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Now showing items 20041-20060 of 40729

TMX2 Is a Crucial Regulator of Cellular Redox State, and Its Dysfunction Causes Severe Brain Developmental Abnormalities

Vandervore, Laura V; Schot, Rachel; Milanese, Chiara; Smits, Daphne J; Kasteleijn, Esmee; Fry, Andrew E; Pilz, Daniela T; Brock, Stefanie; Börklü-Yücel, Esra; Post, Marco; Bahi-Buisson, Nadia; Sánchez-Soler, María José; van Slegtenhorst, Marjon; Keren, Boris; Afenjar, Alexandra; Coury, Stephanie A; Tan, Wen-Hann; Oegema, Renske; de Vries, Linda S; Fawcett, Katherine A; Nikkels, Peter G J; Bertoli-Avella, Aida; Al Hashem, Amal; Alwabel, Abdulmalik A; Tlili-Graiess, Kalthoum; Efthymiou, Stephanie; Zafar, Faisal; Rana, Nuzhat; Bibi, Farah; Houlden, Henry; Maroofian, Reza; Person, Richard E; Crunk, Amy; Savatt, Juliann M; Turner, Lisbeth; Doosti, Mohammad; Karimiani, Ehsan Ghayoor; Saadi, Nebal Waill; Akhondian, Javad; Lequin, Maarten H; Kayserili, Hülya; van der Spek, Peter J; Jansen, Anna C; Kros, Johan M; Verdijk, Robert M; Milošević, Nataša Jovanov; Fornerod, Maarten; Mastroberardino, Pier Giorgio; Mancini, Grazia M S (Cell Press, 2019-12-05)

The redox state of the neural progenitors regulates physiological processes such as neuronal differentiation and dendritic and axonal growth. The relevance of endoplasmic reticulum (ER)-associated oxidoreductases in these ...
Metabolic fingerprinting reveals extensive consequences of GLS hyperactivity

Rumping, Lynne; Pras-Raves, Mia L; Gerrits, Johan; Tang, Yuen Fung; Willemsen, Marcel A; Houwen, Roderick H J; van Haaften, Gijs; van Hasselt, Peter M; Verhoeven-Duif, Nanda M; Jans, Judith J M (Elsevier, 2020-03-01)

Background: High glutaminase (GLS;EC3.5.1.2) activity is an important pathophysiological phenomenon in tumorigenesis and metabolic disease. Insight into the metabolic consequences of high GLS activity contributes to the ...
Forskolin-induced swelling of intestinal organoids correlates with disease severity in adults with cystic fibrosis and homozygous F508del mutations

de Winter-de Groot, Karin M; Berkers, Gitte; Marck-van der Wilt, Rozemarijn E P; van der Meer, Renske; Vonk, Annelotte; Dekkers, Johanna F; Geerdink, Margot; Michel, Sabine; Kruisselbrink, Evelien; Vries, Rob; Clevers, Hans; Vleggaar, Frank P; Elias, Sjoerd G; Heijerman, Harry G M; van der Ent, Cornelis K; Beekman, Jeffrey M (Elsevier, 2020-07)

BACKGROUND: CFTR function measurements in intestinal organoids may help to better characterise individual disease expression in F508del homozygous people. Our objective was to study correlations between CFTR function as ...
Multifactorial risk factors for mortality after chemotherapy and radiotherapy for non-small cell lung cancer

Defraene, Gilles; Dankers, Frank J W M; Price, Gareth; Schuit, Ewoud; van Elmpt, Wouter; Arredouani, Soumia; Lambrecht, Maarten; Nuyttens, Joost; Faivre-Finn, Corinne; De Ruysscher, Dirk (Elsevier Ireland Ltd, 2020-11)

BACKGROUND AND PURPOSE: A higher radiation dose to the heart is known to be associated with increased mortality in non-small cell lung cancer (NSCLC) patients. It is however unknown what the contribution of the heart dose ...
Neonatal care bundles are associated with a reduction in the incidence of intraventricular haemorrhage in preterm infants: a multicentre cohort study

de Bijl-Marcus, Karen; Brouwer, Annemieke Johanna; De Vries, Linda S; Groenendaal, Floris; Wezel-Meijler, Gerda van (BMJ Publishing Group, 2020-07-01)

Objective: To investigate the effect of a nursing intervention bundle, applied during the first 72 hours of life, on the incidence of germinal matrix-intraventricular haemorrhage (GMH-IVH) in very preterm infants. Design: ...
Increased number of T-lymphocytes in post-mortem brain tissue of patients with schizophrenia.

