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Intestinal organoids to model cystic fibrosis

Van Mourik, Peter; Beekman, Jeffrey M.; Van Der Ent, Cornelis K. (European Respiratory Society, 2019-01-01)

CF can be studied using patient-specific intestinal organoids. CFTR protein function in intestinal organoids correlates with clinical disease severity and drug testing in organoids could aid in finding drugs for people ...
Timing and associated predictors of onset of new conduction disturbances requiring permanent pacemaker implantation after transcatheter aortic valve implantation

Kooistra, N. H. M.; Van Mourik, M. S.; Rodriguez-Olivares, R.; Maass, A. H.; Nijenhuis, V. J.; Van De Werf, H.; Ten Berg, J. M.; Kraaijeveld, A. O.; Baan, J., Jr.; Voskuil, M.; Vis, M. M.; Stella, P. R. (Oxford University Press, 2019-10)
Single-Molecule Sequencing: Towards Clinical Applications

Ameur, Adam; Kloosterman, Wigard P.; Hestand, Matthew S. (Elsevier Limited, 2019-01-01)

In the past several years, single-molecule sequencing platforms, such as those by Pacific Biosciences and Oxford Nanopore Technologies, have become available to researchers and are currently being tested for clinical ...
WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene

The Genome of the Netherlands consortium (Nature Publishing Group, 2019-12-01)

Telomere length (TL) regulation is an important factor in ageing, reproduction and cancer development. Genetic, hereditary and environmental factors regulating TL are currently widely investigated, however, their relative ...
Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study

ACS and GC6–74 cohort study groups; van Baarle, D (Public Library of Science, 2019-04)

BACKGROUND: A nonsputum blood test capable of predicting progression of healthy individuals to active tuberculosis (TB) before clinical symptoms manifest would allow targeted treatment to curb transmission. We aimed to ...
Dysregulated miRNome of plasmacytoid dendritic cells from patients with Sjogren's syndrome is associated with processes at the centre of their function

Hillen, Maarten R.; Chouri, Eleni; Wang, Maojie; Blokland, Sofie L.M.; Hartgring, Sarita A.Y.; Concepcion, Arno N.; Kruize, Aike A.; Burgering, Boudewijn M.T.; Rossato, Marzia; Van Roon, Joel A.G.; Radstake, Timothy R.D.J. (Oxford University Press, 2019-12-01)

Objective: A considerable body of evidence supports a role for type-I IFN in the pathogenesis of primary SS (pSS). As plasmacytoid dendritic cells (pDCs) are a major source of type-I IFN, we investigated their molecular ...
The association between exposure to different aspects of shift work and metabolic risk factors in health care workers, and the role of chronotype

Loef, Bette; Van Baarle, Debbie; Van Der Beek, Allard J.; Beekhof, Piet K.; Van Kerkhof, Linda W.; Proper, Karin I. (Public Library of Science, 2019-02-01)

OBJECTIVE: Shift work has been linked to cardio-metabolic diseases, but insight into different shift work-related aspects and chronotype of shift workers and their relation with metabolic risk factors is limited. This study ...
The hallmarks of CMV-specific CD8 T-cell differentiation

van den Berg, Sara P.H.; Pardieck, Iris N.; Lanfermeijer, Josien; Sauce, Delphine; Klenerman, Paul; van Baarle, Debbie; Arens, Ramon (Springer-Verlag, 2019-08-01)

Upon cytomegalovirus (CMV) infection, large T-cell responses are elicited that remain high or even increase over time, a phenomenon named memory T-cell inflation. Besides, the maintained robust T-cell response, CMV-specific ...
Immunological effects of shift work in healthcare workers

Loef, Bette; Nanlohy, Nening M.; Jacobi, Ronald H.J.; van de Ven, Chantal; Mariman, Rob; van der Beek, Allard J.; Proper, Karin I.; van Baarle, Debbie (Nature Publishing Group, 2019-12-01)

The immune system potentially plays an important mechanistic role in the relation between shift work and adverse health effects. To better understand the immunological effects of shift work, we compared numbers and ...
Reply to: New Meta- and Mega-analyses of Magnetic Resonance Imaging Findings in Schizophrenia: Do They Really Increase Our Knowledge About the Nature of the Disease Process?

Karolinska Schizophrenia Project (Elsevier, 2019-04-01)
Ouderen met kanker ook naar de geriater: Het nut van een geriatrisch assessment

van Delden, J.J.; Versteeg, Kathelijne S. (Bohn Stafleu van Loghum, 2019-04)
The diagnostic accuracy of headache measurement instruments: A systematic review and meta-analysis focusing on headaches associated with musculoskeletal symptoms

van der Meer, Hedwig A.; Visscher, Corine M.; Vredeveld, Tom; Nijhuis van der Sanden, Maria W.G.; HH Engelbert, Raoul; Speksnijder, Caroline M. (SAGE Publications Ltd, 2019-09-01)

Aim: To systematically review the available literature on the diagnostic accuracy of questionnaires and measurement instruments for headaches associated with musculoskeletal symptoms. Design: Articles were eligible for ...
Impact of Clinical and Hemodynamic Factors on Coronary Flow Reserve and Invasive Coronary Flow Capacity in Nonobstructed Coronary Arteries: A Patient-Level Pooled Analysis of the DEBATE and ILIAS Studies

