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UMC Repository: Recent submissions

  • Immune inhibitory receptors in host–microbe interaction 
    Rumpret, Matevž (Utrecht University, 2022-03-17)
    The immune system protects the organism from disease, but inappropriate immune responses can also damage it. Inhibitory receptors can dampen immune responses and prevent tissue damage and inflammatory diseases. In the human ...
  • Application of modelling and simulation to optimize anticancer treatment of special patient populations 
    Janssen, Julie M (Utrecht University, 2020-04-23)
    Special patient groups, such as children and pregnant women, are not regularly included in drug development programs. Changes in physiological processes in these patients affect the pharmacokinetics (PK) and pharmacodynamics ...
  • ERS International Congress 2023: highlights from the Interstitial Lung Diseases Assembly 
    Fabbri, Laura; Guiot, Julien; Vermant, Marie; Miądlikowska, Ewa; Estrella, Deborah; Wijsenbeek, Marlies S; Wuyts, Wim; Bargagli, Elena; Froidure, Antoine; Spagnolo, Paolo; Veltkamp, Marcel; Molina-Molina, Maria; McCarthy, Cormac; Antoniou, Katerina; Kreuter, Michael; Moor, Catharina C (European Respiratory Society, 2024-03)
    This article summarises a selection of scientific highlights in the field of interstitial lung diseases (ILDs) presented at the International Congress of the European Respiratory Society in 2023. Translational and clinical ...
  • Mortality surrogates in combined pulmonary fibrosis and emphysema 
    Zhao, An; Gudmundsson, Eyjolfur; Mogulkoc, Nesrin; van Moorsel, Coline; Corte, Tamera J; Vasudev, Pardeep; Romei, Chiara; Chapman, Robert; Wallis, Tim J M; Denneny, Emma; Goos, Tinne; Savas, Recep; Ahmed, Asia; Brereton, Christopher J; van Es, Hendrik W; Jo, Helen; De Liperi, Annalisa; Duncan, Mark; Pontoppidan, Katarina; De Sadeleer, Laurens J; van Beek, Frouke; Barnett, Joseph; Cross, Gary; Procter, Alex; Veltkamp, Marcel; Hopkins, Peter; Moodley, Yuben; Taliani, Alessandro; Taylor, Magali; Verleden, Stijn; Tavanti, Laura; Vermant, Marie; Nair, Arjun; Stewart, Iain; Janes, Sam M; Young, Alexandra L; Barber, David; Alexander, Daniel C; Porter, Joanna C; Wells, Athol U; Jones, Mark G; Wuyts, Wim A; Jacob, Joseph (European Respiratory Society, 2024-04)
    BACKGROUND: Idiopathic pulmonary fibrosis (IPF) with coexistent emphysema, termed combined pulmonary fibrosis and emphysema (CPFE) may associate with reduced forced vital capacity (FVC) declines compared to non-CPFE IPF ...
  • Disease Relapse Rate from Long-Term Follow-Up Data in Löfgren's Syndrome 
    Karakaya, Bekir; Veltkamp, Marcel; van Moorsel, Coline H M; Grutters, Jan C (American Thoracic Society, 2024-04-15)
  • Exercise-induced cardiac troponin release in athletes with versus without coronary atherosclerosis 
    Janssen, Sylvan L.J.E.; de Vries, Femke; Mingels, Alma M.A.; Kleinnibbelink, Geert; Hopman, Maria T.E.; Mosterd, Arend; Velthuis, Birgitta K.; Aengevaeren, Vincent L.; Eijsvogels, Thijs M.H. (2024-04-01)
    The magnitude of exercise-induced cardiac troponin (cTn) elevations is dependent on cardiovascular health status, and previous studies have shown that occult coronary atherosclerosis is highly prevalent among amateur ...
  • Predictive factors of clot propagation in patients with superficial venous thrombosis towards deep venous thrombosis and pulmonary embolism: a systematic review and meta-analysis 
    van Royen, Florien Sophie-Anne; van Smeden, Maarten; van Doorn, Sander; Rutten, Frans H; Geersing, Geert-Jan (BMJ Publishing Group, 2024-04-16)
    OBJECTIVE: A subset of patients with superficial venous thrombosis (SVT) experiences clot propagation towards deep venous thrombosis (DVT) and/or pulmonary embolism (PE). The aim of this systematic review is to identify ...