Sneeboer, Marjolein A.M.; van Mierlo, Hans C.; Stotijn, Evi; MacIntyre, Donald J.; Smith, Colin; Kahn, René S.; Hol, Elly M.; de Witte, Lot D. (Elsevier, 2020-02)
Extended steep ramp test normative values for 19-24-year-old healthy active young adults

Werkman, M S; Bongers, B C; Blatter, T; Takken, T; Wittink, H (Springer-Verlag, 2020-01-01)

PURPOSE: To extend currently available sex and age-specific normative values in children and adolescents for the peak work rate (WRpeak) attained at the steep ramp test (SRT) to healthy active young adults. METHODS: Healthy ...
Mechanical methods for induction of labour

de Vaan, Marieke Dt; Ten Eikelder, Mieke Lg; Jozwiak, Marta; Palmer, Kirsten R; Davies-Tuck, Miranda; Bloemenkamp, Kitty Wm; Mol, Ben Willem J; Boulvain, Michel (John Wiley & Sons Inc., 2019-10-18)

Background: Mechanical methods were the first methods developed to ripen the cervix and induce labour. During recent decades they have been substituted by pharmacological methods. Potential advantages of mechanical methods, ...
Clinical characteristics of women captured by extending the definition of severe postpartum haemorrhage with 'refractoriness to treatment': a cohort study

TeMpOH-1 study group (BioMed Central, 2019-10-17)

BACKGROUND: The absence of a uniform and clinically relevant definition of severe postpartum haemorrhage hampers comparative studies and optimization of clinical management. The concept of persistent postpartum haemorrhage, ...
Association of Copy Number Variation of the 15q11.2 BP1-BP2 Region With Cortical and Subcortical Morphology and Cognition

ENIGMA-CNV Working Group (American Medical Association, 2020-04-01)

Importance: Recurrent microdeletions and duplications in the genomic region 15q11.2 between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental disorders. These structural variants are present in 0.5% ...
Mass balance and metabolite profiling of 14C-guadecitabine in patients with advanced cancer

Roosendaal, Jeroen; Rosing, Hilde; Lucas, Luc; Gebretensae, Abadi; Huitema, Alwin D R; van Dongen, Marloes G; Beijnen, Jos H; Oganesian, Aram (Kluwer Academic Publishers, 2020-08-01)

Purpose The objective of this mass balance trial was to determine the excretory pathways and metabolic profile of the novel anticancer agent guadecitabine in humans after administration of a 14C-radiolabeled dose of ...
Exposure-response analyses of abiraterone and its metabolites in real-world patients with metastatic castration-resistant prostate cancer

van Nuland, M; Groenland, S L; Bergman, A M; Steeghs, N; Rosing, H; Venekamp, N; Huitema, A D R; Beijnen, J H (Springer Nature, 2020-06)

BACKGROUND: Abiraterone acetate is an oral 17α-hydroxylase/C17,20-lyase (CYP17) inhibitor approved for the treatment of metastatic castration-resistant prostate cancer (mCPRC) patients. Previously, a prospective observational ...
Possibilities and limitations of an in vitro three-dimensional bone marrow model for the prediction of clinical responses in patients with relapsed multiple myeloma

Braham, Maaike V.J.; Alblas, Jacqueline; Dhert, Wouter J.A.; Öner, F. Cumhur; Minnema, Monique C. (Ferrata Storti Foundation, 2019-10-30)
Successful treatment of post-traumatic stress disorder reverses DNA methylation marks

