Franz, Eelco; Chu, Mei Ling J.N.; Groot, James A.; van Logchem, Elske M.; Hasrat, Raiza; Kuiling, Sjoerd; Pijnacker, Roan; Mariman, Rob; Trzciński, Krzysztof; van der Klis, Fiona R.M.; Sanders, Elisabeth A.M.; Smit, Lidwien A.M.; Bogaert, Debby; Bosch, Thijs (Elsevier, 2024-08-22)

Our understanding of the normal variation in the upper respiratory tract (URT) microbiota across the human lifespan and how these relate to host, environment, and health is limited. We studied the microbiota of 3,104 saliva ...
European Society of Endocrine Surgeons (ESES) consensus statement on advanced thyroid cancer: Definitions and management

Raffaelli, Marco; Voloudakis, Nikolaos; Barczynski, Marcin; Brauckhoff, Katrin; Durante, Cosimo; Gomez-Ramirez, Joaquin; Koutelidakis, Ioannis; Lorenz, Kerstin; Makay, Ozer; Materazzi, Gabriele; Pandev, Rumen; Randolph, Gregory W.; Tolley, Neil; Vriens, Menno; Musholt, Thomas (John Wiley & Sons Inc., 2024-08-01)
Towards a student-centered education: Validation of the Italian version of the Conceptions of Learning and Teaching questionnaire

Rampoldi, Giulia; Montelisciani, Laura; Jacobs, Johanna C.G.; Russo, Selena; Ardenghi, Stefano; Bani, Marco; Antolini, Laura; Consorti, Fabrizio; Strepparava, Maria Grazia (Giunti Psychometrics, 2024-05-01)

Many medical schools have transitioned from traditional teacher-centred education to active student-centred education. The Conception of Learning and Teaching (COLT) questionnaire investigates teachers’ conceptions of ...
Advances in Radionuclide Therapies for Neuroendocrine Tumor Liver Metastases

Ebbers, Sander Cornelis (Utrecht University, 2024-09-24)

Treating neuroendocrine tumor liver metastases is challenging, and extensive liver disease significantly impacts patient prognosis. Among various treatments, peptide receptor radionuclide therapy (PRRT) with lutetium-177-DOTATATE ...
The efficacy of lamotrigine in bipolar disorder: A systematic review and meta-analysis

Haenen, N.; Kamperman, A. M.; Prodan, A.; Nolen, W. A.; Boks, M. P.; Wesseloo, R. (Blackwell Munksgaard, 2024-08)

Objective: To provide up-to-date clinical guidance on the efficacy of lamotrigine in bipolar disorder (BD). Methods: Eligible studies were identified during a systematic literature search according to PRISMA-guidelines. ...
Association of infertility and recurrent pregnancy loss with the risk of dementia

Liang, Chen; Dobson, Annette J.; Chung, Hsin Fang; van der Schouw, Yvonne T.; Sandin, Sven; Weiderpass, Elisabete; Mishra, Gita D. (Springer Netherlands, 2024-07)

Emerging evidence has shown the association between female reproductive histories (e.g., menarche age, parity, premature and early menopause) and the risk of dementia. However, little attention has been given to infertility ...
Outcomes after gastrectomy according to the Gastrectomy Complications Consensus Group (GCCG) in the Dutch Upper GI Cancer Audit (DUCA)

Leiden, Dutch; Voeten, Daan M; Amsterdam, Cancer; Ruurda, Jelle P; van Berge Henegouwen, Mark I; van Hillegersberg, Richard; Dutch Upper Gastrointestinal Cancer Audit (DUCA) Group (Springer Japan, 2024-09)

Background: In 2019, the Gastrectomy Complications Consensus Group (GCCG) published a standardized set of complications aiming toward uniform reporting of post-gastrectomy complications. This study aimed to report outcomes ...
Maximizing treatment opportunities: assessing protocol waivers' impact on safety and outcome in the Drug Rediscovery Protocol

van Berge Henegouwen, Jade M; Zeverijn, Laurien J; Geurts, Birgit S; Hoes, Louisa R; van der Wijngaart, Hanneke; van der Noort, Vincent; Huitema, Alwin D R; De Vos, Filip Y F; Grünberg, Katrien; Bloemendal, Haiko J; Verheul, Henk M W; Voest, Emile E; Gelderblom, Hans (American Association for Cancer Research Inc., 2024-09-03)

