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Emerging Models to Study Human Microglia In vitro

Jäntti, Henna; Kistemaker, Lois; Buonfiglioli, Alice; De Witte, Lot D; Malm, Tarja; Hol, Elly M (Springer, 2024-08-30)

New in vitro models provide an exciting opportunity to study live human microglia. Previously, a major limitation in understanding human microglia in health and disease has been their limited availability. Here, we provide ...
Clinical aspects of glucocorticoid and selective glucocorticoid receptor modulator therapy in rheumatoid arthritis

Safy-Khan, Mary (Utrecht University, 2024-10-10)

The aims of this thesis were to: 1) resolve various underexplored clinical issues relating to glucocorticoid (GC) therapy for rheumatoid arthritis (RA), and 2) evaluate the effectiveness and safety of selective glucocorticoid ...
Optimization of central venous access care in pediatric oncology patients

van den Bosch, Ceder Hildegard (Utrecht University, 2024-10-03)

Over the years, central venous catheters (CVC) became more popular in the field of paediatric oncology since they provide a reliable long-term venous access route, without the need for repeated venous punctures. Although ...
ALS-associated C21ORF2 variant disrupts DNA damage repair, mitochondrial metabolism, neuronal excitability and NEK1 levels in human motor neurons

Zelina, Pavol; de Ruiter, Anna Aster; Kolsteeg, Christy; van Ginneken, Ilona; Vos, Harmjan R; Supiot, Laura F; Burgering, Boudewijn M T; Meye, Frank J; Veldink, Jan H; van den Berg, Leonard H; Pasterkamp, R Jeroen (BioMed Central, 2024-09-04)

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease leading to motor neuron loss. Currently mutations in > 40 genes have been linked to ALS, but the contribution of many genes and genetic mutations ...
Randomised multicentre effectiveness trial of rapid syndromic testing by panel assay in children presenting to European emergency departments with acute respiratory infections-trial protocol for the ADEQUATE Paediatric trial

ADEQUATE Paediatric Trial Group (BMJ Publishing Group, 2024-04-25)

Introduction Syndromic panel assays, that is, using one test to simultaneously target multiple pathogens with overlapping signs and symptoms, have been integrated into routine paediatric care over the past decade, mainly ...
Effect of COVID-19 vaccination on mortality by COVID-19 and on mortality by other causes, the Netherlands, January 2021–January 2022

de Gier, Brechje; van Asten, Liselotte; Boere, Tjarda M.; van Roon, Annika; van Roekel, Caren; Pijpers, Joyce; van Werkhoven, C. H.Henri; van den Ende, Caroline; Hahné, Susan J.M.; de Melker, Hester E.; Knol, Mirjam J.; van den Hof, Susan (Elsevier, 2023-07-12)

Background: We aimed to estimate vaccine effectiveness (VE) against COVID-19 mortality, and to explore whether an increased risk of non-COVID-19 mortality exists in the weeks following a COVID-19 vaccine dose. Methods: ...
Constructing evidence-based clinical intrapartum care algorithms for decision-support tools

WHO Intrapartum Care Algorithms Working Group (Wiley-Blackwell, 2024-08)

AIM: To describe standardised iterative methods used by a multidisciplinary group to develop evidence-based clinical intrapartum care algorithms for the management of uneventful and complicated labours. POPULATION: Singleton, ...
Discontinuation of neoadjuvant therapy does not influence postoperative short-term outcomes in elderly patients (≥ 70 years) with resectable gastric cancer: a population-based study from the dutch upper gastrointestinal cancer audit (DUCA) data

Wang, Jingpu; Wu, Zhouqiao; de Groot, Eline M.; Challine, Alexandre; Mohammad, Nadia Haj; Mook, Stella; Goense, Lucas; Ruurda, Jelle P.; van Hillegersberg, Richard (Springer Japan, 2024-09)

Background: For the elderly patients with gastric cancer, it may be more challenging to tolerate complete neoadjuvant therapy (NAT). The impact of discontinued NAT on the surgical safety and pathological outcomes of elderly ...
Isoform changes of action potential regulators in the ventricles of arrhythmogenic phospholamban-R14del humanized mouse hearts

Rogalska, Malgorzata E.; Vafiadaki, Elizabeth; Erpapazoglou, Zoi; Haghighi, Kobra; Green, Lisa; Mantzoros, Christos S.; Hajjar, Roger J.; Tranter, Michael; Karakikes, Ioannis; Kranias, Evangelia G.; Stillitano, Francesca; Kafasla, Panagiota; Sanoudou, Despina (W.B. Saunders, 2023-01)

Arrhythmogenic cardiomyopathy (ACM) is characterized by life-threatening ventricular arrhythmias and sudden cardiac death and affects hundreds of thousands of patients worldwide. The deletion of Arginine 14 (p.R14del) in ...
Long-term air pollution exposure and Parkinson's disease mortality in a large pooled European cohort: An ELAPSE study

Cole-Hunter, Thomas; Zhang, Jiawei; So, Rina; Samoli, Evangelia; Liu, Shuo; Chen, Jie; Strak, Maciej; Wolf, Kathrin; Weinmayr, Gudrun; Rodopolou, Sophia; Remfry, Elizabeth; de Hoogh, Kees; Bellander, Tom; Brandt, Jørgen; Concin, Hans; Zitt, Emanuel; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hoffmann, Barbara; Hvidtfeldt, Ulla A.; Jöckel, Karl Heinz; Mortensen, Laust H.; Ketzel, Matthias; Yacamán Méndez, Diego; Leander, Karin; Ljungman, Petter; Faure, Elodie; Lee, Pei Chen; Elbaz, Alexis; Magnusson, Patrik K.E.; Nagel, Gabriele; Pershagen, Göran; Peters, Annette; Rizzuto, Debora; Vermeulen, Roel C.H.; Schramm, Sara; Stafoggia, Massimo; Katsouyanni, Klea; Brunekreef, Bert; Hoek, Gerard; Lim, Youn Hee; Andersen, Zorana J. (Elsevier Limited, 2023-01)

