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Now showing items 21801-21820 of 40729

On Stem Cells, Organoids and Human Disease

Clevers, Hans (Cambridge University Press, 2020-02-01)

Stem cells build our bodies during development, starting from a fertilized oocyte. Subsequently, they maintain and repair our organs for a lifetime. Thus, stem cells hold the promise of eternal life. While this may still ...
Bayesian mixture regression analysis for regulation of Pluripotency in ES cells

Aflakparast, Mehran; Geeven, Geert; De Gunst, Mathisca C.M. (BioMed Central, 2020-01-02)

Background: Observed levels of gene expression strongly depend on both activity of DNA binding transcription factors (TFs) and chromatin state through different histone modifications (HMs). In order to recover the functional ...
Effectiveness of a guided self-help exercise program tailored to patients treated with total laryngectomy: Results of a multi-center randomized controlled trial

Jansen, Femke; Eerenstein, Simone E.J.; Cnossen, Ingrid C.; Lissenberg-Witte, Birgit I.; de Bree, Remco; Doornaert, Patricia; Halmos, György B.; Hardillo, José A.U.; van Hinte, Gerben; Honings, Jimmie; van Uden-Kraan, Cornelia F.; Leemans, C. René; Verdonck-de Leeuw, Irma M. (Elsevier Limited, 2020-04-01)

Objective: To investigate the effectiveness of a guided self-help exercise program on swallowing, speech, and shoulder problems in patients treated with total laryngectomy (TL). Materials and methods: This randomized ...
Antithrombotic Treatment in Cryptogenic Stroke Patients With Patent Foramen Ovale: Systematic Review and Meta-Analysis

Sagris, Dimitrios; Georgiopoulos, Georgios; Perlepe, Kalliopi; Pateras, Konstantinos; Korompoki, Eleni; Makaritsis, Konstantinos; Vemmos, Konstantinos; Milionis, Haralampos; Ntaios, George (Lippincott Williams & Wilkins, 2019-11-01)

Background and Purpose- It is unclear whether treatment with anticoagulants or antiplatelets is the optimal strategy in patients with stroke or transient ischemic attack of undetermined cause and patent foramen ovale that ...
Galectin-9 reflects the interferon signature and correlates with disease activity in systemic autoimmune diseases. Response to: 'Biomarkers: to be or not to be' by Yavuz and Ronnblom: Biomarkers: To be or not to be' by Yavuz and Rönnblom

Van Den Hoogen, Lucas L.; Van Der Heijden, Eefje H.M.; Hillen, Maarten R.; Mertens, Jorre S.; Fritsch-Stork, Ruth D.E.; Radstake, Timothy R.D.J.; Van Roon, Joel A.G. (Elsevier, 2020-01-01)
The noise navigator: a surrogate for respiratory-correlated 4D-MRI for motion characterization in radiotherapy

Navest, R J M; Mandija, S; Bruijnen, T; Stemkens, B; Tijssen, R H N; Andreychenko, A; Lagendijk, J J W; van den Berg, C A T (IOP Publishing Ltd., 2020-01-13)

Respiratory-correlated 4D-MRI can characterize respiratory-induced motion of tumors and organs-at-risk for radiotherapy treatment planning and is a necessity for image guidance of moving tumors treated on an MRI-linac. ...
Quality of life in patients with liver tumors treated with holmium-166 radioembolization

van Roekel, Caren; Smits, Maarten L J; Prince, Jip F; Bruijnen, Rutger C G; van den Bosch, Maurice A A J; Lam, Marnix G E H (Springer Netherlands, 2020-02-01)

Holmium-166 radioembolization is a palliative treatment option for patients with unresectable hepatic malignancies. Its influence on quality of life has not been evaluated yet. Since quality of life is very important in ...
Nutrient-wide association study of 92 foods and nutrients and breast cancer risk

