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UMC Repository: Recent submissions

  • Clinical outcomes in chronic intervillositis of unknown etiology 
    Bos, M.; Harris-Mostert, E. T.M.S.; van der Meeren, L. E.; Baelde, J. J.; Williams, D. J.; Nikkels, P. G.J.; Bloemenkamp, K. W.M.; van der Hoorn, M. L.P. (W.B. Saunders Ltd, 2020-02-01)
    Introduction: Chronic intervillositis of unknown etiology (CIUE) is a histopathological lesion of the placenta that is frequently accompanied by unfavourable pregnancy outcomes, e.g. miscarriage, fetal growth restriction ...
  • A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns 
    PCAWG Tumor Subtypes and Clinical Translation Working Group (Nature Publishing Group, 2020-02-05)
    In cancer, the primary tumour's organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as ...
  • TEG001 Insert Integrity from Vector Producer Cells until Medicinal Product 
    Straetemans, Trudy; Janssen, Anke; Jansen, Koen; Doorn, Ruud; Aarts, Tineke; van Muyden, Anna D D; Simonis, Marieke; Bergboer, Judith; de Witte, Moniek; Sebestyen, Zsolt; Kuball, Jurgen (Cell Press, 2020-02-05)
    Straetemans and colleagues characterized αβT cells engineered to express a defined γδT cell receptor (TEG001) used in a first-in-human clinical study, with TLA in combination with NGS and qPCR. They provide a rapid strategy ...
  • Three-dimensional and four-dimensional flow assessment in congenital heart disease 
    Warmerdam, Evangeline; Krings, Gregor J; Leiner, Tim; Grotenhuis, Heynric B (BMJ Publishing Group, 2020-03-01)
    Congenital heart disease (CHD) is the most common form of congenital defects, with an incidence of 8 per 1000 births. Due to major advances in diagnostics, perioperative care and surgical techniques, the survival rate of ...
  • Optimal timing for prediction of pathologic complete response to neoadjuvant chemoradiotherapy with diffusion-weighted MRI in patients with esophageal cancer 
    Borggreve, Alicia S; Heethuis, Sophie E; Boekhoff, Mick R; Goense, Lucas; van Rossum, Peter S N; Brosens, Lodewijk A A; van Lier, Astrid L H M W; van Hillegersberg, Richard; Lagendijk, Jan J W; Mook, Stella; Ruurda, Jelle P; Meijer, Gert J (Springer-Verlag, 2020-04-01)
    Objective: This study was conducted in order to determine the optimal timing of diffusion-weighted magnetic resonance imaging (DW-MRI) for prediction of pathologic complete response (pCR) to neoadjuvant chemoradiotherapy ...
  • Emerging molecular biomarkers for predicting therapy response in psoriatic arthritis: A review of literature 
    Pouw, Juliëtte; Leijten, Emmerik; Radstake, Timothy; Boes, Marianne (Academic Press Inc., 2020-02-01)
    Psoriatic arthritis (PsA) is a heterogeneous, chronic inflammatory musculoskeletal disorder that affects ~0.1% of the population. PsA may severely impact quality-of-life and constitutes a significant economic burden on our ...
  • A Population Pharmacokinetic Model of Oral Docetaxel Coadministered With Ritonavir to Support Early Clinical Development 
    Yu, Huixin; Janssen, Julie M; Sawicki, Emilia; van Hasselt, J G Coen; de Weger, Vincent A; Nuijen, Bastiaan; Schellens, Jan H M; Beijnen, Jos H; Huitema, Alwin D R (Wiley-Blackwell, 2020-03)
    Oral administration of docetaxel is an attractive alternative for conventional intravenous (IV) administration. The low bioavailability of docetaxel, however, hinders the application of oral docetaxel in the clinic. The ...
  • The risk of not receiving adjuvant chemotherapy after resection of pancreatic ductal adenocarcinoma: a nationwide analysis 
    Dutch Pancreatic Cancer Group (John Wiley & Sons Inc., 2020-02)
    Background: The relation between type of postoperative complication and not receiving chemotherapy after resection of pancreatic ductal adenocarcinoma (PDAC) is unclear. The aim was to investigate which patient factors and ...
