Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

Now showing items 22901-22920 of 40729

Respiratory syncytial, parainfluenza and influenza virus infection in young children with acute lower respiratory infection in rural Gambia

Mackenzie, Grant A; Vilane, Aminata; Salaudeen, Rasheed; Hogerwerf, Lenny; van den Brink, Sharon; Wijsman, Lisa A; Overduin, Pieter; Janssens, Thierry K S; de Silva, Thushan I; van der Sande, Marianne A B; Kampmann, Beate; Meijer, Adam (Nature Publishing Group, 2019-11-29)

Respiratory viral infections contribute significantly to morbidity and mortality worldwide, but representative data from sub-Saharan Africa are needed to inform vaccination strategies. We conducted population-based ...
Accreditation of clinical centres providing primary prevention, secondary prevention and rehabilitation, and sports cardiology: A step towards optimizing quality

Janssen, Arne; Wagenaar, Kim P; Dendale, Paul; Grobbee, Diederick E (Oxford University Press, 2019-11)
The moral and legal status of Health Care Workers in Cluster Randomized Trials: a response to Weijer and Taljaard

van der Graaf, Rieke; van Thiel, Ghislaine J.M.W.; de Hoop, Esther Oomen; Moons, Karel G.M.; Grobbee, Diederick E.; van Delden, Johannes J.M. (Elsevier, 2019-12)

In 2012, Weijer et al published “The Ottawa Statement on the ethical design and conduct of cluster randomized trials”. In 2015, we reflected on this statement and argued that three recommendations in this statement need ...
Cardiovascular guidelines based on high-quality evidence: Are we getting there?

van Dijk, Wouter B; Grobbee, Diederick E (Oxford University Press, 2019-12-01)
Prediction model for pneumonia in primary care patients with an acute respiratory tract infection: Role of symptoms, signs, and biomarkers

Groeneveld, G. H.; Van 'T Wout, J. W.; Aarts, N. J.; Van Rooden, C. J.; Verheij, T. J.M.; Cobbaert, C. M.; Kuijper, E. J.; De Vries, J. J.C.; Van Dissel, J. T. (BioMed Central, 2019-11-20)

Background: Diagnosing pneumonia can be challenging in general practice but is essential to distinguish from other respiratory tract infections because of treatment choice and outcome prediction. We determined predictive ...
Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis: The SMART-MR Study

Zwartbol, M. H. T.; Geerlings, M. I.; Ghaznawi, R.; Hendrikse, J.; van der Kolk, A. G.; UCC-SMART Study Group (American Society of Neuroradiology, 2019-12)

BACKGROUND AND PURPOSE: Intracranial atherosclerosis, a major risk factor for ischemic stroke, is thought to have different atherogenic mechanisms than extracranial atherosclerosis. Studies investigating their relationship ...
Psychosocial factors and hypertension prevalence among Ghanaians in Ghana and Ghanaian migrants in Europe: The RODAM study

Awuah, Raphael Baffour; de-Graft Aikins, Ama; Dodoo, F. Nii Amoo; Meeks, Karlijn A.C.; Beune, Eric J.A.J.; Klipstein-Grobusch, Kerstin; Addo, Juliet; Smeeth, Liam; Bahendeka, Silver K.; Agyemang, Charles (SAGE Publications Inc., 2019-07-01)

Despite progress made to prevent and control hypertension, its prevalence has persisted in many countries. This study examined the associations between psychosocial factors and hypertension among Ghanaian non-migrants and ...
Therapeutic Drug Monitoring of Oral Anticancer Drugs: The Dutch Pharmacology Oncology Group-Therapeutic Drug Monitoring Protocol for a Prospective Study

Groenland, Stefanie L; van Eerden, Ruben A G; Verheijen, Remy B; Koolen, Stijn L W; Moes, Dirk Jan A R; Desar, Ingrid M E; Reyners, Anna K L; Gelderblom, Hans J; van Erp, Nielka P; Mathijssen, Ron H J; Huitema, Alwin D R; Steeghs, Neeltje (Lippincott Williams & Wilkins, 2019-10)

BACKGROUND: Oral anticancer drugs show a high interpatient variability in pharmacokinetics (PK), leading to large differences in drug exposure. For many of these drugs, exposure has been linked to efficacy and toxicity. ...
Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM Trials Group Project

Abdominal Sepsis Study (AbSeS) group on behalf of the Trials Group of the European Society of Intensive Care Medicine (Springer-Verlag, 2019-12)

PURPOSE: To describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, ...
Identification of a tumor-specific allo-HLA-restricted γδTCR

Kierkels, G J J; Scheper, W; Meringa, A D; Johanna, I; Beringer, D X; Janssen, A; Schiffler, M; Aarts-Riemens, T; Kramer, L; Straetemans, T; Heijhuurs, S; Leusen, J H W; San José, E; Fuchs, K; Griffioen, M; Falkenburg, J H; Bongiovanni, L; de Bruin, A; Vargas-Diaz, D; Altelaar, M; Heck, A J R; Shultz, L D; Ishikawa, F; Nishimura, M I; Sebestyén, Z; Kuball, J (The American Society of Hematology, 2019-10-08)