  • Outcome of combined modality treatment in first-line for stage I(E) peripheral T-cell lymphoma; a nationwide population-based cohort study from the Netherlands 
    Meeuwes, Frederik O.; Cancer Organisation, Utrecht, the Netherlands, Netherlands; Plattel, Wouter; Van der Poel, Marjolein W.M.; Kersten, Marie José; Wondergem, Mariëlle; Böhmer, Lara; Woei-A-Jin, F. J.Sherida H.; Visser, Otto; Oostvogels, Rimke; Jansen, Patty M.; Neelis, Karen J.; Crijns, Anne P.G.; Daniëls, Laurien A.; Snijders, Tjeerd J.F.; Vermaat, Joost S.P.; Huls, Gerwin A.; Nijland, Marcel (Ferrata Storti Foundation, 2024-04-01)
    Peripheral T-cell lymphomas (PTCL) comprise a heterogeneous group of mature T-cell neoplasms with an unfavorable prognosis; presentation with stage I(E) disease is uncommon. In clinical practice, an abbreviated chemotherapy ...
  • Intravoxel incoherent motion (IVIM)-derived perfusion fraction mapping for the visual evaluation of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids 
    Slotman, Derk J; Bartels, Lambertus W; Nijholt, Ingrid M; Froeling, Martijn; Huirne, Judith A F; Moonen, Chrit T W; Boomsma, Martijn F (Informa Healthcare, 2024)
    BACKGROUND: A method for periprocedural contrast agent-free visualization of uterine fibroid perfusion could potentially shorten magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) treatment times and ...
  • Arthropathy on X-rays in 363 persons with hemophilia: long-term development, and impact of birth cohort and inhibitor status 
    van Heel, Dayna A M; Foppen, Wouter; Fischer, Kathelijn (Wiley-Blackwell Publishing Ltd, 2024-02)
    BACKGROUND: Arthropathy following repeated bleeding is common in persons with hemophilia. Since the introduction of prophylaxis, treatment has intensified and joint health has improved. However, data on the long-term ...
  • Combining CRISPR-Cas9 and TCR exchange to generate a safe and efficient cord blood-derived T cell product for pediatric relapsed AML 
    Lo Presti, Vania; Meringa, Angelo; Dunnebach, Ester; van Velzen, Alice; Moreira, Aida Valera; Stam, Ronald W; Kotecha, Rishi S; Krippner-Heidenreich, Anja; Heidenreich, Olaf T; Plantinga, Maud; Cornel, Annelisa; Sebestyen, Zsolt; Kuball, Jurgen; van Til, Niek P; Nierkens, S (BioMed Central Ltd., 2024-04-05)
    BACKGROUND: Hematopoietic cell transplantation (HCT) is an effective treatment for pediatric patients with high-risk, refractory, or relapsed acute myeloid leukemia (AML). However, a large proportion of transplanted patients ...
  • Geospatial and multilevel clustering of zero-dose children in Kikwit, Democratic Republic of the Congo in 2022 
    Mutwadi, Armand Malembe; Madinga, Joule Ntwan; Vanlerberghe, Veerle; Mbala, Placide K; van der Sande, Marianne A B (Public Library of Science, 2024-02-29)
    Zero-dose children remain highly vulnerable to vaccine-preventable diseases and can sustain transmission even in highly vaccinated populations. The WHO Immunization Agenda 2030 has prioritised reaching out to these children. ...
  • Malaria risk mapping among children under five in Togo 
    Kombate, Gountante; Kone, Issouf; Douti, Bili; Soubeiga, Kamba André-Marie; Grobbee, Diederick E; van der Sande, Marianne A B (Nature Publishing Group, 2024-04-08)
    Malaria is a major health threat in sub-Sahara Africa, especially for children under five. However, there is considerable heterogeneity between areas in malaria risk reported, associated with environmental and climatic. ...
  • Scoring osteoarthritis reliably in large joints and the spine using whole-body ct: Osteoarthritis computed tomography-score (oact-score) 
    Gielis, Willem Paul; Weinans, Harrie; Nap, Frank J.; Roemer, Frank W.; Foppen, Wouter (MDPI Multidisciplinary Digital Publishing Institute, 2021-12)
    A standardized method to assess structural osteoarthritis (OA) burden thorough the body lacks from literature. Such a method can be valuable in developing personalized treatments for OA. We developed a reliable scoring ...
  • Predictors of major adverse cardiac events among patients with chest pain and low HEART score in the emergency department 
    Ho, Andrew Fu Wah; Yau, Chun En; Ho, Jamie Sin Ying; Lim, Swee Han; Ibrahim, Irwani; Kuan, Win Sen; Ooi, Shirley Beng Suat; Chan, Mark Y.; Sia, Ching Hui; Mosterd, Arend; Gijsberts, Crystel M.; de Hoog, Vince C.; Bank, Ingrid E.M.; Doevendans, Pieter A.; de Kleijn, Dominique P.V. (Elsevier Ireland Ltd, 2024-01-15)
    Aim: For patients who present to the emergency departments (ED) with undifferentiated chest pain, the risk of major adverse cardiac events (MACE) may be underestimated in low-HEART score patients. We aimed to identify ...