  • Biochemical Recurrence in Prostate Cancer: The European Association of Urology Prostate Cancer Guidelines Panel Recommendations 
    Van den Broeck, Thomas; van den Bergh, Roderick C N; Briers, Erik; Cornford, Philip; Cumberbatch, Marcus; Tilki, Derya; De Santis, Maria; Fanti, Stefano; Fossati, Nicola; Gillessen, Silke; Grummet, Jeremy P; Henry, Ann M; Lardas, Michael; Liew, Matthew; Mason, Malcolm; Moris, Lisa; Schoots, Ivo G; van der Kwast, Theodorus; van der Poel, Henk; Wiegel, Thomas; Willemse, Peter-Paul M; Rouvière, Olivier; Lam, Thomas B; Mottet, Nicolas (Elsevier, 2020-03-15)
    Biochemical recurrence (BCR) after primary treatment of localized prostate cancer does not necessarily lead to clinically apparent progressive disease. To aid in prognostication, the European Association of Urology prostate ...
  • Robotic-assisted minimally invasive esophagectomy: past, present and future 
    van Boxel, Gijsbert, I; Kingma, B. Feike; Voskens, Frank J.; Ruurda, Jelle P.; van Hillegersberg, Richard (Pioneer Bioscience Publishing Company (PBPC), 2020-02)
    Esophagectomy for cancer of the esophagus is increasingly performed using minimally invasive techniques. After the introduction of minimally invasive esophagectomy (MIE) in the early 1990’s, robotic-assisted techniques ...
  • Inappropriate laboratory testing in internal medicine inpatients: Prevalence, causes and interventions 
    Vrijsen, B. E.L.; Naaktgeboren, C. A.; Vos, L. M.; van Solinge, W. W.; Kaasjager, H. A.H.; ten Berg, M. J. (Elsevier, 2020-03-01)
    Background: To reduce overutilization of laboratory testing many interventions have been tried, but selecting the most effective intervention for a given setting is challenging. To be sustainable, interventions need to ...
  • Optimization of a clofarabine-based drug combination regimen for the preclinical evaluation of pediatric acute lymphoblastic leukemia 
    Xie, Jinhan; Span, Miriam; van Maarseveen, Erik; Langenhorst, Jurgen; Boddy, Alan V; Sia, Keith C S; Sutton, Rosemary; Venn, Nicola; Punt, Arjen M; Tyrrell, Vanessa; Haber, Michelle; Trahair, Toby; Lau, Loretta; Marshall, Glenn M; Lock, Richard B (Wiley-Liss Inc., 2020-04)
    BACKGROUND: The aim of this study was to improve the predictive power of patient-derived xenografts (PDXs, also known as mouse avatars) to more accurately reflect outcomes of clofarabine-based treatment in pediatric acute ...
  • Assessment of ARX expression, a novel biomarker for metastatic risk in pancreatic neuroendocrine tumors, in endoscopic ultrasound fine-needle aspiration 
    Hackeng, Wenzel M.; Morsink, Folkert H.M.; Moons, Leon M.G.; Heaphy, Christopher M.; Offerhaus, G. Johan A.; Dreijerink, Koen M.A.; Brosens, Lodewijk A.A. (John Wiley & Sons Inc., 2020-04)
    Background: The transcription factors ARX and PDX1, and alternative lengthening of telomeres (ALT) were recently described as prognostic markers for resected non-functional pancreatic neuroendocrine tumors (PanNETs). ALT ...
  • Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies 
    Sebestyen, Zsolt; Prinz, Immo; Déchanet-Merville, Julie; Silva-Santos, Bruno; Kuball, Jurgen (Nature Research, 2020-03)
    Clinical responses to checkpoint inhibitors used for cancer immunotherapy seemingly require the presence of αβT cells that recognize tumour neoantigens, and are therefore primarily restricted to tumours with high mutational ...
  • Validation of randomized controlled trial-derived models for the prediction of postintervention outcomes in chronic limb-threatening ischemia 
    Wijnand, Joep G J; van Koeverden, Ian D; Teraa, Martin; Spreen, Marlon I; Mali, Willem P T M; van Overhagen, Hans; Pasterkamp, Gerard; de Borst, Gert J; Conte, Michael S; Gremmels, Hendrik; Verhaar, Marianne C (Mosby Inc., 2020-03)
    Background: Chronic limb-threatening ischemia (CLTI) represents the most severe form of peripheral artery disease and has a large impact on quality of life, morbidity, and mortality. Interventions are aimed at improving ...
