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Now showing items 19281-19300 of 40729

Involvement of ADAMTS13 and von Willebrand factor in thromboembolic events in patients infected with SARS-CoV-2

Huisman, Albert; Beun, Robert; Sikma, Maaike; Westerink, Jan; Kusadasi, Nuray (Wiley-Blackwell, 2020-10-01)
Supporting learners' self-regulated learning in Massive Open Online Courses

Jansen, Renée; van Leeuwen, Anouschka; Janssen, Jeroen; Conijn, Rianne; Kester, L. (Elsevier Limited, 2020-03)

In MOOCs, learners are typically presented with great autonomy over their learning process. Therefore, learners should engage in self-regulated learning (SRL) in order to successfully study in a MOOC. Learners however often ...
Extracellular Matrix Analysis of Human Renal Arteries in Both Quiescent and Active Vascular State

van Dijk, Christian G M; Louzao-Martinez, Laura; van Mulligen, Elise; Boermans, Bart; Demmers, Jeroen A A; van den Bosch, Thierry P P; Goumans, Marie-José; Duncker, Dirk J; Verhaar, Marianne C; Cheng, Caroline (Multidisciplinary Digital Publishing Institute (MDPI), 2020-06)

In vascular tissue engineering strategies, the addition of vascular-specific extracellular matrix (ECM) components may better mimic the in vivo microenvironment and potentially enhance cell-matrix interactions and subsequent ...
gamma 9 delta 2T cell diversity and the receptor interface with tumor cells

Vyborova, Anna; Beringer, Dennis X; Fasci, Domenico; Karaiskaki, Froso; van Diest, Eline; Kramer, Lovro; de Haas, Aram; Sanders, Jasper; Janssen, Anke; Straetemans, Trudy; Olive, Daniel; Leusen, Jeanette Hw; Boutin, Lola; Nedellec, Steven; Schwartz, Samantha L; Wester, Michael J; Lidke, Keith A; Scotet, Emmanuel; Lidke, Diane; Heck, Albert Jr; Sebestyen, Zsolt; Kuball, Jurgen (American Society for Clinical Investigation, 2020-09-01)

γ9δ2T cells play a major role in cancer immune surveillance, yet the clinical translation of their in vitro promise remains challenging. To address limitations of previous clinical attempts using expanded γ9δ2T cells, we ...
Two Randomized Controlled Trials of Bacillus Calmette-Guerin Vaccination to reduce absenteeism among health care workers and hospital admission by elderly persons during the COVID-19 pandemic: A structured summary of the study protocols for two randomised controlled trials: A structured summary of the study protocols for two randomised controlled trials

BCG-CORONA study team# (BioMed Central, 2020-06-05)

OBJECTIVES: The objectives of these two separate trials are: (1) to reduce health care workers (HCWs) absenteeism; and (2) to reduce hospital admission among the elderly during the COVID-19 pandemic through BCG vaccination. ...
Surgical management and pathological assessment of pancreatoduodenectomy with venous resection: an international survey among surgeons and pathologists

Dutch Pancreatic Cancer Group (John Wiley & Sons Inc., 2021-01)

BACKGROUND: The aim of this survey was to gain insights in the current surgical management and pathological assessment of pancreatoduodenectomy with portal-superior mesenteric vein resection (VR). METHODS: A systematic ...
Performance of gastrointestinal pathologists within a national digital review panel for Barrett's oesophagus in the Netherlands: results of 80 prospective biopsy reviews

Klaver, Esther; van der Wel, Myrtle; Duits, Lucas; Pouw, Roos; Seldenrijk, Kees; Offerhaus, Johan; Visser, Mike; Ten Kate, Fiebo; Biermann, Katharina; Brosens, Lodewijk; Doukas, Michael; Huysentruyt, Clément; Karrenbeld, Arend; Kats-Ugurlu, Gursah; van der Laan, Jaap; van Lijnschoten, Ineke; Moll, Freek; Ooms, Ariadne; Tijssen, Jan; Meijer, Sybren; Bergman, Jacques (BMJ Publishing Group, 2021-01-01)

AIMS: The histopathological diagnosis of low-grade dysplasia (LGD) in Barrett's oesophagus (BO) is associated with poor interobserver agreement and guidelines dictate expert review. To facilitate nationwide expert review ...
Patient engagement in research on rare gynecological tumors

Roze, Joline; Groeneweg, Jolijn; Monroe, Glen; Fransen, Ineke; Gultekin, Murat; Zweemer, Ronald; Verheijen, Rene H M (Lippincott Williams & Wilkins, 2020-12-01)
Effects of bumetanide on neurodevelopmental impairments in patients with tuberous sclerosis complex: An open-label pilot study

Van Andel, Dorinde M.; Sprengers, Jan J.; Oranje, Bob; Scheepers, Floortje E.; Jansen, Floor E.; Bruining, Hilgo (BioMed Central, 2020-05-07)

Background: Tuberous sclerosis complex (TSC) is an autosomal dominant disease that affects multiple organs including the brain. TSC is strongly associated with broad neurodevelopmental disorders, including autism spectrum ...
Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis

