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UMC Repository: Recent submissions

  • New Evidence in the Booming Field of Online Mindfulness: An Updated Meta-analysis of Randomized Controlled Trials 
    Sommers-Spijkerman, Marion; Austin, Judith; Bohlmeijer, Ernst; Pots, Wendy (JMIR Publications Inc., 2021-07)
    Background There is a need to regularly update the evidence base on the effectiveness of online mindfulness-based interventions (MBIs), especially considering how fast this field is growing and developing. Objective This ...
  • Fair allocation of cryopreserved donor oocytes: Towards an accountable process 
    Kool, E. M.; Van Der Graaf, R.; Bos, A. M.E.; Fauser, B. C.J.M.; Bredenoord, A. L. (Oxford University Press, 2021-04-01)
    A growing number of people desire ART with cryopreserved donor oocytes. The allocation of these oocytes to couples and mothers to be is a 2-fold process. The first step is to select a pool of recipients. The second step ...
  • Hemodynamic disturbances and dementia: On the crossroads between vascular brain injury and Alzheimer’s disease pathology 
    Starmans, Naomi (Utrecht University, 2024-11-26)
    Dementia is a common problem among older adults. Due to aging of the population, the number of people with dementia is expected to further increase in the coming decades. It is therefore important to have effective prevention ...
  • Towards a responsible transition to learning healthcare systems in precision medicine: Ethical points to consider 
    Wouters, Roel H.P.; van der Graaf, Rieke; Rigter, Tessel; Bunnik, Eline M.; Ploem, M. Corrette; de Wert, Guido M.W.R.; Dondorp, Wybo J.; Cornel, Martina C.; Bredenoord, Annelien L. (MDPI Multidisciplinary Digital Publishing Institute, 2021-06)
    Learning healthcare systems have recently emerged as a strategy to continuously use experiences and outcomes of clinical care for research purposes in precision medicine. Although it is known that learning healthcare ...
  • The impact of covid-19 from the perspectives of dutch district nurses: A mixed-methods study 
    Veldhuizen, Jessica D.; Zwakhalen, Sandra; Buurman, Bianca M.; Bleijenberg, Nienke (Multidisciplinary Digital Publishing Institute (MDPI), 2021-12-01)
    Little is known about how COVID-19 affects older patients living at home or how it affects district nursing teams providing care to these patients. This study aims to (1) explore, from the perspectives of Dutch district ...
  • Difficult tracheal intubation in neonates and infants. NEonate and Children audiT of Anaesthesia pRactice IN Europe (NECTARINE): a prospective European multicentre observational study 
    NECTARINE Group of the European Society of Anaesthesiology Clinical Trial Network (Oxford University Press, 2021-06)
    Background: Neonates and infants are susceptible to hypoxaemia in the perioperative period. The aim of this study was to analyse interventions related to anaesthesia tracheal intubations in this European cohort and identify ...
  • The role of molecular biomarkers in recurrent glioblastoma trials: an assessment of the current trial landscape of genome-driven oncology 
    van Opijnen, Mark P; de Vos, Filip Y F; Cuppen, Edwin; Geurts, Marjolein; Maas, Sybren L N; Broekman, Marike L D (Humana Press, 2024-09-24)
    For glioblastoma patients, the efficacy-targeted therapy is limited to date. Most of the molecular therapies previously studied are lacking efficacy in this population. More trials are needed to study the actual actionability ...
  • Under Pressure: Complement-Sensitivity of Gram-Negative Bacteria 
    Masson, Frerich (Utrecht University, 2024-10-03)
    Klebsiella pneumoniae is a bacterium commonly found in the environment but also on humans. It usually causes no harm to a healthy person. However, in people with a weak immune system Klebsiella can lead to severe disease ...
  • Use of antibiotics in the early COVID-19 pandemic in Poland, the Netherlands and Spain, from erraticism to (more) logic 
    Opalska, Aleksandra; Gardarsdottir, Helga; Kwa, Marcel; Wójkowska-Mach, Jadwiga; Sabate, Monica; Ballarin, Maria Elena; de Groot, Mark; Leufkens, Hubert (Springer-Verlag, 2024-10)
    INTRODUCTION: In the Spring of 2020, the world was hit with unparalleled impact by the coronavirus pandemic. Antibiotics were widely used, even without good rationale. The aim of our study was to compare the use of antibiotics ...