  • Genetic Analysis of Small Well-differentiated Pancreatic Neuroendocrine Tumors Identifies Subgroups With Differing Risks of Liver Metastases 
    Pea, Antonio; Yu, Jun; Marchionni, Luigi; Noe, Michael; Luchini, Claudio; Pulvirenti, Alessandra; de Wilde, Roeland F; Brosens, Lodewijk A; Rezaee, Neda; Javed, Ammar; Gobbo, Stefano; Regi, Paolo; Salvia, Roberto; Bassi, Claudio; He, Jin; Weiss, Matthew J; Cameron, John L; Offerhaus, G Johan A; Hruban, Ralph H; Lawlor, Rita T; Scarpa, Aldo; Heaphy, Christopher M; Wood, Laura D; Wolfgang, Christopher L (Lippincott Williams & Wilkins, 2020-03-01)
    Objective:The aim of this study was to investigate the key molecular alterations in small primary pancreatic neuroendocrine tumors (PanNETs) associated with the development of liver metastases.Background:Well-differentiated ...
  • Correction to: Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI 
    Ljimani, Alexandra; Caroli, Anna; Laustsen, Christoffer; Francis, Susan; Mendichovszky, Iosif Alexandru; Bane, Octavia; Nery, Fabio; Sharma, Kanishka; Pohlmann, Andreas; Dekkers, Ilona A; Vallee, Jean-Paul; Derlin, Katja; Notohamiprodjo, Mike; Lim, Ruth P; Palmucci, Stefano; Serai, Suraj D; Periquito, Joao; Wang, Zhen Jane; Froeling, Martijn; Thoeny, Harriet C; Prasad, Pottumarthi; Schneider, Moritz; Niendorf, Thoralf; Pullens, Pim; Sourbron, Steven; Sigmund, Eric E (Springer-Verlag, 2020-02)
    The article Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI.
  • Prevalence and risk factors for carriage of ESBL-producing Enterobacteriaceae in a population of Dutch travellers: A cross-sectional study 
    Arcilla, Maris S; Van Hattem, Jarne M; Bootsma, Martin C J; van Genderen, Perry J J; Goorhuis, Abraham; Grobusch, Martin P; Klaassen, Corné H W; Oude Lashof, Astrid M; Schultsz, Constance; Stobberingh, Ellen E; de Jong, Menno D; Penders, John; Verbrugh, Henri A; Melles, Damian C (Elsevier, 2020-01)
    BACKGROUND: We investigated prevalence and predictive factors for ESBL-E carriage in a population of mostly travellers prior to their travel (n = 2216). In addition, we examined ESBL genotype before travel and compared ...
  • Is watch and wait a safe and effective way to treat rectal cancer in older patients? 
    the Dutch Watch-and-Wait Consortium (W.B. Saunders Ltd, 2020-03)
    Introduction: The aim was assess the oncological and functional outcome of the watch-and-wait (W&W) approach in older patients with a clinical (near)complete response after neoadjuvant treatment for rectal cancer. Material ...
  • Radiotherapy quality assurance for mesorectum treatment planning within the multi-center phase II STAR-TReC trial: Dutch results 
    Van Den Ende, Roy P.J.; Peters, Femke P.; Harderwijk, Ernst; Rütten, Heidi; Bouwmans, Liza; Berbee, Maaike; Canters, Richard A.M.; Stoian, Georgiana; Compagner, Kim; Rozema, Tom; De Smet, Mariska; Intven, Martijn P.W.; Tijssen, Rob H.N.; Theuws, Jacqueline; Van Haaren, Paul; Van Triest, Baukelien; Eekhout, Dave; Marijnen, Corrie A.M.; Van Der Heide, Uulke A.; Kerkhof, Ellen M. (BioMed Central, 2020-02-18)
    Background: The STAR-TReC trial is an international multi-center, randomized, phase II study assessing the feasibility of short-course radiotherapy or long-course chemoradiotherapy as an alternative to total mesorectal ...