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An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci

Traumatic Stress Brain Study Group (Springer-Verlag, 2020-03-14)

BACKGROUND: Previous studies using candidate gene and genome-wide approaches have identified epigenetic changes in DNA methylation (DNAm) associated with posttraumatic stress disorder (PTSD). METHODS: In this study, we ...
Voxel-based morphometry and cortical thickness in combat veterans suffering from impulsive aggression

Varkevisser, Tim; van Lutterveld, Remko; Heesink, Lieke; van Honk, Jack; Geuze, Elbert (Cambridge University Press, 2021-06)

BACKGROUND: Problems with impulsive aggression occur in many forms of psychiatric dysfunction, and are a common complaint among combat veterans. The present study sought to examine the neuroanatomical correlates of ...
Proceedings from the 3rd European Clinical Consensus Conference for clinical trials in device-based hypertension therapies

Mahfoud, Felix; Azizi, Michel; Ewen, Sebastian; Pathak, Atul; Ukena, Christian; Blankestijn, Peter J; Böhm, Michael; Burnier, Michel; Chatellier, Gilles; Durand Zaleski, Isabelle; Grassi, Guido; Joner, Michael; Kandzari, David E; Kirtane, Ajay; Kjeldsen, Sverre E; Lobo, Melvin D; Lüscher, Thomas F; McEvoy, John William; Parati, Gianfranco; Rossignol, Patrick; Ruilope, Luis; Schlaich, Markus P; Shahzad, Atif; Sharif, Faisal; Sharp, Andrew S P; Sievert, Horst; Volpe, Massimo; Weber, Michael A; Schmieder, Roland E; Tsioufis, Costas; Wijns, William (Oxford University Press, 2020-04-21)
Multifocal cardiovascular calcification in patients with established cardiovascular disease; prevalence, risk factors, and relation with recurrent cardiovascular disease

On behalf of the UCC-SMART-study group (Elsevier, 2020-04-01)

Aims: The aim is to investigate (multifocal) cardiovascular calcification in patients with established cardiovascular disease (CVD), regarding prevalence, risk factors, and relation with recurrent CVD or vascular interventions. ...
Cardiovascular risk factors and the risk of major adverse limb events in patients with symptomatic cardiovascular disease

Hageman, Steven H.J.; De Borst, Gert Jan; Dorresteijn, Johannes A.N.; Bots, Michiel L.; Westerink, Jan; Asselbergs, Folkert W.; Visseren, Frank L.J. (BMJ Publishing Group, 2020-11-01)

AIM: To determine the relationship between non-high-density lipoprotein cholesterol (non-HDL-c), systolic blood pressure (SBP) and smoking and the risk of major adverse limb events (MALE) and the combination with major ...
Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel

Borén, Jan; Chapman, M John; Krauss, Ronald M; Packard, Chris J; Bentzon, Jacob F; Binder, Christoph J; Daemen, Mat J; Demer, Linda L; Hegele, Robert A; Nicholls, Stephen J; Nordestgaard, Børge G; Watts, Gerald F; Bruckert, Eric; Fazio, Sergio; Ference, Brian A; Graham, Ian; Horton, Jay D; Landmesser, Ulf; Laufs, Ulrich; Masana, Luis; Pasterkamp, Gerard; Raal, Frederick J; Ray, Kausik K; Schunkert, Heribert; Taskinen, Marja-Riitta; van de Sluis, Bart; Wiklund, Olov; Tokgozoglu, Lale; Catapano, Alberico L; Ginsberg, Henry N (Oxford University Press, 2020-06-21)
Circulating Neutrophils Do Not Predict Subclinical Coronary Artery Disease in Women with Former Preeclampsia

Meeuwsen, John A.L.; de Vries, Judith; Zoet, Gerbrand A.; Franx, Arie; Fauser, Bart C.J.M.; Maas, Angela H.E.M.; Velthuis, Birgitta K.; Appelman, Yolande E.; Visseren, Frank L.; Pasterkamp, Gerard; Hoefer, Imo E.; van Rijn, Bas B.; den Ruijter, Hester M.; de Jager, Saskia C.A. (Multidisciplinary Digital Publishing Institute (MDPI), 2020-02-18)

: Introduction: Preeclampsia (PE) represents a hypertensive pregnancy disorder that is associated with increased cardiovascular disease (CVD) risk. This increased risk has been attributed to accelerated atherosclerosis, ...
Linear systems analysis for laminar fMRI: Evaluating BOLD amplitude scaling for luminance contrast manipulations

van Dijk, Jelle A; Fracasso, Alessio; Petridou, Natalia; Dumoulin, Serge O (Nature Publishing Group, 2020-12-01)

A fundamental assumption of nearly all functional magnetic resonance imaging (fMRI) analyses is that the relationship between local neuronal activity and the blood oxygenation level dependent (BOLD) signal can be described ...
Prevalence and Outcomes of Infection Among Patients in Intensive Care Units in 2017

EPIC III Investigators (American Medical Association, 2020-04-21)

Importance: Infection is frequent among patients in the intensive care unit (ICU). Contemporary information about the types of infections, causative pathogens, and outcomes can aid the development of policies for prevention, ...
Author Correction: Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse (Nature Neuroscience, (2016), 19, 8, (1019-1024), 10.1038/nn.4334)