  • Systematic scoping review of cluster randomised trials conducted exclusively in low-income and middle-income countries between 2017 and 2022 
    Goldstein, Cory E; Marouf, Yacine; Johri, Mira; Shaw, Julia F; Sergeant, Anand; Nicholls, Stuart G; Althabe, Fernando; Ferrand, Rashida A; van der Graaf, Rieke; Hemming, Karla; Mbuagbaw, Lawrence; Treweek, Shaun; Welch, Vivian A; Weijer, Charles; Taljaard, Monica (BMJ Publishing Group, 2024-09-17)
    OBJECTIVE: Cluster randomised trials (CRTs) are used for evaluating health-related interventions in low-income and middle-income countries (LMICs) but raise complex ethical issues. To inform the development of future ethics ...
  • Social Value 
    van Delden, Johannes J.M.; van der Graaf, Rieke (Cambridge University Press, 2021-01-01)
    In this chapter we focus on social value in health-related research involving humans, including data driven research. We find that to state a requirement for social value is one thing; to actually evaluate the social value ...
  • Note the Nodes: evaluation of staging procedures and treatment of pediatric extremity rhabdomyosarcoma 
    Terwisscha van Scheltinga, Sheila (Utrecht University, 2024-10-24)
    Rhabdomyosarcoma (RMS) is the most common soft tissue tumor in children. It is a high-grade soft tissue tumor of mesenchymal origin. Lymph node metastases negatively affect prognosis and are relatively common in primary ...
  • Use of antibiotics in the early COVID-19 pandemic in Poland, the Netherlands and Spain, from erraticism to (more) logic 
    Opalska, Aleksandra; Gardarsdottir, Helga; Kwa, Marcel; Wójkowska-Mach, Jadwiga; Sabate, Monica; Ballarin, Maria Elena; de Groot, Mark; Leufkens, Hubert (Springer-Verlag, 2024-10)
    INTRODUCTION: In the Spring of 2020, the world was hit with unparalleled impact by the coronavirus pandemic. Antibiotics were widely used, even without good rationale. The aim of our study was to compare the use of antibiotics ...
  • Does non-invasive prenatal testing affect the livebirth prevalence of Down syndrome in the Netherlands?: A population-based register study 
    de Groot-van der Mooren, Maurike; de Graaf, Gert; Weijerman, Michel E; Hoffer, Mariette J V; Knijnenburg, Jeroen; van der Kevie-Kersemaekers, Anne-Marie M F; Kooper, Angelique J A; Voorhoeve, Els; Sikkema-Raddatz, Birgit; van Zutven, Laura J C M; Srebniak, Malgorzata Ilona; Huijsdens-van Amsterdam, Karin; Engelen, John J M; Smeets, Dominique; van Kaam, Anton H; Cornel, Martina C (John Wiley & Sons Inc., 2021-09)
    Objective: To evaluate if non-invasive prenatal testing (NIPT) affects livebirth (LB) prevalence of Down syndrome (DS) in the Netherlands. Method: Data from clinical genetics laboratories and the Working Party on Prenatal ...
  • X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19 
    Asano, Takaki; Boisson, Bertrand; Onodi, Fanny; Matuozzo, Daniela; Moncada-Velez, Marcela; Maglorius Renkilaraj, Majistor Raj Luxman; Zhang, Peng; Meertens, Laurent; Bolze, Alexandre; Materna, Marie; Korniotis, Sarantis; Gervais, Adrian; Talouarn, Estelle; Bigio, Benedetta; Seeleuthner, Yoann; Bilguvar, Kaya; Zhang, Yu; Neehus, Anna-Lena; Ogishi, Masato; Pelham, Simon J; Le Voyer, Tom; Rosain, Jérémie; Philippot, Quentin; Soler-Palacín, Pere; Colobran, Roger; Martin-Nalda, Andrea; Rivière, Jacques G; Tandjaoui-Lambiotte, Yacine; Chaïbi, Khalil; Shahrooei, Mohammad; Darazam, Ilad Alavi; Olyaei, Nasrin Alipour; Mansouri, Davood; Hatipoğlu, Nevin; Palabiyik, Figen; Ozcelik, Tayfun; Novelli, Giuseppe; Novelli, Antonio; Casari, Giorgio; Aiuti, Alessandro; Carrera, Paola; Bondesan, Simone; Barzaghi, Federica; Rovere-Querini, Patrizia; Tresoldi, Cristina; Franco, Jose Luis; Rojas, Julian; Reyes, Luis Felipe; Bustos, Ingrid G; Spaan, András N; COVID Human Genetic Effort (American Association for the Advancement of Science, 2021-08-19)
    Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare, biochemically deleterious X-linked TLR7 variants ...