Purpose: Although eligibility criteria are essential in trial design, overly restrictive criteria contribute to low accrual and limited generalizability. To enhance trial inclusivity, there has been growing interest in ...
Performance of ChatGPT on Factual Knowledge Questions Regarding Clinical Pharmacy

van Nuland, Merel; Erdogan, Abdullah; Aςar, Cenkay; Contrucci, Ramon; Hilbrants, Sven; Maanach, Lamyae; Egberts, Toine; van der Linden, Paul D (Wiley-Blackwell, 2024-09)

ChatGPT is a language model that was trained on a large dataset including medical literature. Several studies have described the performance of ChatGPT on medical exams. In this study, we examine its performance in answering ...
Predictive validity of the Hand Assessment for Infants in infants at risk of unilateral cerebral palsy

Ryll, Ulrike C.; Krumlinde-Sundholm, Lena; Verhage, Cornelia H.; Sicola, Elisa; Sgandurra, Giuseppina; Bastiaenen, Caroline H.G.; Eliasson, Ann Christin (Wiley-Blackwell, 2021-04)

Aim: To evaluate the sensitivity, specificity, and predictive value of the Hand Assessment for Infants (HAI) in identifying infants at risk of being diagnosed with unilateral cerebral palsy (CP), and to determine cut-off ...
Association of weight loss and weight loss maintenance following diabetes diagnosis by screening and incidence of cardiovascular disease and all-cause mortality: An observational analysis of the ADDITION-Europe trial

Strelitz, Jean; Sharp, Stephen J.; Khunti, Kamlesh; Vos, Rimke C.; Rutten, Guy E.H.M.; Webb, David R.; Witte, Daniel R.; Sandbæk, Annelli; Wareham, Nicholas J.; Griffin, Simon J. (Wiley-Blackwell, 2021-03)

AIMS: Short-term weight loss may lead to remission of type 2 diabetes but the effect of maintained weight loss on cardiovascular disease (CVD) is unknown. We quantified the associations between changes in weight 5 years ...
The mediating role of unhealthy behavior in the relationship between shift work and perceived health

Proper, Karin I.; Jaarsma, Eva; Robroek, Suzan J.W.; Schram, Jolinda L.D.; Boshuizen, Hendriek; Picavet, H. Susan J.; Verschuren, W. M.Monique; van Oostrom, Sandra H. (BioMed Central, 2021-07-02)

Background: Little is known about the relationship between shift work and perceived health, including potential underlying mechanisms such as unhealthy behaviors. The aim of this study was to investigate whether unhealthy ...
The sex difference in gait speed among older adults: how do sociodemographic, lifestyle, social and health determinants contribute?

Sialino, Lena D.; Schaap, Laura A.; van Oostrom, Sandra H.; Picavet, H. Susan J.; Twisk, Johannes W.R.; Verschuren, W. M.Monique; Visser, Marjolein; Wijnhoven, Hanneke A.H. (BioMed Central, 2021-06-02)

Background: This study explores whether a sex difference in sensitivity to (strength of the association) and/or in exposure to (prevalence) determinants of gait speed contributes to the observed lower gait speed among older ...
Sex differences in mental health among older adults: investigating time trends and possible risk groups with regard to age, educational level and ethnicity

Sialino, Lena D.; van Oostrom, Sandra H.; Wijnhoven, Hanneke A.H.; Picavet, Susan; Verschuren, W. M.Monique; Visser, Marjolein; Schaap, Laura A. (Taylor and Francis Ltd., 2021-12)

