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Now showing items 21761-21780 of 40729

Long-term follow-up after rib fixation for flail chest and multiple rib fractures

Beks, Reinier B; de Jong, Mirjam B; Houwert, Roderick M; Sweet, Arthur A R; De Bruin, Ivar G J M; Govaert, Geertje A M; Wessem, Karlijn J P; Simmermacher, Rogier K J; Hietbrink, Falco; Groenwold, Rolf H H; Leenen, Luke P H (Springer International Publishing AG, 2019-08)

PURPOSE: Rib fixation for flail chest has been shown to improve in-hospital outcome, but little is known about treatment for multiple rib fractures and long-term outcome is scarce. The aim of this study was to describe the ...
Fixation of flail chest or multiple rib fractures: current evidence and how to proceed. A systematic review and meta-analysis

Beks, Reinier B; Peek, Jesse; de Jong, Mirjam B; Wessem, Karlijn J P; Öner, Cumhur F; Hietbrink, Falco; Leenen, Luke P H; Groenwold, Rolf H H; Houwert, Roderick M (Springer International Publishing AG, 2019-08)

Purpose: The aim of this systematic review and meta-analysis was to present current evidence on rib fixation and to compare effect estimates obtained from randomized controlled trials (RCTs) and observational studies. ...
Hypercholesterolemia impairs megakaryopoiesis and platelet production in scavenger receptor BI knockout mice

Ouweneel, Amber B.; Hoekstra, Menno; van der Wel, Ezra J.; Schaftenaar, Frank H.; Snip, Olga S.C.; Hassan, Jasmin; Korporaal, Suzanne J.A.; Van Eck, Miranda (Elsevier, 2019-03)

Background and aims: Thrombocytopenia in scavenger receptor BI (SR-BI) knockout mice is suggested to result from augmented platelet clearance induced by elevated intracellular unesterified cholesterol (UC) levels. We ...
Trovafloxacin-induced liver injury: lack in regulation of inflammation by inhibition of nucleotide release and neutrophil movement

Giustarini, Giulio; Vrisekoop, Nienke; Kruijssen, Laura; Wagenaar, Laura; van Staveren, Selma; van Roest, Manon; Bleumink, Rob; Bol-Schoenmakers, Marianne; Weaver, Richard; Koenderman, Leo; Smit, Joost; Pieters, Raymond (2019-02)

The fluoroquinolone trovafloxacin (TVX) is associated with a high risk of drug-induced liver injury (DILI). Although part of the liver damage by TVX+TNF relies on neutrophils, we have recently demonstrated that liver ...
Polygenic risk score as a determinant of risk of non-melanoma skin cancer in a European-descent renal transplant cohort

Stapleton, Caragh P.; Birdwell, Kelly A.; McKnight, Amy Jayne; Maxwell, Alexander P.; Mark, Patrick B.; Sanders, M. Lee; Chapman, Fiona A.; van Setten, Jessica; Phelan, Paul J.; Kennedy, Claire; Jardine, Alan; Traynor, Jamie P.; Keating, Brendan; Conlon, Peter J.; Cavalleri, Gianpiero L. (Elsevier, 2019-03)

Renal transplant recipients have an increased risk of non-melanoma skin cancer (NMSC) compared to in the general population. Here, we show polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) ...
Effectiveness of mechanical bowel preparation versus no preparation on anastomotic leakage in colorectal surgery: a systematic review and meta-analysis

Leenen, Jobbe P.L.; Hentzen, Judith E.K.R.; Ockhuijsen, Henrietta D.L. (Springer Verlag Italia, 2019-06)

It has been a standard practice to perform mechanical bowel preparation (MBP) prior to colorectal surgery to reduce the risk of colorectal anastomotic leakages (CAL). The latest Cochrane systematic review suggests there ...
O2 Pulse Patterns in Male Master Athletes with Normal and Abnormal Exercise Tests

van de Sande, Danny A J P; Schoots, Thijs; Hoogsteen, Jan; Doevendans, Pieter A; Kemps, Hareld M C (Lippincott Williams & Wilkins, 2019-01)

Purpose The clinical relevance of abnormal exercise testing (ET) results (at least 0.1 mV ST segment depression measured during exercise or recovery in three consecutive beats) in athletes without obstructive coronary ...
Structural changes in puborectalis muscle after vaginal delivery

Van de Waarsenburg, M K; van der Vaart, C H; Withagen, M I J (John Wiley & Sons Inc., 2019-02)

Objective: To evaluate the structural composition of the puborectalis muscle before and at several timepoints after first vaginal delivery, by the use of echogenicity and area measurements, in order to explore its recovery. ...
Late-onset Sepsis in Preterm Infants Can Be Detected Preclinically by Fecal Volatile Organic Compound Analysis: A Prospective, Multicenter Cohort Study

Berkhout, Daniel J C; van Keulen, Britt J; Niemarkt, Hendrik J; Bessem, Jet R; de Boode, Willem P; Cossey, Veerle; Hoogenes, Neil; Hulzebos, Christiaan V; Klaver, Ellen; Andriessen, Peter; van Kaam, Anton H; Kramer, Boris W; van Lingen, Richard A; Schouten, Aaron; van Goudoever, Johannes B; Vijlbrief, Daniel C; van Weissenbruch, Mirjam M; Wicaksono, Alfian N; Covington, James A; Benninga, Marc A; de Boer, Nanne K H; de Meij, Tim G J (Oxford University Press, 2019-01-01)

