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Now showing items 22521-22540 of 40729

Assessing causal links between metabolic traits, inflammation and schizophrenia: a univariable and multivariable, bidirectional Mendelian-randomization study

Lin, Bochao D.; Alkema, Anne; Peters, Triinu; Zinkstok, Janneke; Libuda, Lars; Hebebrand, Johannes; Antel, Jochen; Hinney, Anke; Cahn, Wiepke; Adan, Roger; Luykx, Jurjen J. (Oxford University Press, 2019-10-01)

BACKGROUND: Blood immunoreactive biomarkers, such as C-reactive protein (CRP), and metabolic abnormalities have been associated with schizophrenia. Studies comprehensively and bidirectionally probing possible causal links ...
Immunization of young heifers with staphylococcal immune evasion proteins before natural exposure to Staphylococcus aureus induces a humoral immune response in serum and milk

Benedictus, Lindert; Ravesloot, Lars; Poppe, Kim; Daemen, Ineke; Boerhout, Eveline; Van Strijp, Jos; Broere, Femke; Rutten, Victor; Koets, Ad; Eisenberg, Susanne (BioMed Central, 2019-01-07)

Background: Staphylococcus aureus, a leading cause of mastitis in dairy cattle, causes severe mastitis and/or chronic persistent infections with detrimental effects on the cows' wellbeing, lifespan and milk production. ...
The potential use of big data in oncology

Willems, Stefan M; Abeln, Sanne; Feenstra, K Anton; de Bree, Remco; van der Poel, Egge F; Baatenburg de Jong, Robert J; Heringa, Jaap; van den Brekel, Michiel W M (Elsevier Limited, 2019-11-01)

In this era of information technology, big data analysis is entering biomedical sciences. But what is big data, where do they come from and what can we do with it? In this commentary, the main sources of big data are ...
Publisher Correction: Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors (Nature Medicine, (2019), 25, 8, (1260-1265), 10.1038/s41591-019-0493-4)

Cejas, Paloma; Drier, Yotam; Dreijerink, Koen M A; Brosens, Lodewijk A A; Deshpande, Vikram; Epstein, Charles B; Conemans, Elfi B; Morsink, Folkert H M; Graham, Mindy K; Valk, Gerlof D; Vriens, Menno R; Castillo, Carlos Fernandez-Del; Ferrone, Cristina R; Adar, Tomer; Bowden, Michaela; Whitton, Holly J; Da Silva, Annacarolina; Font-Tello, Alba; Long, Henry W; Gaskell, Elizabeth; Shoresh, Noam; Heaphy, Christopher M; Sicinska, Ewa; Kulke, Matthew H; Chung, Daniel C; Bernstein, Bradley E; Shivdasani, Ramesh A (Nature Research, 2019-10-01)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Indications for haematopoietic stem cell transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2019

for the European Society for Blood and Marrow Transplantation (EBMT) (Springer Nature, 2019-10-01)

This is the seventh special EBMT report on the indications for haematopoietic stem cell transplantation for haematological diseases, solid tumours and immune disorders. Our aim is to provide general guidance on transplant ...
Cowper's syringocele in the pediatric population: a retrospective study of 122 patients

Wagemans, M E H M; Tsachouridis, G; Kuijper, C F; de Mooij, K L; Klijn, A J; de Jong, T P V M (Elsevier, 2019-10)

Introduction and objective: Syringocele is a rare cystic dilatation of the duct of Cowper's gland, afflicting mostly the pediatric population. Syringoceles have a wide range of symptoms and may cause urethral obstruction. ...
A head-to-head comparison of conjugation methods for VHHs: Random maleimide-thiol coupling versus controlled click chemistry

van Moorsel, Marc V.A.; Urbanus, Rolf T.; Verhoef, S.; Koekman, C. A.; Vink, Maurice; Vermonden, T.; Maas, Coen; Pasterkamp, Gerard; Schiffelers, Raymond M. (Elsevier, 2019-12-01)