Background: The link between exposure to ambient air pollution and mortality from cardiorespiratory diseases is well established, while evidence on neurodegenerative disorders including Parkinson's Disease (PD) remains ...
The rainbow scale for the assessment of dermatochalasis of the female upper eyelid: A validated scale

Mooij, J. J.; van de Lande, L. S.; Pool, S. M.W.; Stevens, H. P.J.D.; van der Lei, B.; van Dongen, J. A. (Churchill Livingstone, 2023-01)
Measuring the Prevalence of Mental Disorders in Adolescents in Kenya, Indonesia, and Vietnam: Study Protocol for the National Adolescent Mental Health Surveys

Erskine, Holly E.; Blondell, Sarah J.; Enright, Meaghan E.; Shadid, Jamileh; Wado, Yohannes Dibaba; Wekesah, Frederick Murunga; Wahdi, Amirah Ellyza; Wilopo, Siswanto Agus; Vu, Loi Manh; Dao, Hoa Thi Khanh; Nguyen, Vinh Duc; Emerson, Mark R.; Fine, Shoshanna L.; Li, Mengmeng; Blum, Robert W.; Whiteford, Harvey A.; Scott, James G. (Elsevier, 2023-01)

Purpose: In low- and middle-income countries, there are limited data on mental disorders among adolescents. To address this gap, the National Adolescent Mental Health Surveys (NAMHS) will provide nationally representative ...
An international validation of the AO spine subaxial injury classification system

Karamian, Brian A.; Schroeder, Gregory D.; Lambrechts, Mark J.; Canseco, Jose A.; Oner, Cumhur; Vialle, Emiliano; Rajasekaran, Shanmuganathan; Dvorak, Marcel R.; Benneker, Lorin M.; Kandziora, Frank; Schnake, Klaus; Kepler, Christopher K.; Vaccaro, Alexander R.; AO Spine Subaxial Classification Group Members (Springer-Verlag, 2023-01)

Purpose: To validate the AO Spine Subaxial Injury Classification System with participants of various experience levels, subspecialties, and geographic regions. Methods: A live webinar was organized in 2020 for validation ...
Association between spatial neglect and impaired verticality perception after stroke: A systematic review

Embrechts, Elissa; van der Waal, Charlotte; Anseeuw, Dorine; van Buijnderen, Jessica; Leroij, Améline; Lafosse, Christophe; Nijboer, Tanja CW; Truijen, Steven; Saeys, Wim (Elsevier Masson s.r.l., 2023-04)

Background: Although most research on spatial neglect (SN) has focused on spatial perception deficits with regard to the lateral (left-right) axis, deficits of spatial perception with regard to the vertical (up-down) axis, ...
N6-adenosine methylation (m6A) is involved in the life and death decisions of T cells

Calis, J. J.A.; van Loosdregt, J. (Springer Nature, 2023-04)
Career perspectives for young cardiologists in the Netherlands: a steady increase in temporary positions

Vorselaars, V. M.M.; Minneboo, M.; Meijers, W. C.; van der Heijden, A. C.; Haroun, D.; Baggen, V. J.M.; Berger, W. R.; van Hout, G. P.J. (Bohn Stafleu van Loghum, 2023-05)

In the Netherlands, concerns have been raised regarding the high unemployment rates and the lack of permanent positions for young medical specialists. In the current study, we present data on contemporary early career ...
Development of a microlearning intervention regarding nursing nutritional care for older adults: A multi-methods study

ten Cate, Debbie; Dikken, Jeroen; Ettema, Roelof G.A.; Schoonhoven, Lisette; Schuurmans, Marieke J. (Churchill Livingstone, 2023-01)

Background: Nutritional care for older adults provided by hospital and home care nurses and nursing assistants is suboptimal. This is due to several factors including professionals' lack of knowledge and low prioritisation. ...
Fostering reproducibility and generalizability in machine learning for clinical prediction modeling in spine surgery

Yen, Hung Kuan; Yang, Jiun Jen; Groot, Olivier Q.; Yen, Mao Hsu; Hu, Ming Hsiao (Elsevier, 2023-02)
In RA patients without prevalent CVD, incident CVD is mainly associated with traditional risk factors: A 20-year follow-up in the CARRÉ cohort study

Raadsen, R.; Agca, R.; Boers, M.; van Halm, V. P.; Peters, M. J.L.; Smulders, Y.; Beulens, J. W.J.; Blom, M. T.; Stehouwer, C. D.A.; Voskuyl, A. E.; Lems, W. F.; Nurmohamed, M. T. (W.B. Saunders, 2023-02)

Objectives: To extend our investigation of cardiovascular diseases (CVD) in rheumatoid arthritis (RA) patients to a follow up of more than 20 years, with a special focus on patients without prevalent CVD. Methods: The CARRÉ ...
MR signature matching (MRSIGMA) implementation for true real-time free-breathing volumetric imaging with sub-200 ms latency on an MR-Linac

Siddiq, Saad; Murray, Victor; Tyagi, Neelam; Borman, Pim; Gui, Chengcheng; Crane, Christopher; Wu, Can; Otazo, Ricardo (John Wiley & Sons Inc., 2024-09)

PURPOSE: Develop a true real-time implementation of MR signature matching (MRSIGMA) for free-breathing 3D MRI with sub-200 ms latency on the Elekta Unity 1.5T MR-Linac. METHODS: MRSIGMA was implemented on an external ...

Now showing items 4741-4760 of 40729