  • The good, the bad and the ugly: pandemic priority decisions and triage 
    Flaatten, Hans; Van Heerden, Vernon; Jung, Christian; Beil, Michael; Leaver, Susannah; Rhodes, Andrew; Guidet, Bertrand; deLange, Dylan W (BMJ Publishing Group, 2021-12-01)
    In this analysis we discuss the change in criteria for triage of patients during three different phases of a pandemic like COVID-19, seen from the critical care point of view. Availability of critical care beds has become ...
  • The impact of end-of-life care on ICU outcome 
    Flaatten, Hans; deLange, Dylan; Jung, Christian; Beil, Michael; Guidet, Bertrand (Springer-Verlag, 2021-05)
  • Intervalverlenging bij omalizumab behandeling van patiënten met chronische urticaria 
    Meertens, M. A.J.; Alizadeh Aghdam, M.; Pieterse, R. H.; Kentie, P. A.; Rijken, F.; Knulst, A. C.; Röckmann, Heike (DCHG Partners in Mediscne Communicatie, 2021-08)
    Deze studie bevat een gedetailleerde analyse van omalizumab behandelintervallen in een grote populatie met onderliggende actieve ziekte. De resultaten van deze studie zijn in 2020 in JACI in practice gepubliceerd. We ...
  • Verdenking op allergische reactie op COVID-19 vaccinatie: praktische overwegingen 
    Meertens, M. A.J.; Versluis, A.; Knulst, A. C.; Röckmann, Heike (DCHG Partners in Mediscne Communicatie, 2021-08)
    Momenteel wordt er in de strijd tegen COVID-19 wereldwijd massaal gevaccineerd, ook in Nederland. Deze massale vaccinatie brengt ook vragen met zich mee over mogelijke allergische reacties die op kunnen treden. In dit ...
  • Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders 
    Nabais, Marta F.; Laws, Simon M.; Lin, Tian; Vallerga, Costanza L.; Armstrong, Nicola J.; Blair, Ian P.; Kwok, John B.; Mather, Karen A.; Mellick, George D.; Sachdev, Perminder S.; Wallace, Leanne; Henders, Anjali K.; Zwamborn, Ramona A.J.; Hop, Paul J.; Lunnon, Katie; Pishva, Ehsan; Roubroeks, Janou A.Y.; Soininen, Hilkka; Tsolaki, Magda; Mecocci, Patrizia; Lovestone, Simon; Kłoszewska, Iwona; Vellas, Bruno; Furlong, Sarah; Garton, Fleur C.; Henderson, Robert D.; Mathers, Susan; McCombe, Pamela A.; Needham, Merrilee; Ngo, Shyuan T.; Nicholson, Garth; Pamphlett, Roger; Rowe, Dominic B.; Steyn, Frederik J.; Williams, Kelly L.; Anderson, Tim J.; Bentley, Steven R.; Dalrymple-Alford, John; Fowder, Javed; Gratten, Jacob; Halliday, Glenda; Hickie, Ian B.; Kennedy, Martin; Lewis, Simon J.G.; Montgomery, Grant W.; Pearson, John; Pitcher, Toni L.; van Rheenen, Wouter; van den Berg, Leonard H.; Veldink, Jan H.; the Australian Imaging Biomarkers and Lifestyle study; the Alzheimer’s Disease Neuroimaging Initiative (BioMed Central, 2021-03-26)
    Background: People with neurodegenerative disorders show diverse clinical syndromes, genetic heterogeneity, and distinct brain pathological changes, but studies report overlap between these features. DNA methylation (DNAm) ...