Targeted delivery of therapeutics is an attractive strategy for vascular diseases. Recently, variable domains of heavy-chain-only antibodies (VHHs) have gained momentum as targeting ligands to achieve this. Targeting ligands ...
Portrait of a cancer: mutational signature analyses for cancer diagnostic

Van Hoeck, Arne; Tjoonk, Niels H.; van Boxtel, Ruben; Cuppen, Edwin (BioMed Central, 2019-05-15)

Background: In the past decade, systematic and comprehensive analyses of cancer genomes have identified cancer driver genes and revealed unprecedented insight into the molecular mechanisms underlying the initiation and ...
Prognostic factors and survival in MEN1 patients with gastrinomas: Results from the DutchMEN study group (DMSG)

van Beek, Dirk-Jan; Nell, Sjoerd; Pieterman, Carolina R C; de Herder, Wouter W; van de Ven, Annenienke C; Dekkers, Olaf M; van der Horst-Schrivers, Anouk N; Drent, Madeleine L; Bisschop, Peter H; Havekes, Bas; Borel Rinkes, Inne H M; Vriens, Menno R; Valk, Gerlof D (Wiley-Liss Inc., 2019-11-01)

BACKGROUND AND OBJECTIVES: Gastrinomas are the most prevalent functioning neuroendocrine tumors (NET) in multiple endocrine neoplasia type 1 (MEN1). Guidelines suggest medical therapy in most patients, but surgery may be ...
Applicability of Transcutaneous Oxygen Tension Measurement in the Assessment of Chronic Limb-Threatening Ischemia

Leenstra, Bernard; Wijnand, Joep; Verhoeven, Bart; Koning, Olivier; Teraa, Martin; Verhaar, Marianne C; de Borst, Gert J (SAGE Publications Inc., 2020-03)

Transcutaneous oxygen tension measurement (TcPO2) is widely applied for the evaluation of chronic limb-threatening ischemia (CLTI). Nevertheless, studies that focused on the clinical value of TcPO2 have shown varying ...
Microglia in post-mortem brain tissue of patients with bipolar disorder are not immune activated

Psychiatric Donor Program of the Netherlands Brain Bank (NBB-Psy) (Nature Publishing Group, 2019-05-24)

Genetic, epidemiological, and biomarker studies suggest that the immune system is involved in the pathogenesis of bipolar disorder (BD). It has therefore been hypothesized that immune activation of microglia, the resident ...
Clinical applicability of low levels of thyroglobulin autoantibodies as cutoff point for thyroglobulin autoantibody positivity

Dekker, Bernadette L.; Van Der Horst-Schrivers, Anouk N.A.; Sluiter, Wim J.; Brouwers, Adrienne H.; Lentjes, Eef G.W.M.; Heijboer, Annemieke C.; Muller Kobold, Anneke C.; Links, Thera P. (Mary Ann Liebert Inc., 2019-01-01)

Background: Thyroglobulin (Tg) is an established tumor marker in differentiated thyroid carcinoma (DTC). However, Tg assays can be subject to interference by autoantibodies against Tg (TgAbs). No clinical consensus exists ...
Does breast milk adiponectin affect BMI and cardio-metabolic markers in childhood?

Van Rossem, Lenie; Smit, Henriette A.; Lentjes, Eef G.W.M.; Maitimu-Smeele, Inge; Brunekreef, Bert; Koppelman, Gerard H.; Wijga, Alet H. (Cambridge University Press, 2019-04-28)

Observational studies suggest that breast-feeding is associated with a more favourable BMI and cardio-metabolic markers, but potential underlying mechanisms are unclear. As serum adiponectin has an important function in ...
High rate of unexpected lymphatic drainage patterns and a high accuracy of the sentinel lymph node biopsy in oral cancer after previous neck treatment

den Toom, Inne J; Boeve, Koos; van Weert, Stijn; Bloemena, Elisabeth; Brouwers, Adrienne H; Hoekstra, Otto S; de Keizer, Bart; van der Vegt, Bert; Willems, Stefan M; Leemans, C René; Witjes, Max J H; de Bree, Remco (Elsevier Limited, 2019-07)