γδT cells are key players in cancer immune surveillance because of their ability to recognize malignant transformed cells, which makes them promising therapeutic tools in the treatment of cancer. However, the biological ...
Why would procalcitonin perform better in patients with a SOFA-score less than 8?

van Oers, Jos A H; Nijsten, Maarten W; de Jong, Evelien; Beishuizen, Albertus; de Lange, Dylan W (Elsevier, 2019-12)
External Validation of Two Models to Predict Delirium in Critically Ill Adults Using Either the Confusion Assessment Method-ICU or the Intensive Care Delirium Screening Checklist for Delirium Assessment

Wassenaar, Annelies; Schoonhoven, Lisette; Devlin, John W; van Haren, Frank M P; Slooter, Arjen J C; Jorens, Philippe G; van der Jagt, Mathieu; Simons, Koen S; Egerod, Ingrid; Burry, Lisa D; Beishuizen, Albertus; Matos, Joaquim; Donders, A Rogier T; Pickkers, Peter; van den Boogaard, Mark (Lippincott Williams & Wilkins, 2019-10)

OBJECTIVES: To externally validate two delirium prediction models (early prediction model for ICU delirium and recalibrated prediction model for ICU delirium) using either the Confusion Assessment Method-ICU or the Intensive ...
Prophylactic Haloperidol Effects on Long-term Quality of Life in Critically Ill Patients at High Risk for Delirium: Results of the REDUCE Study

Rood, Paul J T; Zegers, Marieke; Slooter, Arjen J C; Beishuizen, Albert; Simons, Koen S; van der Voort, Peter H J; van der Woude, Meta C E; Spronk, Peter E; van der Hoeven, Johannes G; Pickkers, Peter; van den Boogaard, Mark (Lippincott Williams & Wilkins, 2019-08)

BACKGROUND: Delirium incidence in intensive care unit patients is high and associated with impaired long-term outcomes. The use of prophylactic haloperidol did not improve short-term outcome among critically ill adults at ...
Defining perioperative neurocognitive disorders: still more to clarify

Çizmeci, Elif A; Slooter, Arjen J C (Oxford University Press, 2019-09)
Pharmacological Management of Delirium

Neerland, Bjørn Erik; Neufeld, Karin J; Slooter, Arjen J C (American Medical Association, 2019-09)
Moderate positive predictive value of a multiplex real-time PCR on whole blood for pathogen detection in critically ill patients with sepsis

van de Groep, Kirsten; Bos, Martine P; Varkila, Meri R J; Savelkoul, Paul H M; Ong, David S Y; Derde, Lennie P G; Juffermans, Nicole P; van der Poll, Tom; Bonten, Marc J M; Cremer, Olaf L (Springer-Verlag, 2019-10)

A novel multiplex real-time PCR for bloodstream infections (BSI-PCR) detects pathogens directly in blood. This study aimed at determining the positive predictive value (PPV) of BSI-PCR in critically ill patients with sepsis. ...
Epidemiology and outcomes of source control procedures in critically ill patients with intra-abdominal infection

van de Groep, Kirsten; Verhoeff, Tessa L; Verboom, Diana M; Bos, Lieuwe D; Schultz, Marcus J; Bonten, Marc J M; Cremer, Olaf L (Elsevier, 2019-08)

PURPOSE: To describe the characteristics and procedural outcomes of source control interventions among Intensive Care Unit (ICU) patients with severe intra-abdominal-infection (IAI). MATERIAL AND METHODS: We identified ...
Personalised reimbursement: a risk-sharing model for biomarker-driven treatment of rare subgroups of cancer patients

van Waalwijk van Doorn-Khosrovani, S B; Pisters-van Roy, A; van Saase, L; van der Graaff, M; Gijzen, J; Sleijfer, S; Hoes, L R; van Berge Henegouwen, J M; van der Wijngaart, H; van der Velden, D L; van Werkhoven, E; Retel, V P; van Harten, W H; Huitema, A D R; Timmers, L; Gelderblom, H; Verheul, H M W; Voest, E E (Oxford University Press, 2019-05-01)
Profile of the SeptiCyte™ LAB gene expression assay to diagnose infection in critically ill patients

Verboom, D M; Koster-Brouwer, M E; Varkila, Mrj; Bonten, Mjm; Cremer, O L (Taylor and Francis Ltd., 2019-02)

Sepsis is a severe and frequently occurring clinical syndrome, caused by the inflammatory response to infections. Recent studies on the human transcriptome during sepsis have yielded several gene-expression assays that ...
Understanding heterogeneity in biologic phenotypes of acute respiratory distress syndrome by leukocyte expression profiles

Bos, Lieuwe Dj; Scicluna, Brendon P; Ong, David Y; Cremer, Olaf; van der Poll, Tom; Schultz, Marcus J (American Thoracic Society, 2019-07-01)

Rationale: Two biologic phenotypes of acute respiratory distress syndrome (ARDS) have been identified based on plasma protein markers in four previous studies. Objectives: To determine if blood leukocyte gene expression ...

Now showing items 22901-22920 of 40729