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Now showing items 4301-4320 of 40729

Long-term safety of hyaluronidase-facilitated subcutaneous immunoglobulin 10%: a European post-authorization study

Ellerbroek, Pauline M; Hanitsch, Leif G; Witte, Torsten; Lougaris, Vassilios; Hagen, P Martin van; Paassen, Pieter van; Chen, Jie; Fielhauer, Katharina; McCoy, Barbara; Nagy, Andras; Yel, Leman (Taylor and Francis Ltd., 2024)

Aim: To assess the long-term safety of hyaluronidase-facilitated subcutaneous immunoglobulin (fSCIG) 10% in European routine clinical practice. Materials & methods: This prospective, noninterventional, open-label, ...
Left Ventricular Diastolic Dysfunction across Levels of Kidney Function: A Cross-Sectional Study Based on Routine Clinical Practice Data

Porras, Cindy P.; Dal Canto, Elisa; van Ommen, Anne Mar L.; Handoko, M. Louis; Haitjema, Saskia; de Groot, Mark C.H.; Bots, Michiel L.; Verhaar, Marianne C.; Vernooij, Robin W.M. (Multidisciplinary Digital Publishing Institute (MDPI), 2024-09-01)

Left ventricular diastolic dysfunction (LVDD) commonly coexists with kidney dysfunction. In this study, we investigated the presence of abnormalities in echocardiography parameters indicative of LVDD across stages of kidney ...
Impact of COVID-19 mitigation measures on perinatal outcomes in the Netherlands

PREPARE Consortium (Elsevier, 2024-11)

Objective: Investigate the acute impact of COVID-19 mitigation measures implemented in March 2020 on a comprehensive range of perinatal outcomes. Study design: National registry-based quasi-experimental study. Methods: We ...
Human Milk Oligosaccharides in Combination with Galacto- and Long-Chain Fructo-Oligosaccharides Enhance Vaccination Efficacy in a Murine Influenza Vaccination Model

Azarmi, Mehrdad; Seyed Toutounchi, Negisa; Hogenkamp, Astrid; Thijssen, Suzan; Overbeek, Saskia A.; Garssen, Johan; Folkerts, Gert; van’t Land, Belinda; Braber, Saskia (Multidisciplinary Digital Publishing Institute (MDPI), 2024-09-01)

Early-life nutrition significantly impacts vaccination efficacy in infants, whose immune response to vaccines is weaker compared to adults. This study investigated vaccination efficacy in female C57Bl/6JOlaHsd mice (6 weeks ...
Introducing patient stories in health sciences education: the learning experiences of students: the learning experiences of students

Janssens, Astrid; Børgesen, Kirsten; Kragh-Sørensen, Anne; Jensen, Janni Lykke; Nürnberg, Henrik; Hoeck, Bente (BioMed Central, 2024-09-15)

BACKGROUND: It has been advocated that the development of medical school curricula must be informed by students, doctors in training, educators, employers, other health and social care professionals and patients, families ...
High-dose chemotherapy for patients with stage III breast cancer with homologous recombination deficiency: a discrete choice experiment among healthcare providers

Verbeek, Joost G.E.; Azarang, Leyla; Pilli, Luis E.; De Jong, Vincent M.T.; Jager, Agnes; Linn, Sabine C.; Retèl, Valesca P.; Van Harten, Wim H. (2024-09-10)

BACKGROUND AND PURPOSE: High-dose chemotherapy with autologous stem cell rescue (HDCT) is currently under investigation as a potential therapy for patients with stage III HER2-negative breast cancer with homologous ...
Automated dose evaluation on daily cone-beam computed tomography for breast cancer patients

Groot Koerkamp, Maureen; Stijnman, Peter; Houweling, Antonetta; Zachiu, Cornel; Kotte, Alexis; Raaymakers, Bas (Elsevier Ireland Ltd, 2024-11)

Background and purpose: Our goal was to develop a workflow to automatically evaluate delivered dose on daily cone beam computed tomography (CBCT) in all breast cancer patients to assess dosimetric impact of anatomical ...
Early-Life Risk Factors for Carotid Intima-Media Thickness and Carotid Stiffness in Adolescence

van der Linden, Isabelle A; Roodenburg, Rozan; Nijhof, Sanne L; van der Ent, Cornelis K; Venekamp, Roderick P; van der Laan, Sabine E I; Schipper, Henk S (American Medical Association, 2024-09-20)

