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UMC Repository: Recent submissions

  • Unexpected low frequency of respiratory symptoms in an HIV-positive urban sub-Saharan population compared to an HIV-negative control group 
    Kummerow, Maren; Shaddock, Erica; Klipstein-Grobusch, Kerstin; Barth, Roos; Grobbee, Diederick; Venter, Francois; Feldman, Charles; Vos, Alinda (AOSIS (Pty) Ltd, 2019-09-26)
    Background: Chronic respiratory illnesses and respiratory infections are common in HIV-positive populations. It seems reasonable that HIV-positive people experience more respiratory symptoms, such as coughing and breathlessness, ...
  • Diagnostic Yield of Next Generation Sequencing in Genetically Undiagnosed Patients with Primary Immunodeficiencies: a Systematic Review 
    Yska, Hemmo A F; Elsink, Kim; Kuijpers, Taco W; Frederix, Geert W J; van Gijn, Mariëlle E; van Montfrans, Joris M (Springer New York, 2019-08-15)
    BACKGROUND: As the application of next generation sequencing (NGS) is moving to earlier stages in the diagnostic pipeline for primary immunodeficiencies (PIDs), re-evaluation of its effectiveness is required. The aim of ...
  • Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm–Associated Regions to Potential Candidate Genes 
    Netherlands Brain Bank (Wiley-Blackwell, 2019-05-07)
    Background: We previously showed that intracranial aneurysm (IA)–associated single-nucleotide polymorphisms are enriched in promoters and putative enhancers identified in the human circle of Willis, on which IAs develop, ...
  • Potential for Reducing Time to Referral for Colorectal Cancer Patients in Primary Care 
    van Erp, Nicole F; Helsper, Charles W; Olyhoek, Saskia M; Janssen, Ramon R T; Winsveen, Amber; Peeters, Petra H M; de Wit, Niek J (Annals of Family Medicine, Inc, 2019-09-01)
    PURPOSE: An optimal diagnostic process in primary care is pivotal for reducing cancer-related disease burden. This study aims to explore reasons for long times to referral for Dutch colorectal cancer (CRC) patients in ...
  • A guide to systematic review and meta-analysis of prognostic factor studies 
    Riley, Richard D.; Moons, Karel G.M.; Snell, Kym I.E.; Ensor, Joie; Hooft, Lotty; Altman, Douglas G.; Hayden, Jill; Collins, Gary S.; Debray, Thomas P.A. (BMJ Publishing Group, 2019-01-31)
    Prognostic factors are associated with the risk of future health outcomes in individuals with a particular health condition or some clinical start point (eg, a particular diagnosis). Research to identify genuine prognostic ...
  • The identification of a RNA splice variant in TULP1 in two siblings with early-onset photoreceptor dystrophy 
    Verbakel, Sanne K.; Fadaie, Zeinab; Klevering, B. Jeroen; van Genderen, Maria M.; Feenstra, Ilse; Cremers, Frans P.M.; Hoyng, Carel B.; Roosing, Susanne (John Wiley & Sons Inc., 2019-06-01)
    Background: Early-onset photoreceptor dystrophies are a major cause of irreversible visual impairment in children and young adults. This clinically heterogeneous group of disorders can be caused by mutations in many genes. ...
  • Development of grading scales of pedal sensory loss using Mokken scale analysis on the Rotterdam Diabetic Foot Study Test Battery data 
    Rinkel, Willem D.; Aziz, M. Hosein; Van Neck, Johan W.; Cabezas, Manuel Castro; van der Ark, L. Andries; Coert, J. Henk (John Wiley & Sons Inc., 2019-11-01)
    Introduction: Loss of sensation due to diabetes-related neuropathy often leads to diabetic foot ulceration. Several test instruments are used to assess sensation, such as static and moving 2-point discrimination (S2PD, ...
  • Predicting ulcer-free survival using the discriminative value of screening test locations 
    Rinkel, Willem D.; van der Oest, Mark J.W.; Dijkstra, Don A.; Castro Cabezas, Manuel; Coert, Jan Hendrik (John Wiley & Sons Inc., 2019-03-01)
    Background: Current guidelines recommend screening the feet of diabetic subjects with a 10-g monofilament or tuning fork. We investigated which tests and locations on the feet have the best predictive value regarding 1-year ...
  • Attributable sources of community-acquired carriage of Escherichia coli containing β-lactam antibiotic resistance genes: a population-based modelling study 
    ESBL Attribution Consortium (Elsevier, 2019-08)
    BACKGROUND: Extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC), plasmid-mediated AmpC-producing E coli (pAmpC-EC), and other bacteria are resistant to important β-lactam antibiotics. ESBL-EC and pAmpC-EC ...
  • BMP-2 gene delivery in cell-loaded and cell-free constructs for bone regeneration 
    Loozen, Loek D.; Kruyt, Moyo C.; Kragten, Angela H.M.; Schoenfeldt, Ted; Croes, Michiel; Oner, Cumhur F.; Dhert, Wouter J.A.; Alblas, Jacqueline (Public Library of Science, 2019-01-01)
    To induce osteogenicity in bone graft substitutes, plasmid-based expression of BMP-2 (pBMP-2) has been successfully applied in gene activated matrices based on alginate polymer constructs. Here, we investigated whether ...