Objectives: Older women report lower mental health compared to men, yet little is known about the nature of this sex difference. Therefore, this study investigates time trends and possible risk groups. Method: Data from ...
Is leadership of nurses associated with nurse-reported quality of care? A cross-sectional survey

den Breejen-de Hooge, Linda E.; van Os-Medendorp, Harmieke; Hafsteinsdóttir, Thóra B. (SAGE Publications Ltd, 2021-03)

Background: Nurses need to exhibit stronger leadership by taking more responsibility and accountability to improve healthcare quality and patient safety. Aims: The aim of this study was to determine the association between ...
Feasibility of a hybrid clinical trial for respiratory virus detection in toddlers during the influenza season

Muñoz-Ramírez, Soledad; Escribano-López, Begoña; Rodrigo-Casares, Vallivana; Vergara-Hernández, Carlos; Gil-Mary, Desamparados; Sorribes-Monrabal, Ignacio; Garcés-Sánchez, María; Muñoz-Del-Barrio, María-Jesús; Albors-Fernández, Ana-María; Úbeda-Sansano, María-Isabel; Planelles-Cantarino, María-Victoria; Largo-Blanco, Ester-María; Suárez-Vicent, Eva; García-Rubio, Javier; Bruijning-Verhagen, Patricia; Orrico-Sánchez, Alejandro; Díez-Domingo, Javier (BioMed Central, 2021-12-05)

BACKGROUND: Traditional clinical trials are conducted at investigator sites. Participants must visit healthcare facilities several times for the trial procedures. Decentralized clinical trials offer an interesting alternative. ...
Immunogenicity and safety of a quadrivalent high-dose inactivated influenza vaccine compared with a standard-dose quadrivalent influenza vaccine in healthy people aged 60 years or older: a randomized Phase III trial

QHD00011 study team (Landes Bioscience, 2021-12-02)

A quadrivalent high-dose inactivated influenza vaccine (IIV4-HD) is licensed for adults ≥65 y of age based on immunogenicity and efficacy studies. However, IIV4-HD has not been evaluated in adults aged 60-64 y. This study ...
Insulin Therapy in Type 2 Diabetes Is Associated With Barriers to Activity and Worse Health Status: A Cross-Sectional Study in Primary Care

Boels, Anne Meike; Rutten, Guy; Cleveringa, Frits; van Avendonk, Mariëlle; Vos, Rimke (Frontiers Media S. A., 2021-03-10)

Introduction: Many individuals with type 2 diabetes mellitus (T2DM) experience "psychological insulin resistance". Consequently, it could be expected that insulin therapy may have negative effects on psychological outcomes ...
Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054): long-term, health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial

Bührer, Emanuel; Kicinski, Michal; Mandala, Mario; Pe, Madeline; Long, Georgina V.; Atkinson, Victoria; Blank, Christian U.; Haydon, Andrew; Dalle, Stéphane; Khattak, Adnan; Carlino, Matteo S.; Meshcheryakov, Andrey; Sandhu, Shahneen; Puig, Susana; Schadendorf, Dirk; Jamal, Rahima; Rutkowski, Piotr; van den Eertwegh, Alfonsus J.M.; Coens, Corneel; Grebennik, Dmitri; Krepler, Clemens; Robert, Caroline; Eggermont, Alexander M.M. (Elsevier Limited, 2024-09)

Background: In the European Organisation for Research and Treatment of Cancer (EORTC) 1325-MG/KEYNOTE-054 study, adjuvant pembrolizumab improved recurrence-free survival and distant-metastasis-free survival in patients ...
Barriers and facilitators to implement the redispensing of unused oral anticancer drugs in clinical care: A hybrid-effectiveness type I study

Smale, Elisabeth M.; Verkerk, Eva W.; Heerdink, Eibert R.; Egberts, Toine C.G.; van den Bemt, Bart J.F.; Bekker, Charlotte L. (2024-09)

Background: Minimizing medication waste through the redispensing of oral anticancer drugs (OADs) that were unused by patients provides economic and environmental benefits, but this is not yet universally implemented in ...

Now showing items 4801-4820 of 40729