Background: The intestinal microbiota has increasingly been considered to play a role in the etiology of late-onset sepsis (LOS). We hypothesize that early alterations in fecal volatile organic compounds (VOCs), reflecting ...
Current treatment and outcomes of traumatic sternal fractures—a systematic review

Klei, Dorine; de Jong, Mirjam; Öner, FC; Leenen, Luke; van Wessem, Karlijn (Springer-Verlag, 2019-06)

PURPOSE: Traumatic sternal fractures are rare injuries. The most common mechanism of injury is direct blunt trauma to the anterior chest wall. Most (> 95%) sternal fractures are treated conservatively. Surgical fixation ...
Fib3-3 as a Biomarker for Osteoarthritis in a Rat Model with Metabolic Dysregulation

de Visser, Huub M; Sanchez, Christelle; Mastbergen, Simon C; Lafeber, Floris P J G; Henrotin, Yves E; Weinans, Harrie (SAGE Publications Inc., 2019-07)

Objective Fibulin-3 is a glycoprotein highly expressed in osteoarthritic cartilage and inhibits angiogenesis and chondrocyte differentiation. Recent studies have indicated that fibulin-3 has potential value as a biomarker ...
Trends in systolische bloeddruk in de Longitudinal Aging Study Amsterdam (LASA) tussen 1995 en 2016.

Bots, Michael L; de Boer, Annemarijn; Vaartjes, Ilonca (Nederlandse Hartstichting, 2019-11)
Kerncijfers over hart- en vaatziekten.

de Boer, Annemarijn; van Dis, I.; Vaartjes, Ilonca; Bots, Michael L (Nederlandse Hartstichting, 2019-11)
Literature Review of Case Reports on Lyme Borreliosis Associated Atrioventricular Conduction Block in Europe between the years 2000-2017

van der Heyden, MAG (Taipei : Society of Adaptive Science in Taiwan, 2019)
Fetal methotrexate syndrome: A systematic review of case reports

Verberne, Eline A.; de Haan, Emma; van Tintelen, J. Peter; Lindhout, Dick; van Haelst, Mieke M. (Elsevier, 2019-08-01)

Methotrexate is a folic acid antagonist known to be teratogenic in humans. Several cases of congenital malformations after fetal exposure to methotrexate have been published, resulting in the establishment of the ‘fetal ...
Prospective Validation of Gallium-68 Prostate Specific Membrane Antigen-Positron Emission Tomography/Computerized Tomography for Primary Staging of Prostate Cancer REPLY: Prospective Validation of Gallium-68 Prostate Specific Membrane Antigen-Positron Emission Tomography/Computerized Tomography for Primary Staging of Prostate Cancer REPLY

van Kalmthout, Ludwig W M; van Melick, Harm E; Lavalaye, Jules; Meijer, Richard P; Kooistra, Anko; de Klerk, John M H; Braat, Arthur J A T; Kaldeway, H Peter; de Bruin, P C; de Keizer, Bart; Lam, Marnix G E H (Elsevier, 2020-03)
POSEIDON trial phase 1B results: Safety, efficacy and circulating tumor DNA response of the beta isoform-sparing PI3K inhibitor taselisib (GDC-0032) combined with tamoxifen in hormone receptor positive metastatic breast cancer patients

Baird, Richard D.; van Rossum, Annelot G.J.; Oliveira, Mafalda; Beelen, Karin; Gao, Meiling; Schrier, Mariette; Mandjes, Ingrid A.M.; Garcia-Corbacho, Javier; Vallier, Anne Laure; Dougall, Greig; van Werkhoven, Erik; Linossi, Constanza; Kumar, Sanjeev; van Tinteren, Harm; Callari, Maurizio; Beddowes, Emma; Perez-Garcia, Jose Manuel; Rosing, Hilde; Platte, Else; Nederlof, Petra; Schot, Margaret; de Vries Schultink, Aurelia; Bernards, Rene; Saura, Cristina; Gallagher, William; Cortes, Javier; Caldas, Carlos; Linn, Sabine C. (American Association for Cancer Research Inc., 2019-11-15)

Purpose: The strategy of combining endocrine therapy with PI3K-mTOR inhibition has shown promise in estrogen receptor (ER)–positive breast cancer, but new agents and combinations with a better therapeutic index are urgently ...
Intestinal organoids for Cystic Fibrosis research

de Poel, E.; Lefferts, J. W.; Beekman, J. M. (Elsevier, 2020-03)

Significant progress has been made in the development of CFTR modulator therapy; however, current CFTR modulator therapies are only available for a minority of the CF-patient population. Additionally, heterogeneity in in ...
Cardiac and respiration-induced brain deformations in humans quantified with high-field MRI

Sloots, Jacob-Jan; Biessels, Geert Jan; Zwanenburg, Jaco J M (Academic Press Inc., 2020-04-15)

Microvascular blood volume pulsations due to the cardiac and respiratory cycles induce brain tissue deformation and, as such, are considered to drive the brain's waste clearance system. We have developed a high-field ...
Disease progression in paediatric- and adult-onset sclerosing cholangitis: Results from two independent Dutch registries

Joosse, Maria E.; Haisma, Sjoukje M.; Sterk, Marlou F.M.; van Munster, Kim N.; Ponsioen, Cyriel I.J.; Houwen, Roderick H.J.; Koot, Bart G.P.; de Meij, Tim; van Rheenen, Patrick F.; de Koning, Barbara A.E. (Wiley-Blackwell, 2019-09-01)

Background & Aims: Sclerosing cholangitis (SC) is a severe liver disease leading to destruction of bile ducts. It is believed to run a milder course in children than in adults. To test this assumption, we evaluated ...

Now showing items 21761-21780 of 40729