RATIONALE: This study evaluates the lymphatic drainage patterns and determines the accuracy of the sentinel lymph node biopsy (SLNB) in patients diagnosed with a cT1-2N0 OSCC and a history of neck surgery or radiotherapy ...
Prognostic value of the nodal yield in head and neck squamous cell carcinoma: A systematic review

de Kort, Willem W B; Maas, Sybren L N; Van Es, Robert J J; Willems, Stefan M (John Wiley & Sons Inc., 2019-08)

Objective: Literature analysis on the prognostic factor of the nodal yield (NY) in neck dissections (NDs), which in general surgical oncology is a strong prognosticator and quality-of-care marker. Methods: We performed a ...
Predicting individualized mortality probabilities for patients with squamous cell carcinoma of the maxilla: Novel models with clinical and histopathological predictors

Slieker, Fons J B; de Bree, Remco; Van Cann, Ellen M (John Wiley & Sons Inc., 2019-10-01)

BACKGROUND: The aim of this article was to develop prediction models that calculate postoperative 2- and 5-year mortality probabilities of patients with squamous cell carcinoma of the maxilla (MSCC). METHODS: Data were ...
Differences between physicians' and nurse practitioners' viewpoints on reasons for clozapine underprescription

Okhuijsen-Pfeifer, Cynthia; Cohen, Dan; Bogers, Jan P A M; de Vos, Cato M H; Huijsman, Elianne A H; Kahn, René S; Luykx, Jurjen J (John Wiley & Sons Inc., 2019-07)

INTRODUCTION: Clozapine (CLZ) is the only proven effective therapy for treatment-resistant schizophrenia, but it is underutilized across the globe. Previous findings suggest a lack of experience with CLZ prescription and ...
Arthroscopic Determination of Cartilage Proteoglycan Content and Collagen Network Structure with Near-Infrared Spectroscopy

Sarin, Jaakko K; Nykänen, Olli; Tiitu, Virpi; Mancini, Irina A D; Brommer, Harold; Visser, Jetze; Malda, Jos; van Weeren, P René; Afara, Isaac O; Töyräs, Juha (Springer Netherlands, 2019-08)

Conventional arthroscopic evaluation of articular cartilage is subjective and insufficient for assessing early compositional and structural changes during the progression of post-traumatic osteoarthritis. Therefore, in ...
Criteria for Early-Phase Diffuse Idiopathic Skeletal Hyperostosis: Development and Validation

Kuperus, Jonneke S; Oudkerk, Sytse F; Foppen, Wouter; Mohamed Hoesein, Firdaus A; Gielis, Willem Paul; Waalwijk, Job; Regan, Elizabeth A; Lynch, David A; Oner, F Cumhur; de Jong, Pim A; Verlaan, Jorrit-Jan (Radiological Society of North America Inc., 2019-05)

Background: Diffuse idiopathic skeletal hyperostosis (DISH) is a condition characterized by the formation of new bone along the anterolateral spinal column at four adjacent vertebral bodies. Purpose: To propose and validate ...
Development and Validation of a Prediction Model for Prehospital Triage of Trauma Patients

van Rein, Eveline A J; van der Sluijs, Rogier; Voskens, Frank J; Lansink, Koen W W; Houwert, R Marijn; Lichtveld, Rob A; de Jongh, Mariska A; Dijkgraaf, Marcel G W; Champion, Howard R; Beeres, Frank J P; Leenen, Luke P H; van Heijl, Mark (American Medical Association, 2019-05)

Importance: Prehospital trauma triage protocols are used worldwide to get the right patient to the right hospital and thereby improve the chance of survival and avert lifelong disabilities. The American College of Surgeons ...

Now showing items 22521-22540 of 40729