  • Accuracy of the Delirium Observational Screening Scale (DOS) as a screening tool for delirium in patients with advanced cancer 
    Neefjes, Elisabeth C.W.; Van Der Vorst, Maurice J.D.L.; Boddaert, Manon S.A.; Verdegaal, Bea A.T.T.; Beeker, Aart; Teunissen, Saskia C.C.; Beekman, Aartjan T.F.; Zuurmond, Wouter W.A.; Berkhof, Johannes; Verheul, Henk M.W. (BioMed Central, 2019-02-19)
    Background: The Delirium Observation Screening Scale (DOS) was developed to facilitate early recognition of delirium by nurses during routine clinical care. It has shown good validity in a variety of patient populations, ...
  • Radical-functionalized plasma polymers: Stable biomimetic interfaces for bone implant applications 
    Akhavan, Behnam; Croes, Michiel; Wise, Steven G.; Zhai, Chongpu; Hung, Juichien; Stewart, Callum; Ionescu, Mihail; Weinans, Harrie; Gan, Yixiang; Amin Yavari, S.; Bilek, Marcela M.M. (Elsevier, 2019-09-01)
    Application of bio-functionalized coatings on bone implantable devices is a promising approach to direct rapid bone-implant integration. Plasma polymer (PP) films have become increasingly popular as platforms for surface ...
  • Arterial Stiffness and Its Relationship to Cardiorespiratory Fitness in Children and Young Adults with a Fontan Circulation 
    Noortman, Laurien C M; Haapala, Eero A; Takken, Tim (Springer New York, 2019-04)
    There are no previous studies on arterial stiffness and its associations with cardiorespiratory fitness in young Fontan patients. Therefore, we examined the arterial stiffness and its relationship to cardiorespiratory ...
  • Physical exercise training for type 3 spinal muscular atrophy 
    Bartels, Bart; Montes, Jacqueline; van der Pol, W Ludo; de Groot, Janke F (John Wiley & Sons Inc., 2019-03-01)
    BACKGROUND: Physical exercise training might improve muscle and cardiorespiratory function in spinal muscular atrophy (SMA). Optimization of aerobic capacity or other resources in residual muscle tissue through exercise ...
  • Slow segmentation of faces in Autism Spectrum Disorder 
    van den Boomen, C.; Fahrenfort, J. J.; Snijders, T. M.; Kemner, C. (Elsevier Limited, 2019-04)
    Atypical visual segmentation, affecting object perception, might contribute to face processing problems in Autism Spectrum Disorder (ASD). The current study investigated impairments in visual segmentation of faces in ASD. ...
  • Near-home heart failure care 
    Groenewegen, Amy; Rutten, Frans H (Oxford University Press, 2019-01)
  • The evolving facets of bacterial vaginosis: implications for HIV transmission 
    McKinnon, Lyle R; Achilles, Sharon; Bradshaw, Catriona S; Burgener, Adam; Crucitti, Tania; Fredricks, David N; Jaspan, Heather B; Kaul, Rupert; Kaushic, Charu; Klatt, Nichole; Kwon, Douglas S; Marrazzo, Jeanne M; Masson, Lindi; McClelland, Scott; Ravel, Jacques; van de Wijgert, Janneke H H M; Vodstrcil, Lenka A; Tachedjian, Gilda (Mary Ann Liebert Inc., 2019-03)
    Bacterial vaginosis (BV) is a common yet poorly understood vaginal condition that has become a major focus of HIV transmission and immunology research. Varied terminologies are used by clinicians and researchers to describe ...
  • Integrating molecular nuclear imaging in clinical research to improve anticancer therapy 
    de Vries, Elisabeth G E; Kist de Ruijter, Laura; Lub-de Hooge, Marjolijn N; Dierckx, Rudi A; Elias, Sjoerd G; Oosting, Sjoukje F (Nature Publishing Group, 2019-04)
    Effective patient selection before or early during treatment is important to increasing the therapeutic benefits of anticancer treatments. This selection process is often predicated on biomarkers, predominantly biospecimen ...
  • Exploring causality of the association between smoking and Parkinson's disease 
    Gallo, Valentina; Vineis, Paolo; Cancellieri, Mariagrazia; Chiodini, Paolo; Barker, Roger A.; Brayne, Carol; Pearce, Neil; Vermeulen, Roel; Panico, Salvatore; Bueno-de-Mesquita, Bas; Vanacore, Nicola; Forsgren, Lars; Ramat, Silvia; Ardanaz, Eva; Arriola, Larraitz; Peterson, Jesper; Hansson, Oskar; Gavrila, Diana; Sacerdote, Carlotta; Sieri, Sabina; Kühn, Tilman; Katzke, Verena A.; van der Schouw, Yvonne T.; Kyrozis, Andreas; Masala, Giovanna; Mattiello, Amalia; Perneczky, Robert; Middleton, Lefkos; Saracci, Rodolfo; Riboli, Elio (Oxford University Press, 2019-06-01)
    BACKGROUND: The aim of this paper is to investigate the causality of the inverse association between cigarette smoking and Parkinson's disease (PD). The main suggested alternatives include a delaying effect of smoking, ...
  • VISUAL ACUITY IN PSEUDOXANTHOMA ELASTICUM 
    Risseeuw, Sara; Ossewaarde-van Norel, Jeannette; Klaver, Caroline C.W.; Colijn, Johanna M.; Imhof, Saskia M.; van Leeuwen, Redmer (Lippincott Williams & Wilkins, 2019-08)
    PURPOSE: To assess the age-specific proportion of visual impairment in patients with pseudoxanthoma elasticum (PXE) and to compare this with foveal abnormality and similar data of late age-related macular degeneration ...