Heath, Alicia K; Muller, David C; van den Brandt, Piet A; Papadimitriou, Nikos; Critselis, Elena; Gunter, Marc; Vineis, Paolo; Weiderpass, Elisabete; Fagherazzi, Guy; Boeing, Heiner; Ferrari, Pietro; Olsen, Anja; Tjønneland, Anne; Arveux, Patrick; Boutron-Ruault, Marie-Christine; Mancini, Francesca Romana; Kühn, Tilman; Turzanski-Fortner, Renée; Schulze, Matthias B; Karakatsani, Anna; Thriskos, Paschalis; Trichopoulou, Antonia; Masala, Giovanna; Contiero, Paolo; Ricceri, Fulvio; Panico, Salvatore; Bueno-de-Mesquita, Bas; Bakker, Marije F; van Gils, Carla H; Olsen, Karina Standahl; Skeie, Guri; Lasheras, Cristina; Agudo, Antonio; Rodríguez-Barranco, Miguel; Sánchez, Maria-José; Amiano, Pilar; Chirlaque, María-Dolores; Barricarte, Aurelio; Drake, Isabel; Ericson, Ulrika; Johansson, Ingegerd; Winkvist, Anna; Key, Tim; Freisling, Heinz; His, Mathilde; Huybrechts, Inge; Christakoudi, Sofia; Ellingjord-Dale, Merete; Riboli, Elio; Tsilidis, Konstantinos K; Tzoulaki, Ioanna (BioMed Central Ltd., 2020-01-13)

BACKGROUND: Several dietary factors have been reported to be associated with risk of breast cancer, but to date, unequivocal evidence only exists for alcohol consumption. We sought to systematically assess the association ...
Consensus-based technical recommendations for clinical translation of renal T1 and T2 mapping MRI

Dekkers, Ilona A; de Boer, Anneloes; Sharma, Kaniska; Cox, Eleanor F; Lamb, Hildo J; Buckley, David L; Bane, Octavia; Morris, David M; Prasad, Pottumarthi V; Semple, Scott I K; Gillis, Keith A; Hockings, Paul; Buchanan, Charlotte; Wolf, Marcos; Laustsen, Christoffer; Leiner, Tim; Haddock, Bryan; Hoogduin, Johannes M; Pullens, Pim; Sourbron, Steven; Francis, Susan (Springer-Verlag, 2020-02)

To develop technical recommendations on the acquisition and post-processing of renal longitudinal (T1) and transverse (T2) relaxation time mapping. A multidisciplinary panel consisting of 18 experts in the field of renal ...
Subarachnoid Hemorrhage and Cerebral Perfusion Are Associated with Brain Volume Decrease in a Cohort of Predominantly Mild Traumatic Brain Injury Patients

van der Kleij, Lisa A; De Vis, Jill B; Restivo, Matthew C; Turtzo, L Christine; Hendrikse, Jeroen; Latour, Lawrence L (Mary Ann Liebert Inc., 2020-02-15)

Biomarkers are needed to identify traumatic brain injury (TBI) patients at risk for accelerated brain volume loss and its associated functional impairment. Subarachnoid hemorrhage (SAH) has been shown to affect cerebral ...
Coping strategies of patients with advanced lung or colorectal cancer in six European countries: Insights from the ACTION Study

on behalf of the ACTION consortium (John Wiley & Sons Inc., 2020-02)

Objective: Even when medical treatments are limited, supporting patients’ coping strategies could improve their quality of life. Greater understanding of patients’ coping strategies, and influencing factors, can aid ...
Transferring effective interventions for cancer-related fatigue from the adjuvant to the advanced cancer session: does it work?

May, A M (Oxford University Press, 2020-01)
On the magnetic field dependence of deuterium metabolic imaging

de Graaf, Robin A.; Hendriks, Arjan D.; Klomp, Dennis W.J.; Kumaragamage, Chathura; Welting, Dimitri; Arteaga de Castro, Catalina S.; Brown, Peter B.; McIntyre, Scott; Nixon, Terence W.; Prompers, Jeanine J.; De Feyter, Henk M. (John Wiley & Sons Inc., 2020-03-01)