Stegehuis, Valerie; Wijntjens, Gilbert; Bax, Matthijs; Meuwissen, Martijn; Chamuleau, Steven; Voskuil, Michiel; Di Mario, Carlo; Vrints, Christiaan; Haude, Michael; Serruys, Patrick; Piek, Jan; van de Hoef, Tim (Elsevier, 2019-10-01)
Prevention of Infanticide and Suicide in the Postpartum Period - The Importance of Emergency Care

Luykx, Jurjen J.; Di Florio, Arianna; Bergink, Veerle (American Medical Association, 2019-12-01)
Molecular Pathology of Tumors of the Central Nervous System

Kristensen, B W; Priesterbach-Ackley, L P; Petersen, J K; Wesseling, P (Oxford University Press, 2019-08)

Since the update of the 4th edition of the WHO Classification of Central Nervous System (CNS) Tumors published in 2016, particular molecular characteristics are part of the definition of a subset of these neoplasms. This ...
Seeking the state of the art in standardized measurement of health care resource use and costs in juvenile idiopathic arthritis: A scoping review

Kip, Michelle M.A.; Currie, Gillian; Marshall, Deborah A.; Grazziotin Lago, Luiza; Twilt, Marinka; Vastert, Sebastiaan J.; Swart, Joost F.; Wulffraat, Nico; Yeung, Rae S.M.; Benseler, Susanne M.; Ijzerman, Maarten J.; Bonsel, Gouke; Feldman, Brian M.; Hoppenreijs, Esther; Lang, Bianca; Leblanc, Claire; Sepulveda, Ana; Toupin-April, Karine; Van Pelt, Philomine; Van Royen-Kerkhof, Annet (BioMed Central Ltd., 2019-05-06)

Background: This study aims to describe current practice in identifying and measuring health care resource use and unit costs in economic evaluations or costing studies of juvenile idiopathic arthritis (JIA). Methods: A ...
Restoring T cell tolerance, exploring the potential of histone deacetylase inhibitors for the treatment of juvenile idiopathic arthritis

Nijhuis, Lotte; Peeters, Janneke G.C.; Vastert, Sebastiaan J.; Van Loosdregt, Jorg (Frontiers Media S. A., 2019-02-07)

Juvenile Idiopathic Arthritis (JIA) is characterized by a loss of immune tolerance. Here, the balance between the activity of effector T (Teff) cells and regulatory T (Treg) cells is disturbed resulting in chronic inflammation ...
Deletions and loss-of-function variants in TP63 associated with orofacial clefting

Khandelwal, Kriti D.; van den Boogaard, Marie José H.; Mehrem, Sarah L.; Gebel, Jakob; Fagerberg, Christina; van Beusekom, Ellen; van Binsbergen, Ellen; Topaloglu, Ozan; Steehouwer, Marloes; Gilissen, Christian; Ishorst, Nina; van Rooij, Iris A.L.M.; Roeleveld, Nel; Christensen, Kaare; Schoenaers, Joseph; Bergé, Stefaan; Murray, Jeffrey C.; Hens, Greet; Devriendt, Koen; Ludwig, Kerstin U.; Mangold, Elisabeth; Hoischen, Alexander; Zhou, Huiqing; Dötsch, Volker; Carels, Carine E.L.; van Bokhoven, Hans (Springer Nature, 2019-07-01)

We aimed to identify novel deletions and variants of TP63 associated with orofacial clefting (OFC). Copy number variants were assessed in three OFC families using microarray analysis. Subsequently, we analyzed TP63 in a ...
Outcomes of allogeneic haematopoietic stem cell transplantation from HLA-matched and alternative donors: a European Society for Blood and Marrow Transplantation registry retrospective analysis

Shouval, Roni; Fein, Joshua A; Labopin, Myriam; Kröger, Nicolaus; Duarte, Rafael F; Bader, Peter; Chabannon, Christian; Kuball, Jurgen; Basak, Grzegorz Wladyslaw; Dufour, Carlo; Galimard, Jacques-Emmanuel; Polge, Emmanuelle; Lankester, Arjan; Montoto, Silvia; Snowden, John A; Styczynski, Jan; Yakoub-Agha, Ibrahim; Mohty, Mohamad; Nagler, Arnon (Lancet Publishing Group, 2019-11)

BACKGROUND: The introduction of donors other than HLA-matched siblings has been a pivotal change in stem cell transplantation. We aimed to assess the evolution of outcomes within donor groups over time and explore whether ...
Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups

Rothwell, Simon; Chinoy, Hector; Lamb, Janine A.; Miller, Frederick W.; Rider, Lisa G.; Wedderburn, Lucy R.; McHugh, Neil J.; Mammen, Andrew L.; Betteridge, Zoe E.; Tansley, Sarah L.; Bowes, John; Vencovský, Ji I.; Deakin, Claire T.; Dankó, Katalin; Vidya, Limaye; Selva-O'Callaghan, Albert; Pachman, Lauren M.; Reed, Ann M.; Molberg, Yvind; Benveniste, Olivier; Mathiesen, Pernille R.; Radstake, Timothy R.D.J.; Doria, Andrea; De Bleecker, Jan; Lee, Annette T.; Hanna, Michael G.; Machado, Pedro M.; Ollier, William E.; Gregersen, Peter K.; Padyukov, Leonid; O'Hanlon, Terrance P.; Cooper, Robert G.; Lundberg, Ingrid E. (Elsevier, 2019-07-01)

OBJECTIVES: Idiopathic inflammatory myopathies (IIM) are a spectrum of rare autoimmune diseases characterised clinically by muscle weakness and heterogeneous systemic organ involvement. The strongest genetic risk is within ...

Now showing items 22081-22100 of 40729