IMPORTANCE: Atherogenesis starts during childhood, making childhood and adolescence an important window of opportunity to prevent atherosclerotic cardiovascular disease later in life. OBJECTIVE: To identify early-life risk ...
Global estimates on the number of people blind or visually impaired by Uncorrected Refractive Error: a meta-analysis from 2000 to 2020

Vision Loss Expert Group of the Global Burden of Disease Study; the GBD 2019 Blindness and Vision Impairment Collaborators (Springer Nature, 2024-08)

Background: Uncorrected refractive error (URE) is a readily treatable cause of visual impairment (VI). This study provides updated estimates of global and regional vision loss due to URE, presenting temporal change for ...
Early surgical outcome for Tetralogy Of Fallot In An African Setting; A Tanzanian experience using retrospective analysis of hospital data

Majani, Naizihijwa; Sharau, Godwin; Mlawi, Vivienne; Kalezi, Zawadi; Mongella, Stella; Letara, Nuru; Nkya, Deogratias; Kubhoja, Sulende; Chillo, Pilly; Slieker, Martijn; Janabi, Mohamed; Grobbee, Diederick; Kisenge, Peter (BioMed Central, 2024-09-14)

Background: Tetralogy of Fallot (TOF) is typically treated in infancy but often done late in many resource-limited countries, jeopardizing surgical outcomes. This study examined the early results of children undergoing ...
Availability of Evidence for Predictive Machine Learning Algorithms in Primary Care: A Systematic Review

Rakers, Margot M.; van Buchem, Marieke M.; Kucenko, Sergej; de Hond, Anne; Kant, Ilse; van Smeden, Maarten; Moons, Karel G.M.; Leeuwenberg, Artuur M.; Chavannes, Niels; Villalobos-Quesada, María; van Os, Hendrikus J.A. (American Medical Association, 2024-09-12)

Importance: The aging and multimorbid population and health personnel shortages pose a substantial burden on primary health care. While predictive machine learning (ML) algorithms have the potential to address these ...
Ccn2 Deletion Reduces Cardiac Dysfunction, Oxidative Markers, and Fibrosis Induced by Doxorubicin Administration in Mice

Tejera-Muñoz, Antonio; Cortés, Marcelino; Rodriguez-Rodriguez, Alianet; Tejedor-Santamaria, Lucia; Marchant, Vanessa; Rayego-Mateos, Sandra; Gimeno-Longas, Maria José; Leask, Andrew; Nguyen, Tri Q.; Martín, María; Tuñón, Jose; Rodríguez, Isabel; Ruiz-Ortega, Marta; Rodrigues-Díez, Raul R. (Multidisciplinary Digital Publishing Institute (MDPI), 2024-09)

Cellular Communication Network Factor 2 (CCN2) is a matricellular protein implicated in cell communication and microenvironmental signaling. Overexpression of CCN2 has been documented in various cardiovascular pathologies, ...
Genome-wide CRISPR/Cas9 library screen identifies C16orf62 as a host dependency factor for porcine deltacoronavirus infection

Ma, Ningning; Zhang, Mengjia; Zhou, Jiaru; Jiang, Changsheng; Ghonaim, Ahmed H.; Sun, Yumei; Zhou, Pei; Guo, Guanghao; Evers, Anouk; Zhu, Hongmei; He, Qigai; Lebbink, Robert Jan; Bosch, Berend Jan; Li, Wentao (Taylor and Francis Ltd., 2024-12-01)

Porcine deltacoronavirus (PDCoV) is an emerging pathogen that can cause severe diarrhoea and high mortality in suckling piglets. Moreover, evidence of PDCoV infection in humans has raised concerns regarding potential public ...
Genetically inferred birthweight, height, and puberty timing and risk of osteosarcoma

