The acquired thrombotic risk factor known as lupus anticoagulant (LA) is detected as a phospholipid-dependent prolongation of the clotting time and is the most clinically relevant antiphospholipid antibody within the ...

In my PhD thesis, I explore how cancer cells hijack processes meant for healthy tissue growth. Healthy regeneration of our intestine relies on special cells called stem cells. Stem cells get instructions from nearby cells ...

Eating disorders, such as anorexia nervosa (AN) and binge eating disorder (BED), pose a significant health burden, yet current treatment options fail to reach and cure all patients. Furthermore, there is still much to be ...

Hearing loss is one of the most common conditions worldwide. Almost half a billion people globally suffer from disabling hearing loss, and this number is expected to increase in the coming years. Hearing aids are often ...

Antibiotic resistance poses a challenge to conventional infection treatments and can alter bacterial sensitivity to components of the immune system. In chapter 2, the impact of developing resistance to the last-resort ...

The skin, the body's largest external organ, serves as the primary interface with the outside world. Psoriasis, a chronic skin condition, involves a complex interplay of immunological and environmental factors, initially ...

In recent years, the transformative potential of data science in reshaping various sectors, including healthcare, has become evident. This thesis explores the application of data science in cardiovascular research, which ...

Amyotrophic lateral sclerosis (ALS) is a devastating, fatal neurodegenerative disease with a high variability of both symptoms and associated life expectancy. People with ALS, and their families, are faced with the prospect ...

Falls – and subsequent fractures – are the primary cause of accident-related death in the elderly. Due to the ageing population, the incidence of falls and fractures increases. This thesis aims to improve the care of ...

A growing number of patients with kidney failure, mainly female, are dealing with a chronic variant of heart failure characterized by a gradual stiffening and impaired relaxation of the heart. Comorbidities, such as obesity, ...