Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

  • Toll-like receptor 7-adapter complex modulates interferon-α production in HIV-stimulated plasmacytoid dendritic cells 
    Patamawenu, Andy A; Wright, Nathaniel E; Shofner, Tulley; Evans, Sean; Manion, Maura M; Doria-Rose, Nicole; Migueles, Stephen A; Mendoza, Daniel; Peterson, Bennett; Wilhelm, Christopher; Rood, Julia; Berkley, Amy; Cogliano, Nancy A; Liang, C Jason; Tesselaar, Kiki; Miedema, Frank; Bess, Julian; Lifson, Jeffrey; Connors, Mark (Public Library of Science, 2019-01-01)
    Plasmacytoid dendritic cells (PDCs) and their production of interferon-alpha (IFN-α) are believed to play an important role in human immunodeficiency virus, type I (HIV-1) pathogenesis. PDCs produce IFN-α and other ...
  • Immune Effector Functions of Human IgG2 Antibodies against EGFR 
    Rösner, Thies; Kahle, Steffen; Montenegro, Francesca; Matlung, Hanke L; Jansen, J H Marco; Evers, Mitchell; Beurskens, Frank; Leusen, Jeanette H W; van den Berg, Timo K; Valerius, Thomas (American Association for Cancer Research Inc., 2019-01)
    Three FDA-approved epidermal growth factor receptor (EGFR) antibodies (cetuximab, panitumumab, necitumumab) are clinically available to treat patients with different types of cancers. Interestingly, panitumumab is of human ...
  • CD123 expression levels in 846 acute leukemia patients based on standardized immunophenotyping 
    Bras, Anne E; de Haas, Valerie; van Stigt, Arthur; Jongen-Lavrencic, Mojca; Beverloo, H Berna; Te Marvelde, Jeroen G; Zwaan, C Michel; van Dongen, Jacques J M; Leusen, Jeanette H W; van der Velden, Vincent H J (Wiley-Liss Inc., 2019-03-01)
    Background: While it is known that CD123 is normally strongly expressed on plasmacytoid dendritic cells and completely absent on nucleated red blood cells, detailed information regarding CD123 expression in acute leukemia ...
  • CD47 Blockade and Rituximab in Non-Hodgkin’s Lymphoma 
    Valerius, Thomas; Rösner, Thies; Leusen, Jeanette H W (Massachussetts Medical Society, 2019-01-31)
  • Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering 
    van der Schoot, Johan M S; Fennemann, Felix L; Valente, Michael; Dolen, Yusuf; Hagemans, Iris M; Becker, Anouk M D; Le Gall, Camille M; van Dalen, Duco; Cevirgel, Alper; van Bruggen, Jaco A C; Engelfriet, Melanie; Caval, Tomislav; Bentlage, Arthur E H; Fransen, Marieke F; Nederend, Maaike; Leusen, Jeanette H W; Heck, Albert J R; Vidarsson, Gestur; Figdor, Carl G; Verdoes, Martijn; Scheeren, Ferenc A (American Association for the Advancement of Science, 2019-08-28)
    Hybridoma technology is instrumental for the development of novel antibody therapeutics and diagnostics. Recent preclinical and clinical studies highlight the importance of antibody isotype for therapeutic efficacy. However, ...
  • Validation of Whole-slide Digitally Imaged Melanocytic Lesions: Does Z-Stack Scanning Improve Diagnostic Accuracy? 
    Sturm, Bart; Creytens, David; Cook, Martin G; Smits, Jan; van Dijk, Marcory C R F; Eijken, Erik; Kurpershoek, Eline; Küsters-Vandevelde, Heidi V N; Ooms, Ariadne H A G; Wauters, Carla; Blokx, Willeke A M; van der Laak, Jeroen A W M (Elsevier, 2019-01-01)
    Background: Accurate diagnosis of melanocytic lesions is challenging, even for expert pathologists. Nowadays, whole-slide imaging (WSI) is used for routine clinical pathology diagnosis in several laboratories. One of the ...