Gianferante, D. Matthew; Moore, Amy; Spector, Logan G.; Wheeler, William; Yang, Tianzhong; Hubbard, Aubrey; Gorlick, Richard; Patiño-Garcia, Ana; Lecanda, Fernando; Flanagan, Adrienne M.; Amary, Fernanda; Andrulis, Irene L.; Wunder, Jay S.; Thomas, David M.; Ballinger, Mandy L.; Serra, Massimo; Hattinger, Claudia; Demerath, Ellen; Johnson, Will; Birmann, Brenda M.; De Vivo, Immaculata; Giles, Graham; Teras, Lauren R.; Arslan, Alan; Vermeulen, Roel; Sample, Jeannette; Freedman, Neal D.; Huang, Wen Yi; Chanock, Stephen J.; Savage, Sharon A.; Berndt, Sonja I.; Mirabello, Lisa (Elsevier, 2024-10)

Introduction: Several studies have linked increased risk of osteosarcoma with tall stature, high birthweight, and early puberty, although evidence is inconsistent. We used genetic risk scores (GRS) based on established ...
Quantifying hospital-Associated costs, and accompanying travel costs and productivity losses, before and after withdrawing TNF-α inhibitors in juvenile idiopathic arthritis

Florax, Anna A.; Doeleman, Martijn J.H.; De Roock, Sytze; Van Der Linden, Naomi; Schatorje, Ellen; Currie, Gillian; Marshall, Deborah A.; Jzerman, Maarten J.I.; Yeung, Rae S.M.; Benseler, Susanne M.; Vastert, Sebastiaan J.; Wulffraat, Nico M.; Swart, Joost F.; Kip, Michelle M.A.; for UCAN-CAN DU and UCAN CURE consortia (Oxford University Press, 2024-09-01)

Objective: To quantify differences in hospital-Associated costs, and accompanying travel costs and productivity losses, before and after withdrawing TNF-α inhibitors (TNFi) in JIA patients. Methods: This was a retrospective ...
Tools and recommendations for commissioning and quality assurance of deformable image registration in radiotherapy

Bosma, Lando S.; Hussein, Mohammad; Jameson, Michael G.; Asghar, Soban; Brock, Kristy K.; McClelland, Jamie R.; Poeta, Sara; Yuen, Johnson; Zachiu, Cornel; Yeo, Adam U.; the 2021 ESTRO Physics Workshop on Commissioning and Quality Assurance for Deformable Image Registration in Radiotherapy (Elsevier, 2024-10)

Multiple tools are available for commissioning and quality assurance of deformable image registration (DIR), each with their own advantages and disadvantages in the context of radiotherapy. The selection of appropriate ...
MR-contrast enhanced mammography (CEM) for follow-up of breast cancer patients: a "pros and cons" debate

Camps-Herrero, Julia; Pijnappel, Ruud; Balleyguier, Corinne (Springer-Verlag, 2024-10)

Abstract: Women with a personal history of breast cancer (PHBC) are at an increased risk of either a local recurrence or a new primary breast cancer. Thus, surveillance is essential for the detection of recurrent disease ...
Examining the overlap between tinnitus and depression questionnaires—protocol for an ICF based content analysis

Fuchten, Denise; Smit, Adriana L.; Stegeman, Inge (Frontiers Media S. A., 2024-09-03)

Introduction: Tinnitus is a common phenomenon with an estimated prevalence of 14.4% in the adult population. The experienced severity of tinnitus varies significantly among this population. Psychological factors have been ...
Association of Lamotrigine Plasma Concentrations With Efficacy and Toxicity in Patients With Epilepsy: A Retrospective Study

Lee, Ze Ning; van Nuland, Merel; Bognàr, Tim; Leijten, Frans S.S.; van der Elst, Kim C.M. (Lippincott Williams & Wilkins, 2024-10-01)

Background: There is limited evidence to support the currently suggested lamotrigine (LTG) therapeutic reference range of 2.5–15 mg/L for the treatment of seizures. The objective of this study was to evaluate the association ...
A joint model of longitudinal pharmacokinetic and time-to-event data to study exposure-response relationships: a proof-of-concept study with alectinib

Lin, Lishi; van der Noort, Vincent; Steeghs, Neeltje; Ruiter, Gerrina; Beijnen, Jos H; Huitema, Alwin D R (Springer-Verlag, 2024-09)

PURPOSE: In exposure-response analyses of oral targeted anticancer agents, longitudinal plasma trough concentrations are often aggregated into a single value even though plasma trough concentrations can vary over time due ...

Now showing items 4301-4320 of 40729