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Now showing items 29321-29340 of 40729

Advances in congenital and postnatal cytomegalovirus infections

Gunkel, J. (Utrecht University, 2017-06-30)

Congenital CMV infection (cCMV) is the most prevalent viral infection worldwide and the leading cause of non-genetic sensorineural hearing loss. Early diagnosis of cCMV infection is advantageous as it allows for regular ...
Genetic lipid disorders, Familial Dysbetalipoproteinemia and cardiovascular disease

Koopal, C. (Utrecht University, 2017-04-13)

Background Cardiovascular disease (CVD) is a large worldwide medical burden, with yearly increasing morbidity and mortality. An important risk factor for CVD are high cholesterol levels, with low-density lipoprotein ...
Post-mortem computed tomography angiography utilizing barium sulfate to identify microvascular structures: a preliminary phantom model and case study

Haakma, Wieke; Rohde, Marianne; Kuster, Lidy; Uhrenholt, Lars; Pedersen, Michael; Boel, Lene Warner Thorup (Elsevier, 2016-12-01)

We investigated the use of computer tomography angiography (CTA) to visualize microvascular structures in a vessel-mimicking phantom and post-mortem (PM) bodies. A contrast agent was used based on 22% barium sulfate, 20% ...
The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomas

D'Andrea, Aleco; Gritti, Ilaria; Nicoli, Paola; Giorgio, Marco; Doni, Mirko; Conti, Annalisa; Bianchi, Valerio; Casoli, Lucia; Sabò, Arianna; Mironov, Alexandre; Beznoussenko, Galina V.; Amati, Bruno (Impact Journals, 2016)

The oncogenic transcription factor Myc is required for the progression and maintenance of diverse tumors. This has led to the concept that Myc itself, Myc-activated gene products, or associated biological processes might ...
Effects of high-intensity interval training on central haemodynamics and skeletal muscle oxygenation during exercise in patients with chronic heart failure

Spee, Ruud F.; Niemeijer, Victor M.; Wijn, Pieter F. F.; Doevendans, Pieter A.; Kemps, Hareld M. C. (Oxford University Press, 2016-12-01)

Background High-intensity interval training (HIT) improves exercise capacity in patients with chronic heart failure (CHF). Moreover, HIT was associated with improved resting cardiac function. However, the extent to which ...
The telephone lifestyle intervention 'Hartcoach' has modest impact on coronary risk factors: A randomised multicentre trial

Leemrijse, Chantal J; Peters, Ron J G; von Birgelen, Clemens; Van Dijk, Liset; Van Hal, John M C; Kuijper, Aaf F M; Snaterse, Marjolein; Veenhof, Cindy (Oxford University Press, 2016-10-01)

Background Unhealthy diets and inactivity are still common among patients with cardiovascular diseases. This study evaluates the effects of the telephonic lifestyle intervention 'Hartcoach' on risk factors and self-management ...
The Fate of Revascularization for Peripheral Arterial Disease

Bodewes, T.C.F. (Utrecht University, 2017-06-23)
Novel techniques for 7 tesla breast MRI

van der Velden, T.A. (Utrecht University, 2017-05-23)

This thesis introduced several new techniques to the field of 7 tesla breast MRI, enabling high field multi-parametric MR imaging and, potentially, patient specific treatment planning. Chapter 2 described the development ...
Societal and eonomic aspects of inflammatory bowel diseases

Severs, M. (Utrecht University, 2017-06-08)
Risk stratification in acute coronary syndrome

Chan, Mark Y. (Utrecht University, 2017-06-06)
FIBROBLAST GROWTH FACTOR RECEPTORS IN HEAD AND NECK CANCER: TRANSLATIONAL STUDIES ON PROGNOSIS AND THERAPY

Koole, K. (Utrecht University, 2017-07-06)

Objective Fibroblast growth factor receptors (FGFR1–4) are promising therapeutic targets in multiple types of solid tumors. However, for head and neck squamous cell carcinoma (HNSCC) evidence on FGFR is limited. We have ...
Modelling Autistic Features in Mice Using Quantitative Genetic Approaches

Molenhuis, Remco T; Bruining, Hilgo; Kas, Martien J (Springer, 2017)

Animal studies provide a unique opportunity to study the consequences of genetic variants at the behavioural level. Human studies have identified hundreds of risk genes for autism spectrum disorder (ASD) that can lead to ...
Oligodendroglial myelination requires astrocyte-derived lipids