Meye, Frank J; Soiza-Reilly, Mariano; Smit, Tamar; Diana, Marco A; Schwarz, Martin K; Mameli, Manuel (Nature Research, 2020-04)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

for the 16p11.2 European Consortium, for the ENIGMA-CNV working group (Springer Nature, 2020-03-01)

Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We ...
The genetic architecture of the human cerebral cortex

Alzheimer's Disease Neuroimaging Initiative (American Association for the Advancement of Science, 2020-03-20)

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, ...
Preclinical Detection of Non-catheter Related Late-onset Sepsis in Preterm Infants by Fecal Volatile Compounds Analysis: A Prospective, Multi-center Cohort Study

Berkhout, Daniel J C; Niemarkt, Hendrik J; Andriessen, Peter; Vijlbrief, Daniel C; Bomers, Marije K; Cossey, Veerle; Hulzebos, Christian V; van Kaam, Anton H; Kramer, Boris W; van Lingen, Richard A; Wicaksono, Alfian N; Covington, James A; van Weissenbruch, Mirjam M; Benninga, Marc A; de Boer, Nanne K H; de Meij, Tim G J (Lippincott Williams & Wilkins, 2020-04-01)

BACKGROUND: Late onset sepsis (LOS) in preterm infants is preceded by fecal volatile organic compound (VOC) alterations, suggesting an etiologic role of gut microbiota in LOS rather than being primarily caused by central ...
ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

for the ENIGMA Consortium (Nature Publishing Group, 2020-03-20)

This review summarizes the last decade of work by the ENIGMA (Enhancing NeuroImaging Genetics through Meta Analysis) Consortium, a global alliance of over 1400 scientists across 43 countries, studying the human brain in ...
Minimally Invasive Esophagectomy: A Consensus Statement

Cerfolio, Robert J; Laliberte, Anne-Sophie; Blackmon, Shanda; Ruurda, Jelle P; van Hillegersberg, Richard; Sarkaria, Inderpal; Louie, Brian E (Elsevier, 2020-10)

Background: Minimally invasive esophagectomy (MIE) is increasingly performed in various ways. The lack of international definitions and nomenclature makes accurate comparison of outcomes difficult. Methods: An international, ...
Safety and feasibility of minimally invasive surgical interventions for esophageal and gastric cancer in the acute setting: a nationwide cohort study

Dutch Upper G.I. Cancer Audit (DUCA) group (Springer New York, 2021-03)

BACKGROUND: Minimally invasive esophagectomy and gastrectomy are increasingly performed and might be superior to their open equivalents in an elective setting. The aim of this study was to evaluate whether minimally invasive ...
New automated analysis to monitor neutrophil function point-of-care in the intensive care unit after trauma

Hesselink, Lillian; Spijkerman, Roy; de Fraiture, Emma; Bongers, Suzanne; Van Wessem, Karlijn J P; Vrisekoop, Nienke; Koenderman, Leo; Leenen, Luke P H; Hietbrink, Falco (Springer Science + Business Media, 2020-03-14)

BACKGROUND: Patients often develop infectious complications after severe trauma. No biomarkers exist that enable early identification of patients who are at risk. Neutrophils are important immune cells that combat these ...
On the origin of low-density neutrophils

Hassani, Marwan; Hellebrekers, Pien; Chen, Na; van Aalst, Corneli; Bongers, Suus; Hietbrink, Falco; Koenderman, Leo; Vrisekoop, Nienke (Oxford University Press, 2020-05-01)

Here we elaborate on the origin of low(er)-density neutrophils (LDNs) to better understand the variation found in literature. Supplemented with original data, we test the hypothesis that buoyant density of neutrophils is ...
Patient-reported burden of intensified surveillance and surgery in high-risk individuals under pancreatic cancer surveillance

Overbeek, Kasper A; Cahen, Djuna L; Kamps, Anne; Konings, Ingrid C A W; Harinck, Femme; Kuenen, Marianne A; Koerkamp, Bas Groot; Besselink, Marc G; van Eijck, Casper H; Wagner, Anja; Ausems, Margreet G E; van der Vlugt, Manon; Fockens, Paul; Vleggaar, Frank P; Poley, Jan-Werner; van Hooft, Jeanin E; Bleiker, Eveline M A; Bruno, Marco J; Dutch Familial Pancreatic Cancer Surveillance Study Group (Springer Netherlands, 2020-07)

In high-risk individuals participating in a pancreatic cancer surveillance program, worrisome features warrant for intensified surveillance or, occasionally, surgery. Our objectives were to determine the patient-reported ...
Computer-Aided Diagnosis in Multiparametric Magnetic Resonance Imaging Screening of Women With Extremely Dense Breasts to Reduce False-Positive Diagnoses

Verburg, Erik; van Gils, Carla H; Bakker, Marije F; Viergever, Max A; Pijnappel, Ruud M; Veldhuis, Wouter B; Gilhuijs, Kenneth G A (Lippincott Williams & Wilkins, 2020-07)

OBJECTIVES: To reduce the number of false-positive diagnoses in the screening of women with extremely dense breasts using magnetic resonance imaging (MRI), we aimed to predict which BI-RADS 3 and BI-RADS 4 lesions are ...

Now showing items 19561-19580 of 40729