Deuterium metabolic imaging (DMI) is a novel MR-based method to spatially map metabolism of deuterated substrates such as [6,6’-2H2]-glucose in vivo. Compared with traditional 13C-MR-based metabolic studies, the MR sensitivity ...
Validating faster DENSE measurements of cardiac-induced brain tissue expansion as a potential tool for investigating cerebral microvascular pulsations

Adams, Ayodeji L.; Viergever, Max A.; Luijten, Peter R.; Zwanenburg, Jaco J.M. (Academic Press Inc., 2020-03-01)

Displacement Encoding with Stimulated Echoes (DENSE) has recently shown potential for measuring cardiac-induced cerebral volumetric strain in the human brain. As such, it may provide a powerful tool for investigating the ...
Role of HLA-B exon 1 in graft-versus-host disease after unrelated haemopoietic cell transplantation: a retrospective cohort study

International Histocompatibility Working Group in Hematopoietic Cell Transplantation (Lancet Publishing Group, 2020-01-01)

BACKGROUND: The success of unrelated haemopoietic cell transplantation (HCT) is limited by graft-versus-host disease (GVHD), which is the main post-transplantation challenge when HLA-matched donors are unavailable. A ...
Acalabrutinib monotherapy in patients with Waldenström macroglobulinemia: a single-arm, multicentre, phase 2 study

Owen, Roger G; McCarthy, Helen; Rule, Simon; D'Sa, Shirley; Thomas, Sheeba K; Tournilhac, Olivier; Forconi, Francesco; Kersten, Marie José; Zinzani, Pier Luigi; Iyengar, Sunil; Kothari, Jaimal; Minnema, Monique C; Kastritis, Efstathios; Aurran-Schleinitz, Thérèse; Cheson, Bruce D; Walter, Harriet; Greenwald, Daniel; Chen, Dih-Yih; Frigault, Melanie M; Hamdy, Ahmed; Izumi, Raquel; Patel, Priti; Wei, Helen; Lee, Sun Ku; Mittag, Diana; Furman, Richard R (Lancet Publishing Group, 2020-02)

BACKGROUND: Chemoimmunotherapy is typically the standard of care for patients with Waldenström macroglobulinemia; however, infectious and hematologic toxic effects are problematic. Acalabrutinib is a selective, potent ...
2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD

ESC Scientific Document Group (Oxford University Press, 2020-01-07)
Maternal and neonatal bleeding complications in relation to peripartum management in women with Von Willebrand disease: A systematic review

Punt, M. C.; Waning, M. L.; Mauser-Bunschoten, E. P.; Kruip, M. J.H.A.; Eikenboom, J.; Nieuwenhuizen, L.; Makelburg, A. B.U.; Driessens, M. H.E.; Duvekot, J. J.; Peters, M.; Middeldorp, J. M.; Bloemenkamp, K. W.M.; Schutgens, R. E.G.; Lely, A. T.; Van Galen, K. P.M. (Churchill Livingstone, 2020-01)

Women with Von Willebrand disease (VWD) have an increased risk of developing postpartum hemorrhage (PPH). Our aim is to evaluate peripartum management strategies in relation to maternal and neonatal bleeding complications ...
Desmoplastic melanoma: The role of pure and mixed subtype in sentinel lymph node biopsy and survival

Laeijendecker, Annelien E; El Sharouni, Mary-Ann; Sigurdsson, Vigfús; van Diest, Paul J (John Wiley & Sons Inc., 2020-01)

Background: Desmoplastic melanoma (DM) is an uncommon type of melanoma. Two histological subtypes of DM can be distinguished: pure and mixed (PDM and MDM). We hypothesized that discrimination between these subtypes is ...
Balancing workload of nurses: Linear mixed effects modelling to estimate required nursing time on surgical wards

van den Oetelaar, Wilhelmina Francisca Johanna Maria; van Rhenen, Willem; Stellato, Rebecca K.; Grolman, Wilko (Wiley-Blackwell Publishing Ltd, 2020-01)

Aim: Quantifying the relation between patient characteristics and care time and explaining differences in nursing time between wards. Design: Academic hospital in the Netherlands. Six surgical wards, capacity 15–30 beds, ...

Now showing items 21801-21820 of 40729