Camargo, Nutabi; Goudriaan, Andrea; van Deijk, Anne-Lieke F; Otte, Willem M.; Brouwers, Jos F H M; Lodder, Hans; Gutmann, David H; Nave, Klaus-Armin; Dijkhuizen, Rick M.; Mansvelder, Huibert D; Chrast, Roman; Smit, August B; Verheijen, Mark H.G. (Public Library of Science, 2017-05-26)

In the vertebrate nervous system, myelination of axons for rapid impulse propagation requires the synthesis of large amounts of lipids and proteins by oligodendrocytes and Schwann cells. Myelin membranes are thought to be ...
A Participatory Design Approach to Develop a Web-Based Self-Care Program Supporting Early Rehabilitation among Patients after Total Laryngectomy

Cnossen, Ingrid C.; van Uden-Kraan, Cornelia F.; Eerenstein, Simone E. J.; Rinkel, Rico N.P.M.; Aalders, Ijke J.; Van Den Berg, Klaske; de Goede, Cees J T; Van Stijgeren, Ans J.; Cruijff-Bijl, Yvonne; De Bree, Remco; Leemans, C René; Verdonck-De Leeuw, Irma M. (S. Karger AG, 2015)

To develop a Web-based self-care program for patients after total laryngectomy according to a participatory design approach. Methods: We conducted a needs assessment with laryngectomees (n = 9) and their partners (n = 3) ...
Erratum: Endovascular therapy is effective and safe for patients with severe ischemic stroke: Pooled analysis of Interventional Management of Stroke III and Multicenter Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke in the Netherlands Data (Stroke (2015) 46 (3416-3422) DOI: 10.1161/STROKEAHA.115.011397)

Broderick, Joseph P.; Berkhemer, Olvert A.; Palesch, Yuko Y.; Dippel, Diederik W J; Foster, Lydia D.; Roos, Y.B.W.E.M.; van der Lugt, A.; Tomsick, Thomas A.; Majoie, Charles B L M; van Zwam, Wim H; Demchuk, Andrew M.; van Oostenbrugge, R. J.; Khatri, Pooja; Lingsma, Hester F.; Hill, Michael D.; Roozenbeek, Bob; Jauch, Edward C.; Jovin, Tudor G.; Yan, Bernard; von Kummer, R.; Molina, Carlos A.; Goyal, Mayank; Schonewille, Wouter J.; Mazighi, M.; Engelter, Stefan T.; Anderson, Craig S.; Spilker, Judith; Carrozzella, Janice; Ryckborst, Karla J.; Janis, L. Scott; Simpson, Kit N. (Lippincott Williams & Wilkins, 2016-01-01)
The contribution of the in-vivo fate of an oil depot to drug absorption

Kalicharan, R. W.; Oussoren, C; Schot, Peter; Rijk, de, E.; Vromans, H. (Elsevier, 2017-08-07)

Sustained release of lipophilic compounds can be achieved with oil depots. These parenteral formulations are generally injected in the vastus lateralis and deltoid muscle. It is known that the absorption rate differs between ...
Can routine chest radiography be used to diagnose mild COPD?: A nested case-control study

den Harder, A M; Snoek, A M; Leiner, T; Suyker, W J; de Heer, L M; Budde, R P J; Lammers, J W J; de Jong, P A; Gondrie, M J A (Elsevier Ireland Ltd, 2017-07)

OBJECTIVES: To determine whether mild stage chronic obstructive pulmonary disease (COPD) can be detected on chest radiography without substantial overdiagnosis. METHODS: A retrospective nested case-control study (case:control, ...
HIV and risk of cardiovascular disease in sub-Saharan Africa: Rationale and design of the Ndlovu Cohort Study

Vos, Alinda; Tempelman, Hugo; Devillé, Walter; Barth, Roos; Wensing, Annemarie; Kretzschmar, Mirjam; Klipstein-Grobusch, Kerstin; Hoepelman, Andy; Tesselaar, Kiki; Aitken, Sue; Madzivhandila, Mashudu; Uiterwaal, Cuno; Venter, Francois; Coutinho, Roel; Grobbee, Diederick E (Oxford University Press, 2017-07)

Background The largest proportion of people living with HIV resides in sub-Saharan Africa (SSA). Evidence from developed countries suggests that HIV infection increases the relative risk of cardiovascular disease (CVD) by ...
First birth following spindle transfer for mitochondrial replacement therapy: hope and trepidation

Alikani, Mina; Fauser, Bart C.J.; García-Valesco, Juan Antonio; Simpson, Joe Leigh; Johnson, Martin H. (Elsevier, 2017-04-01)
Breast cancer risk after oocyte donation: should we really be concerned?

Fauser, Bart CJM; Garcia-Velasco, Juan A. (Elsevier, 2017-05-01)

Now showing items 29321-29340 of 40729