  • Extracellular vesicles in diagnosing chronic coronary syndromes: the bumpy road to clinical implementation 
    Dekker, Mirthe; Waissi, Farahnaz; Timmerman, Nathalie; Silvis, Max J.M.; Timmers, Leo; de Kleijn, Dominique P.V. (Multidisciplinary Digital Publishing Institute (MDPI), 2020-12-01)
    Coronary artery disease (CAD), comprising both acute coronary syndromes (ACS) and chronic coronary syndromes (CCS), remains one of the most important killers throughout the entire world. ACS is often quickly diagnosed by ...
  • Immunomodulation of the NLRP3 Inflammasome in Atherosclerosis, Coronary Artery Disease, and Acute Myocardial Infarction 
    Silvis, Max J.M.; Demkes, Evelyne J.; Fiolet, Aernoud T.L.; Dekker, Mirthe; Bosch, Lena; van Hout, Gerardus P.J.; Timmers, Leo; de Kleijn, Dominique P.V. (Springer New York, 2021-02)
    Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity worldwide. Atherosclerosis is responsible for the majority of cardiovascular disorders with inflammation as one of its driving processes. ...
  • Cranberries effectief als UWI-profylaxe? 
    Platteel, Tamara; Venekamp, Roderick (Bohn Stafleu van Loghum, 2024-03)
  • OrgaSegment: deep-learning based organoid segmentation to quantify CFTR dependent fluid secretion 
    Lefferts, Juliet W; Kroes, Suzanne; Smith, Matthew B; Niemöller, Paul J; Nieuwenhuijze, Natascha D A; Sonneveld van Kooten, Heleen N; van der Ent, Cornelis K; Beekman, Jeffrey M; van Beuningen, Sam F B (Springer Nature, 2024-03-13)
    Epithelial ion and fluid transport studies in patient-derived organoids (PDOs) are increasingly being used for preclinical studies, drug development and precision medicine applications. Epithelial fluid transport properties ...
  • Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies 
    O'Keefe, James H; Tintle, Nathan L; Harris, William S; O'Keefe, Evan L; Sala-Vila, Aleix; Attia, John; Garg, G Manohar; Hure, Alexis; Bork, Christian Sørensen; Schmidt, Erik Berg; Venø, Stine Krogh; Chien, Kuo-Liong; Chen, Yun-Yu Amelia; Egert, Sarah; Feldreich, Tobias Rudholm; Ärnlöv, Johan; Lind, Lars; Forouhi, Nita G; Geleijnse, Johanna M; Pertiwi, Kamalita; Imamura, Fumiaki; de Mello Laaksonen, Vanessa; Uusitupa, W Matti; Tuomilehto, Jaakko; Laakso, Markku; Lankinen, Maria Anneli; Laurin, Danielle; Carmichael, Pierre-Hugues; Lindsay, Joan; Leander, Karin; Laguzzi, Federica; Swenson, Brenton R; Longstreth, William T; Manson, JoAnn E; Mora, Samia; Cook, Nancy R; Marklund, Matti; Melo van Lent, Debora; Murphy, Rachel; Gudnason, Vilmundur; Ninomiya, Toshihara; Hirakawa, Yoichiro; Qian, Frank; Sun, Qi; Hu, Frank; Ardisson Korat, Andres V; Risérus, Ulf; Lázaro, Iolanda; Samieri, Cecilia; Le Goff, Mélanie; Helmer, Catherine; Steur, Marinka; Voortman, Trudy; Ikram, M Kamran; Tanaka, Toshiko; Das, Jayanta K; Ferrucci, Luigi; Bandinelli, Stefania; Tsai, Michael; Guan, Weihua; Garg, Parveen; Verschuren, W M Monique; Boer, Jolanda M A; Biokstra, Anneke; Virtanen, Jyrki; Wagner, Michael; Westra, Jason; Albuisson, Luc; Yamagishi, Kazumasa; Siscovick, David S; Lemaitre, Rozenn N; Mozaffarian, Dariush (Lippincott Williams and Wilkins, 2024-01)
    BACKGROUND: The effect of marine omega-3 PUFAs on risk of stroke remains unclear. METHODS: We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and ...