Nabais, Marta F.; Lin, Tian; Benyamin, Beben; Williams, Kelly L.; Garton, Fleur C.; Vinkhuyzen, Anna A.E.; Zhang, Futao; Vallerga, Costanza L.; Restuadi, Restuadi; Freydenzon, Anna; Zwamborn, Ramona A.J.; Hop, Paul J.; Robinson, Matthew R.; Gratten, Jacob; Visscher, Peter M.; Hannon, Eilis; Mill, Jonathan; Brown, Matthew A.; Laing, Nigel G.; Mather, Karen A.; Sachdev, Perminder S.; Ngo, Shyuan T.; Steyn, Frederik J.; Wallace, Leanne; Henders, Anjali K.; Needham, Merrilee; Veldink, Jan H.; Mathers, Susan; Nicholson, Garth; Rowe, Dominic B.; Henderson, Robert D.; McCombe, Pamela A.; Pamphlett, Roger; Yang, Jian; Blair, Ian P.; McRae, Allan F.; Wray, Naomi R. (Nature Publishing Group, 2020-12-01)

We conducted DNA methylation association analyses using Illumina 450K data from whole blood for an Australian amyotrophic lateral sclerosis (ALS) case–control cohort (782 cases and 613 controls). Analyses used mixed linear ...
Chorea is a pleiotropic clinical feature of mutated fused-in-sarcoma in amyotrophic lateral sclerosis

Flies, C. M.; Veldink, J. H. (Informa Healthcare, 2020-05)

Around 10% of all amyotrophic lateral sclerosis (ALS) cases are familial and around 3–5% are fused-in-sarcoma (FUS)-related in Europe. We report a 43-year-old patient with a pathogenic FUS mutation (c.1561C>G p.(Arg521Gly) ...
Genetic cross-disorder analysis in psychiatry: From methodology to clinical utility

Schijven, Dick; Veldink, Jan H.; Luykx, Jurjen J. (Cambridge University Press, 2020-05-01)

Genome-wide association studies have uncovered hundreds of loci associated with psychiatric disorders. Cross-disorder studies are among the prime ramifications of such research. Here, we discuss the methodology of the most ...
ExpansionHunter Denovo: A computational method for locating known and novel repeat expansions in short-read sequencing data

Dolzhenko, Egor; Bennett, Mark F.; Richmond, Phillip A.; Trost, Brett; Chen, Sai; Van Vugt, Joke J.F.A.; Nguyen, Charlotte; Narzisi, Giuseppe; Gainullin, Vladimir G.; Gross, Andrew M.; Lajoie, Bryan R.; Taft, Ryan J.; Wasserman, Wyeth W.; Scherer, Stephen W.; Veldink, Jan H.; Bentley, David R.; Yuen, Ryan K.C.; Bahlo, Melanie; Eberle, Michael A. (BioMed Central, 2020-04-28)

Repeat expansions are responsible for over 40 monogenic disorders, and undoubtedly more pathogenic repeat expansions remain to be discovered. Existing methods for detecting repeat expansions in short-read sequencing data ...
What does age at onset in ALS tell us about the genetic basis of the disease?

Veldink, Jan Herman (BMJ Publishing Group, 2019-03)
The project MinE databrowser: bringing large-scale whole-genome sequencing in ALS to researchers and the public

Project MinE ALS Sequencing Consortium¶ (Informa Healthcare, 2019-08)

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive fatal neurodegenerative disease affecting one in 350 people. The aim of Project MinE is to elucidate the pathophysiology of ALS through whole-genome sequencing ...
Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy

Project MinE ALS GWAS Consortium; International League Against Epilepsy Consortium on Complex Epilepsies (Elsevier, 2020-08)

Because hyper-excitability has been shown to be a shared pathophysiological mechanism, we used the latest and largest genome-wide studies in amyotrophic lateral sclerosis (n = 36,052) and epilepsy (n = 38,349) to determine ...
Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids

van den Brink, Susanne C.; Alemany, Anna; van Batenburg, Vincent; Moris, Naomi; Blotenburg, Marloes; Vivié, Judith; Baillie-Johnson, Peter; Nichols, Jennifer; Sonnen, Katharina F.; Martinez Arias, Alfonso; van Oudenaarden, Alexander (Nature Research, 2020-06-18)

Gastruloids are three-dimensional aggregates of embryonic stem cells that display key features of mammalian development after implantation, including germ-layer specification and axial organization1–3. To date, the expression ...
Humans are animals, but are animals human enough? A systematic review and meta-analysis on interspecies differences in renal drug clearance

Jansen, Katja; Pou Casellas, Carla; Groenink, Lucianne; Wever, Kimberley E.; Masereeuw, Rosalinde (Elsevier Limited, 2020-04)

Various animal models are used to study pharmacokinetics (PK) of drugs in development. Human renal clearance (CLr) should be predictable through interpolation from animal data by allometric scaling. Based on this premise, ...
Crowning the Kinetochore: The Fibrous Corona in Chromosome Segregation

Kops, Geert J.P.L.; Gassmann, Reto (Elsevier Limited, 2020-08)

The kinetochore is at the heart of chromosome segregation in mitosis and meiosis. Rather than a static linker complex for chromatin and spindle microtubules, it is highly dynamic in composition, size, and shape. While known ...
Airway organoids as models of human disease

van der Vaart, J.; Clevers, H. (Wiley-Blackwell, 2021-05)

Studies developing and applying organoid technology have greatly increased in volume and visibility over the past decade. Organoids are three-dimensional structures that are established from pluripotent stem cells (PSCs) ...

Now showing items 19281-19300 of 40729