Vinkers, Christiaan H.; Geuze, Elbert; van Rooij, Sanne J.H.; Kennis, Mitzy; Schür, Remmelt R.; Nispeling, Danny M.; Smith, Alicia K.; Nievergelt, Caroline M.; Uddin, Monica; Rutten, Bart P.F.; Vermetten, Eric; Boks, Marco P. (Springer Nature, 2021-04)

Epigenetic mechanisms play a role in the detrimental effects of traumatic stress and the development of post-traumatic stress disorder (PTSD). However, it is unknown whether successful treatment of PTSD restores these ...
Congenital Uterine Malformation by Experts (CUME): diagnostic criteria for T-shaped uterus

Ludwin, A; Coelho Neto, M A; Ludwin, I; Nastri, C O; Costa, W; Acién, M; Alcazar, J L; Benacerraf, B; Condous, G; DeCherney, A; De Wilde, R-L; Diamond, M P; Emanuel, M H; Guerriero, S; Hurd, W; Levine, D; Lindheim, S; Pellicer, A; Petraglia, F; Saridogan, E; Martins, W P (John Wiley & Sons Inc., 2020-06)

OBJECTIVES: To identify uterine measurements that are reliable and accurate to distinguish between T-shaped and normal/arcuate uterus, and define T-shaped uterus, using Congenital Uterine Malformation by Experts (CUME) ...
Optimizing Survival Predictions of Hypopharynx Cancer: Development of a Clinical Prediction Model

Arends, Coralie R; Petersen, Japke F; van der Noort, Vincent; Timmermans, Adriana J; Leemans, C René; de Bree, Remco; van den Brekel, Michiel W M; Stuiver, Martijn M (John Wiley & Sons Inc., 2020-09-01)

Objectives: To develop and validate a clinical prediction model (CPM) for survival in hypopharynx cancer, thereby aiming to improve individualized estimations of survival. Methods: Retrospective cohort study of hypopharynx ...
Two-dimensional ultrasound measurements vs. magnetic resonance imaging-derived ventricular volume of preterm infants with germinal matrix intraventricular haemorrhage

Beijst, Casper; Dudink, Jeroen; Wientjes, Rens; Benavente-Fernandez, Isabel; Groenendaal, Floris; Brouwer, Margaretha J.; Išgum, Ivana; de Jong, Hugo W.A.M.; de Vries, Linda S. (Springer-Verlag, 2020-02-01)

Background: Post-haemorrhagic ventricular dilatation can be measured accurately by MRI. However, two-dimensional (2-D) cranial US can be used at the bedside on a daily basis. Objective: To assess whether the ventricular ...
PICU Admission Rates in Pediatric Cancer and Hematopoietic Stem Cell Transplant Patients Receiving High-flow Nasal Cannula Oxygen Therapy on the General Ward

Van Dorst, Mila; Van Gestel, Josephus P.J.; Van Grotel, Martine; Versluijs, Birgitta; Van Den Heuvel-Eibrink, Marry M.; Nijman, Joppe; Wösten-Van Asperen, Roelie M. (Lippincott Williams & Wilkins, 2020-01-01)

Summary:The use of high-flow nasal cannula (HFNC) oxygen therapy is growing as an alternative to standard oxygen. However, its use in patients treated for malignancies, including hematopoietic stem cell transplantation ...
Dynamics of intestinal carriage of Extended-spectrum Beta-lactamase producing Enterobacteriaceae in the Dutch general population (2014-2016)

van den Bunt, Gerrita; Fluit, Ad C; Bootsma, Martin C J; Duijkeren, Engeline van; Scharringa, Jelle; Pelt, Wilfrid van; Bonten, Marc J M (Oxford University Press, 2020-10-15)

BACKGROUND: In the Netherlands, the prevalence of intestinal extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) carriage in community-dwelling subjects is ~5%. Little is known about the dynamics of ...
A polygenic resilience score moderates the genetic risk for schizophrenia

The Schizophrenia Working Group of the Psychiatric Genomics Consortium; Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH) (Springer Nature, 2021-03)

Based on the discovery by the Resilience Project (Chen R. et al. Nat Biotechnol 34:531–538, 2016) of rare variants that confer resistance to Mendelian disease, and protective alleles for some complex diseases, we posited ...

Now showing items 20041-20060 of 40729