  • Cellular Senescence and the Kidney: Potential Therapeutic Targets and Tools 
    Knoppert, Sebastiaan N; Valentijn, Floris A; Nguyen, Tri Q; Goldschmeding, Roel; Falke, Lucas L (Frontiers Media S. A., 2019)
    Chronic kidney disease (CKD) is an increasing health burden (affecting approximately 13.4% of the population). Currently, no curative treatment options are available and treatment is focused on limiting the disease ...
  • Modifying graft-versus-host disease in a humanized mouse model by targeting macrophages or b-cells 
    Hogenes, Marieke C.H.; Van Dorp, Suzanne; Van Kuik, Joyce; Monteiro, Filipa R.P.; Ter Hoeve, Natalie; Guedes, Liane; Van Dijk, Marijke R.; Martens, Anton C.; De Weger, Roel A. (Hindawi Publishing Corporation, 2019-01-01)
    Humanized mouse models can well be modified to study specific aspects of Graft-versus-Host Disease (GvHD). This paper shows the results of both macrophage depletion and (early) B-cell depletion in a humanized mouse model ...
  • A super-SILAC based proteomics analysis of diffuse large B-cell lymphoma-NOS patient samples to identify new proteins that discriminate GCB and non-GCB lymphomas 
    van der Meeren, L E; Kluiver, J; Rutgers, B; Alsagoor, Y; Kluin, P M; van den Berg, A; Visser, L (Public Library of Science, 2019-01-01)
    Diffuse large B-cell lymphoma-not otherwise specified (DLBCL-NOS) is a large and heterogeneous subgroup of non-Hodgkin lymphoma. DLBCL can be subdivided into germinal centre B-cell like (GCB) and activated B-cell like (ABC ...
  • Use of Pharmacogenetic Drugs by the Dutch Population 
    Alshabeeb, Mohammad A; Deneer, Vera H M; Khan, Amjad; Asselbergs, Folkert W (Frontiers Media S. A., 2019)
    Introduction: The Dutch Pharmacogenetics Working Group (DPWG) indicated a list of actionable genotypes that affect patients' response to more 50 drugs; these drugs which show variable effects based on patients' genetic ...
  • Pharmacokinetics and safety of tobramycin nebulization with the I-neb and PARI-LC Plus in children with cystic fibrosis: A randomized, crossover study 
    van Velzen, Annelies J; Uges, Joris W F; Heijerman, Harry G M; Arets, Bert G M; Nuijsink, Marianne; van der Wiel-Kooij, Els C; van Maarseveen, Erik M; van Zanten, Gijsbert A; Pullens, Bas; Touw, Daan J; Janssens, Hettie M (Wiley-Blackwell, 2019-09)
    AIMS: We aimed to compare the pharmacokinetics (PK) and safety profile of tobramycin inhalation solution (TIS) using the I-neb device to the standard PARI-LC Plus nebulizer in children with cystic fibrosis. METHODS: A ...
  • Harmonization of Busulfan Plasma Exposure Unit (BPEU): A Community-Initiated Consensus Statement 
    McCune, Jeannine S; Quinones, Christine M; Ritchie, James; Carpenter, Paul A; van Maarseveen, Erik; Yeh, Rosa F; Anasetti, Claudio; Boelens, Jaap J; Hamerschlak, Nelson; Hassan, Moustapha; Kang, Hyoung Jin; Kanda, Yoshinobu; Paci, Angelo; Perales, Miguel-Angel; Shaw, Peter J; Seewaldt, Victoria L; Savani, Bipin N; Hsieh, Angela; Poon, Betsy; Mohty, Mohamad; Pulsipher, Michael A; Pasquini, Marcelo; Dupuis, L Lee (Elsevier, 2019-09)
    Busulfan therapeutic drug monitoring (TDM) is often used to achieve target plasma exposures. Variability in busulfan plasma exposure units (BPEU) is a potential source for misinterpretation of publications and protocols ...
  • Paracrine Proangiogenic Function of Human Bone Marrow-Derived Mesenchymal Stem Cells Is Not Affected by Chronic Kidney Disease 
    van Rhijn-Brouwer, Femke C C; van Balkom, Bas W M; Papazova, Diana A; Hazenbrink, Diënty H M; Meijer, Anke J; Brete, Isaac; Briceno, Vidalmar; van Zuilen, Arjan D; Toorop, Raechel J; Fledderus, Joost O; Gremmels, Hendrik; Verhaar, Marianne C (Hindawi Publishing Corporation, 2019)
    Background: Cell-based therapies are being developed to meet the need for curative therapy in chronic kidney disease (CKD). Bone marrow- (BM-) derived mesenchymal stromal cells (MSCs) enhance tissue repair and induce ...
  • Clinical Relevance of Genetic Analysis in Patients With Pituitary Adenomas: A Systematic Review 
    van den Broek, Medard F M; van Nesselrooij, Bernadette P M; Verrijn Stuart, Annemarie A; van Leeuwaarde, Rachel S; Valk, Gerlof D (Frontiers Media S. A., 2019-12-10)
    Pituitary adenomas (PA) are amongst the most prevalent intracranial tumors, causing complications by hormonal overproduction or deficiency and tumor mass effects, with 95% of cases occurring sporadically. Associated germline ...
  • De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder 
    The Deciphering Developmental Disorders Study (Cell Press, 2019-04-04)
    The Mediator is an evolutionarily conserved, multi-subunit complex that regulates multiple steps of transcription. Mediator activity is regulated by the reversible association of a four-subunit module comprising CDK8 or ...
  • A framework to develop semiautomated surveillance of surgical site infections: An international multicenter study 
    Van Rooden, Stephanie M.; Tacconelli, Evelina; Pujol, Miquel; Gomila, Aina; Kluytmans, Jan A.J.W.; Romme, Jannie; Moen, Gonny; Couvé-Deacon, Elodie; Bataille, Camille; Rodríguez Banõ, Jesús; Lanz, Joaquín; Van Mourik, Maaike S.M. (Cambridge University Press, 2020-02)
    Objective:Automated surveillance of healthcare-associated infections reduces workload and improves standardization, but it has not yet been adopted widely. In this study, we assessed the performance and feasibility of an ...
  • Circadian rhythms and the molecular clock in cardiovascular biology and disease 
    Crnko, Sandra; Du Pré, Bastiaan C; Sluijter, Joost P G; Van Laake, Linda W (Nature Research, 2019-07)
    The Earth turns on its axis every 24 h; almost all life on the planet has a mechanism - circadian rhythmicity - to anticipate the daily changes caused by this rotation. The molecular clocks that control circadian rhythms ...
  • Treatment Responsiveness in KCNT1-Related Epilepsy 
    Fitzgerald, Mark P.; Fiannacca, Martina; Smith, Douglas M.; Gertler, Tracy S.; Gunning, Boudewijn; Syrbe, Steffen; Verbeek, Nienke; Stamberger, Hannah; Weckhuysen, Sarah; Ceulemans, Berten; Schoonjans, An Sofie; Rossi, Massimiliano; Demarquay, Geneviève; Lesca, Gaetan; Olofsson, Kern; Koolen, D. A.; Hornemann, Frauke; Baulac, Stephanie; Rubboli, Guido; Minks, Kelly Q.; Lee, Bohoon; Helbig, Ingo; Dlugos, Dennis; Møller, Rikke S.; Bearden, David (Springer New York, 2019-07-15)
    Pathogenic variants in KCNT1 represent an important cause of treatment-resistant epilepsy, for which an effective therapy has been elusive. Reports about the effectiveness of quinidine, a candidate precision therapy, have ...
  • Screening op kindermishandeling: wat levert het op? 
    Schouten, Maartje C.M.; Sittig, Judith S.; Van De Putte, Elise M. (Bohn Stafleu van Loghum, 2019-07-25)
    In the Netherlands, child abuse is a national problem and often not recognized in medical settings. As a consequence, it has become mandatory to use a screening instrument for child abuse at emergency departments and ...
  • Aberrant Function of the C-Terminal Tail of HIST1H1E Accelerates Cellular Senescence and Causes Premature Aging 
    hist1h1e (Cell Press, 2019-09-05)
    Histones mediate dynamic packaging of nuclear DNA in chromatin, a process that is precisely controlled to guarantee efficient compaction of the genome and proper chromosomal segregation during cell division and to accomplish ...